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Journal Articles

Spliceosome mutations: 1 plus 1 does not always equal 2

Andrea Pellagatti, Jacqueline Boultwood
Journal: Blood
Blood (2020) 136 (13): 1471–1472.
https://doi.org/10.1182/blood.2020008215
Published: 2020
Journal Articles

UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells

Samantha A. Swenson, Tyler J. Gilbreath, Heather Vahle, R. Willow Hynes-Smith, Jared H. Graham, Henry C.-H. Law, Catalina Amador, Nicholas T. Woods, Michael R. Green, Shannon M. Buckley
Journal: Blood
Blood (2020) 136 (3): 299–312.
https://doi.org/10.1182/blood.2019002102
Published: 2020
Includes: Supplemental data
Journal Articles

CTX-712, a Novel Clk Inhibitor Targeting Myeloid Neoplasms with SRSF2 Mutation

Akinori Yoda, PhD, Daisuke Morishita, PhD, Akio Mizutani, PhD, Yoshihiko Satoh, PhD, Yotaro Ochi, MD, Yasuhito Nannya, MD PhD, Hideki Makishima, MD PhD, Hiroshi Miyake, PhD, Seishi Ogawa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 404.
https://doi.org/10.1182/blood-2019-131559
Published: 2019
Journal Articles

Results of a Clinical Trial of H3B-8800, a Splicing Modulator, in Patients with Myelodysplastic Syndromes (MDS), Acute Myeloid Leukemia (AML) or Chronic Myelomonocytic Leukemia (CMML)

David P. Steensma, MD, Martin Wermke, MD, Virginia M. Klimek, MD, Peter L Greenberg, MD, Patricia Font, Rami S. Komrokji, MD, Jay Yang, MD, Andrew M. Brunner, MD, Hetty E. Carraway, MD MBA, Lionel Ades, MD PhD, Aref Al-Kali, MD, Juan Manuel Alonso Dominguez, MD PhD MSc, Ana Alonso, MD, Catherine C. Coombs, MD, H. Joachim Deeg, MD, William B. Donnellan, MD, James M. Foran, MD, Guillermo Garcia-Manero, MD, Michael B. Maris, MD, Malgorzata McMasters, MD, Jean-Baptiste Micol, MD, Jaime Perez De Oteyza, MD PhD, Felicitas Thol, MD, Eunice S. Wang, MD, Justin M. Watts, MD, Silvia Buonamici, PhD, Amy Kim, MSPh PhD, Vikram Gourineni, MS, PharmD, Alyssa J Marino, Nathalie Rioux, MSc, PhD, Joanne Schindler, MD, Sherri Smith, MS, Huilan Yao, PhD, Xiaobin Yuan, Kun Yu, PhD, Uwe Platzbecker
Journal: Blood
Blood (2019) 134 (Supplement_1): 673.
https://doi.org/10.1182/blood-2019-123854
Published: 2019
Journal Articles

SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Acute Myeloid Leukemia Models

Heekyung Chung, PhD, Emily Creger, Lauren Sitts, Kevin Chiu, Chi-Ching Mak, PhD, Sunil KC, PhD, Betty Tam, PhD, Gail Bucci, Josh Stewart, Timothy Phalen, PhD, Steven Cha, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1377.
https://doi.org/10.1182/blood-2019-130500
Published: 2019
Journal Articles

Identification of Novel Therapeutic Targets in Atm-Deficient Lymphomas Using a Whole Genome CRISPR/CAS-9 Screen

Tatjana Stankovic, MD PhD, Nicholas Davies, PhD, Louise J Tee, Andrew D Beggs, Malcolm Taylor, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1504.
https://doi.org/10.1182/blood-2019-129974
Published: 2019
Journal Articles

Use of Machine Learning in 2074 Cases of Acute Myeloid Leukemia for Genetic Risk Profiling

Shaun Fleming, MBBS,, Cheng-Hong Tsai, MD MSc, Hartmut Döhner, MD, Konstanze Döhner, Elli Papaemmanuil, PhD, Hwei-Fang Tien, MD, PhD, John Reynolds, PhD, Andrew H. Wei, PhD FRACP, FRCPA, MBBS, Hsin-An Hou
Journal: Blood
Blood (2019) 134 (Supplement_1): 1392.
https://doi.org/10.1182/blood-2019-128243
Published: 2019
Journal Articles

Impact of Somatic Mutations on Outcome in Patients > 60 Years Old with Newly Diagnosed AML Treated with Response-Adapted Sequential Azacitidine and Induction Chemotherapy within the DRKS00004519 Trial (RAS-AZIC) of the East German Study Group of Hematology and Oncology (OSHO)

Nadja Jaekel, Susann Schulze, MD, Udo Siebolts, MD, Anja Haak, PhD, Nikolaos Pazaitis, MD, Michael Cross, PhD, Dietger Niederwieser, MD, Mathias Hänel, MD, Georg Maschmeyer, MD, Maxi Wass, MD, Lukas Heukamp, MB PhD, Roopika Menon, Miriam Bertrand, Claudia Wickenhauser, MD, Oana Brosteanu, PhD, Haifa Kathrin Al-Ali, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1420.
https://doi.org/10.1182/blood-2019-127865
Published: 2019
Journal Articles

Probing Aberrant Splicing in a Novel Model of SF3B1-Mutant Myelodysplastic Syndromes

Courtnee Clough, Stephanie Busch, B.S., Joey Pangallo, B.S., Robert K. Bradley, PhD, Sergei Doulatov, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1706.
https://doi.org/10.1182/blood-2019-129176
Published: 2019
Journal Articles

Epigenomic Determinants of Transcriptional Activity in ASXL1 -Mutant Chronic Myelomonocytic Leukemia

Moritz Binder, MDMPH, Alexandre Gaspar Maia, PhD, Ryan M. Carr, MD PhD, Christopher Pin, PhD, Kurt Berger, Bonnie Alver, PhD, Keith Robertson, PhD, David Marks, PhD, Martin Fernandez-Zapico, MD, Mrinal M Patnaik, MDMBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2987.
https://doi.org/10.1182/blood-2019-123191
Published: 2019
Journal Articles

Hotspot U2AF1 Mutations Determine Missplicing Selectivity: Novel Mechanisms Altering Splicing Factors

Vera Adema, PhD, Courtney E Hershberger, BS, Wencke Walter, PhD, Cassandra M Kerr, MS, Stephan Hutter, PhD, Yasunobu Nagata, MD PhD, Hassan Awada, Sunisa Kongkiatkamon, Christina Snider, Milo Co, Manja Meggendorfer, PhD, Aziz Nazha, MD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Francesc Sole, PhD, Richard A Padgett, PhD, Torsten Haferlach, MD, Jaroslaw P. Maciejewski, MD PhD, Valeria Visconte, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2985.
https://doi.org/10.1182/blood-2019-129367
Published: 2019
Journal Articles

Impact of U2AF1 Mutations on Clinical Characteristics and RNA Splicing in Myelodysplastic Syndromes (MDS)

Bing Li, MD, Jinqin Liu, Tiejun Qin, Zefeng Xu, MD, Gang Huang, PhD, Zhijian Xiao, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2979.
https://doi.org/10.1182/blood-2019-126346
Published: 2019
Journal Articles

Biomarkers of Response to Romiplostim in Patients with Lower-Risk Myelodysplastic Syndrome (MDS) and Thrombocytopenia - Results of the Europe Trial By the Emsco Network

Uwe Platzbecker, MD, Anne Sophie Kubasch, MD, Aristoteles Giagounidis, MD, Georgia Metzgeroth, Anna Jonasova, MD PhD, Regina Herbst, MD, Jose Miguel Torregrosa Diaz, Benoit De Renzis, MD, Katharina Götze, Marie-Luise Huetter-Kroenke, MD, Marie-Pierre Gourin, Borhane Slama, MD, Sophie Dimicoli-Salazar, MD, Pascale Cony-Makhoul, MD, Kamel Laribi, MD, Sophie Park, MD PhD, Katja Jersemann, Oliver Tiebel, MD, Katja Sockel, MD, Silke Gloaguen, MSc, Anna Mies, Fatiha Chermat, Christian Thiede, MD, Rosa Sapena, Richard F. Schlenk, MD, Pierre Fenaux, MD PhD, Lionel Ades, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2998.
https://doi.org/10.1182/blood-2019-129047
Published: 2019
Journal Articles

Luspatercept Significantly Reduces Red Blood Cell (RBC) Transfusion Burden, Regardless of Gene Mutation Frequency, Spectrum, and Prognostic Significance, Among Patients (Pts) with LR-MDS Enrolled in the MEDALIST Trial

Uwe Platzbecker, Diana Dunshee, Rami S. Komrokji, MD, Ghulam J. Mufti, Guillermo Garcia-Manero, MD, Rena Buckstein, MD FRCPC, Valeria Santini, MD, María Díez-Campelo, MD PhD, Mikkael A. Sekeres, MD MS, Wendy L. See, Kevin Tsai, Alberto Risueño, Jianglin Ma, Martin Schwickart, Anita Rampersad, Jennie Zhang, Abderrahmane Laadem, Daniel Menezes, Kyle MacBeth, PhD, Peter G. Linde, Joseph G. Reynolds, PhD, Alan F. List, MD, Pierre Fenaux, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2999.
https://doi.org/10.1182/blood-2019-123655
Published: 2019
Journal Articles

Critical Requirement of U2AF1 in the Maintenance and Function of Hematopoietic Stem Cells

Avik Dutta, PhD, Yue Yang, PhD, Bao Le, Golam Mohi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1195.
https://doi.org/10.1182/blood-2019-132007
Published: 2019
Journal Articles

Interactome Analysis of APOBEC3B in Multiple Myeloma

Yasuhiro Kazuma, MD, Kotaro Shirakawa, MD PhD, Anamaria Daniela Sarca, MD, Yoshihito Horisawa, MD, Hirofumi Fukuda, MD, Hiroyuki Matsui, MD, Hiroyuki Yamazaki, MD, Tadahiko Matsumoto, MD, Fumiko Tanabe, Ryo Morishita, PhD, Shinji Ito, PhD, Akifumi Takaori-Kondo, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1259.
https://doi.org/10.1182/blood-2019-126856
Published: 2019
Journal Articles

Genetic Vulnerabilities of DNMT3A R882H in Myeloid Malignancies

Malgorzata Gozdecka, PhD, Monika Dudek, MSc, Konstantinos Tzelepis, Aristi Damaskou, MSc, Vijay Baskar, PhD, Penny Wright, Graham Duddy, Eshwar Meduri, PhD, Milena Mazan, PhD, Kosuke Yusa, PhD, Brian J. P. Huntly, PhD MRCP, MB, FRCPath, George S. Vassiliou, FRCPath, MRCP, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 111.
https://doi.org/10.1182/blood-2019-126505
Published: 2019
Journal Articles

Genome Wide Transcriptomic Analysis Identifies Dysregulated Splicing Factor Profile with Molecular and Functional Role in Multiple Myeloma

Anil Aktas Samur, PhD, Mehmet Kemal Samur, PhD, Michael A Lopez, Sanika Derebail, Kenneth C. Anderson, MD, Herve Avet-Loiseau, MD PhD, Giovanni Parmigiani, PhD, Mariateresa Fulciniti, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 361.
https://doi.org/10.1182/blood-2019-129114
Published: 2019
Journal Articles

SM09419, a Novel, Small-Molecule CDC-like Kinase (CLK) Inhibitor, Demonstrates Strong Inhibition of the Wnt Signaling Pathway and Antitumor Effects in Mantle Cell Lymphoma Models

Heekyung Chung, PhD, Emily Creger, Lauren Sitts, Kevin Chiu, Chi-Ching Mak, PhD, Sunil KC, PhD, Betty Tam, PhD, Gail Bucci, Josh Stewart, Timothy Phalen, PhD, Steven Cha, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4059.
https://doi.org/10.1182/blood-2019-124812
Published: 2019
Journal Articles

Identification of ST3GAL6-AS1 Interactive Protein in Multiple Myeloma

Ying Shen, MD, Fangmei Li, PhD, Dong Wu, MD, Yue Peng, Wanhong Zhao, MD, Yun Yang, MD, Jianli Wang, MD, Ju Bai, PhD, Yan Xu, Aili He
Journal: Blood
Blood (2019) 134 (Supplement_1): 4365.
https://doi.org/10.1182/blood-2019-125210
Published: 2019