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Journal Articles

High-Level ROR1 and BCL2, Cancer-Stemness, and BCL2 Mutations Associate with Venetoclax Resistance in Chronic Lymphocytic Leukemia

Emanuela M. Ghia, PhD, Laura Z. Rassenti, PhD, Michael Y. Choi, MD, Elvin Chu, George F. Widhopf II, PhD, Thomas J. Kipps, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 476.
https://doi.org/10.1182/blood-2019-131426
Published: 2019
Journal Articles

Enhanced Transduction Lentivector Gene Therapy for Treatment of Older Patients with X-Linked Severe Combined Immunodeficiency

Suk See De Ravin, MD, PhD, Sandra Anaya O'Brien, Nana Kwatemaa, RN, MSN, CCRP, Narda Theobald, BS, Siyuan Liu, Janet Lee, BS, Lela Kardava, Taylor Liu, Frederick Goldman, MDMS, Susan Moir, Jack Bleesing, MD PhD, Benedicte Neven, MD PhD, Jennifer Puck, MD, Morton J Cowan, MD, Ewelina Mamcarz, MD, Stephen Gottschalk, MD, Michael M Meagher, PhD, Luigi Notarangelo, MD, Elizabeth Kang, MD, Xiaolin Wu, PhD, Harry L. Malech, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 608.
https://doi.org/10.1182/blood-2019-127439
Published: 2019
Journal Articles

IL-33 Therapy Prevents Acute Lung Injury after Transplantation Via IL-9-Producing Type 2 Innate Lymphoid Cells Induction

Hua Jiang, PhD, Abdulraouf Ramadan, PhD, Becquet Laurine, MS, Tu Szu-Wei, Hong Liu, MS, Courtney Rowan, MD, Xiaowen Liu, PhD, Huanmei Wu, PhD, Jun Wan, PhD, Sophie Paczesny, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 583.
https://doi.org/10.1182/blood-2019-123821
Published: 2019
Journal Articles

Homeostatic Regulation of Apoptosis Governs Thymus Regeneration

Sinéad Kinsella, MSc,PhD, Kirsten Cooper, Lorenzo Iovino, MD, Paul DeRoos, Reema Jain, PhD, Jarrod A Dudakov, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 587.
https://doi.org/10.1182/blood-2019-131513
Published: 2019
Journal Articles

Minorities Do Not Have Worse Outcomes for Diffuse Large B Cell Lymphoma (DLBCL) If Optimally Managed

Bei Hu, MD, Tommy Chen, Danielle Boselli, MS, Rupali Bose, MS, MBA, James T. Symanowski, PhD, Derek Raghavan, MDPhDFACP,FRACP, Amy Soni, MD, Steven I Park, MD, Belinda R Avalos, MD, Edward A Copelan, Ryan Jacobs, MD, Nilanjan Ghosh, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 425.
https://doi.org/10.1182/blood-2019-123998
Published: 2019
Journal Articles

Optimal Dual-Targeted CAR Construct Simultaneously Targeting Bcma and GPRC5D Prevents Bcma-Escape Driven Relapse in Multiple Myeloma

Carlos Fernandez de Larrea, MD PhD, Mette Staehr, PhD, Andrea Lopez, Yunxin Chen, MBBS, Terence J Purdon, MS, Khong Y. Ng, PhD, Hans Wendel, MD, Renier J. Brentjens, MD PhD, Eric L Smith, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 136.
https://doi.org/10.1182/blood-2019-126145
Published: 2019
Journal Articles

Favorable Outcomes of Newly Diagnosed Intravascular Large B-Cell Lymphoma Patients Treated with R-CHOP Combined with High-Dose Methotrexate Plus Intrathecal Chemotherapy: Results from a Multicenter Phase 2 Trial (PRIMEUR-IVL)

Kazuyuki Shimada, MD, Motoko Yamaguchi, MD PhD, Yoshiko Atsuta, MD PhD, Kosei Matsue, MD PhD, Keijiro Sato, MD, Shigeru Kusumoto, MD PhD, Hirokazu Nagai, MD PhD, Jun Takizawa, MD PhD, Noriko Fukuhara, MD PhD, Koji Nagafuji, MD PhD, Kana Miyazaki, MD PhD, Eiichi Ohtsuka, MD, Masataka Okamoto, MD PhD, Yasumasa Sugita, MD PhD, Toshiki Uchida, MD PhD, Satoshi Kayukawa, MD, Atsushi Wake, MD PhD, Daisuke Ennishi, MD PhD, Yukio Kondo, MD, Tohru Izumi, MD, Yoshihiro Kin, MD, Kunihiro Tsukasaki, MD PhD, Daigo Hashimoto, Masaaki Yuge, MD PhD, Atsumi Yanagisawa, Yachiyo Kuwatsuka, MD PhD, Satoko Shimada, MD, Yasufumi Masaki, MD PhD, Nozomi Niitsu, MD PhD, Hitoshi Kiyoi, MD PhD, Ritsuro Suzuki, MD PhD, Takashi Tokunaga, MD PhD, Shigeo Nakamura, MD, Tomohiro Kinoshita, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 350.
https://doi.org/10.1182/blood-2019-126798
Published: 2019
Journal Articles

In Vitro Effects of the Novel Platelet αIIbβ3 Receptor Antagonist RUC-4 on the Verifynow Assays: Potential for Point-of-Care Monitoring of RUC-4 Therapy

Ohad S. Bentur, MD, Barry S. Coller, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 166.
https://doi.org/10.1182/blood-2019-124548
Published: 2019
Journal Articles

The Role of Calreticulin in Normal Hematopoiesis and Neoplastic Hematopoiesis of Myeloproliferative Neoplasms

Kotaro Shide, MD PhD, Takuro Kameda, MD PhD, Ayako Kamiunten, MD, Yoshinori Ozono, MD, Yuki Tahira, MD, Masaaki Sekine, MD, Masaya Ono, MD PhD, Takako Yokomizo, PhD, Sho Kubota, Keiichi Akizuki, MD, Yoko Kubuki, MD PhD, Tomonori Hidaka, MD, Goro Sashida, MD PhD, Kazuya Shimoda, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 309.
https://doi.org/10.1182/blood-2019-130034
Published: 2019
Journal Articles

Statins Enhance Killing of Multiple Myeloma Cells By the BCL-2 Inhibitor Venetoclax and the MCL-1 Inhibitor S63845

David Fruman, PhD, Dennis Juarez, B.S., Grace Diep, Undergraduate, Falisha Nguyen, Undergraduate, Vikas A. Gupta, MD PhD, Lawrence H. Boise, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4413.
https://doi.org/10.1182/blood-2019-131218
Published: 2019
Journal Articles

Identification of a Pharmacodynamic Biomarker for SEL24/MEN1703, a First-in-Class Dual PIM/FLT3 Kinase Inhibitor for Acute Myeloid Leukemia, and Its Implementation in the First-in-Human Study CLI24-001

Andrea Tomirotti, PhD, Giuseppe Merlino, Alessio Fiascarelli, PhD, Simone Baldini, MD, Alessia Tagliavini, Elisa Borella, Milena Mazan, PhD, Krzysztof Brzózka, PhD, Alessandro Bressan, Andrea Pellacani, PhD MD, Massimiliano Salerno, Monica Binaschi, PhD, Daniela Bellarosa
Journal: Blood
Blood (2019) 134 (Supplement_1): 5087.
https://doi.org/10.1182/blood-2019-124800
Published: 2019
Journal Articles

Relapsed or Refractory Angioimmunoblastic T-Cell Lymphoma (r/r AITL) North Asian Patients after Failure of First-Line Therapy: A Pooled Analysis of Two Pralatrexate Studies

Jun Zhu, MD, Ee-Min Yeoh, BSc, Yoshinobu Maeda, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5290.
https://doi.org/10.1182/blood-2019-124080
Published: 2019
Journal Articles

PARP Inhibitors Are Effective in IDH1/2 Mutant MDS and AML Resistant to Targeted IDH Inhibitors

Rana Gbyli, MS, Yuanbin Song, MD, Wei Liu, PhD, Yimeng Gao, PhD, Namrata S Chandhok, MD, Xiaoying Fu, MD, Xiaman Wang, MD PhD, Amisha Patel, MS, Ranjini Sundaram, PhD, Toma Tebaldi, PhD, Giulia Biancon, PhD, Anastasia Ardasheva, BS, Ashley Qin, Mukhtar Sadykov, MD, Padmavathi Mamillapalli, BS, Richard Flavell, PhD, Thomas Prebet, MD PhD, Ranjit Bindra, MD PhD, Stephanie Halene, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4222.
https://doi.org/10.1182/blood-2019-130814
Published: 2019
Journal Articles

Regulation of Coagulation by Polyphosphate

Nicola J. Mutch, BSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-18.
https://doi.org/10.1182/blood-2019-121062
Published: 2019
Journal Articles

Autophagy in the Hematopoietic System

Anna K. Simon, PhD, Sandrine Obba, Hanlin Zhang, PhD, Thomas Riffelmacher, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-44.
https://doi.org/10.1182/blood-2019-121093
Published: 2019
Journal Articles

Beyond Acute Leukemia: Learner Perceptions of Inpatient Hematology Education and Deficiencies in Non-Malignant Topics

Andrew O'Brien, MD, Rakesh P. Mehta, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5797.
https://doi.org/10.1182/blood-2019-123271
Published: 2019
Journal Articles

The Innate Immune Sensor Sting Promotes Donor CD8 + T Cell Activation and Recipient APC Death Early after Preclinical Allogeneic Hematopoietic Stem Cell Transplantation

Cameron S. Bader, BS, Henry Barreras, MPH, Casey O. Lightbourn, BS, MS, Sabrina N. Copsel, PhD, Dietlinde Wolf, PhD, Jingjing Meng, PhD, Jeonghyun Ahn, PhD, Krishna V Komanduri, MD, Bruce R. Blazar, MD, Lei Jin, PhD MSc, Glen N. Barber, PhD, Sabita Roy, PhD, Robert B. Levy, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3202.
https://doi.org/10.1182/blood-2019-130197
Published: 2019
Journal Articles

Characterizing C5 Inhibition with the SMART-Ig Anti-hC5 Antibody Crovalimab in PNH Patients Using Free Available Paratopes

Alexandre Sostelly, M.Eng., PhD, Antoine Soubret, Christoph Bucher, MD, Simon Buatois, Jean-Eric Charoin, Gregor Jordan, Barbara Klughammer, PhD, Andreas Dieckmann, Taku Fukuzawa, PhD, Keisuke Gotanda, Kenji Shinomiya, Sung-Soo Yoon, MD PhD, Jens P. Panse, Junichi Nishimura, MD PhD, Alexander Röth, MD PhD, Zsolt Nagy, MD PhD, Régis Peffault de Latour, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1227.
https://doi.org/10.1182/blood-2019-126911
Published: 2019
Journal Articles

Interactome Analysis of APOBEC3B in Multiple Myeloma

Yasuhiro Kazuma, MD, Kotaro Shirakawa, MD PhD, Anamaria Daniela Sarca, MD, Yoshihito Horisawa, MD, Hirofumi Fukuda, MD, Hiroyuki Matsui, MD, Hiroyuki Yamazaki, MD, Tadahiko Matsumoto, MD, Fumiko Tanabe, Ryo Morishita, PhD, Shinji Ito, PhD, Akifumi Takaori-Kondo, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1259.
https://doi.org/10.1182/blood-2019-126856
Published: 2019
Journal Articles

A Quantitative Systems Pharmacology (QSP) Model to Predict Receptor Occupancy of Bruton's Tyrosine Kinase (BTK) Inhibitors in Peripheral Blood Mononuclear Cells, Bone Marrow and Lymph Nodes of Patients with B-Cell Malignancies

Srikumar Sahasranaman, PhD, Oleg Demin, Jr., Dmitry Shchelokov, Veronika Musatova, Nageshwar Budha, PhD, Ying Ou, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1289.
https://doi.org/10.1182/blood-2019-129133
Published: 2019