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Journal Articles

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

Katherine Wood, PhD BA, Brittany Durgin, PhD, Heidi M Schmidt, BSE, Scott Hahn, Jeffrey Baust, Tim Bachman, Dario A. Vitturi, PhD, Samit Ghosh, Solomon Fiifi Ofori-Acquah, Ana Mora, MD, Mark T Gladwin, MD, Adam Straub, PhD

Blood (2019) 134 (Supplement_1): 3619.

https://doi.org/10.1182/blood-2019-124159

Published: 2019

Journal Articles

The Effect of the Soluble Guanylate Cyclase Stimulator Olinciguat on Renal Function and Biomarkers of Inflammation and Renal Injury in Sickle Cell Mice

Boris Tchernychev, PhD, Raghunath Ramanarasimhaiah, MD, Guang Liu, PhD, Katherine Hall, PhD, Regina Margaret Graul, PhD, Jaime Masferrer, PhD

Blood (2019) 134 (Supplement_1): 3554.

https://doi.org/10.1182/blood-2019-127361

Published: 2019

Journal Articles

Soluble Guanylate Cyclase Modulators Effect Fetal Hemoglobin Levels through a Non-cGMP-Protein Kinase G Signaling Pathway

Bin Sun, PhD, Valerie Miller, MS, Karin P Potoka, MD, Yukio Nakamura, MD PhD, Mark T Gladwin, MD, Grant C. Bullock, MD PhD

Blood (2018) 132 (Supplement 1): 1060.

https://doi.org/10.1182/blood-2018-99-120306

Published: 2018

Journal Articles

The Effect of the Soluble Guanylyl Cyclase Stimulator Olinciguat on ƴ-Globin Gene Induction in K562 Cells

Joy Miyashiro, Asha Pant, Boris Tchernychev, PhD, Todd G Milne, Mark G Currie, Regina Margaret Graul, Jaime Masferrer

Blood (2018) 132 (Supplement 1): 1078.

https://doi.org/10.1182/blood-2018-99-116011

Published: 2018

Journal Articles

Synergistic Platelet Inhibitory Effects of Riociguat and Nitric Oxide Are Decreased By Protein Binding

Yifeng WU, MD, Alan D Michelson, MD, Andrew L Frelinger, III, PhD

Blood (2018) 132 (Supplement 1): 4971.

https://doi.org/10.1182/blood-2018-99-117070

Published: 2018

Journal Articles

Nitric Oxide Promotes Human Hematopoietic Stem Cell Homing and Engraftment Via cGMP-Pkg Signaling

Xinxin Huang, PhD, Bin Guo, PhD, Maegan L. Capitano, PhD, Hal E. Broxmeyer, PhD

Blood (2018) 132 (Supplement 1): 807.

https://doi.org/10.1182/blood-2018-99-112993

Published: 2018

Journal Articles

The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice

Boris Tchernychev, Susanne Feil, Peter Germano, William Warren, Elisabeth Lonie, Robert Feil, Todd G Milne, John Hadcock, Yueh-Tyng Chien, Mark G Currie, Regina Margaret Graul

Blood (2017) 130 (Supplement 1): 447.

https://doi.org/10.1182/blood.V130.Suppl_1.447.447

Published: 2017

Journal Articles

Multiple-Ascending-Dose Study of the Soluble Guanylate Cyclase Stimulator, IW-1701, in Healthy Subjects

Robert S Mittleman, MD MS, FACC, Phebe Wilson, MS, Kristine Sykes, B.S., Marina Mihova, MHA, Jennifer G Chickering, PhD, Dennis Ruff, MD, Michael Hall, MD, Todd G Milne, Mark G Currie, Yueh-Tyng Chien

Blood (2017) 130 (Supplement 1): 3533.

https://doi.org/10.1182/blood.V130.Suppl_1.3533.3533

Published: 2017

Journal Articles

Intravascular Hemolysis Leads to Increased Esophagus Smooth Muscle Contractions in Mice: Implication for Dysphagia and Odynophagia

Fabio H Silva, PhD, Eduardo C Alexandre, PhD, Fabiano B Calmasini, PhD, Carla Fernanda Franco-Penteado, BSc, PhD, Edson Antunes, PhD, Kleber Yotsumoto Fertrin, MD PhD, Fernando Ferreira Costa, MD PhD

Blood (2017) 130 (Supplement 1): 3470.

https://doi.org/10.1182/blood.V130.Suppl_1.3470.3470

Published: 2017

Journal Articles

Thrombospondin-1 Polymorphisms Are Associated with Chronic Kidney Disease in Sickle Cell Anemia

Seethal A. Jacob, MD, Enrico M. Novelli, MD MS, Jeffrey S. Isenberg, MD MPH, Melanie E. Garrett, MS, Yanxia Chu, MD, Karen L. Soldano, BS, Kenneth I. Ataga, MD, Marilyn J. Telen, MD, Allison E. Ashley-Koch, PhD, Yingze Zhang, PhD, Gregory J Kato, MD

Blood (2016) 128 (22): 2491.

https://doi.org/10.1182/blood.V128.22.2491.2491

Published: 2016

Journal Articles

Revisiting the hyperhemolysis paradigm

Mark T. Gladwin

Blood (2015) 126 (6): 695–696.

https://doi.org/10.1182/blood-2015-06-649491

Published: 2015

Journal Articles

Acute Inflammatory Processes Are Induced By Hemolysis and Reversed By Hydroxyurea

Camila Bononi Almeida, Ph.D., Lucas Eduardo Botelho Souza, M.Sc., Fabio Trindade Maranhão Costa, PhD, Claudio Werneck, Ph.D., Dimas T. Covas, MD, PhD, Fernando Ferreira Costa, MD, PhD, Nicola Conran, PhD

Blood (2013) 122 (21): 951.

https://doi.org/10.1182/blood.V122.21.951.951

Published: 2013

Journal Articles

Does the NO/sGC/cGMP/PKG pathway play a stimulatory role in platelets?

Stepan Gambaryan, Andreas Friebe, Ulrich Walter

Blood (2012) 119 (22): 5335–5336.

https://doi.org/10.1182/blood-2011-12-396374

Published: 2012

Journal Articles

Genotype of Beta Thalassemia Patients As Predictors for Prognosis & Management without Blood Transfusion,

Saqib Hussain Ansari, MBBS, MSc, Tahir S Shamsi, MD, Mohammed Tahir Khan, MBBS, MS, Muneera Bohray, Tasneem Farzana, Kousar Perveen, Sajida Erum

Blood (2011) 118 (21): 3199.

https://doi.org/10.1182/blood.V118.21.3199.3199

Published: 2011

Journal Articles

Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation

Guoying Zhang, Binggang Xiang, Anping Dong, Radek C. Skoda, Alan Daugherty, Susan S. Smyth, Xiaoping Du, Zhenyu Li

Blood (2011) 118 (13): 3670–3679.

https://doi.org/10.1182/blood-2011-03-341107

Published: 2011

Includes: Supplemental data

Journal Articles

Platelet Aggregation Is Inhibited by Nitrite Reduction to Nitric Oxide In Blood

Alan N. Schechter, Sirada Srihirun, Thanaporn Sriwantana, Supeenun Unchern, Egarit Noulsri, Kovit Pattanapanyasat, Suthat Fucharoen, Barbora Piknova, Nathawut Sibmooh

Blood (2010) 116 (21): 3189.

https://doi.org/10.1182/blood.V116.21.3189.3189

Published: 2010

Journal Articles

Hydroxyurea Induces Fetal Hemoglobin Expression by Activating cAMP Signaling Pathways In a cAMP- and cGMP-Dependent Manner; New Hypothesis to Account for a Role of Non-Erythroid Cells In Fetal Hemoglobin Induction

Tohru Ikuta, MD, PhD, Diana Gutsaeva, James Parkerson, Shobha Yerigenahally, C. Alvin Head

Blood (2010) 116 (21): 1622.

https://doi.org/10.1182/blood.V116.21.1622.1622

Published: 2010

Journal Articles

Biphasic Roles for the Soluble Guanylyl Cyclase (sGC) In Platelet Activation In Mice

Guoying Zhang, Binggang Xiang, PhD, Radek C. Skoda, MD, Susan S. Smyth, MD, PhD, Xiaoping Du, MD, PhD, Zhenyu Li, MD, PhD

Blood (2010) 116 (21): 486.

https://doi.org/10.1182/blood.V116.21.486.486

Published: 2010

Journal Articles

GATA-2 and GATA-6 Involvement in Hydroxycarbamide Action On Endothelial Cells in Sickle Cell Disease.

Pauline Lansiaux, Sandrine Laurance, Michelle Hauchecorne, Emmanuelle Verger, Jacques Elion, Claudine Lapouméroulie

Blood (2009) 114 (22): 818.

https://doi.org/10.1182/blood.V114.22.818.818

Published: 2009

Journal Articles

Up-Regulation of NO/cGMP Signaling Pathway in Corpus Cavernosum of Sickle Cell Disease Transgenic Mice

Mário Angelo Claudino, B.Sc., Ph.D, Carla Fernanda Franco-Penteado, B.Sc., M.Sc., Ph.D, Marcus A.F. Corat, B.Sc., M.Sc., Ph.D, Luiz Augusto C Passos, B.Sc., M.Sc., Ph.D, Ana Paula Gimenes, B.Sc, Edson Antunes, B.Sc., M.Sc., Ph.D, Fernando F. Costa, PhD, MD

Blood (2008) 112 (11): 2495.

https://doi.org/10.1182/blood.V112.11.2495.2495

Published: 2008

NARROW

Smooth Muscle Cytochrome b5 Reductase 3 Deficiency Accelerates Pulmonary Hypertension Development in Sickle Cell Mice

The Effect of the Soluble Guanylate Cyclase Stimulator Olinciguat on Renal Function and Biomarkers of Inflammation and Renal Injury in Sickle Cell Mice

Soluble Guanylate Cyclase Modulators Effect Fetal Hemoglobin Levels through a Non-cGMP-Protein Kinase G Signaling Pathway

The Effect of the Soluble Guanylyl Cyclase Stimulator Olinciguat on ƴ-Globin Gene Induction in K562 Cells

Synergistic Platelet Inhibitory Effects of Riociguat and Nitric Oxide Are Decreased By Protein Binding

Nitric Oxide Promotes Human Hematopoietic Stem Cell Homing and Engraftment Via cGMP-Pkg Signaling

The Clinical-Stage sGC Stimulator IW-1701 Prevents Increase of Plasma Biomarkers of Intravascular Inflammation and Suppresses Leukocyte-Endothelial Interactions in Tnfα-Treated Mice

Multiple-Ascending-Dose Study of the Soluble Guanylate Cyclase Stimulator, IW-1701, in Healthy Subjects

Intravascular Hemolysis Leads to Increased Esophagus Smooth Muscle Contractions in Mice: Implication for Dysphagia and Odynophagia

Thrombospondin-1 Polymorphisms Are Associated with Chronic Kidney Disease in Sickle Cell Anemia

Revisiting the hyperhemolysis paradigm

Acute Inflammatory Processes Are Induced By Hemolysis and Reversed By Hydroxyurea

Does the NO/sGC/cGMP/PKG pathway play a stimulatory role in platelets?

Genotype of Beta Thalassemia Patients As Predictors for Prognosis & Management without Blood Transfusion,

Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation

Platelet Aggregation Is Inhibited by Nitrite Reduction to Nitric Oxide In Blood

Hydroxyurea Induces Fetal Hemoglobin Expression by Activating cAMP Signaling Pathways In a cAMP- and cGMP-Dependent Manner; New Hypothesis to Account for a Role of Non-Erythroid Cells In Fetal Hemoglobin Induction

Biphasic Roles for the Soluble Guanylyl Cyclase (sGC) In Platelet Activation In Mice

GATA-2 and GATA-6 Involvement in Hydroxycarbamide Action On Endothelial Cells in Sickle Cell Disease.

Up-Regulation of NO/cGMP Signaling Pathway in Corpus Cavernosum of Sickle Cell Disease Transgenic Mice

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American Society of Hematology

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American Society of Hematology

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