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Journal Articles

Hypersialylation Protects Multiple Myeloma Cells from NK Cell-Mediated Immunosurveillance and This Can be Overcome By Targeted Desialylation Using a Sialyltransferase Inhibitor

John Daly, MSc, Subhashis Sarkar, PhD, Alessandro Natoni, PhD, Robert Henderson, MB BCh, Dawn Swan, Mattias Carlsten, MD PhD, Michael E O'Dwyer, MD

Blood (2019) 134 (Supplement_1): 138.

https://doi.org/10.1182/blood-2019-126613

Published: 2019

Journal Articles

Identification of ST3GAL6-AS1 Interactive Protein in Multiple Myeloma

Ying Shen, MD, Fangmei Li, PhD, Dong Wu, MD, Yue Peng, Wanhong Zhao, MD, Yun Yang, MD, Jianli Wang, MD, Ju Bai, PhD, Yan Xu, Aili He

Blood (2019) 134 (Supplement_1): 4365.

https://doi.org/10.1182/blood-2019-125210

Published: 2019

Journal Articles

Silencing Long Non-Coding RNA ST3GAL6-AS1 Inhibits Adhesion and Migration of Myeloma Cells in Vitro

Ying Shen, MD, Yuandong Feng, MD, Hongli Chen, Yachun Jia, Yue Peng, Ru Zhang, MD, Yun Yang, MD, Jian-Li Wang, MD PhD, Ju Bai, PhD, Fang-Xia Wang, MD PhD, Yan Xu, Jinsong Hu, PhD, Aili He, MD

Blood (2018) 132 (Supplement 1): 4470.

https://doi.org/10.1182/blood-2018-99-114660

Published: 2018

Journal Articles

Inhibition of Sialylation Impairs Adhesion on Madcam-1 and E-Selectin and Sensitize Multiple Myeloma Cells to Bortezomib in a Xenograft Mouse Model

Alessandro Natoni, PhD, Mariah Farrell, BS, Heather Fairfield, MS, Lucy Kirkham-McCarthy, MSc, Matt Macauley, PhD, Michaela Reagan, PhD, Michael E O'Dwyer, MD

Blood (2018) 132 (Supplement 1): 3204.

https://doi.org/10.1182/blood-2018-99-118361

Published: 2018

Journal Articles

Mesenchymal Stromal Cell Sialylation Enhances Immune Suppression in Multiple Myeloma

Kevin Lynch, BSc, MSc, O'Malley Grace, BSc, Aideen Ryan, BSc,PhD, Thomas Ritter, BSc, PhD, Michael O'Dwyer, MD

Blood (2017) 130 (Supplement 1): 124.

https://doi.org/10.1182/blood.V130.Suppl_1.124.124

Published: 2017

Journal Articles

Interleukin-6 Drives Multiple Myeloma Progression through Upregulating of CD147/Emmprin Expression and Its Sialylation

Yanmeng Wang, Rong Fan, Li Lei, PhD, Aiying Wang, Xiaman Wang, Shen Ying, Hongli Chen, Caoilfhionn Connolly, MD, Kim De Veirman, Aili He, MD, Karin Vanderkerken, PhD, Michael O'Dwyer, MD, Jinsong Hu, PhD

Blood (2017) 130 (Supplement 1): 3037.

https://doi.org/10.1182/blood.V130.Suppl_1.3037.3037

Published: 2017

Journal Articles

Targeting Siglec-7: A Novel Immunotherapeutic Approach to Potentiate the Cytotoxic Functions of Natural Killer Cells Against Multiple Myeloma

John Daly, MSc, Tony Duggan, BSc, Jinsong Hu, PhD, Alessandro Natoni, PhD, Subhashis Sarkar, PhD, Lucy Kirkham-McCarthy, MSc, Cian McEllistrim, MD, Janusz Krawczyk, MD, Michael O'Dwyer, MD

Blood (2017) 130 (Supplement 1): 1799.

https://doi.org/10.1182/blood.V130.Suppl_1.1799.1799

Published: 2017

Journal Articles

Effects of Platelet Circulatory Age on Platelet Function

Moritz Stolla, MD, Renata Grozovsky, PhD, Melissa M Lee-Sundlov, PhD, Herve Falet, PhD, Karin M. Hoffmeister, MD

Blood (2016) 128 (22): 413.

https://doi.org/10.1182/blood.V128.22.413.413

Published: 2016

Journal Articles

Bone Marrow Macrophage Galectin-3 Regulates Platelet Production through Recognition of O-Glycans on Megakaryocytes

Melissa M Lee-Sundlov, PhD, Renata Grozovsky, PhD, Silvia Giannini, PhD, Martina McGrath, MD, Haley E Ramsey, PhD MSc, Martha Sola-Visner, MD, Karin M. Hoffmeister, MD

Blood (2016) 128 (22): 409.

https://doi.org/10.1182/blood.V128.22.409.409

Published: 2016

Journal Articles

Species-Specific Roles for a2,3- and a2,6-Linked Sialic Acid Residues in PECAM-1-Mediated Homophilic Interactions

Panida Lertkiatmongkol, MSc, Cathy Paddock, Peter J. Newman, PhD

Blood (2015) 126 (23): 3450.

https://doi.org/10.1182/blood.V126.23.3450.3450

Published: 2015

Journal Articles

Recognition of Megakaryocyte-Specific T-Antigen By Macrophages Negatively Regulates Platelet Production in Bone Marrow

Melissa M. Lee-Sundlov, PhD, Renata Grozovsky, PhD, Silvia Giannini, PhD, Martina McGrath, MD, Haley Elizabeth Ramsey, PhD MSc, Reza Abdi, MD, Martha Sola-Visner, MD, Karin M. Hoffmeister, MD

Blood (2015) 126 (23): 420.

https://doi.org/10.1182/blood.V126.23.420.420

Published: 2015

Journal Articles

E-Selectin Ligand Expression Increases with Progression of Myeloma and Induces Drug Resistance in a Murine Transplant Model, Which Is Overcome By the Glycomimetic E-Selectin Antagonist, GMI-1271

Alessandro Natoni, PhD, Theodore A.G. Smith, PhD, Niamh Keane, MB, MRCP, Silvia C. Locatelli-Hoops, PhD, Isabela Oliva, William E. Fogler, PhD, John L. Magnani, PhD, Michael O'Dwyer, MD

Blood (2015) 126 (23): 1805.

https://doi.org/10.1182/blood.V126.23.1805.1805

Published: 2015

Journal Articles

ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes

Nandini Mondal, Alexander Buffone, Jr, Gino Stolfa, Aristotelis Antonopoulos, Joseph T. Y. Lau, Stuart M. Haslam, Anne Dell, Sriram Neelamegham

Blood (2015) 125 (4): 687–696.

https://doi.org/10.1182/blood-2014-07-588590

Published: 2015

Includes: Multimedia, Supplemental data

Journal Articles

T-Antigen Expression Causes Macrothrombocytopenia and Extensive Hemophagocytosis in Mice Lacking the Sialyltransferase ST3Gal-I Specifically in Megakaryocytes

Renata Grozovsky, PhD, Silvia Giannini, Haley Ramsey, PhD, Martha Sola-Visner, MD, Karin M Hoffmeister, MD

Blood (2014) 124 (21): 94.

https://doi.org/10.1182/blood.V124.21.94.94

Published: 2014

Journal Articles

Platelets Regulate Thrombopoietin Production: The Missing Link

Karin M Hoffmeister, MD, Hervé Falet, PhD, Renata Grozovsky, PhD

Blood (2014) 124 (21): SCI-52.

https://doi.org/10.1182/blood.V124.21.SCI-52.SCI-52

Published: 2014

Journal Articles

The Ashwell-Morell Receptor Regulates Hepatic Thrombopoietin Production Via JAK2-STAT3 Signaling in Vivo and in Vitro

Renata Grozovsky, PhD, Antonija Jurak Begonja, John H. Hartwig, Prof, Herve Falet, PhD, Karin M Hoffmeister, MD

Blood (2014) 124 (21): 2.

https://doi.org/10.1182/blood.V124.21.2.2

Published: 2014

Journal Articles

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma

Siobhan V. Glavey, Salomon Manier, Alessandro Natoni, Antonio Sacco, Michele Moschetta, Michaela R. Reagan, Laura S. Murillo, Ilyas Sahin, Ping Wu, Yuji Mishima, Yu Zhang, Wenjing Zhang, Yong Zhang, Gareth Morgan, Lokesh Joshi, Aldo M. Roccaro, Irene M. Ghobrial, Michael E. O’Dwyer

Blood (2014) 124 (11): 1765–1776.

https://doi.org/10.1182/blood-2014-03-560862

Published: 2014

Includes: Supplemental data

Journal Articles

Low Expression Of The FUCA1 Gene Is An Adverse Prognostic Factor In Myeloma and Combined With High Sialyltransferase Gene Expression Identifies Patients At Increased Risk Of Early Disease Progression and Death

Siobhan Glavey, MD, Ping Wu, MBBS, MSc, Laura S Murillo, PhD, Catherine Loughrey, MSc, Aldo M Roccaro, MD, PhD, Gareth J Morgan, MD PhD, Irene M. Ghobrial, MD, Lokesh Joshi, PhD, Michael E O'Dwyer, MD, FRCPI, FRCPath

Blood (2013) 122 (21): 1864.

https://doi.org/10.1182/blood.V122.21.1864.1864

Published: 2013

Journal Articles

Sialic Acid Loss Regulates Platelet Survival and Integrity

Renata Grozovsky, PhD, Gerard Jansen, MD, PhD, MSC, Karin M. Hoffmeister, MD

Blood (2013) 122 (21): 3504.

https://doi.org/10.1182/blood.V122.21.3504.3504

Published: 2013

Journal Articles

Circulatory Glycan-Modifying Enzymes As Systemic Regulators In Blood Cell Development

Joseph Lau, PhD

Blood (2013) 122 (21): 3686.

https://doi.org/10.1182/blood.V122.21.3686.3686

Published: 2013

NARROW

Hypersialylation Protects Multiple Myeloma Cells from NK Cell-Mediated Immunosurveillance and This Can be Overcome By Targeted Desialylation Using a Sialyltransferase Inhibitor

Identification of ST3GAL6-AS1 Interactive Protein in Multiple Myeloma

Silencing Long Non-Coding RNA ST3GAL6-AS1 Inhibits Adhesion and Migration of Myeloma Cells in Vitro

Inhibition of Sialylation Impairs Adhesion on Madcam-1 and E-Selectin and Sensitize Multiple Myeloma Cells to Bortezomib in a Xenograft Mouse Model

Mesenchymal Stromal Cell Sialylation Enhances Immune Suppression in Multiple Myeloma

Interleukin-6 Drives Multiple Myeloma Progression through Upregulating of CD147/Emmprin Expression and Its Sialylation

Targeting Siglec-7: A Novel Immunotherapeutic Approach to Potentiate the Cytotoxic Functions of Natural Killer Cells Against Multiple Myeloma

Effects of Platelet Circulatory Age on Platelet Function

Bone Marrow Macrophage Galectin-3 Regulates Platelet Production through Recognition of O-Glycans on Megakaryocytes

Species-Specific Roles for a2,3- and a2,6-Linked Sialic Acid Residues in PECAM-1-Mediated Homophilic Interactions

Recognition of Megakaryocyte-Specific T-Antigen By Macrophages Negatively Regulates Platelet Production in Bone Marrow

E-Selectin Ligand Expression Increases with Progression of Myeloma and Induces Drug Resistance in a Murine Transplant Model, Which Is Overcome By the Glycomimetic E-Selectin Antagonist, GMI-1271

ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes

T-Antigen Expression Causes Macrothrombocytopenia and Extensive Hemophagocytosis in Mice Lacking the Sialyltransferase ST3Gal-I Specifically in Megakaryocytes

Platelets Regulate Thrombopoietin Production: The Missing Link

The Ashwell-Morell Receptor Regulates Hepatic Thrombopoietin Production Via JAK2-STAT3 Signaling in Vivo and in Vitro

The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma

Low Expression Of The FUCA1 Gene Is An Adverse Prognostic Factor In Myeloma and Combined With High Sialyltransferase Gene Expression Identifies Patients At Increased Risk Of Early Disease Progression and Death

Sialic Acid Loss Regulates Platelet Survival and Integrity

Circulatory Glycan-Modifying Enzymes As Systemic Regulators In Blood Cell Development

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American Society of Hematology

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American Society of Hematology

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