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Journal Articles

Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520

Matteo Marchesini, PhD, Andrea Gherli, Anna Montanaro, Samuel Kitara, Claudia Sorrentino, Luca Pagliaro, Anne-Marie Lund Winter, Chiara Rompietti, Donatella Stilli, Federica Rizzi, Kimberly Stegmaier, MD, Paolo Sportoletti, William Dalby-Brown, Giovanni Roti

Blood (2019) 134 (Supplement_1): 407.

https://doi.org/10.1182/blood-2019-125616

Published: 2019

Journal Articles

Artesunate Inhibits Graft-Versus-Host Disease in Mice Via a Mechanism of Inducing Mitochondrial Calcium Overloading in Activated T Cells

Ying Wang, PhD, Shan He, PhD, Yongnian Liu, Robert Hooper, PhD, Hongshuang Yu, Yuanyuan Tian, Bui Tien, Bryant M Schultz, John W Elrod, PhD, Jonathan Soboloff, Yi Zhang, MD PhD

Blood (2019) 134 (Supplement_1): 4432.

https://doi.org/10.1182/blood-2019-131115

Published: 2019

Journal Articles

The MAP3K Apoptosis Signal-Regulating Kinase 1 (ASK1) Functions As a Calcium-Dependent Regulator of Platelet Activation Downstream of the G(α) q -PLC Signaling Axis

Randall J. Derstine, M.S., Meghna U. Naik, M.Sc., Ulhas P. Naik, PhD FAHA

Blood (2016) 128 (22): 3720.

https://doi.org/10.1182/blood.V128.22.3720.3720

Published: 2016

Journal Articles

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

Giovanni Roti, MD PhD, Jun Qi, PhD, Samuel Kitara, Anthony C. Varca, Marta Sanchez-Martin, PhD, Andrew L. Kung, MD PhD, Adolfo A. Ferrando, MD PhD, James E. Bradner, MD, Kimberly Stegmaier, MD

Blood (2016) 128 (22): 889.

https://doi.org/10.1182/blood.V128.22.889.889

Published: 2016

Journal Articles

Therapeutic Synergy from Combined Inhibition of the SERCA Channel and MAPK Signaling Pathway in MAPK-Dependent Leukemia

Meng Wang, MD PhD MRCP, Ugur Eskiocak, PhD, Michalis Agathokleous, PhD, Stacy Yuan, Charles Crawley, MD(London) FRCP FCPath, Sean J. Morrison, PhD

Blood (2015) 126 (23): 1264.

https://doi.org/10.1182/blood.V126.23.1264.1264

Published: 2015

Journal Articles

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

Giovanni Roti, MD, Jun Qi, PhD, Angela Su, B.S., Antony Varca, B.S., Jon C Aster, MD PhD, James E. Bradner, Kimberly Stegmaier, MD

Blood (2014) 124 (21): 2158.

https://doi.org/10.1182/blood.V124.21.2158.2158

Published: 2014

Journal Articles

A Small Molecule, Shikonin, Dually Functions As a Proteasome Inhibitor and a Necroptosis Inducer In Multiple Myeloma Cells

Naoko Wada, MD, Yawara Kawano, MD, PhD, Shiho Fujiwara, MD, Yoshitaka Kikukawa, MD, PhD, Yutaka Okuno, MD, PhD, Hiroaki Mitsuya, MD, PhD, Hiroyuki Hata, MD, PhD

Blood (2013) 122 (21): 3172.

https://doi.org/10.1182/blood.V122.21.3172.3172

Published: 2013

Journal Articles

Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies

Giovanni Roti, MD.Ph.D, Annie Carlton, B.S., Kenneth N. Ross, Ph.D, Michele Markstein, Ph.D, Kostandin Pajcini, Ph.D, Norbert Perrimon, Ph.D, Andrew L. Kung, MD, PhD, Warren S. Pear, MD, PhD, Stephen C. Blacklow, MD, PhD, Jon C Aster, MD, PhD, Kimberly Stegmaier, MD

Blood (2011) 118 (21): 555.

https://doi.org/10.1182/blood.V118.21.555.555

Published: 2011

Journal Articles

Carbon Nanotubes Activate Store Operated Calcium Entry (SOCE) In Human Platelets Manifested by STIM1 Capping

Silvia H. Lacerda, PhD, Jana Semberova, MD, Karel Holada, PhD, Olga Simakova, PhD, Jan Simak, PhD

Blood (2010) 116 (21): 3190.

https://doi.org/10.1182/blood.V116.21.3190.3190

Published: 2010

Journal Articles

Systems Biology to Predict Platelet Function

Scott L. Diamond, PhD

Blood (2010) 116 (21): SCI-38.

https://doi.org/10.1182/blood.V116.21.SCI-38.SCI-38

Published: 2010

Journal Articles

Morphological Changes of Platelets from Patients with Von Willebrand Disease Types 2B and 3 Suggest That Von Willebrand Factor Intervenes in Platelet Formation from Megakaryocytes.

Paquita Nurden, Alan T Nurden, Jean-Max Pasquet, Jocelyne Enouf, Cécile Faurie-Bonnafous, Sylvia La Marca, Margherita Punzo, Luciano Baronciani, Augusto B. Federici

Blood (2008) 112 (11): 1238.

https://doi.org/10.1182/blood.V112.11.1238.1238

Published: 2008

Journal Articles

Inositol 1,4,5-Trisphosphate Receptors Mediating Spontaneous Ca 2+ Oscillation Favors Proliferation in Human Mesenchymal Stem Cells from Bone Marrow.

Rong Tao, MBBS, MSc, Chu-Pak Lau, M.D., Gui-Rong Li, PhD

Blood (2006) 108 (11): 2572.

https://doi.org/10.1182/blood.V108.11.2572.2572

Published: 2006

Journal Articles

Severe Thrombocytopenia with Impaired Megakaryocytopoiesis in a Family with von Willebrand Disease Type 2B.

Paquita Nurden, MD, PhD, Najet Debili, PhD, William Vainchenker, MD, PhD, Jean-Max Pasquet, PhD, Regis Bobe, PhD, Raymonde Bredoux, PhD, Alan T. Nurden, PhD, Jocelyne Enouf, PhD

Blood (2005) 106 (11): 733.

https://doi.org/10.1182/blood.V106.11.733.733

Published: 2005

Journal Articles

Enhancement of ATRA-induced cell differentiation by inhibition of calcium accumulation into the endoplasmic reticulum: cross-talk between RARα and calcium-dependent signaling

Sophie Launay, Maurizio Giannı̀, Luisa Diomede, Laura M. Machesky, Jocelyne Enouf, Béla Papp

Blood (2003) 101 (8): 3220–3228.

https://doi.org/10.1182/blood-2002-09-2730

Published: 2003

Journal Articles

Lineage-Specific Modulation of Calcium Pump Expression During Myeloid Differentiation

Sophie Launay, Maurizio Giannı̀, Tünde Kovàcs, Raymonde Bredoux, Arlette Bruel, Pascal Gélébart, Fabien Zassadowski, Christine Chomienne, Jocelyne Enouf, Béla Papp

Blood (1999) 93 (12): 4395–4405.

https://doi.org/10.1182/blood.V93.12.4395

Published: 1999

NARROW

Targeting the Activating Mutations of NOTCH1 in T-Cell Lymphoblastic Leukemia with a New SERCA Inhibitor CAD204520

Artesunate Inhibits Graft-Versus-Host Disease in Mice Via a Mechanism of Inducing Mitochondrial Calcium Overloading in Activated T Cells

The MAP3K Apoptosis Signal-Regulating Kinase 1 (ASK1) Functions As a Calcium-Dependent Regulator of Platelet Activation Downstream of the G(α) q -PLC Signaling Axis

Leukemia-Specific Delivery of Mutant NOTCH1 Targeted Therapy

Therapeutic Synergy from Combined Inhibition of the SERCA Channel and MAPK Signaling Pathway in MAPK-Dependent Leukemia

Selectively Targeting Mutated NOTCH1 with a Folate-Thapsigargin Derivative

A Small Molecule, Shikonin, Dually Functions As a Proteasome Inhibitor and a Necroptosis Inducer In Multiple Myeloma Cells

Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies

Carbon Nanotubes Activate Store Operated Calcium Entry (SOCE) In Human Platelets Manifested by STIM1 Capping

Systems Biology to Predict Platelet Function

Morphological Changes of Platelets from Patients with Von Willebrand Disease Types 2B and 3 Suggest That Von Willebrand Factor Intervenes in Platelet Formation from Megakaryocytes.

Inositol 1,4,5-Trisphosphate Receptors Mediating Spontaneous Ca 2+ Oscillation Favors Proliferation in Human Mesenchymal Stem Cells from Bone Marrow.

Severe Thrombocytopenia with Impaired Megakaryocytopoiesis in a Family with von Willebrand Disease Type 2B.

Enhancement of ATRA-induced cell differentiation by inhibition of calcium accumulation into the endoplasmic reticulum: cross-talk between RARα and calcium-dependent signaling

Lineage-Specific Modulation of Calcium Pump Expression During Myeloid Differentiation

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American Society of Hematology

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American Society of Hematology

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