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Journal Articles

Cirmtuzumab Inhibits Non-Canonical Wnt Signaling without Enhancing Canonical Wnt/β-Catenin Signaling in Chronic Lymphocytic Leukemia

Han Zhang, PhD, Suping Zhang, PhD, Emanuela M. Ghia, PhD, Michael Y. Choi, MD, Jieyu Zhang, MS, Liguang Chen, PhD, George F. Widhopf II, PhD, Laura Z. Rassenti, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2652.
https://doi.org/10.1182/blood-2018-99-119606
Published: 2018
Journal Articles

High IGF1R Expression Is Associated with Worse Prognosis in CLL and Impacts Response to PI3K-δ Inhibitor Treatment

Annika Scheffold, Billy Michael Chelliah Jebaraj, PhD, Johannes Bloehdorn, MD, Eugen Tausch, MD, Jasmin Bahlo, PhD, Sandra Robrecht, PhD, Kirsten Fischer, MD, Michael Hallek, MD, Hartmut Döhner, MD, Daniel Mertens, PhD, Stephan Stilgenbauer, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 390.
https://doi.org/10.1182/blood.V130.Suppl_1.390.390
Published: 2017
Journal Articles

Structural Features of ROR1 Required for Complexing with ROR2 and Enhancing Chemokine-Induced Migration and Leukemia-Cell Proliferation, Which Can be Blocked By the Anti-ROR1 Mab Cirmtuzumab (UC-961)

Jian Yu, PhD, Liguang Chen, MD PhD, George F. Widhopf, II, PhD, Suping Zhang, PhD, Bing Cui, PhD, Rongrong Wu, PhD, Ling Zhang, PhD, Thomas J. Kipps, MD, PhD
Journal: Blood
Blood (2015) 126 (23): 1741.
https://doi.org/10.1182/blood.V126.23.1741.1741
Published: 2015
Journal Articles

Investigating the Efficacy of Ofatumumab and Rituximab in Abrogating the Survival of NOTCH1 Mutated Chronic Lymphocytic Leukaemic (CLL) Cells

Odette Middleton, Alison McCaig, Mike Leach, Alison Michie, Helen Wheadon
Journal: Blood
Blood (2014) 124 (21): 3289.
https://doi.org/10.1182/blood.V124.21.3289.3289
Published: 2014
Journal Articles

ROR1 Isoforms Are Constitutively Phosphorylated in Chronic Lymphocytic Leukemia (CLL) - a Survival Factor for CLL Cells

Hakan Mellstedt, MD, PhD., Mohammad Hojjat-Farsangi, PhD, Ladan Mansouri, MD, Anders Osterborg, MD, PhD, Hodjattallah Rabbani, PhD
Journal: Blood
Blood (2011) 118 (21): 1778.
https://doi.org/10.1182/blood.V118.21.1778.1778
Published: 2011
Journal Articles

CML Patients Present Additional Mutations in Cancer Related Genes When Tested At Diagnosis

Carlo Gambacorti-Passerini, MD, Simona Valletta, M.Sc., Alessandra Stasia, MD, Alexander Leeksma, Nitesh Sharma, Christian Rizzo, Enrico Maria Pogliani, MD, Alessandra Pirola, M.Sc., Rocco Piazza, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 2739.
https://doi.org/10.1182/blood.V118.21.2739.2739
Published: 2011
Journal Articles

The Activation of Wnt5a-Mediated Non Canonical Wnt Signaling in Human Bone Marrow Osteoprogenitor Cells Increases Osteoblastogenesis and Counterbalances the Inhibitory Effect of Myeloma Cells on Ror2/FZD5 Expression,

Marina Bolzoni, Paola Storti, PhD, Daniela Guasco, Mirca Lazzaretti, PhD, Eugenia Martella, MD, Cristina Mancini, MD, Luca Agnelli, PhD, Sabrina Bonomini, Antonino Neri, MD, Gaetano Donofrio, PhD, Nicola Giuliani, M.D., Ph.D.
Journal: Blood
Blood (2011) 118 (21): 3928.
https://doi.org/10.1182/blood.V118.21.3928.3928
Published: 2011
Journal Articles

Myeloma Cells Inhibit the Non-Canonical Wnt Co-Receptor Ror2 in Human Mesenchymal/Osteoprogenitor Cells: Effect of Wnt5a/Ror2 Pathway Activation On MM-Induced Impairment of the Osteogenic Differentiation Process.

Marina Bolzoni, Simona Colla, Paola Storti, Gaetano Donofrio, Manuela Abeltino, Valentina Sgobba, Sabrina Bonomini, Vittorio Rizzoli, Nicola Giuliani
Journal: Blood
Blood (2009) 114 (22): 741.
https://doi.org/10.1182/blood.V114.22.741.741
Published: 2009