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Journal Articles

Oncogene-Independent Adaptation of Pre-B Cell Receptor Signaling Confers Drug Resistance and Signaling Plasticity in Ph-like ALL

Christian Hurtz, PhD, Gerald Wertheim, MD, PhD, Joseph Patrick Loftus, BS, Daniel Blumenthal, PhD, Anne Lehman, Yong Li, Bryan Manning, Katherine D Cummins, BMBS, Janis K Burkhardt, PhD, Alexander E. Perl, MD, Martin Carroll, MD, Sarah K. Tasian, MD

Blood (2019) 134 (Supplement_1): 747.

https://doi.org/10.1182/blood-2019-123514

Published: 2019

Journal Articles

Significant In Vivo Sensitivity to Aurora Kinase Inhibition in TCF3-Hlf rearranged Acute Lymphoblastic Leukemia

Bill H. Chang, MD PhD, Jessica Leonard, MD, Joelle Wolf, Michelle Degnin, BS, Kyle Lenz, MD, Beth Wilmot, PhD, Charles G. Mullighan, MBBS, MD, Mignon L. Loh, MD, Stephen P. Hunger, MD, Jeffrey W. Tyner, PhD, Brian J. Druker, MD

Blood (2018) 132 (Supplement 1): 4026.

https://doi.org/10.1182/blood-2018-99-115706

Published: 2018

Journal Articles

Exon Skipping of AIMP2 and Lymphomagenesis

Doyeun Kim, PhD, Seulki Song, Dae-Yoon Kim, Dongchan Kim, Nam Hoon Kwon, PhD, Byung-Su Kim, MD PhD, Hyun Jung Lee, MD, Hyo Jung Kim, MD PhD, Jung Lim Lee, MD, Sung-Soo Yoon, MD PhD, Yoon Kyung Jeon, MD PhD, Sunghoon Kim, Youngil Koh, MD PhD

Blood (2018) 132 (Supplement 1): 2630.

https://doi.org/10.1182/blood-2018-99-117596

Published: 2018

Journal Articles

CD79a Is Associated with Central Nervous System Infiltration of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Lennart Lenk, PhD MSc, Fotini Vogiatzi, PhD, Michela Carlet, PhD, Christian Vokuhl, MD, Gunnar Cario, MD, Martin Schrappe, MD PhD, Irmela Jeremias, MD PhD, Stephan Fuhrmann, MD, Elias Hobeika, PhD, Hassan Jumaa, Prof. Dr., Ameera Alsadeq, PhD, Denis Martin Schewe, MD

Blood (2018) 132 (Supplement 1): 386.

https://doi.org/10.1182/blood-2018-99-114595

Published: 2018

Journal Articles

Mechanisms Underlying Augmented Lymphomagenesis by LUBAC; Possible Accumulation of AID-Mediated Somatic Mutations

Tomoyasu Jo, MD, Momoko Nishikori, MD PhD, Yoshiteru Sasaki, MD PhD, Yasunori Kogure, MD PhD, Keisuke Kataoka, MD PhD, Seishi Ogawa, MD PhD, Kazuhiro Iwai, MD PhD, Akifumi Takaori-Kondo, MD PhD

Blood (2018) 132 (Supplement 1): 775.

https://doi.org/10.1182/blood-2018-99-111097

Published: 2018

Journal Articles

Targeting XIAP Via Degradation of MDM-2 By MX69 in Aggressive Lymphomas

Sumera Khan, MSc, MD, Kyle Runckel, BS, Cory Mavis, BSc, MSc, Matthew J. Barth, MD, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2018) 132 (Supplement 1): 5379.

https://doi.org/10.1182/blood-2018-99-118480

Published: 2018

Journal Articles

The Gef Domain of the BCR-FGFR1 Chimeric Kinase Attenuates SCLL Progression through the RhoA/Rock/Pten Signaling Axis

Tianxiang Hu, PhD, Yating Chong, MSc, Sumin Lu, PhD, John Kenneth Cowell, PhD DSc, FRCPath

Blood (2018) 132 (Supplement 1): 4325.

https://doi.org/10.1182/blood-2018-99-119204

Published: 2018

Journal Articles

Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling

Lai N Chan, Christian Hurtz, PhD, Huimin Geng, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Jae-Woong Lee, PhD, Kadriye Nehir Cosgun, PhD, B Hilda Ye, PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 1336.

https://doi.org/10.1182/blood-2018-99-115514

Published: 2018

Journal Articles

Synergistic Dual Inhibition of BCR-ABL1 and the Unfolded Protein Response Causes p38 MAPK-Mediated Cell Death and Sensitizes BCR-ABL1 + Acute Lymphoblastic Leukemia to Dexamethasone

Margherita Vieri, MSc, Christian Preisinger, Mirle Schemionek, Azam Salimi, John B. Patterson, Afshin Samali, Tim H Brümmendorf, MD, Iris Appelmann, MD, Behzad Kharabi Masouleh, MD

Blood (2018) 132 (Supplement 1): 4674.

https://doi.org/10.1182/blood-2018-99-110967

Published: 2018

Journal Articles

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

Lai N Chan, Seyedmehdi Shojaee, PhD, Christian Hurtz, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Teresa Sadras, PhD, Deborah L White, PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 568.

https://doi.org/10.1182/blood-2018-99-115536

Published: 2018

Journal Articles

Pre-BCR Surrogate Light Chain Components VPREB1 and IGLL1 Function As Pre-BCR-Independent Tumor Suppressors in Acute Lymphoblastic Leukemia

Kadriye Nehir Cosgun, PhD, Rudi W Hendriks, PhD, Ross A Dickins, PhD, Nora Heisterkamp, PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 570.

https://doi.org/10.1182/blood-2018-99-115522

Published: 2018

Journal Articles

A Spic/BCLAF1 Complex Suppresses Pre-B Cell Receptor Signaling in Response to RAG-Mediated DNA Breaks

Deepti Soodgupta, PhD, Lynn S White, Jeffrey J Bednarski, MD PhD

Blood (2017) 130 (Supplement 1): 619.

https://doi.org/10.1182/blood.V130.Suppl_1.619.619

Published: 2017

Journal Articles

Phospholipase Cgamma Pathway-Dependent mTOR Signaling Controls IL-7-Mediated Early B Cell Development

Mei Yu, PhD, Chen Yuhong, PhD, Hu Zeng, PhD, Yongwei Zheng, PhD, Guoping Fu, PhD, Wen Zhu, Ulrich Broeckel, MD, Praful Aggarwal, Amy Turner, Geoffrey A.M. Neale, PhD, Nan Zhu, PhD, Hongbo Chi, PhD, Renren Wen, PhD, Demin Wang, PhD

Blood (2017) 130 (Supplement 1): 620.

https://doi.org/10.1182/blood.V130.Suppl_1.620.620

Published: 2017

Journal Articles

BCL6 Enables RAS-Driven Pre-B Cell Transformation in Acute Lymphoblastic Leukemia

Lai N Chan, Christian Hurtz, PhD, Rebecca Caesar, Seyedmehdi Shojaee, PhD, Gang Xiao, PhD, Huimin Geng, PhD, Mignon L. Loh, MD, B. Hilda Ye, PhD, Steven Kornblau, MD, Markus Muschen, MD

Blood (2017) 130 (Supplement 1): 1211.

https://doi.org/10.1182/blood.V130.Suppl_1.1211.1211

Published: 2017

Journal Articles

DOCK2 Knockdown Mitigates Disease Progression in Murine Models Harboring a FLT3/ITD Mutation

Min Wu, PhD, Li Li, MD PhD, Bao Nguyen, MS, Donald Small, MD PhD, Amy S. Duffield, MD PhD

Blood (2017) 130 (Supplement 1): 1216.

https://doi.org/10.1182/blood.V130.Suppl_1.1216.1216

Published: 2017

Journal Articles

Role of HO-1 in B Lymphocyte Proliferation and Development in Mice

Jishi Wang, Dan Ma, MD, Zhengyu Yu, Ping Wang, Zhen Zhou, Qin Fang, Sishi Tang, Zhengchang He, Ping Liu

Blood (2017) 130 (Supplement 1): 1012.

https://doi.org/10.1182/blood.V130.Suppl_1.1012.1012

Published: 2017

Journal Articles

Two Hematopoietic Transcription Factors, RUNX1 and FUBP1, Control the Expression of KIT Oncogene in Pre-B Lymphoblasts

Lydie Debaize, Hélène Jakobczyk, Anne-Gaëlle Rio, Stéphane Avner, PhD, Aurélien Serandour, PhD, Frédéric Chalmel, PhD, Gilles Salbert, PhD, Marie-Dominique Galibert, PharmD/PhD, Virginie Gandemer, MD PhD, Marie-Berengere Troadec, PhD

Blood (2017) 130 (Supplement 1): 2469.

https://doi.org/10.1182/blood.V130.Suppl_1.2469.2469

Published: 2017

Journal Articles

Signal-Transducing Adaptor Protein-2 Blocks B Cell Recovery Under Hematological Stress at Pre-B Stage Via TLR4 Signaling

Michiko Ichii, MD PhD, Kenji Oritani, MD PhD, Hirohiko Shibayama, MD PhD, Jun Toda, MD, Hideaki Saito, MD, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Tadashi Matsuda, Yuzuru Kanakura, MD PhD

Blood (2017) 130 (Supplement 1): 1155.

https://doi.org/10.1182/blood.V130.Suppl_1.1155.1155

Published: 2017

Journal Articles

CD25 Enables Oncogenic BCR-Signaling and Represents a Therapeutic Target in B Cell Malignancies

Jaewoong Lee, PhD, Huimin Geng, PhD, Zhengshan Chen, MDPhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, Ari Melnick, MD, Elisabeth Paietta, PhD, Markus Muschen, MDPhD

Blood (2017) 130 (Supplement 1): 3834.

https://doi.org/10.1182/blood.V130.Suppl_1.3834.3834

Published: 2017

Journal Articles

Redundant JAK, SRC and PI3 Kinase Signaling Pathways Regulate Cell Survival in Human Ph-like ALL Cell Lines and Primary Cells

Christian Hurtz, PhD, Sarah K Tasian, MD, Gerald Wertheim, MD, PhD, Bruce Ruggeri, Matthew C. Stubbs, Alexander E. Perl, MD, Martin Carroll, MD

Blood (2017) 130 (Supplement 1): 717.

https://doi.org/10.1182/blood.V130.Suppl_1.717.717

Published: 2017

NARROW

Oncogene-Independent Adaptation of Pre-B Cell Receptor Signaling Confers Drug Resistance and Signaling Plasticity in Ph-like ALL

Significant In Vivo Sensitivity to Aurora Kinase Inhibition in TCF3-Hlf rearranged Acute Lymphoblastic Leukemia

Exon Skipping of AIMP2 and Lymphomagenesis

CD79a Is Associated with Central Nervous System Infiltration of Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Mechanisms Underlying Augmented Lymphomagenesis by LUBAC; Possible Accumulation of AID-Mediated Somatic Mutations

Targeting XIAP Via Degradation of MDM-2 By MX69 in Aggressive Lymphomas

The Gef Domain of the BCR-FGFR1 Chimeric Kinase Attenuates SCLL Progression through the RhoA/Rock/Pten Signaling Axis

Ras-Driven B-Cell Transformation Targets Developmental Rewiring of Cytokine to Pre-B Cell Receptor Signaling

Synergistic Dual Inhibition of BCR-ABL1 and the Unfolded Protein Response Causes p38 MAPK-Mediated Cell Death and Sensitizes BCR-ABL1 + Acute Lymphoblastic Leukemia to Dexamethasone

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

Pre-BCR Surrogate Light Chain Components VPREB1 and IGLL1 Function As Pre-BCR-Independent Tumor Suppressors in Acute Lymphoblastic Leukemia

A Spic/BCLAF1 Complex Suppresses Pre-B Cell Receptor Signaling in Response to RAG-Mediated DNA Breaks

Phospholipase Cgamma Pathway-Dependent mTOR Signaling Controls IL-7-Mediated Early B Cell Development

BCL6 Enables RAS-Driven Pre-B Cell Transformation in Acute Lymphoblastic Leukemia

DOCK2 Knockdown Mitigates Disease Progression in Murine Models Harboring a FLT3/ITD Mutation

Role of HO-1 in B Lymphocyte Proliferation and Development in Mice

Two Hematopoietic Transcription Factors, RUNX1 and FUBP1, Control the Expression of KIT Oncogene in Pre-B Lymphoblasts

Signal-Transducing Adaptor Protein-2 Blocks B Cell Recovery Under Hematological Stress at Pre-B Stage Via TLR4 Signaling

CD25 Enables Oncogenic BCR-Signaling and Represents a Therapeutic Target in B Cell Malignancies

Redundant JAK, SRC and PI3 Kinase Signaling Pathways Regulate Cell Survival in Human Ph-like ALL Cell Lines and Primary Cells

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American Society of Hematology

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ASH Publications

American Society of Hematology

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