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Journal Articles

Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1 -Mutant Relapsed or Refractory Acute Myeloid Leukemia

Sung Choe, PhD, Hongfang Wang, PhD, Courtney D. DiNardo, MD MSc, Eytan M. Stein, MD, Stephane De Botton, Amir T. Fathi, MD, Martin S. Tallman, MD, Hagop M. Kantarjian, MD, Richard M. Stone, MD, Lynn Quek, MD PhD, Zenon Konteatis, PhD, Lenny Dang, PhD, Vickie Zhang, PhD, Hua Liu, PhD, Eyal C. Attar, MD, Bin Wu, PhD

Blood (2019) 134 (Supplement_1): 545.

https://doi.org/10.1182/blood-2019-122671

Published: 2019

Journal Articles

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Yixin Yao, PhD, Yang Liu, MD, Hui Zhang, Angela Leeming, Joseph Mitchell McIntosh, Preetesh Jain, MBBS,MDDM,PhD, Liang Zhang, MD PhD, Krystle Nomie, PhD, Michael L. Wang, MD

Blood (2019) 134 (Supplement_1): 1506.

https://doi.org/10.1182/blood-2019-126738

Published: 2019

Journal Articles

Identification of FASN-Dependent Onco-Metabolic Regulation of the Pentose Phosphate Pathway (PPP) and Nucleotide Metabolism in Non-Hodgkin Lymphoma (NHL)

Ravi Dashnamoorthy, PhD, Afshin Beheshti, PhD, Xiaoyang Su, PhD, Ying Chen, PhD, Maisarah Mokhtar, B.S, Gregory Dolnikowski, Frederick Lansigan, MD, William B Kinlaw, III, MD, Sandeep Dave, MD, Andrew M. Evens, DO, MSc

Blood (2019) 134 (Supplement_1): 1573.

https://doi.org/10.1182/blood-2019-126382

Published: 2019

Journal Articles

Inhibition of TLR4 Signaling Affects Mitochondrial Fitness Overcoming Bortezomib Resistance in Myeloma Plasma Cells

Cesarina Giallongo, PhD, Daniele Tibullo, PhD, Giuseppina Camiolo, Fabrizio Puglisi, Daniela Cambria, Alessandro Barbato, Nunziatina Laura Parrinello, PhD, Alessandra Romano, MD PhD, Concetta Conticello, MD, Angela Amorini, PhD, Giovanni Li Volti, MD PhD, Giuseppe Lazzarino, Giuseppe A. Palumbo, MD PhD, Francesco Di Raimondo, MD

Blood (2019) 134 (Supplement_1): 3073.

https://doi.org/10.1182/blood-2019-129812

Published: 2019

Journal Articles

Higher Stability of Mutant IDH1/2 mRNA As Compared to Wild-Type mRNA in Patients with Acute Myeloid Leukemia

Maher Albitar, MD, Marina Y Konopleva, MD PhD, Ivan De Dios, BS, Jeffrey Justin Estella, BS, MS, Spiraggelos Antzoulatos, Steven M. Kornblau, MD, Antonio Cavazos, Sanam Loghavi, MD, Koichi Takahashi, MD, Hagop M. Kantarjian, MD, Courtney D. DiNardo, MDMSc

Blood (2019) 134 (Supplement_1): 2730.

https://doi.org/10.1182/blood-2019-127383

Published: 2019

Journal Articles

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

Cheuk-Him Man, David T. Scadden, MD, Francois Mercier, MD FRCPC, Nian Liu, Wentao Dong, Gregory Stephanopoulos, PhD, Li Jiang, PhD, Yookyung Jung, PhD, Charles Lin, PhD, Anskar Y.-H. Leung, MD PhD

Blood (2019) 134 (Supplement_1): 3765.

https://doi.org/10.1182/blood-2019-123604

Published: 2019

Journal Articles

Nicotinamide (NAM) Modulates Transcriptional Signature of Ex Vivo Cultured UCB CD34+ Cells (Omidubicel) and Preserves Their Stemness and Engraftment Potential

Tracey Lodie, PhD, Julian Adams, PhD, Dima Yackoubov, Msc, Yair Steinhardt, MSc, Dorit Ashengrau, Adi Bitansky, Alina Maliutina, Sherry Cohen, Boaz Buhenvald, PhD, Moshe Shahor, PhD, Nathan Dinowitz, PhD, Vered Caspi, PhD, Amnon Peled, PhD, Tony Peled, MSc

Blood (2019) 134 (Supplement_1): 3718.

https://doi.org/10.1182/blood-2019-131124

Published: 2019

Journal Articles

Inhibition of Anti-Apoptotic Mcl-1 Exerts Anti-Leukemia Activity through Modulation of Leukemia-Stromal Interactions and Metabolic Functions in AML

Bing Z Carter, PhD, Po Yee Mak, Marc Warmoes, Wenjing Tao, Philip Lorenzi, Vivian Ruvolo, MS, Lin Tan, Justin Cidado, PhD, Lisa Drew, PhD, Michael Andreeff, MD PhD

Blood (2019) 134 (Supplement_1): 3727.

https://doi.org/10.1182/blood-2019-124453

Published: 2019

Journal Articles

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

Sravanti Rangaraju, MBBS, Silvia Marino, PhD, G. David Roodman, MD PhD, Larry D. Cripe, MD, Baskar Ramdas, PhD, Lakshmi Reddy Palam, PhD, Katie J Sargent, RN, Hamid Sayar, MD MSc, Heiko Konig, MD PhD, Reuben Kapur, PhD, H. Scott Boswell, MD

Blood (2019) 134 (Supplement_1): 5051.

https://doi.org/10.1182/blood-2019-124384

Published: 2019

Journal Articles

A Functional Analysis of SNP on Anthracycline-Induced Cardiotoxicity in a Uniform Genetic Background Using CRISPR/Cas9 Mediated Single-Base-Edited iPSCs

Takayuki Nakamura, MD, Shinichi Mizuno, MD PhD, Hidetoshi Ozawa, Yoshitaka Yamasaki, MD, Shuki Oya, MD, Satoshi Morishige, MD, Kazutoshi Aoyama, MD PhD, Maki Ymaguchi, MD PhD, Ritsuko Seki, PhD, Fumihiko Mouri, MD PhD, Koichi Osaki, MD, Koji Nagafuji, MD PhD

Blood (2019) 134 (Supplement_1): 5748.

https://doi.org/10.1182/blood-2019-123932

Published: 2019

Journal Articles

Relationship of Host Genetic Factors with Severe Malaria in Nigerian Children

Olukemi Amodu, PhD, Binal N. Shah, Subulade Ademola, PhD, Bamidele Tayo, PhD, Victor R Gordeuk, MD

Blood (2019) 134 (Supplement_1): 942.

https://doi.org/10.1182/blood-2019-132190

Published: 2019

Journal Articles

SIRT3 Sumoylation Contributes to Chemoresistance in AML

Jiao MA, PhD, Bin Liu, MSc, Dan Yu, BSc, Wayne Tam, MD PhD, Jianmin Yang, PhD, Jinke Cheng, PhD

Blood (2018) 132 (Supplement 1): 3929.

https://doi.org/10.1182/blood-2018-99-110898

Published: 2018

Journal Articles

Adaptation to Metabolic Stress By Mondoα in Common B-Cell Acute Lymphoblastic Leukemia

Alexandra Sipol, Andreas Petry, Erik Hameister, Agnes Görlach, Jürgen Ruland, Stefan Burdach, Poul Sorensen

Blood (2018) 132 (Supplement 1): 3888.

https://doi.org/10.1182/blood-2018-99-114014

Published: 2018

Journal Articles

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Etienne De Braekeleer, PhD MSc, Joanne Hsu, BS, Celine Hervieu, MSc, Konstantinos Tzelepis, PhD, Stefano Indraccolo, MD, Alan J. Warren, PhD FRCP, FRCPath, Irmela Jeremias, MD PhD, David Fernandez Antoran, PhD, Phil H Jones, PhD, Margaret A. Goodell, PhD, George S. Vassiliou

Blood (2018) 132 (Supplement 1): 2615.

https://doi.org/10.1182/blood-2018-99-118827

Published: 2018

Journal Articles

Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl

Akshay A D'Cruz, PhD, Mary Speir, PhD, Meghan Bliss-Moreau, PhD, Sylvia Dietrich, PhD, Alyce A Chen, PhD, Mathilde Gavillet, MD PhD, Kate E Lawlor, PhD, James E Vince, PhD, Michelle Kelliher, PhD, Razq Hakem, PhD, Manolis Pasparakis, PhD, David A Williams, MD, Maria Ericsson, PhD, Ben A Croker, PhD

Blood (2018) 132 (Supplement 1): 276.

https://doi.org/10.1182/blood-2018-99-110051

Published: 2018

Journal Articles

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

Blood (2018) 132 (Supplement 1): 2543.

https://doi.org/10.1182/blood-2018-99-119262

Published: 2018

Journal Articles

Age-Dependent Decrease in Requirement for Glycolysis in Hematopoietic Stem Cells

Watanuki Shintaro, Hiroshi Kobayashi, MD PhD, Daiki Karigane, MDPhD, Yukako Ootomo, Ayumi Okinaga, Shinichiro Okamoto, MD PhD, Keiyo Takubo, MD PhD

Blood (2018) 132 (Supplement 1): 328.

https://doi.org/10.1182/blood-2018-99-111616

Published: 2018

Journal Articles

Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death

Shigeharu Ueki, Takahiro Tokunaga, Rossana C. N. Melo, Hidekazu Saito, Kohei Honda, Mineyo Fukuchi, Yasunori Konno, Masahide Takeda, Yohei Yamamoto, Makoto Hirokawa, Shigeharu Fujieda, Lisa A. Spencer, Peter F. Weller

Blood (2018) 132 (20): 2183–2187.

https://doi.org/10.1182/blood-2018-04-842260

Published: 2018

Includes: Multimedia, Supplemental data

Journal Articles

Glucose-6-Phosphate Dehydrogenase Deficiency in Blood Donors Is Associated with Decreased Post-Transfusion Red Cell Recovery

Richard O Francis, MD PhD, Danamarie Belpulsi, MD, Mark Soffing, PharmD, Randy Yeh, MD, Esther E Coronel, MD, Arif Sheikh, MD, Steven Spitalnik, MD, Eldad A. Hod, MD

Blood (2017) 130 (Supplement 1): 706.

https://doi.org/10.1182/blood.V130.Suppl_1.706.706

Published: 2017

Journal Articles

Loss of NRF2 Function Worsens the Pathophysiology of Sickle Cell Disease in a Transgenic Mouse Model

Xingguo Zhu, PhD, Betty S. Pace, MD

Blood (2017) 130 (Supplement 1): 960.

https://doi.org/10.1182/blood.V130.Suppl_1.960.960

Published: 2017

NARROW

Molecular Mechanisms Mediating Relapse Following Ivosidenib Monotherapy in Patients with IDH1 -Mutant Relapsed or Refractory Acute Myeloid Leukemia

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Identification of FASN-Dependent Onco-Metabolic Regulation of the Pentose Phosphate Pathway (PPP) and Nucleotide Metabolism in Non-Hodgkin Lymphoma (NHL)

Inhibition of TLR4 Signaling Affects Mitochondrial Fitness Overcoming Bortezomib Resistance in Myeloma Plasma Cells

Higher Stability of Mutant IDH1/2 mRNA As Compared to Wild-Type mRNA in Patients with Acute Myeloid Leukemia

Epigenetic Activation of the pH Regulator MCT4 in Acute Myeloid Leukemia Exploits a Fundamental Metabolic Process of Enhancing Cell Growth through Proton Shifting

Nicotinamide (NAM) Modulates Transcriptional Signature of Ex Vivo Cultured UCB CD34+ Cells (Omidubicel) and Preserves Their Stemness and Engraftment Potential

Inhibition of Anti-Apoptotic Mcl-1 Exerts Anti-Leukemia Activity through Modulation of Leukemia-Stromal Interactions and Metabolic Functions in AML

Cooperativity between Flt3/Syk and Proteasome Inhibitors in Flt3mutant/Wildtype AML, By Acting on the Oxphos and Wnt Endpoints of Syk and p62SQSTM1 Pathways Prohibits Protective Autophagy; While Downregulation of NRF2, NQO1, Jun, and b-Catenin Bypasses Interfering RAS or WT1 Co-Mutations

A Functional Analysis of SNP on Anthracycline-Induced Cardiotoxicity in a Uniform Genetic Background Using CRISPR/Cas9 Mediated Single-Base-Edited iPSCs

Relationship of Host Genetic Factors with Severe Malaria in Nigerian Children

SIRT3 Sumoylation Contributes to Chemoresistance in AML

Adaptation to Metabolic Stress By Mondoα in Common B-Cell Acute Lymphoblastic Leukemia

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

Age-Dependent Decrease in Requirement for Glycolysis in Hematopoietic Stem Cells

Charcot-Leyden crystal formation is closely associated with eosinophil extracellular trap cell death

Glucose-6-Phosphate Dehydrogenase Deficiency in Blood Donors Is Associated with Decreased Post-Transfusion Red Cell Recovery

Loss of NRF2 Function Worsens the Pathophysiology of Sickle Cell Disease in a Transgenic Mouse Model

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American Society of Hematology

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ASH Publications

American Society of Hematology

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