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Journal Articles

Integrated Functional Genomic and Pharmacological Characterization of the Kinome of Myeloma Cells

Ricardo De Matos Simoes, PhD, Eugen Dhimolea, PhD, Ryosuke Shirasaki, MD PhD, Sara Gandolfi, MD, Geoffrey Matthews, PhD, Michal Sheffer, PhD, Olga Dashevsky, PhD, Brian Glassner, PhD, Constantine S. Mitsiades, MD PhD

Blood (2017) 130 (Supplement 1): 2501.

https://doi.org/10.1182/blood.V130.Suppl_1.2501.2501

Published: 2017

Journal Articles

Transforming Growth Factor- β1 Signaling in Vascular Endothelial Cells Inhibits Hematopoietic Stem Cell Regeneration

Derek Zachman, MS, Devorah C Goldman, PhD, Chandan Guha, MD PhD, Beth Wilmot, William H. Fleming, MD PhD

Blood (2016) 128 (22): 1493.

https://doi.org/10.1182/blood.V128.22.1493.1493

Published: 2016

Journal Articles

Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma

Lu Dai, Jimena Trillo-Tinoco, Yueyu Cao, Karlie Bonstaff, Lisa Doyle, Luis Del Valle, Denise Whitby, Chris Parsons, Krzysztof Reiss, Jovanny Zabaleta, Zhiqiang Qin

Blood (2015) 126 (26): 2821–2831.

https://doi.org/10.1182/blood-2015-07-658823

Published: 2015

Includes: Supplemental data

Journal Articles

Mucin 20 (MUC20) Modulates Proteasome Assembly Chaperones through the c-MET Pathway and Is a Biomarker of Proteasome Inhibitor Sensitivity in Myeloma

Huihan Wang, MD, PhD, Veerabhadran Baladandayuthapani, PhD, Heather Yan Lin, PhD, Xiaobin Wang, MD, Bingzong Li, MD, PhD, Xing-Ding Zhang, PhD, Isere Kuiatse, PhD, Hua Wang, PhD, Dongmin Gu, MD, PhD, Liye Zhong, PhD, Wencai Ma, PhD, Richard E. Davis, MD, Robert Z. Orlowski, MD, PhD

Blood (2014) 124 (21): 274.

https://doi.org/10.1182/blood.V124.21.274.274

Published: 2014

Journal Articles

Phase II Study Of The c-MET Inhibitor ARQ 197 (Tivantinib) In Patients With Relapsed Or Relapsed/Refractory Multiple Myeloma (RRMM)

Robert Z. Orlowski, M.D., Ph.D, Shadia Zaman, Ph.D., Sheeba K. Thomas, M.D., Raymond Alexanian, M.D., Jatin J. Shah, M.D., Donna M. Weber, M.D., Michael Wang, MD, Ashley N. Holloway, R.N., Veerabhadran Baladandayuthapani, Ph.D., Heather Yan Lin, Ph.D., Min Fu, Christine M. Stellrecht, Ph.D., Claudia Morales de Partovi, B.S., Varsha Gandhi, PhD

Blood (2013) 122 (21): 1953.

https://doi.org/10.1182/blood.V122.21.1953.1953

Published: 2013

Journal Articles

Phase II Study of the c-Met Inhibitor ARQ 197 (Tivantinib) in Patients with Relapsed Multiple Myeloma.

Stephan Joseph Dorkhom, D.O., Shadia Zaman, Ph.D., Sheeba K. Thomas, MD, Raymond Alexanian, M.D., Jatin J. Shah, M.D., Donna M. Weber, M.D., Michael Wang, M.D., Martha L. Anderson, R.N., Veerabhadran Baladandayuthapani, Ph.D., Yan Heather Lin, Ph.D., Min Fu, Ph.D., Christine M. Stellrecht, Ph.D., Claudia Morales de Partovi, B.S., Varsha V. Gandhi, Ph.D., Robert Z. Orlowski, M.D., Ph.D.

Blood (2012) 120 (21): 2976.

https://doi.org/10.1182/blood.V120.21.2976.2976

Published: 2012

Journal Articles

Enhanced c-Met activity promotes G-CSF–induced mobilization of hematopoietic progenitor cells via ROS signaling

Blood (2011) 117 (2): 419–428.

https://doi.org/10.1182/blood-2009-06-230359

Published: 2011

Includes: Supplemental data

Journal Articles

Expression of the c-Met Oncogene Correlates with Favorable Progression Free Survival In Classical Hodgkin Lymphoma

Chuanhui Xu, Anke Van Den Berg, PhD, Wouter Plattel, drs., Nele Ruther, Huang Xin, Sr, Miao Wang, Gustaaf Van Imhoff, MD, PhD, Andreas Viardot, Peter Möller, Sibrand Poppema, MD, PhD, Lydia Visser, PhD

Blood (2010) 116 (21): 3880.

https://doi.org/10.1182/blood.V116.21.3880.3880

Published: 2010

Journal Articles

Mechanism of Action of a Novel c-Met Inhibitor MK2461 In Multiple Myeloma

Vijay G. Ramakrishnan, PhD, Teresa Kimlinger, Jessica Haug, Timothy Halling, Linda Wellik, S. Vincent Rajkumar, MD, Shaji Kumar, MD

Blood (2010) 116 (21): 4078.

https://doi.org/10.1182/blood.V116.21.4078.4078

Published: 2010

Journal Articles

Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B Cell Lymphoma.

Shahab Uddin, PhD, Azhar Hussain, MBBS, Prashant Bavi, MD, Khawla Al-Kuraya, MD

Blood (2009) 114 (22): 4787.

https://doi.org/10.1182/blood.V114.22.4787.4787

Published: 2009

Journal Articles

The HGF/c-Met Signaling Pathway in Hodgkin Lymphoma.

Chuanhui Xu, Anke Van Den Berg, PhD, Arjan Diepstra, Miao Wang, Debora Jong, Hans JTWM Vos, Peter Moller, MD, Sibrand Poppema, MD, PhD, Lydia Visser

Blood (2009) 114 (22): 1551.

https://doi.org/10.1182/blood.V114.22.1551.1551

Published: 2009

Journal Articles

Crosstalk between the α2β1 integrin and c-met/HGF-R regulates innate immunity

Karissa D. McCall-Culbreath, Zhengzhi Li, Mary M. Zutter

Blood (2008) 111 (7): 3562–3570.

https://doi.org/10.1182/blood-2007-08-107664

Published: 2008

Journal Articles

G-CSF Induces Expression of Both Hepatocyte Growth Factor (HGF) and Its Receptor (c-Met) in Human Hematopoietic Stem/Progenitor Cells and Mature Myeloid Cells - Novel Evidence That during Mobilization the HGF-c-Met Axis Counterbalances G-CSF-Induced Attenuation of the SDF-1-CXCR4 Axis.

Ali Jalili, PhD, Neeta Shirvaikar, MSc, Sara Ilnitsky, BSc, A. Robert Turner, MD, Mariusz Z. Ratajczak, MD, PhD, Anna Janowska-Wieczorek, MD, PhD

Blood (2007) 110 (11): 2203.

https://doi.org/10.1182/blood.V110.11.2203.2203

Published: 2007

Journal Articles

NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor

Wenlin Du, Yutaka Hattori, Taketo Yamada, Kunio Matsumoto, Toshikazu Nakamura, Morihiko Sagawa, Takemi Otsuki, Takako Niikura, Toshihiro Nukiwa, Yasuo Ikeda

Blood (2006) 109 (7): 3042–3049.

https://doi.org/10.1182/blood-2006-02-003103

Published: 2006

Journal Articles

Human Pancreatic Mesenchymal Stem Cells Produce Blood in the Non-Injury Fetal Sheep Model.

Adel Ersek, BS, Angelina Daisy Goodrich, Ph.D, Christopher D. Porada, Ph.D, John S. Pixley, M.D.,Ph.D, Maria Graca Almeida-Porada, M.D., Ph.D, Esmail D. Zanjani, Ph.D

Blood (2006) 108 (11): 2558.

https://doi.org/10.1182/blood.V108.11.2558.2558

Published: 2006

Journal Articles

The Tyrosine Kinase c-Met Is Selectively Expressed on Motile Hematopoietic Progenitors Following G-CSF Administration and Promotes Mobilization by Regulating Stem Cell Niche Components.

Melania Tesio, MSc, Alexander Kalinkovich, MD, PhD, Amir Schajnovitz, Msc, Ayelet Dar, PhD, Orit Kollet, PhD, Polinna Goichberg, PhD, Isabelle Petit, PhD, Silvia Giordano, MD,PhD, Massimo Aglietta, MD, Wanda Piacibello, MD, Tsvee Lapidot, PhD

Blood (2006) 108 (11): 3376.

https://doi.org/10.1182/blood.V108.11.3376.3376

Published: 2006

Journal Articles

IL-6, IGF-1 and IL-21 Act in Synergy with HGF in Myeloma Cells by Inducing the HGF-Receptor c-Met.

Håkon Hov, MD, Unn-Merethe Fagerli, MD, Erming Tian, BS, Anders Waage, MD, PhD, Magne Borset, MD, PhD, Anders Sundan, PhD

Blood (2006) 108 (11): 3438.

https://doi.org/10.1182/blood.V108.11.3438.3438

Published: 2006

Journal Articles

Contribution of HGF to Liver Regeneration by Strong Mobilization of Bone Marrow Stem Cells.

Fumihito Tajima, Hiroyuki Tsuchitya, Kenichi Nishikawa, Toshirou Okazaki, Goushi Shiota

Blood (2006) 108 (11): 1680.

https://doi.org/10.1182/blood.V108.11.1680.1680

Published: 2006

Journal Articles

Involvement of Lipid Raft Domain Signaling in Ex Vivo Maintenance of Hematopoietic Progenitor Cells.

Louisa Wirthlin, BA, Todd E. Meyerrose, BS, Michael H. Creer, MD, Jan A. Nolta, PhD

Blood (2005) 106 (11): 4216.

https://doi.org/10.1182/blood.V106.11.4216.4216

Published: 2005

Journal Articles

C-met Receptor as a Potential Target for the Treatment of Patients with Multiple Myeloma.

Marcin Majka, PhD, Artur Jurczyszyn, MD, PhD, Anna Zebzda, MSci, Wojciech Czogala, MD, Ewa Lesko, MSci, Zbigniew Rudzki, MD, PhD, Jolanta Gozdzik, MD, PhD, Teresa Wolska-Smolen, MD, PhD, Aleksander B. Skotnicki, MD, PhD, Mariusz Z. Ratajczak, MD, PhD

Blood (2005) 106 (11): 3395.

https://doi.org/10.1182/blood.V106.11.3395.3395

Published: 2005

NARROW

Integrated Functional Genomic and Pharmacological Characterization of the Kinome of Myeloma Cells

Transforming Growth Factor- β1 Signaling in Vascular Endothelial Cells Inhibits Hematopoietic Stem Cell Regeneration

Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma

Mucin 20 (MUC20) Modulates Proteasome Assembly Chaperones through the c-MET Pathway and Is a Biomarker of Proteasome Inhibitor Sensitivity in Myeloma

Phase II Study Of The c-MET Inhibitor ARQ 197 (Tivantinib) In Patients With Relapsed Or Relapsed/Refractory Multiple Myeloma (RRMM)

Phase II Study of the c-Met Inhibitor ARQ 197 (Tivantinib) in Patients with Relapsed Multiple Myeloma.

Enhanced c-Met activity promotes G-CSF–induced mobilization of hematopoietic progenitor cells via ROS signaling

Expression of the c-Met Oncogene Correlates with Favorable Progression Free Survival In Classical Hodgkin Lymphoma

Mechanism of Action of a Novel c-Met Inhibitor MK2461 In Multiple Myeloma

Inhibition of Fatty Acid Synthase Suppresses c-Met Receptor Kinase and Induces Apoptosis in Diffuse Large B Cell Lymphoma.

The HGF/c-Met Signaling Pathway in Hodgkin Lymphoma.

Crosstalk between the α2β1 integrin and c-met/HGF-R regulates innate immunity

G-CSF Induces Expression of Both Hepatocyte Growth Factor (HGF) and Its Receptor (c-Met) in Human Hematopoietic Stem/Progenitor Cells and Mature Myeloid Cells - Novel Evidence That during Mobilization the HGF-c-Met Axis Counterbalances G-CSF-Induced Attenuation of the SDF-1-CXCR4 Axis.

NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor

Human Pancreatic Mesenchymal Stem Cells Produce Blood in the Non-Injury Fetal Sheep Model.

The Tyrosine Kinase c-Met Is Selectively Expressed on Motile Hematopoietic Progenitors Following G-CSF Administration and Promotes Mobilization by Regulating Stem Cell Niche Components.

IL-6, IGF-1 and IL-21 Act in Synergy with HGF in Myeloma Cells by Inducing the HGF-Receptor c-Met.

Contribution of HGF to Liver Regeneration by Strong Mobilization of Bone Marrow Stem Cells.

Involvement of Lipid Raft Domain Signaling in Ex Vivo Maintenance of Hematopoietic Progenitor Cells.

C-met Receptor as a Potential Target for the Treatment of Patients with Multiple Myeloma.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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