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Journal Articles

MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells

Blood (2020) 136 (5): 553–571.

https://doi.org/10.1182/blood.2019003940

Published: 2020

Includes: Multimedia, Supplemental data

Journal Articles

Inhibition of Anti-Apoptotic Mcl-1 Exerts Anti-Leukemia Activity through Modulation of Leukemia-Stromal Interactions and Metabolic Functions in AML

Bing Z Carter, PhD, Po Yee Mak, Marc Warmoes, Wenjing Tao, Philip Lorenzi, Vivian Ruvolo, MS, Lin Tan, Justin Cidado, PhD, Lisa Drew, PhD, Michael Andreeff, MD PhD

Blood (2019) 134 (Supplement_1): 3727.

https://doi.org/10.1182/blood-2019-124453

Published: 2019

Journal Articles

Separate Roles of Asparagine and Glutamine in Cytostatic Effect of L-Asparaginase - Stable Isotope Tracing Approach

Katerina Hlozkova, PhD, Alpesh Thakker, PhD, Natividad Alquézar-Artieda, Marketa Zaliova, MD PhD, Jan Trka, Prof., MD PhD, Daniel A Tennant, PhD, Julia Starkova, PhD

Blood (2019) 134 (Supplement_1): 2575.

https://doi.org/10.1182/blood-2019-127911

Published: 2019

Journal Articles

CRISPR-Cas9 Screen Identifies Me2 , a Mitochondrial Malic Enzyme, As a Molecule Relevant for MCL1 Inhibitor Resistance in AML

Fumihiko Nakao, MD, Takuji Yamauchi, MD PhD, Yuichiro Semba, MD PhD, Jumpei Nogami, PhD, Koichi Akashi, MD PhD, Takahiro Maeda, MD PhD

Blood (2019) 134 (Supplement_1): 912.

https://doi.org/10.1182/blood-2019-129237

Published: 2019

Journal Articles

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Yixin Yao, PhD, Yang Liu, MD, Hui Zhang, Angela Leeming, Joseph Mitchell McIntosh, Preetesh Jain, MBBS,MDDM,PhD, Liang Zhang, MD PhD, Krystle Nomie, PhD, Michael L. Wang, MD

Blood (2019) 134 (Supplement_1): 1506.

https://doi.org/10.1182/blood-2019-126738

Published: 2019

Journal Articles

Leukemia Stem Cells in Relapsed AML Patients Are Uniquely Dependent on Nicotinamide Metabolism

Courtney L Jones, PhD, Brett M Stevens, PhD, Rachel Culp-Hill, BS, Travis Nemkov, Angelo D'Alessandro, PhD, Shanshan Pei, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD

Blood (2018) 132 (Supplement 1): 429.

https://doi.org/10.1182/blood-2018-99-111366

Published: 2018

Journal Articles

EVI1 in Acute Myeloid Leukemia Triggers Metabolic Reprograming Associated with Leukemogenesis and Increases Sensitivity to L-Aspalaginase

Yusuke Saito, MD PhD, Daisuke Sawa, MD, Mariko Kinoshita, MD, Ai Yamada, MD, Sachiyo Kamimura, MD, Kazuhiro Morishita, MD PhD, Tomoyoshi Soga, PhD, Hiroshi Moritake, MD PhD

Blood (2018) 132 (Supplement 1): 2601.

https://doi.org/10.1182/blood-2018-99-111581

Published: 2018

Journal Articles

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

Asumi Yokota, PhD, Lulu Zhang, PhD, Xiaomei Yan, MD PhD, Xiaomin Feng, MD PhD, Lijun Wen, MS, George Freudiger, Maria Rife, Ally Woeste, Yoshihiro Hayashi, MD PhD, Gang Huang, PhD

Blood (2018) 132 (Supplement 1): 1311.

https://doi.org/10.1182/blood-2018-99-112529

Published: 2018

Journal Articles

High Glutathione and NAD(P)H Levels, and Increased Protein Folding Capacity Are Involved in Mediating Proteasome Inhibitor-Resistance in Multiple Myeloma

Lenka Besse, Andrej Besse, Marianne Kraus, Jürgen Bader, Christoph Driessen, MD

Blood (2017) 130 (Supplement 1): 1258.

https://doi.org/10.1182/blood.V130.Suppl_1.1258.1258

Published: 2017

Journal Articles

HEME Degradation Enzyme Biliverdin IXb Reductase Is Required for Stem Cell Glutamine Metabolism

Zongdong Li, PhD, Wadie F. Bahou, MD

Blood (2017) 130 (Supplement 1): 3763.

https://doi.org/10.1182/blood.V130.Suppl_1.3763.3763

Published: 2017

Journal Articles

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

Meng Li, PhD, Ying-Ling Chiang, PhD, Costas Lyssiotis, PhD, Matthew Teater, PhD, Hao Shen, MD, Ling Wang, MS, Jun Young Hong, BS, Hui Jin, PhD, Cihangir Duy, PhD, Sucharita Mistry, PhD, Leandro Cerchietti, MD, Justin Cross, PhD, Lewis Cantley, MD, Hening Lin, PhD, Ari Melnick, MD

Blood (2017) 130 (Supplement 1): 643.

https://doi.org/10.1182/blood.V130.Suppl_1.643.643

Published: 2017

Journal Articles

Lower Levels of LPI in Thalassemia Major Patients Treated with Deferasirox

Alice Pecoraro, DR, Angela Vitrano, PhD, Antonio Troia, DR, Maria Fustaneo, MD, Lorella Pitrolo, MD, Paolo Rigano, MD, Aurelio Maggio, MD, Rosalba Di Marzo, DR

Blood (2016) 128 (22): 4821.

https://doi.org/10.1182/blood.V128.22.4821.4821

Published: 2016

Journal Articles

Therapy Resistant CML Stem Cells Are Dependent on Mitochondrial Oxidative Metabolism for Their Survival

Elodie Marie Kuntz, Pablo Baquero, PhD, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Eyal Gottlieb, PhD, G. Vignir Helgason, PhD

Blood (2016) 128 (22): 932.

https://doi.org/10.1182/blood.V128.22.932.932

Published: 2016

Journal Articles

Shwachman-Diamond Syndrome: Energetic Stress, Calcium Homeostasis and mTOR Pathway

Carlo Dufour, MD, Silvia Ravera, PhD, Simone Cesaro, MD, Roberta Bottega, PhD, Cesare Usai, PhD, Cipolli Marco, MD, Anna Savoia, Paolo Degan, PhD, Michela Faleschini, Paola Cuccarolo, Marta Columbaro, Fabio Corsolini, Enrico Cappelli, PhD

Blood (2015) 126 (23): 2410.

https://doi.org/10.1182/blood.V126.23.2410.2410

Published: 2015

Journal Articles

Glutaminase Inhibitor CB-839 Synergizes with Pomalidomide in Preclinical Multiple Myeloma Models

Francesco Parlati, PhD, Mathew Gross, BS, Julie Janes, MS, Evan Lewis, PhD, Andy MacKinnon, PhD, Mirna Rodriguez, BS, Peter Shwonek, BS, Mark Bennett, PhD

Blood (2014) 124 (21): 4720.

https://doi.org/10.1182/blood.V124.21.4720.4720

Published: 2014

Journal Articles

Metabolic Re-Programming in Notch-Activated T-ALL By mTOR Inhibitor AZD2014 Combined with L-Asparaginase

Yoko Tabe, MD PhD, Masako Harada, PhD, Yuka Miyamae, Tsutomu Fujimura, Saiko Kazuno, Takashi Ueno, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 3626.

https://doi.org/10.1182/blood.V124.21.3626.3626

Published: 2014

Journal Articles

Biomarkers of Response to the Glutaminase Inhibitor CB-839 in Multiple Myeloma Cells

Andrew Mackinnon, PhD, Mark Bennett, PhD, Mirna Rodriguez, BS, Francesco Parlati, PhD

Blood (2014) 124 (21): 3429.

https://doi.org/10.1182/blood.V124.21.3429.3429

Published: 2014

Journal Articles

Efficacy of Novel Glutaminase Inhibitor CB-839 in Acute Myeloid Leukemia

Polina Matre, PhD, Maryam Shariati, Juliana Velez, Yuan Qi, Sergej Konoplev, MD PhD, Xiaoping Su, PhD, Courtney D. DiNardo, MD, Naval Daver, MD, Ravi Majeti, MD PhD, Michael Andreeff, MD PhD, Steven M. Chan, MD PhD, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 3763.

https://doi.org/10.1182/blood.V124.21.3763.3763

Published: 2014

Journal Articles

Novel Nanomolar Potency Mitochondrial Complex I Inhibitor Iacs-1131 Selectively Kills Oxphos-Dependent AML Cells

Polina Matre, PhD, Marina Protopopova, Ningping Feng, Jason Gay, Jennifer Greer, Juliana Velez, Hong Mu, MD PhD, Alessia Lodi, Surendar Tadi, Shannon Sweeney, Michael Andreeff, MD PhD, Stefano Tiziani, M. Emilia DiFrancesco, Joseph Marszalek, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 622.

https://doi.org/10.1182/blood.V124.21.622.622

Published: 2014

Journal Articles

Metabolomic Profiling Identifies Mechanisms Regulating Hypoxia-Induced Drug Resistance In Multiple Myeloma

Patricia Maiso, PhD, Daisy Huynh, MPS, Yosra Aljawai, MS, John M. Asara, PhD, Antonio Sacco, BS, Michele Moschetta, MD, Yuji Mishima, PhD, Aldo M Roccaro, MD, PhD, Alec Kimmelman, MD, PhD, Irene M. Ghobrial, MD

Blood (2013) 122 (21): 121.

https://doi.org/10.1182/blood.V122.21.121.121

Published: 2013

NARROW

MDH1-mediated malate-aspartate NADH shuttle maintains the activity levels of fetal liver hematopoietic stem cells

Inhibition of Anti-Apoptotic Mcl-1 Exerts Anti-Leukemia Activity through Modulation of Leukemia-Stromal Interactions and Metabolic Functions in AML

Separate Roles of Asparagine and Glutamine in Cytostatic Effect of L-Asparaginase - Stable Isotope Tracing Approach

CRISPR-Cas9 Screen Identifies Me2 , a Mitochondrial Malic Enzyme, As a Molecule Relevant for MCL1 Inhibitor Resistance in AML

Identify AMPK-Mediated Autophagy and Oxphos As a Novel Metabolic Vulnerability for Targeted Therapy in Mantle Cell Lymphoma

Leukemia Stem Cells in Relapsed AML Patients Are Uniquely Dependent on Nicotinamide Metabolism

EVI1 in Acute Myeloid Leukemia Triggers Metabolic Reprograming Associated with Leukemogenesis and Increases Sensitivity to L-Aspalaginase

Mll -Partial Tandem Duplication ( Mll -PTD) Causes Pseudohypoxia and Hypermethylation of the Epigenome through Suppression of Mitochondrial Complex II

High Glutathione and NAD(P)H Levels, and Increased Protein Folding Capacity Are Involved in Mediating Proteasome Inhibitor-Resistance in Multiple Myeloma

HEME Degradation Enzyme Biliverdin IXb Reductase Is Required for Stem Cell Glutamine Metabolism

SIRT3 Is a Novel Metabolic Driver of and Therapeutic Target for Chemotherapy Resistant Dlbcls

Lower Levels of LPI in Thalassemia Major Patients Treated with Deferasirox

Therapy Resistant CML Stem Cells Are Dependent on Mitochondrial Oxidative Metabolism for Their Survival

Shwachman-Diamond Syndrome: Energetic Stress, Calcium Homeostasis and mTOR Pathway

Glutaminase Inhibitor CB-839 Synergizes with Pomalidomide in Preclinical Multiple Myeloma Models

Metabolic Re-Programming in Notch-Activated T-ALL By mTOR Inhibitor AZD2014 Combined with L-Asparaginase

Biomarkers of Response to the Glutaminase Inhibitor CB-839 in Multiple Myeloma Cells

Efficacy of Novel Glutaminase Inhibitor CB-839 in Acute Myeloid Leukemia

Novel Nanomolar Potency Mitochondrial Complex I Inhibitor Iacs-1131 Selectively Kills Oxphos-Dependent AML Cells

Metabolomic Profiling Identifies Mechanisms Regulating Hypoxia-Induced Drug Resistance In Multiple Myeloma

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American Society of Hematology

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ASH Publications

American Society of Hematology

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