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Journal Articles

A Novel Assay of Neutrophil Extracellular Traps (NETs) Formation Independently Predicts DIC and Identifies the Rationale for Anti-IL-8 Therapies

Simon Timothy Abrams, PhD BSc, Ben Morton, MBChB, MD, Yasir Alhamdi, MBChB, PhD, Mohmad Alsabani, Zhenxing Cheng, Steven Lane, PhD, Ingeborg Welters, PhD, Guozheng Wang, MD PhD, Cheng-Hock Toh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 440.
https://doi.org/10.1182/blood-2019-128493
Published: 2019
Journal Articles

CRISPR/Cas9 Mediated ELANE Knock-out Restores Survival and Granulocytic Differentiation of HL60 Cells Expressing Mutant Neutrophil Elastase: Is Neutrophil Elastase a Dispensible Granulocyte Protease?

Vahagn Makaryan, MD, Isabella N. Archibald, Merideth L. Kelley, MS, Breanna Fletcher, BSc, David C. Dale, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 435.
https://doi.org/10.1182/blood-2019-124988
Published: 2019
Journal Articles

Analysis of Metformin Effects on Bone Marrow Fibrosis and Disease Progression in Primary Myelofibrosis Patients: Preliminary Results of an Open Label Phase II Trial (FIBROMET)

Paula De Melo Campos, MD, Katia B Pagnano, MD PhD, Rubia Mancuso, Francisco Breno S. Teófilo, Juan L Coelho-Silva, BSc, MSc, Fernanda I Della Via, MSc, Leandro Luiz Lopes Freitas, MD PhD, Hernandes F. Carvalho, PhD, Fernando Ferreira Costa, MD PhD, Fabiola Traina, MD PhD, Sara T Olalla Saad, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 554.
https://doi.org/10.1182/blood-2019-130648
Published: 2019
Journal Articles

Cxcl8 Expands Hematopoietic Stem and Progenitor Cells and Alters Their Interaction with the Endothelial Niche

Donn L Calkins, BS, Jami L Shaffer, B.S., Emily M Teets, B.S., Alex M Belardo, Serine Avagyan, MD PhD, Leonard I Zon, MD, Bradley W Blaser, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 527.
https://doi.org/10.1182/blood-2019-126151
Published: 2019
Journal Articles

Allogeneic Anti-Bcma CAR-T Cells Show Tumour Specific Killing Against Primary Multiple Myeloma Cells from Different Genomic Sub-Groups

Ana M Metelo, PhD, Ieuan Walker, BSc, MSc, MBBS, Agnieszka Jozwik, PhD, Charlotte Graham, MRCP, BSc, MBBS, Charlotte Attwood, BMedSci, MBBS, MRCP, FRCPath, Katy Sanchez, BSc, MSc, Alan Dunlop, BSc, MSc, Kirsty Cuthill, FRCPath,MBBS,MRCP,PhD, Carmel Rice, FRACP, FRCPA, MBBS, Matthew Streetly, MD, Trevor Bentley, BSc, Bijan Boldajipour, PhD, Cesar Sommer, PhD, Barbra Sasu, PhD, Reuben Benjamin, FRCPath, MRCP, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1834.
https://doi.org/10.1182/blood-2019-124312
Published: 2019
Journal Articles

Identifying Cytokine Biomarkers of Response to Pegylated-Interferon Therapy in Polycythemia Vera and Essential Thrombocythemia: Correlative Analysis from the MPN-RC 111/112 Trials

Andrew Dunbar, MD, Heidi E. Kosiorek, MS, Aishwarya Krishnan, Erin McGovern, BA, Young Park, BS, Minal A Patel, MPH, Rona Singer Weinberg, PhD, Abdulraheem Yacoub, MD, Amylou C. Dueck, PhD, John Mascarenhas, MD, Ross L. Levine, MD, Ronald Hoffman, MD, Raajit K. Rampal, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1661.
https://doi.org/10.1182/blood-2019-129571
Published: 2019
Journal Articles

Therapeutic Targeting of Monokine Production Is a Promising Strategy to Attenuate Cytokine-Release Syndrome in CAR-T Cell Therapy

Muneyoshi Futami, MD PhD, Keisuke Suzuki, MS, Satomi Kato, BS, Yoshio Tahara, MS, Yoichi Imai, MD PhD, Takayuki Mimura, PhD, Yoshihiro Watanabe, PhD, Arinobu Tojo, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2067.
https://doi.org/10.1182/blood-2019-129601
Published: 2019
Journal Articles

Immunosuppressive Diversity of Umbilical Cord-Derived Mesenchymal Stromal Cells

Tokiko Nagamura-Inoue, MD PhD, Atsuko Takahashi, MT., Yuki Yamamoto, MT, Akiko Hori, Yuta Miharu, MT, Kazuo Ogami, MT, Miwako Narita, MD PhD, Fumitaka Nagamura, MD PhD, Arinobu Tojo, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3584.
https://doi.org/10.1182/blood-2019-128627
Published: 2019
Journal Articles

The Pro-Adhesive and Reduced Angiogenic Properties of Endothelial Colony Forming Cells (ECFC) from JAK2 V617F MPN Patients Are Not Related to the Expression of the JAK2 mutation in These Cells: A Potential Role of ADAM17

Bruno Kosa Lino Duarte, Stephanie Ospina-Prieto, PhD, Lucia Helena Siqueira, Jessica O F Guanaes, MSc, Fernando Ferreira Costa, MD PhD, Margareth C Ozelo, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3618.
https://doi.org/10.1182/blood-2019-131488
Published: 2019
Journal Articles

Biomarker Assessment of Venous Thromboembolism in Cancer Patients Receiving Checkpoint Blockade

Shadi Swaidani, MD PhD, Joanna Roopkumar, MBBS, MPH, Young Jun-Shim, PhD, Cathy Charles, Slato Paul, Suman Kundu, MBA, Pauline Funchain, MD, Patricia Rayman, Paul G. Pavicic, C. Marcela Diaz-Montero, PhD, Alok A Khorana, MD, Keith R McCrae, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3648.
https://doi.org/10.1182/blood-2019-130911
Published: 2019
Journal Articles

Sickle Cell Disease Patients Have Altered Number and Function of Dendritic Cells

Renata Sesti-Costa, PhD, Carolina Lanaro, BSc, PhD, Dulcinéia Martins de Albuquerque, BSc, PhD, Sara T Olalla Saad, PhD, Fernando Ferreira Costa, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3569.
https://doi.org/10.1182/blood-2019-129854
Published: 2019
Journal Articles

Gene Expression and Cytokine Analyses Identify Markers of Progression from CLL-like Monoclonal B-Cell Lymphocytosis to Chronic Lymphocytic Leukemia

Gonzalo Blanco, PhD, Anna Puiggros, PhD, Barbara Sherry, PhD, Lara Nonell, Eulalia Puigdecanet, Pui Yan Chiu, Yasmine Kieso, MSCR, Gerardo Ferrer, PhD, Magdalena Arnal, María Rodríguez-Rivera, Eva Gimeno, MD PhD, Eugenia Abella, Kanti R Rai, MD, Pau Abrisqueta, MD PhD, Xavier Calvo, MD PhD, Francesc Bosch, MD PhD, Ana Ferrer, MD PhD, Nicholas Chiorazzi, MD, Blanca Espinet, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3027.
https://doi.org/10.1182/blood-2019-122038
Published: 2019
Journal Articles

Vitamin D and Inflammatory Markers in Children with Sickle Cell Disease

Margaret T. Lee, MD, Adiba Ashrafi, MS, Mady Hornig, MA, MD, Amelia Boehme, PhD MSPH, Nancy S. Green, MD, Gary M. Brittenham, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2312.
https://doi.org/10.1182/blood-2019-129771
Published: 2019
Journal Articles

Association between Inflammatory Markers and Abnormal Neurological, Neurocognitive and Magnetic Resonance Imaging (MRI) Findings in Children with Sickle Cell Anemia in Uganda

Amelia Boehme, PhD MSPH, Adiba Ashrafi, MS, Richard Idro, MMED, PhD, Paul Bangirana, MS, PhD, Deogratias Munube, MD, Robert Opoka, MMED, Philip Kasirye, MMED, Margaret T. Lee, MD, Nancy S. Green, MD, Mady Hornig, MA, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2300.
https://doi.org/10.1182/blood-2019-131560
Published: 2019
Journal Articles

Hematopoietic Stem and Progenitor Cells Manifest Direct Migration Towards Secreted DEK in a CXCR2- and G Protein Signaling-Dependent Manner

Maegan L. Capitano, PhD, Yasser Sammour, Maureen Legendre, Scott Cooper, MS, David Markovitz, MD, Hal E. Broxmeyer, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1196.
https://doi.org/10.1182/blood-2019-128738
Published: 2019
Journal Articles

A Phase 2a Study of the LSD1 Inhibitor Img-7289 (bomedemstat) for the Treatment of Myelofibrosis

Kristen Pettit, MD, Aaron T. Gerds, MD MS, Abdulraheem Yacoub, MD, Justin M. Watts, MD, Maciej Tartaczuch, MD, Terrence J Bradley, MD, Jake Shortt, MBBS FRACP FRCPA PhD, William S. Stevenson, MBBS,PhD, Natasha Joan Curtin, MDFRACP,FRCPA, James M. Rossetti, DO, Kate Burbury, MBBS, FRACP, FRCPA, DPhil, Georges Natsoulis, PhD, Amber Jones, MA, Moshe Talpaz, MD, Jennifer Peppe, BS, David M Ross, MD PhD, Hugh Young Rienhoff, Jr., MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 556.
https://doi.org/10.1182/blood-2019-123244
Published: 2019
Journal Articles

Phase I Clinical Trial of CK0801 (cord blood regulatory T cells) in Patients with Bone Marrow Failure Syndrome (BMF) Including Aplastic Anemia, Myelodysplasia and Myelofibrosis

Tapan M. Kadia, MD, Hongbing Ma, MD PhD, Ke Zeng, MD PhD, Mitsutaka Nishimoto, MD PhD, Mi-Ae Lyu, PhD, Meixian Huang, Musa Yilmaz, MD, Courtney D. DiNardo, MDMSc, Ghayas C. Issa, MD, Simrit Parmar, MBBS, Swami P. Iyer, MD, Parameswaran Hari, MBBS, MD, Naval G. Daver, MD, Elias Jabbour, MD, Gautam M. Borthakur, MD, Srdan Verstovsek, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1221.
https://doi.org/10.1182/blood-2019-127702
Published: 2019
Journal Articles

Increased Release of Soluble MD-2 in Sickle Cell Disease and Its Role in Pro-Inflammatory Signaling in Endothelial Cells

Ping Zhang, PhD, John D Belcher, PhD, Julia Nguyen, Fuad Abdulla, Gregory M Vercellotti, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 208.
https://doi.org/10.1182/blood-2019-122912
Published: 2019
Journal Articles

Identification of a Heme Activation Site on the MD-2/TLR4 Complex

John D Belcher, PhD, Ping Zhang, PhD, Julia Nguyen, Zachary Monroe Kiser, BS, PhD, John O Trent, PhD, Gregory M Vercellotti, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 209.
https://doi.org/10.1182/blood-2019-123788
Published: 2019
Journal Articles

Correlative Analyses of Patient and Clinical Characteristics Associated with Efficacy in Tisagenlecleucel-Treated Relapsed/Refractory Diffuse Large B-Cell Lymphoma Patients in the Juliet Trial

Jason R. Westin, MD, Constantine S. Tam, MBBS, MD, Peter Borchmann, MD, Ulrich Jaeger, MD, Joseph P. McGuirk, DO, Harald Holte, MD PhD, Edmund K. Waller, PhDMD, Samantha Jaglowski, MDMPH, Michael R. Bishop, MD, Charalambos Andreadis, MD MSCE, Stephen Ronan Foley, MD FRCPC, Isabelle Fleury, MD, P Joy Ho, MBBS(Syd) DPhil(Oxon) FRACP FRCPA FFSc(RCPA), Stephan Mielke, MD, Takanori Teshima, MD, Stephen J Schuster, MD, Veronika Bachanova, MD PhD, Richard T. Maziarz, MD, Koen Van Besien, MD PhD, Koji Izutsu, MD PhD, Marie Jose Kersten, MD PhD, John M. Magenau, MD, Nina D. Wagner-Johnston, MD, Koji Kato, MD PhD, Paolo Corradini, Xia Han, MS, Ranjan Tiwari, MSc, Sergei Agoulnik, PhD, Lamis K. Eldjerou, MD, Lida Bubuteishvili Pacaud, MD, Gilles A. Salles, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4103.
https://doi.org/10.1182/blood-2019-129107
Published: 2019