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Journal Articles

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

Yawara Kawano, MD PhD, Takayuki Sasano, Saki Kushima, Yuki Inada, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD

Blood (2019) 134 (Supplement_1): 3097.

https://doi.org/10.1182/blood-2019-125756

Published: 2019

Journal Articles

The Purine Metabolic Enzyme AMPD1 Is a Novel Therapeutic Target for Multiple Myeloma

Yawara Kawano, MD PhD, Yuki Inada, Takayuki Sasano, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD

Blood (2018) 132 (Supplement 1): 5614.

https://doi.org/10.1182/blood-2018-99-118603

Published: 2018

Journal Articles

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

Susumu Goyama, MD PhD, Shiori Shikata, Yasutaka Hayashi, Yuto Izawa, Janet Schibler, Hiroyuki Iwamura, Dphil, Motoki Saito, PhD, Satoshi Kofuji, Kazutaka Sumita, Atsuo T Sasaki, James C. Mulloy, PhD, Toshio Kitamura, MD PhD

Blood (2016) 128 (22): 750.

https://doi.org/10.1182/blood.V128.22.750.750

Published: 2016

Journal Articles

NT5C2 As a Major Contributor to Thiopurine Resistance at ALL Relapse Via Multiple Mechanisms

Takaya Moriyama, MD, Julia Meyer, PhD, Shuguang Liu, PhD, Xujie Zhao, Zhaohong Ying, MD, William L. Carroll, MD, Jun J Yang, PhD

Blood (2015) 126 (23): 446.

https://doi.org/10.1182/blood.V126.23.446.446

Published: 2015

Journal Articles

De Novo Purine Biosynthesis in Drug Resistance and Tumor Relapse of Childhood ALL

Hui Li, PhD, Benshang Li, Fan Yang, Caiwen Duan, Yun Bai, Jun J Yang, PhD, Jing Chen, MD PhD, Arend von Stackelberg, MD, Hongzhuan Chen, PhD, JingYan Tang, MD, Adolfo A. Ferrando, MD PhD, Jinghui Zhang, PhD, Shengyue Wang, Renate Kirschner-Schwabe, PhD, Bin-Bing S. Zhou, PhD

Blood (2015) 126 (23): 2627.

https://doi.org/10.1182/blood.V126.23.2627.2627

Published: 2015

Journal Articles

Serum Metabolomics Uncovers a New Therapeutic Target in Diffuse Large B Cell Lymphoma (DLBCL)

Leandro Cerchietti, MD, Chen Qiuying, PhD, ShaoNing Yang, MS, Wang Chunjie, MS, Steven Gross, PhD

Blood (2012) 120 (21): 1648.

https://doi.org/10.1182/blood.V120.21.1648.1648

Published: 2012

Journal Articles

Involvement of NFAT Signaling in Function and Anti-Tumor Reactivity of NK Cells

Julia S Wild, Benjamin J Schmiedel, PhD, Melanie Märklin, Lothar Kanz, MD, Martin R Müller, MD, PhD, Helmut R Salih, MD

Blood (2012) 120 (21): 1887.

https://doi.org/10.1182/blood.V120.21.1887.1887

Published: 2012

Journal Articles

Salvage Therapy with Everolimus Reduces the Severity of Treatment-Refractory Chronic Graft-Versus-Host Disease without Impairing Disease Control: A Dual Center Experience

Stephan Mielke, MD, Mathias Lutz, Medical Student, Judith Schmidhuber, Medical Student, Markus Kapp, MD, Julia Ammer, MD, Hermann Einsele, MD, Götz Ulrich Grigoleit, MD, Ernst Holler, MD, Daniel Wolff, MD

Blood (2012) 120 (21): 4173.

https://doi.org/10.1182/blood.V120.21.4173.4173

Published: 2012

Journal Articles

The Association of the Polymorphisms of IMPDH1 Gene and Acute Graft-Versus-Host Disease After Related and Unrelated Hematopoietic Stem Cell Transplantation

Lifei Zhang, Haowen Xiao, Weijie Cao, Xiaoyu Lai, Yi Luo, Jimin Shi, Yamin Tan, Jingsong He, Wanzhuo Xie, Li Li, Xiaoli Zhu, Jie Sun, Guoqin Wei, Yingjia Wang, Xiaohong Yu, Zhen Cai, Maofang Lin, Xiujin Ye, He Huang, MD, PhD

Blood (2010) 116 (21): 2377.

https://doi.org/10.1182/blood.V116.21.2377.2377

Published: 2010

Journal Articles

Mycophenolic Acid Inhibits the Proliferation and Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Guanosine Depletion.

Weijie Cao, Lizhen Liu, Xiaoyu Lai, Xiaohong Yu, He Huang, MD, PhD

Blood (2009) 114 (22): 1454.

https://doi.org/10.1182/blood.V114.22.1454.1454

Published: 2009

Journal Articles

Post-Renal Transplant De Novo Non-Skin Malignancies in Mycophenolate Mofetil- and Calcineurin Inhibitor-Based Immunosuppression.

Lohith Bachegowda, MD, MRCP, Diptesh Gupta, MD, MRCP, Ajoy Bharadwaj, MD, Karthik Ranganna, TIM Adamowicz, DO, Anil Kumar, MD

Blood (2009) 114 (22): 1683.

https://doi.org/10.1182/blood.V114.22.1683.1683

Published: 2009

Journal Articles

Therapeutic Nucleic Acids: A Potential Source of Resistance to Cancer, Antiviral and Immunosuppressive Therapy.

Raymund Buhmann, Ting Yang, Monica Schifferer, Martin Obermeier, Gundula Jaeger, Hans-Jochem Kolb

Blood (2008) 112 (11): 1614.

https://doi.org/10.1182/blood.V112.11.1614.1614

Published: 2008

Journal Articles

Clinical-Biomarker Correlations in Adult AML Patients in a Phase I Trial of AVN944 Support Observations of Clinical Effect and Provide Hypotheses for Patient Selection Criteria for Further Clinical Trials.

Rebecca B. Klisovic, MD, Steven Coutre, MD, Tibor J. Kovacsovics, MD, Hagop M. Kantarjiam, MD, Guido J. Tricot, MD, Jeffrey W. Strovel, PhD, Thomas Genna, RhP, David K. Bol, PhD, Michael Hamilton, MD, Beverly S. Mitchell, MD

Blood (2007) 110 (11): 896.

https://doi.org/10.1182/blood.V110.11.896.896

Published: 2007

Journal Articles

Forced Expression of the “IY” Mutant Inosine Monophosphate Dehydrogenase II Results in Physiologically Significant Resistance to Mycophenolic Acid In Vitro.

Mark A. Schroeder, MD, John F. DiPersio, MD/PhD, Michael P. Rettig, PhD, Julie K. Ritchey

Blood (2006) 108 (11): 5480.

https://doi.org/10.1182/blood.V108.11.5480.5480

Published: 2006

Journal Articles

Genetic and Biochemical Biomarkers of IMPDH Inhibition in Phase I Dose Escalation of AVN-944 for Hematologic Malignancies.

Jeffrey W. Strovel, PhD, Marion Chakiath, M.S, Pachai Natarajan, M.S., Tammy Lawrence, M.S., Karina M. Zuck, Ph.D., Lenore Urbani, Ph.D., Beverly S. Mitchell, M.D., David K. Bol, Ph.D.

Blood (2006) 108 (11): 2590.

https://doi.org/10.1182/blood.V108.11.2590.2590

Published: 2006

Journal Articles

Treatment of Severe Aplastic Anemia with Combined Immunosuppression: Antithymocyte Globulin (ATG), Cyclosporine A (CSA), and Mycophenolate Mofetil (MMF).

Phillip Scheinberg, MD, Olga Nunez, RN, Colin O. Wu, Neal S. Young, MD

Blood (2005) 106 (11): 3758.

https://doi.org/10.1182/blood.V106.11.3758.3758

Published: 2005

Journal Articles

Inosine Monophosphate Dehydrogenase II Mutant (Thr-333-Ile + Ser-351-Tyr) Does Not Confer Resistance to Mycophenolic Acid In Vivo.

Mark A. Schroeder, MD, Michael P. Rettig, PhD, Julie K. Ritchey, John F. DiPersio, MD, PhD

Blood (2005) 106 (11): 5226.

https://doi.org/10.1182/blood.V106.11.5226.5226

Published: 2005

Journal Articles

The IMPDH Inhibitor VX-944 Demonstrates In Vivo Efficacy in an Aggressive Leukemia Model.

Jugnu Jain, PhD, Jianguo Ma, PhD, Brinley Furey, BS, Christian Recher, MS, Cecile Demur, PhD, Srinivasu Poondru, PhD, Jianbo Zhang, PhD, Shaolan Li, MD, Brant Firestone, BS, Karen Olson, PhD, Maura Murphy, PhD, Jennifer Taylor, PhD, Greg Henkel, PhD, Edward Ball, MD, Yung-Mae Yao, PhD, Susan Almquist, MS, Russell Hoover, PhD

Blood (2004) 104 (11): 2530.

https://doi.org/10.1182/blood.V104.11.2530.2530

Published: 2004

Journal Articles

A Novel Inosine Monophosphate Dehydrogenase Inhibitor VX-944 Overcomes Conventional Drug-Resistance in Multiple Mueloma Cells in the Bone Marrow Microenvironment.

Kenji Ishitsuka, M.D., Ph.D, Teru Hideshima, M.D., Ph.D, Makoto Hamasaki, M.D., Ph.D, Raje Noopur, M.D., Ph.D, Kumar Shaji, M.D., Ph.D, Hiroshi Yasui, M.D., Ph.D, Aldo M. Roccaro, M.D., Dharminder Chauhan, Ph.D, Klaus Podar, M.D., Ph.D, Yu-Zu Tai, Ph.D, Jugnu Jain, Ph.D, Kenneth C. Anderson, M.D., Ph.D

Blood (2004) 104 (11): 2468.

https://doi.org/10.1182/blood.V104.11.2468.2468

Published: 2004

NARROW

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

The Purine Metabolic Enzyme AMPD1 Is a Novel Therapeutic Target for Multiple Myeloma

Inhibition of Impdh As an Effective Treatment for MLL-Fusion Leukemia

NT5C2 As a Major Contributor to Thiopurine Resistance at ALL Relapse Via Multiple Mechanisms

De Novo Purine Biosynthesis in Drug Resistance and Tumor Relapse of Childhood ALL

Serum Metabolomics Uncovers a New Therapeutic Target in Diffuse Large B Cell Lymphoma (DLBCL)

Involvement of NFAT Signaling in Function and Anti-Tumor Reactivity of NK Cells

Salvage Therapy with Everolimus Reduces the Severity of Treatment-Refractory Chronic Graft-Versus-Host Disease without Impairing Disease Control: A Dual Center Experience

The Association of the Polymorphisms of IMPDH1 Gene and Acute Graft-Versus-Host Disease After Related and Unrelated Hematopoietic Stem Cell Transplantation

Mycophenolic Acid Inhibits the Proliferation and Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Guanosine Depletion.

Post-Renal Transplant De Novo Non-Skin Malignancies in Mycophenolate Mofetil- and Calcineurin Inhibitor-Based Immunosuppression.

Therapeutic Nucleic Acids: A Potential Source of Resistance to Cancer, Antiviral and Immunosuppressive Therapy.

Clinical-Biomarker Correlations in Adult AML Patients in a Phase I Trial of AVN944 Support Observations of Clinical Effect and Provide Hypotheses for Patient Selection Criteria for Further Clinical Trials.

Forced Expression of the “IY” Mutant Inosine Monophosphate Dehydrogenase II Results in Physiologically Significant Resistance to Mycophenolic Acid In Vitro.

Genetic and Biochemical Biomarkers of IMPDH Inhibition in Phase I Dose Escalation of AVN-944 for Hematologic Malignancies.

Treatment of Severe Aplastic Anemia with Combined Immunosuppression: Antithymocyte Globulin (ATG), Cyclosporine A (CSA), and Mycophenolate Mofetil (MMF).

Inosine Monophosphate Dehydrogenase II Mutant (Thr-333-Ile + Ser-351-Tyr) Does Not Confer Resistance to Mycophenolic Acid In Vivo.

The IMPDH Inhibitor VX-944 Demonstrates In Vivo Efficacy in an Aggressive Leukemia Model.

A Novel Inosine Monophosphate Dehydrogenase Inhibitor VX-944 Overcomes Conventional Drug-Resistance in Multiple Mueloma Cells in the Bone Marrow Microenvironment.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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