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Journal Articles

Biomarker Profile for Prediction of Patient Response to Smac Mimetic Monotherapy in Pediatric Precursor B-Cell Acute Lymphoblastic Leukemia

Julia Zinngrebe, MD, Ferdinand Schlichtig, Malcolm Meyer, Johann M. Kraus, Elena Boldrin, PhD, Hans A. Kestler, Lüder Hinrich Meyer, MD, Pamela Fischer-Posovszky, Klaus-Michael Debatin, MD

Blood (2019) 134 (Supplement_1): 2082.

https://doi.org/10.1182/blood-2019-130967

Published: 2019

Journal Articles

Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl

Akshay A D'Cruz, PhD, Mary Speir, PhD, Meghan Bliss-Moreau, PhD, Sylvia Dietrich, PhD, Alyce A Chen, PhD, Mathilde Gavillet, MD PhD, Kate E Lawlor, PhD, James E Vince, PhD, Michelle Kelliher, PhD, Razq Hakem, PhD, Manolis Pasparakis, PhD, David A Williams, MD, Maria Ericsson, PhD, Ben A Croker, PhD

Blood (2018) 132 (Supplement 1): 276.

https://doi.org/10.1182/blood-2018-99-110051

Published: 2018

Journal Articles

Interim Phase 2 Clinical Trial Results for LCL161, an Oral Smac Mimetic, in Patients with Intermediate or High Risk Myelofibrosis

Naveen Pemmaraju, MD, Bing Z Carter, PhD, Hagop M. Kantarjian, MD, Prithviraj Bose, MD, Tapan Kadia, MD, Elias J. Jabbour, MD, Courtney D. DiNardo, MDMSc, Naval Daver, MD, Zeev Estrov, MD, Jorge E. Cortes, MD, Guillermo Garcia-Manero, MD, Lingsha Zhou, Po Yee Mak, Karina Salinas, RN, Carla Kay Tuttle, RN, Sherry Pierce, BSN, BA, Uday Popat, MD, Srdan Verstovsek, MD PhD

Blood (2017) 130 (Supplement 1): 256.

https://doi.org/10.1182/blood.V130.Suppl_1.256.256

Published: 2017

Journal Articles

Enhancement of Allo-NK Cell Activity in Myeloid Leukemia Cell Line KG-1a after Combined with Aclacinomycin

Yongbin Ye, MDPhD, Xiaojun Xu, MDPhD, Yanhong Chen, MM, Mingwan Zhang, MM, Dafa Qiu, MM, Ziwen Guo, MB, Huiqing He, MB

Blood (2017) 130 (Supplement 1): 5074.

https://doi.org/10.1182/blood.V130.Suppl_1.5074.5074

Published: 2017

Journal Articles

Anti-Tumor Phagocytic Cell Activation in Multiple Myeloma By the IAP Antagonist LCL161: Results of a Phase II Clinical Trial

P. Leif Bergsagel, MD, Martha Q. Lacy, MD, David Dingli, MD PhD, Shaji K. Kumar, MD, Sikander Ailawadhi, MD, Angela Dispenzieri, MD, Francis Buadi, MD, Morie A. Gertz, MD, A. Keith Stewart, MD, Craig B. Reeder, MD, Heidi E. Kosiorek, MS, Amylou C. Dueck, PhD, Yi Lin, MD PhD, Asher Alban Chanan-Khan, MD, Marta Chesi, PhD

Blood (2015) 126 (23): 3039.

https://doi.org/10.1182/blood.V126.23.3039.3039

Published: 2015

Journal Articles

Targeting the X-Linked Inhibitor of Apoptosis Protein (XIAP) Can Promote Tumor Cell Death, and Increase the Cytotoxic Effects of Chemotherapy Agents in in Vitro and In Vivo Models of Rituximab-Resistant Lymphoma

Kyle L. Runckel, BS, Cory Mavis, MSc, Joseph Skitzki, Juan J Gu, PhD, Francisco J. Hernandez-Ilizaliturri, MD, Myron S. Czuczman, MD

Blood (2015) 126 (23): 590.

https://doi.org/10.1182/blood.V126.23.590.590

Published: 2015

Journal Articles

Survivin Is a Master Regulator of Mesenchymal Stem Cell Functions and Potential Therapeutic Target for Mesenchymal Stem Cell Expansion

Pratibha Singh, PhD, Seiji Fukuda, MD PhD, Mary R. Saunders, PhD, Louis M. Pelus, PhD

Blood (2014) 124 (21): 774.

https://doi.org/10.1182/blood.V124.21.774.774

Published: 2014

Journal Articles

The SMAC Mimetic Lcl-161 Augments the in Vitro and in Vivo anti-Tumor Activity of Rituximab and Chemotherapy in Rituximab Relapse/Refractory Lymphoma Models

Kyle L. Runckel, BS, Joseph Skitzki, MD, Francisco Hernandez, MD, Myron S. Czuczman, MD

Blood (2014) 124 (21): 3110.

https://doi.org/10.1182/blood.V124.21.3110.3110

Published: 2014

Journal Articles

Smac Mimetic-Mediated Sensitization Of Childhood ALL Cells For Drug-Induced Apoptosis Independent Of TNFα and NFκB Signaling Pathways

Karin Schmelz, PhD, Nina Weichert, MD, Jutta Proba, Marie-Sophie Erdmann, Patrick Hundsdoerfer, MD

Blood (2013) 122 (21): 2911.

https://doi.org/10.1182/blood.V122.21.2911.2911

Published: 2013

Journal Articles

IAP Antagonists Are a Novel Class Of Immunomodulators That Induce Complete Response In Vk*MYC Myeloma By Stimulating Plasmacytoid Dendritic Cells To Secrete IFNa

Marta Chesi, PhD, Victoria Garbitt, Stephen Palmer, P. Leif Bergsagel, MD

Blood (2013) 122 (21): 128.

https://doi.org/10.1182/blood.V122.21.128.128

Published: 2013

Journal Articles

The Survivin Suppressant YM155 (Sepantronium Bromide) Has Potent Pre-Clinical Activity Against Pediatric Acute Myeloid Leukemia

Erica B. Little, BSc, BCApSc, MSc, Amanda M. Smith, BBMSc (Hons), Andjelija Zivanovic, BPharm (Hons), MSc, Alfred K.S. Liu, BSc, Shannon Waldron, BAppSc, Wendy J. Ingram, BSc (Hons), PhD, Andrew R. Hallahan, MBBS, FRACP, Andrew S. Moore, MBBS, FRACP, PhD

Blood (2013) 122 (21): 3957.

https://doi.org/10.1182/blood.V122.21.3957.3957

Published: 2013

Journal Articles

Birinapant Enhances Bendamustine-Induced Apoptosis In Activated B Cell-Diffuse Large Cell Lymphoma Cells

Indira D Joshi, Ph.D., Mitchell R Smith, MD, PhD

Blood (2013) 122 (21): 5150.

https://doi.org/10.1182/blood.V122.21.5150.5150

Published: 2013

Journal Articles

The Role of the IAP Livin in Megakaryocytes Differentiation and Thrombopoiesis

Ihab Abd-Elrahman, Varda R Deutsch, PhD, Marjorie Pick, PhD, Sigi Kay, PhD, Tzahi Neuman, MD, Riki Perlman, Dina Ben-Yehuda, MD

Blood (2012) 120 (21): 3297.

https://doi.org/10.1182/blood.V120.21.3297.3297

Published: 2012

Journal Articles

The SMAC Mimetic Lcl-161 Demonstrates Anti-Tumor Activity As a Single Agent and Decreases the Apoptotic Threshold of Chemotherapy Agents in Rituximab-Chemotherapy Sensitive and Resistant Lymphoma Pre-Clinical Models

Kyle Runckel, BS, Cory Mavis, BSc, MSc, Joseph Skitzki, MD, Myron S. Czuczman, MD, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2012) 120 (21): 61.

https://doi.org/10.1182/blood.V120.21.61.61

Published: 2012

Journal Articles

The Ratio of Alternate BIRC5 (Survivin) Splice Variants Correlates with Refractory Disease and Poor Outcome in Children with Acute Myeloid Leukemia: A Report From the Children's Oncology Group,

Andrew S. Moore, MBBS, FRACP, Todd A. Alonzo, PhD, Robert B. Gerbing, M.A., Beverly Lange, MD, Nyla A. Heerema, PhD, Janet Franklin, MD, MPH, Susana C. Raimondi, PhD, Betsy A. Hirsch, PhD, Alan S. Gamis, MD, MPH, Soheil Meshinchi, MD, Ph.D.

Blood (2011) 118 (21): 3555.

https://doi.org/10.1182/blood.V118.21.3555.3555

Published: 2011

Journal Articles

New SMAC-Mimetic Compounds Strongly Induce In Vitro Apoptosis of Human Lymphocytes From Patients with Chronic Lymphocytic Leukemia

Francesco Onida, MD, Cinzia Scavullo, MS, Federica Servida, MS, Giorgia Saporiti, MD, Pierfausto Seneci, D., Chem., Gianluigi Reda, MD, Wilma Barcellini, MD, Agostino Cortelezzi, Domenico Delia, PhD, Giorgio Lambertenghi Deliliers, MD

Blood (2010) 116 (21): 1835.

https://doi.org/10.1182/blood.V116.21.1835.1835

Published: 2010

Journal Articles

Blockade of Aurora Kinase Activity Enhances Apo2L/TRAIL Sensitivity In Multiple Myeloma

Paolo Lunghi, PhD, Laura Mazzera, Manuela Abeltino, Nicola Giuliani, Antonio Bonati, MD

Blood (2010) 116 (21): 4059.

https://doi.org/10.1182/blood.V116.21.4059.4059

Published: 2010

Journal Articles

The Role of Inhibitor of Apoptosis Proteins Family Expression In Acute Myeloid Leukemia Patients

Agnieszka Pluta, MD, PhD, Agata Wrzesien-Kus, MD, PhD, Barbara Cebula-Obrzut, PhD, Konrad Stepka, MD, Anna Wolska, MD, Olga Grzybowska-Izydorczyk, MD, PhD, Magdalena Czemerska, MD, Piotr Smolewski, MD, PhD, Tadeusz Robak, MD, PhD, Agnieszka Wierzbowska, MD, PhD

Blood (2010) 116 (21): 2728.

https://doi.org/10.1182/blood.V116.21.2728.2728

Published: 2010

Journal Articles

The Prognostic Role of Smac/DIABLO Protein Expression in Acute Myeloid Leukemia.

Agnieszka Pluta, Agata Wrzesien-Kus, Barbara Cebula, Anna Wolska, Anna Szmigielska-Kaplon, Magdalena Czemerska, Piotr Smolewski, Tadeusz Robak, Agnieszka Wierzbowska

Blood (2009) 114 (22): 2626.

https://doi.org/10.1182/blood.V114.22.2626.2626

Published: 2009

Journal Articles

Second Mitochondria-Derived Activator of Caspases Mimetic Compounds (Smac) Enhance Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) Pro-Apoptotic Effect On Human Myeloid Leukemia Cell Lines.

Federica Servida, MS, Cinzia Scavullo, MS, Daniele Lecis, MS, Pierfausto Seneci, D.Chem., Carmelo Drago, D.Chem., Carmelo CarloStella, MD, Leonardo Manzoni, D.Chem., Giorgio Lambertenghi Deliliers, MD, Domenico Delia, MD, Francesco Onida, MD

Blood (2009) 114 (22): 2756.

https://doi.org/10.1182/blood.V114.22.2756.2756

Published: 2009

NARROW

Biomarker Profile for Prediction of Patient Response to Smac Mimetic Monotherapy in Pediatric Precursor B-Cell Acute Lymphoblastic Leukemia

Padi4 Regulates NET Formation and Inflammatory Cell Death Downstream of Mlkl

Interim Phase 2 Clinical Trial Results for LCL161, an Oral Smac Mimetic, in Patients with Intermediate or High Risk Myelofibrosis

Enhancement of Allo-NK Cell Activity in Myeloid Leukemia Cell Line KG-1a after Combined with Aclacinomycin

Anti-Tumor Phagocytic Cell Activation in Multiple Myeloma By the IAP Antagonist LCL161: Results of a Phase II Clinical Trial

Targeting the X-Linked Inhibitor of Apoptosis Protein (XIAP) Can Promote Tumor Cell Death, and Increase the Cytotoxic Effects of Chemotherapy Agents in in Vitro and In Vivo Models of Rituximab-Resistant Lymphoma

Survivin Is a Master Regulator of Mesenchymal Stem Cell Functions and Potential Therapeutic Target for Mesenchymal Stem Cell Expansion

The SMAC Mimetic Lcl-161 Augments the in Vitro and in Vivo anti-Tumor Activity of Rituximab and Chemotherapy in Rituximab Relapse/Refractory Lymphoma Models

Smac Mimetic-Mediated Sensitization Of Childhood ALL Cells For Drug-Induced Apoptosis Independent Of TNFα and NFκB Signaling Pathways

IAP Antagonists Are a Novel Class Of Immunomodulators That Induce Complete Response In Vk*MYC Myeloma By Stimulating Plasmacytoid Dendritic Cells To Secrete IFNa

The Survivin Suppressant YM155 (Sepantronium Bromide) Has Potent Pre-Clinical Activity Against Pediatric Acute Myeloid Leukemia

Birinapant Enhances Bendamustine-Induced Apoptosis In Activated B Cell-Diffuse Large Cell Lymphoma Cells

The Role of the IAP Livin in Megakaryocytes Differentiation and Thrombopoiesis

The SMAC Mimetic Lcl-161 Demonstrates Anti-Tumor Activity As a Single Agent and Decreases the Apoptotic Threshold of Chemotherapy Agents in Rituximab-Chemotherapy Sensitive and Resistant Lymphoma Pre-Clinical Models

The Ratio of Alternate BIRC5 (Survivin) Splice Variants Correlates with Refractory Disease and Poor Outcome in Children with Acute Myeloid Leukemia: A Report From the Children's Oncology Group,

New SMAC-Mimetic Compounds Strongly Induce In Vitro Apoptosis of Human Lymphocytes From Patients with Chronic Lymphocytic Leukemia

Blockade of Aurora Kinase Activity Enhances Apo2L/TRAIL Sensitivity In Multiple Myeloma

The Role of Inhibitor of Apoptosis Proteins Family Expression In Acute Myeloid Leukemia Patients

The Prognostic Role of Smac/DIABLO Protein Expression in Acute Myeloid Leukemia.

Second Mitochondria-Derived Activator of Caspases Mimetic Compounds (Smac) Enhance Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) Pro-Apoptotic Effect On Human Myeloid Leukemia Cell Lines.

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American Society of Hematology

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American Society of Hematology

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