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Journal Articles

Myeloma Derived Extracellular Vesicles Containing Endoplasmic Reticulum Remodel the Bone Marrow Microenvironment Towards a Pro-Tumoral Senescent Phenotype

Yu Sun, BSc, MSc, PhD, Jayna J Mistry, BSc, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Christopher R Marlein, PhD, Anna Haestier, Cesar A. Gomez, MD PhD FRCPath, Christopher J Morris, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 689.

https://doi.org/10.1182/blood-2019-128268

Published: 2019

Journal Articles

Evaluation of the Functional Effects of an African American Glucose-6-Phosphate Dehydrogenase (G6PD) Polymorphism (Val68Met) on RBC Hemolytic Propensity and Post-Transfusion Recovery in a Humanized Mouse Model

Ling Wang, MD PhD, Benjamin Zuchelkowski, Derek Sinchar, Minying Yang, Sebastien Gingras, Tamir Kanias, PhD, Janet S Lee, Daniel Kim-Shapiro, Grier Page, PhD BS, MS, Mark T Gladwin, MD

Blood (2019) 134 (Supplement_1): 102.

https://doi.org/10.1182/blood-2019-124926

Published: 2019

Journal Articles

Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide

Sinto Chirackal, PhD, Esteban Braggio, PhD, Rahman Atiqur, PhD, Gregory J Ahmann, BS, Yuan Xiao Zhu, PhD, A. Keith Stewart, MB, ChB, Marta Chesi, PhD, P. Leif Bergsagel, MD, Rafael Fonseca, MD

Blood (2019) 134 (Supplement_1): 4410.

https://doi.org/10.1182/blood-2019-124967

Published: 2019

Journal Articles

Cathelicidin Antimicrobial Peptide Expression Is Inversely Associated with Absolute Neutrophil Counts in Pediatric HCT Recipients

Jos Domen, PhD, Hung-Wen Yeh, PhD, Nancy L Shreve, Lei Sun, MD, Yongwu Li, MD, Katrina D Walters, CCRC, Jignesh Dalal, MD, Rakesh K. Goyal, MBBS,MDMRCP

Blood (2019) 134 (Supplement_1): 3294.

https://doi.org/10.1182/blood-2019-131471

Published: 2019

Journal Articles

NK Cells Lacking CD38 Are Resistant to Oxidative Stress-Induced Death

Frank Cichocki, PhD, Karrune Woan, MD PhD, Cheng-Ying Wu, Bruce R. Blazar, MD, Ryan Bjordahl, PhD, Bahram Valamehr, PhD, Jeffrey S. Miller, MD

Blood (2019) 134 (Supplement_1): 3215.

https://doi.org/10.1182/blood-2019-124490

Published: 2019

Journal Articles

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Jayna J Mistry, BSc, Christopher R Marlein, PhD, Jamie A Moore, BSc, MSc, Charlotte Hellmich, MBBChir, Iain Macauley, PhD BSc, Naiara Beraza, PhD, Yu Sun, BSc, MSc, PhD, Adam Morfakis, BSc, Angela Patterson, PhD, Rebecca H Horton, Devina Divekar, Christopher J Morris, PhD, Anna Haestier, Bsc, PgD MBBS, MRCOG, Federica Di Palma, PhD, Kristian M Bowles, MBBS, PhD, Stuart A Rushworth, PhD

Blood (2019) 134 (Supplement_1): 2490.

https://doi.org/10.1182/blood-2019-128241

Published: 2019

Journal Articles

Glycolysis Restoration Attenuates Damaged Bone Marrow Endothelial Cells

Zhong-Shi Lyu, PhD, Wei-Li Yao, Qi Wen, MD, Hong-Yan Zhao, MD, Fei-Fei Tang, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Hsiang-Ying Lee, PhD, Xiao-Jun Huang, Yuan Kong, MD PhD

Blood (2019) 134 (Supplement_1): 2491.

https://doi.org/10.1182/blood-2019-122794

Published: 2019

Journal Articles

Stat3 Is Activated By ROS to Uniquely Regulate Primitive Erythropoiesis

Zachary C. Murphy, PhD, Kathleen E. McGrath, PhD, James Palis, MD

Blood (2019) 134 (Supplement_1): 2216.

https://doi.org/10.1182/blood-2019-127229

Published: 2019

Journal Articles

Protein Cysteine Sulfenylation By CD36-Dependent Reactive Oxygen Species Signaling Promotes Platelet Activation

Moua Yang, PhD, Calvin Harberg, Wenjing Chen, Sarah L. Wynia-Smith, PhD, Kate S. Carroll, PhD, Jacek Zielonka, PhD, Roy L. Silverstein, MD, Brian C. Smith, PhD

Blood (2019) 134 (Supplement_1): 2338.

https://doi.org/10.1182/blood-2019-122465

Published: 2019

Journal Articles

Mechanistic Insights into the Inhibition of T Regulatory Cells By Dasatinib May Predict Immunostimulatory Effects in CML Patients

Patrick Harrington, MRCP, FRCPath, Richard Dillon, MA, PhD MRCP, FRCPath, Philippe Rousselot, MD PhD, Deepti Radia, Yvonne Francis, Claire N Harrison, Professor, Shahram Kordasti, MD PhD, Hugues De Lavallade

Blood (2019) 134 (Supplement_1): 1635.

https://doi.org/10.1182/blood-2019-129135

Published: 2019

Journal Articles

Heme Overload Triggers Xanthine Oxidase Release and Mediates the Inflammatory Response

Heidi M Schmidt, BSE, Eric Kelley, PhD, Adam Straub, PhD

Blood (2019) 134 (Supplement_1): 3529.

https://doi.org/10.1182/blood-2019-130274

Published: 2019

Journal Articles

Modelling Single Cell B-Cell Receptor Signaling Reveals Enhanced Activity in Primary CLL Cells Compared to Non-Malignant Cells While Fundamental Network Circuit Topology Remains Stable Even with Novel Therapeutic Inhibitors

Daniel Mertens, PhD, Christine Wolf, PhD, Carsten Maus, PhD, Michael Persicke, Katharina Filarsky, PhD, Hartmut Döhner, Peter Lichter, PhD, Thomas Höfer, PhD, Stephan Stilgenbauer, MD

Blood (2019) 134 (Supplement_1): 4275.

https://doi.org/10.1182/blood-2019-127837

Published: 2019

Journal Articles

Results of a Flow Cytometry Assay Measuring Oxidative Stress Relief As a Predictor of Immunomodulatory Drugs (IMIDs) Sensitivity in Myeloma

Luke Mountjoy, DO, Sinto Chirackal, PhD, Tania Jain, MD, Marlene Girardo, MS, Jeremy Larsen, MD, Rafael Fonseca, MD

Blood (2018) 132 (Supplement 1): 4443.

https://doi.org/10.1182/blood-2018-99-113710

Published: 2018

Journal Articles

A Potential Mechanism for the Antioxidant Compound Kushen Injection Targeting the ROS Signaling Pathway in Acute Myeloid Leukemia

Yanxia Jin, PhD, Qian Yang, Li Liang, Lu Ding, Yuxing Liang, Dongdong Zhang, Tian Yang, Mingfeng Zhao, MD PhD, Fuling Zhou

Blood (2018) 132 (Supplement 1): 5221.

https://doi.org/10.1182/blood-2018-99-114066

Published: 2018

Journal Articles

AMPK Regulates the Expression of the Fe-S Cluster Assembly Enzyme (ISCU) and ALAS2, Modulating Cellular Iron Metabolism and Increasing Hemoglobin Synthesis

Ping La, Silvia Pires Lourenco, MSc, Laura Breda, PhD, Stefano Rivella

Blood (2018) 132 (Supplement 1): 851.

https://doi.org/10.1182/blood-2018-99-112175

Published: 2018

Journal Articles

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Etienne De Braekeleer, PhD MSc, Joanne Hsu, BS, Celine Hervieu, MSc, Konstantinos Tzelepis, PhD, Stefano Indraccolo, MD, Alan J. Warren, PhD FRCP, FRCPath, Irmela Jeremias, MD PhD, David Fernandez Antoran, PhD, Phil H Jones, PhD, Margaret A. Goodell, PhD, George S. Vassiliou

Blood (2018) 132 (Supplement 1): 2615.

https://doi.org/10.1182/blood-2018-99-118827

Published: 2018

Journal Articles

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

Blood (2018) 132 (Supplement 1): 2543.

https://doi.org/10.1182/blood-2018-99-119262

Published: 2018

Journal Articles

NOX2 Derived Superoxide Induces Pro-Tumoral p16INK4a Driven Senescence in the AML Bone Marrow Microenvironment

Charlotte Hellmich, MBBChir, BSc, MRCP, Amina Abdul-Aziz, MSc, Yu Sun, BSc, MSc, Christopher Richard Marlein, BSc, Eoghan Forde, Rachel E Piddock, BSc, Manar Shafat, MSc, Adam Morfakis, BSc, Mehta Tarang, Federica Di Palma, Christopher Ingham, Angela Collins, MBBS, Anna Haestier, Bsc, PgD MBBS, MRCOG, Judith Campisi, PhD, Kristian Bowles, MBBS, PhD, Stuart Rushworth, PhD BSc

Blood (2018) 132 (Supplement 1): 2770.

https://doi.org/10.1182/blood-2018-99-115274

Published: 2018

Journal Articles

Peroxiredoxin II ( PRDX2 ) Is a Novel Candidate Gene for Congenital Dyserythropoietic Anemia

Myesa Emberesh, MBBS, Katie Giger Seu, PhD, Sana Emberesh, MBBS, Lisa Trump, Mary Risinger, PhD, Wenying Zhang, MD PhD, Ammar Husami, Carolyn Lutzko, PhD, Vinod Gidvani-Diaz, Robert B. Lorsbach, MD PhD, Theodosia A. Kalfa, MD PhD

Blood (2018) 132 (Supplement 1): 3605.

https://doi.org/10.1182/blood-2018-99-120056

Published: 2018

Journal Articles

Arsenic Trioxide Encapsulated in MSC-Derived Extracellular Vesicles: A Novel Therapy for aGVHD in Mice

Xiao Liu, Ya-Nan Wang, Gao-chao Zhang, Yan Su, MD, Qiu-sha Huang, Chen-Cong Wang, Hai-Xia Fu, Yun He, Qian-Ming Wang, Xiang-Yu Zhao, Xiao-Su Zhao, Meng Lv, Ying-Jun Chang, Lan-Ping Xu, Kai-Yan Liu, Xiao-Jun Huang, Xiaohui Zhang, MD

Blood (2018) 132 (Supplement 1): 5673.

https://doi.org/10.1182/blood-2018-99-114904

Published: 2018

NARROW

Myeloma Derived Extracellular Vesicles Containing Endoplasmic Reticulum Remodel the Bone Marrow Microenvironment Towards a Pro-Tumoral Senescent Phenotype

Evaluation of the Functional Effects of an African American Glucose-6-Phosphate Dehydrogenase (G6PD) Polymorphism (Val68Met) on RBC Hemolytic Propensity and Post-Transfusion Recovery in a Humanized Mouse Model

Myeloma Cells Addicted to Glutamine for Biomass Production Are Sensitive to Lenalidomide

Cathelicidin Antimicrobial Peptide Expression Is Inversely Associated with Absolute Neutrophil Counts in Pediatric HCT Recipients

NK Cells Lacking CD38 Are Resistant to Oxidative Stress-Induced Death

Superoxide Drives PI3 Kinase Mediated Mitochondria Transfer from the Bone Marrow Microenvironment to Hematopoietic Stem Cells in Response to Salmonella Typhimurium

Glycolysis Restoration Attenuates Damaged Bone Marrow Endothelial Cells

Stat3 Is Activated By ROS to Uniquely Regulate Primitive Erythropoiesis

Protein Cysteine Sulfenylation By CD36-Dependent Reactive Oxygen Species Signaling Promotes Platelet Activation

Mechanistic Insights into the Inhibition of T Regulatory Cells By Dasatinib May Predict Immunostimulatory Effects in CML Patients

Heme Overload Triggers Xanthine Oxidase Release and Mediates the Inflammatory Response

Modelling Single Cell B-Cell Receptor Signaling Reveals Enhanced Activity in Primary CLL Cells Compared to Non-Malignant Cells While Fundamental Network Circuit Topology Remains Stable Even with Novel Therapeutic Inhibitors

Results of a Flow Cytometry Assay Measuring Oxidative Stress Relief As a Predictor of Immunomodulatory Drugs (IMIDs) Sensitivity in Myeloma

A Potential Mechanism for the Antioxidant Compound Kushen Injection Targeting the ROS Signaling Pathway in Acute Myeloid Leukemia

AMPK Regulates the Expression of the Fe-S Cluster Assembly Enzyme (ISCU) and ALAS2, Modulating Cellular Iron Metabolism and Increasing Hemoglobin Synthesis

The Nucleotide Kinase Nadk Is Required for ROS Detoxification and Constitutes a Metabolic Vulnerability of NOTCH1-Driven T-ALL

Increased Methylation of Deamidated Asparagines and Aspartates in Stored Red Blood Cells from Glucose 6-Phosphate Dehydrogenase-Deficient Blood Donors

NOX2 Derived Superoxide Induces Pro-Tumoral p16INK4a Driven Senescence in the AML Bone Marrow Microenvironment

Peroxiredoxin II ( PRDX2 ) Is a Novel Candidate Gene for Congenital Dyserythropoietic Anemia

Arsenic Trioxide Encapsulated in MSC-Derived Extracellular Vesicles: A Novel Therapy for aGVHD in Mice

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American Society of Hematology

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American Society of Hematology

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