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Journal Articles

Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism

Clinical Trials & Observations
Vincent Ten Cate, JĂ¼rgen H. Prochaska, Andreas Schulz, Thomas Koeck, Alejandro Pallares Robles, Michael Lenz, Lisa Eggebrecht, Steffen Rapp, Marina Panova-Noeva, H. Ardeschir Ghofrani, F. Joachim Meyer, Christine Espinola-Klein, Karl J. Lackner, Matthias Michal, Alexander K. Schuster, Konstantin Strauch, Alexander M. Zink, Volker Laux, Stefan Heitmeier, Stavros V. Konstantinides, Thomas MĂ¼nzel, Miguel A. Andrade-Navarro, Kirsten Leineweber, Philipp S. Wild
Journal: Blood
Blood (2021) 137 (19): 2681–2693.
https://doi.org/10.1182/blood.2019004571
Published: 2021
Includes: Supplemental data
Journal Articles

Transcriptomic Profile of Bone Marrow-Derived Mesenchymal Stromal Cells of Pediatric Pre-B Acute Lymphoblastic Leukemia Patients and Healthy Donors after Interaction with Leukemic Cells

Tuba Ă–zdemì‡r Sanci, MSc, Hilal Ă–zdaÄŸ, PhD, Yasin Köksal, MSc, Seda Tasır Yılmaz, MSc, Husniye Nese Yarali, MD, Namik Yasar Ă–zbek, MD, Habibe Meltem Ă–zgĂ¼ner, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3957.
https://doi.org/10.1182/blood-2019-128282
Published: 2019
Journal Articles

Safety and Efficacy of Midostaurin in Combination with High-Dose Daunorubicin in 7+3 Induction for Acute Myeloid Leukemia with FLT3 Mutation

Yehuda E. Deutsch, MD, Robert Wilkinson, PharmD, Amanda Brahim, PharmD, Stephanie Boisclair, MD, Jose Sandoval-Sus, MD, Annie Kuehnel, APRN, Terrence J Bradley, MD, Chetasi Talati, MD, Ellen Madarang, PharmD, Jillian Lykon, PharmD, Justin M. Watts, MD, David A Sallman, MD, Kendra L. Sweet, MD, Jeffrey E. Lancet, MD, Hugo F. Fernandez, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3896.
https://doi.org/10.1182/blood-2019-129331
Published: 2019
Journal Articles

Small Molecule-Induced, Selective STAT3 Degradation Leads to Anti-Tumor Activity in STAT3-Dependent Heme Malignancies

Fred Csibi, Nan Ji, PhD, Bin Yang, Karen Yuan, Michele Mayo, Haojing Rong, PhD, Scott Rusin, Kirti Sharma, Christine Loh, PhD, Henry Li, PhD, Sharon Townson, Jesse Chen, PhD, Hari Kamadurai, PhD, Duncan Walker, PhD, Jared Gollob, PhD MD, Nello Mainolfi, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3803.
https://doi.org/10.1182/blood-2019-128981
Published: 2019
Journal Articles

Nicotinamide (NAM) Modulates Transcriptional Signature of Ex Vivo Cultured UCB CD34+ Cells (Omidubicel) and Preserves Their Stemness and Engraftment Potential

Tracey Lodie, PhD, Julian Adams, PhD, Dima Yackoubov, Msc, Yair Steinhardt, MSc, Dorit Ashengrau, Adi Bitansky, Alina Maliutina, Sherry Cohen, Boaz Buhenvald, PhD, Moshe Shahor, PhD, Nathan Dinowitz, PhD, Vered Caspi, PhD, Amnon Peled, PhD, Tony Peled, MSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 3718.
https://doi.org/10.1182/blood-2019-131124
Published: 2019
Journal Articles

Inhibition of BMP-Smad Pathway Reduces Leukemic Stemness in Pediatric AML

Xin Long, PhD, Chris Man, PhD, Padmini Narayanan, PhD, Elizabeth Seashore, MD, Michele Redell, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3731.
https://doi.org/10.1182/blood-2019-129074
Published: 2019
Journal Articles

Superior Pre-Clinical Efficacy of Novel Protac Based BET Degrader in a Large Acute Myeloid Leukemia Cohort

Malathi Kandarpa, PhD, Luke F. Peterson, PhD, Harish Potu, PhD, Yihong Liu, Avery Polk, Shaomeng Wang, PhD, Moshe Talpaz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3936.
https://doi.org/10.1182/blood-2019-131759
Published: 2019
Journal Articles

Expanding on Current Definitions of Hematologic Improvement in MDS, CMML and AML: Landmark Analyses of 1301 Patients Treated with Azacitidine in the Austrian Registry of Hypomethylating Agents By the AGMT-Study Group

Lisa Pleyer, Michael Pfeilstocker, MD, Reinhard Stauder, MD MSc, Sonja Heibl, MD, Heinz Sill, MD, Michael Girschikofsky, MD, Margarete Stampfl-Mattersberger, MD, Christoph Tinchon, MD, Andreas Petzer, MD, Clemens A. Schmitt, MD, Sonia Vallet, MD, Inga Mandac, MD, Klaus Geissler, MD, Wolfgang R. Sperr, MD, Michael Leisch, MD, Alexander Egle, MD, Thomas Melchardt, MD PhD, Julia Fusinato, BSc, Gudrun Piringer, MD MSc, Armin Zebisch, MD, Sigrid Machherndl-Spandl, MD, Dominik Wolf, MD, Felix Keil, MD, Richard Greil, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3821.
https://doi.org/10.1182/blood-2019-128153
Published: 2019
Journal Articles

Inhibition of the MiR-185-PAK6-Mediated Survival and Metabolic Pathways Selectively Targets Drug-Resistant CML Stem/Progenitor Cells

Andrew Wu, BSc, Katharina Rothe, PhD, Min Chen, PhD, Hanyang Lin, PhD, Artem Babaian, PhD, Ryan Yen, BSc, Donna L. Forrest, MD, Xiaoyan Jiang, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4138.
https://doi.org/10.1182/blood-2019-127826
Published: 2019
Journal Articles

Characterization of Monoclonal Gammopathy of Undetermined Significance Progression to Multiple Myeloma through Meta-Analysis of GEO Data

Jihad Aljabban, MMSc, BA, David Chen, BS, Francesca Cottini, MD, Saad Syed, BS, Nabeal Aljabban, BS, Sharjeel Syed, BS, Tiffany Hughes, PhD, David Feldman, BS, Dexter Hadley, MD PhD, Don M. Benson, Jr., MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4395.
https://doi.org/10.1182/blood-2019-129699
Published: 2019
Journal Articles

Hematological Count Recovery in Patients Undergoing Treatment with Chimeric Antigen Receptor T Cells (CAR T)

Tania Jain, MD, Andrea Knezevic, MS, Martina Pennisi, Josel D Ruiz, MPH, Sean M. Devlin, PhD, Molly A. Maloy, MS, Elizabeth Halton, NP-BC AOCNP, Claudia Diamonte, RN, Michael Scordo, MD, Craig S. Sauter, MD, Elena Mead, MD, Bianca Santomasso, MD PhD, M. Lia Palomba, MD, Gunjan L. Shah, MDMS, Connie Lee Batlevi, MD PhD, Eric L Smith, MD PhD, Sergio A. Giralt, MD, Renier J. Brentjens, MD PhD, Jae H. Park, MD, Miguel-Angel Perales, MD, Sham Mailankody, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4455.
https://doi.org/10.1182/blood-2019-127480
Published: 2019
Journal Articles

Multiple Myeloma Pathogenesis: The Role of Junb in Bone Marrow Angiogenesis

Fengjuan Fan, PhD, Stefano Malvestiti, MD, Yujia Shen, PhD, Eugenio Morelli, MD, Yuji Mishima, MD, Anja Seckinger, Dirk Hose, MD, Latifa Bakiri, PhD, Sonia Vallet, MD, Martin Sattler, PhD, Aldo M. Roccaro, MD PhD, Hartmut Goldschmidt, MD, Martin Percherstorfer, MD, Chunyan Sun, MD PhD, Yu Hu, MD PhD, Erwin F Wagner, PhD, Piefrancesco Tassone, MD, Irene M. Ghobrial, MD, Dirk Jaeger, MD, Klaus Podar, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4341.
https://doi.org/10.1182/blood-2019-128854
Published: 2019
Journal Articles

Effect of Cyclosporine Inhalation Solution (CIS) on Lung Function and Inflammatory Biomarkers in Patients with Hematopoietic Stem Cell Transplant (HSCT) Associated Bronchiolitis Obliterans Syndrome (BOS)

Janhavi Athale, MD, Nicole J Gormley, MD, Robert Reger, MS, Sara Alsaaty, MS, Debra Reda, BSN, Tatyana Worthy, MSN, Ankit Saxena, Ph. D, Xin Tian, Ph. D, Richard W. Childs, MD, Anthony F Suffredini, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4552.
https://doi.org/10.1182/blood-2019-122966
Published: 2019
Journal Articles

Reversible TET Inhibitor As a Hematopoietic Stem Cell Booster: A Novel Strategy to Improve Stem Cell Function

Sunisa Kongkiatkamon, Yihong Guan, PhD, Anand Tiwari, Phillip J Maciejewski, Dale Grabowski, BS, Sergei Vatolin, PhD, Vera Adema, PhD, Cassandra M Kerr, MS, Yasunobu Nagata, MD PhD, Milo Co, Christina Snider, Hassan Awada, Jibran Durrani, Yvonne Parker, Daniel J. Lindner, Mikkael A. Sekeres, MD MS, Valeria Visconte, PhD, James G Phillips, PhD, Jaroslaw P. Maciejewski, MD PhD, Babal K. Jha, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2472.
https://doi.org/10.1182/blood-2019-129056
Published: 2019
Journal Articles

Rspo-LGR4 Cooperates with HOXA9 to Sustain Self-Renewal in Acute Myeloid Leukemia

Nunki Hassan, Basit Salik, Alastair Duly, PhD, Jenny Yingzi Wang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2669.
https://doi.org/10.1182/blood-2019-129704
Published: 2019
Journal Articles

Combination of the MEK Inhibitor Trametinib and Pyrvinium Pamoate Efficiently Targets RAS Pathway-Mutated Acute Myeloid Leukemia in Preclinical Models

Justine Decroocq, MD, Rudy Birsen, MD, Jordi Mano, MSc, Guillemette Fouquet, Mathilde Gotanègre, MSc, Laury Poulain, PhD, Sarah Mouche, Anne-Sophie Alary, Adrien Grenier, MD PhD, Fetta Mazed, PhD, Johanna Mondesir, MD, Nicolas Chapuis, PharmD, PhD, Aicha Boughalem, MD, Marc Le Lorc'h, Ivan C Moura, PhD, Olivier Hermine, MD PhD, Isabelle Radford-Weiss, Jean-Emmanuel Sarry, PhD, Eric Pasmant, MD PhD, Olivier Kosmider, PharmD, PhD, Didier Bouscary, MD PhD, Jerome Tamburini, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2671.
https://doi.org/10.1182/blood-2019-123418
Published: 2019
Journal Articles

Improved Anti-Leukemic Pre-Clinical Efficacy of a Protac Based MDM2 Degrader in a Large AML Cohort

Malathi Kandarpa, PhD, Luke F. Peterson, PhD, Harish Potu, PhD, Megha Ramappan, Yihong Liu, Avery Polk, Shaomeng Wang, PhD, Moshe Talpaz, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2670.
https://doi.org/10.1182/blood-2019-131949
Published: 2019
Journal Articles

Venetoclax and Azacitidine for Older Newly Diagnosed Patients with Acute Myeloid Leukemia: A Single-Institution Pilot Study Using Measurable Residual Disease to Guide Therapy

Amanda Winters, MD PhD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Brett M. Stevens, PhD, Shanshan Pei, PhD, Jeffrey Schowinsky, Diana Abbott, PhD, Andrew Hammes, MS, Molly Nakic, Lindsey Lyle, Keri Halsema, Dwight Macero, PA-C, Alex Hirose, Chelsey Boggs, Angie Falco, Natalie Monson, Shirstine Rahkola, Sarah Wright, Tyler D'Ovidio, Clayton Smith, MD, Craig T Jordan, PhD, Daniel A Pollyea, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2638.
https://doi.org/10.1182/blood-2019-122120
Published: 2019
Journal Articles

Growth Factor-Dependent Activation of a MYC-Induced Latent AML Program in Human Hematopoietic Cells

Elizabeth Bulaeva, Davide Pellacani, PhD, Naoto Nakamichi, MD PhD, Philip Beer, MD PhD, Colin Hammond, Alireza Lorzadeh, Michelle Moksa, Annaick Carles, Misha Bilenky, Sylvain Lefort, PhD, Jeremy Shu, Brian T. Wilhelm, PhDBSc, Andrew P. Weng, MD PhD, Martin Hirst, PhD, Connie J. Eaves, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2533.
https://doi.org/10.1182/blood-2019-122768
Published: 2019
Journal Articles

Single Cell Signaling Responses Stratify Immune and Leukemia Cell Populations in Acute Myeloid Leukemia

Kathryn I Sunthankar, MD, Benjamin J Reisman, BS, Candace H Cote, BS, Paul Brent Ferrell, Jr., MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2680.
https://doi.org/10.1182/blood-2019-129602
Published: 2019