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Journal Articles

Phase I/II Clinical Trial of Lenalidomide in Combination with AT101 for the Treatment of Relapsed B-Cell Chronic Lymphocytic Leukemia (B-CLL)

Aneel Paulus, MDMS, Pooja Advani, MBBS, Betsy R. Laplant, MS, Sharoon Akhtar, MPhil, Taimur Sher, MD, Candido E. Rivera, MD, James M. Foran, MD, Vivek Roy, MD, Gerardo Colon-Otero, MD, Sikander Ailawadhi, MD, Asher Alban Chanan-Khan, MD

Blood (2015) 126 (23): 5299.

https://doi.org/10.1182/blood.V126.23.5299.5299

Published: 2015

Journal Articles

Targeting the Apoptotic Pathway by TW-37, a Novel Bcl-2 Family Small Molecule Inhibitor, In CLL Primary Samples

Beatriz Herreros, Shaomeng Wang, Maria E. Rodriguez, Margarita Sanchez-Beato, Elena Domenech, Raul Cordoba, Julio Delgado, Jose A Garcia-Marco, MD, PhD, Juan F. Garcia, José Francisco Tomás, Joaquín Martínez-López, Jose Luis Bello, Antonia Rodriguez, Raquel Villuendas, Miguel A. Piris

Blood (2010) 116 (21): 2470.

https://doi.org/10.1182/blood.V116.21.2470.2470

Published: 2010

Journal Articles

L-Gossypol Inhibits NF- κB, Down Regulates Mcl-1 and Induces Apoptosis of Primary Acute Myeloid Leukaemia Cells.

Chris J Pepper, Hani Y Osman, Saman Hewamana, Elisabeth J Walsby, Alan K Burnett, Steven Knapper

Blood (2009) 114 (22): 4813.

https://doi.org/10.1182/blood.V114.22.4813.4813

Published: 2009

Journal Articles

Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells

Kumudha Balakrishnan, William G. Wierda, Michael J. Keating, Varsha Gandhi

Blood (2008) 112 (5): 1971–1980.

https://doi.org/10.1182/blood-2007-12-126946

Published: 2008

Includes: Supplemental data

Journal Articles

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2–transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)

Shinichi Kitada, Christina L. Kress, Maryla Krajewska, Lee Jia, Maurizio Pellecchia, John C. Reed

Blood (2008) 111 (6): 3211–3219.

https://doi.org/10.1182/blood-2007-09-113647

Published: 2008

Includes: Supplemental data

Journal Articles

L-Gossypol Has Significant In Vitro Activity Against Primary Acute Myeloid Leukaemia Cells, Inducing Apoptosis through the Intrinsic Pathway.

Hani Y. Osman, MD, Steven Knapper, DM, Alan K. Burnett, MD

Blood (2007) 110 (11): 4180.

https://doi.org/10.1182/blood.V110.11.4180.4180

Published: 2007

Journal Articles

Induction of Apoptosis and Anti-Tumor Effects of a Novel Pan Inhibitor of Bcl-2 and Mcl-1 Apogossypolone (ApoG2) in Multiple Myeloma Cells.

Jie Lin, Yongji Wu, Shujie Wang, Dajun Yang, Yongqiang Zhao

Blood (2006) 108 (11): 2601.

https://doi.org/10.1182/blood.V108.11.2601.2601

Published: 2006

Journal Articles

Bcl-2 Antagonist ApoGossypol (NSC736630) Displays Single-Agent Activity in Bcl-2 Transgenic Mice and Has Superior Efficacy and Pharmacology with Less Toxicity Compared to Gossypol (NSC19048).

Shinichi Kitada, MD, PhD, Lee Jia, Ph.D., Lori C. Coward, Ph.D., Greg S. Gorman, Ph.D., Patricia Noker, Ph.D., Maurizio Pellecchia, Ph.D., John C. Reed, M.D., Ph.D.

Blood (2006) 108 (11): 2487.

https://doi.org/10.1182/blood.V108.11.2487.2487

Published: 2006

Journal Articles

Effects of Gossypol Acetate on Proliferation and Apoptosis in Lymphoblastoid Cell Line and Primary ALL and CLL Cells.

Yongqiang Zhao, MD, Wei Cheng, MD, Baolai Hua, MD, Shujie Wang, MD, Dajun Yang, MD

Blood (2005) 106 (11): 4405.

https://doi.org/10.1182/blood.V106.11.4405.4405

Published: 2005

Journal Articles

R-(−)-Gossypol (AT101) Binds to Bcl-2 Family Proteins and Induces Apoptosis in CLL.

Carlos E. Prada, MD, Januario E. Castro, MD, Dayong Zhai, PhD, Shinichi Kitada, MD, PhD, John C. Reed, MD, PhD, Thomas J. Kipps, MD, PhD

Blood (2005) 106 (11): 2978.

https://doi.org/10.1182/blood.V106.11.2978.2978

Published: 2005

Journal Articles

AT 101, an Inhibitor of Bcl-2 Family Members Is Cytotoxic to a Heterogeneous Group of CLL Samples and Synergistic with Rituximab.

Danelle F. James, MD, Carlos E. Prada, MD, Januario E. Castro, MD, Thomas J. Kipps, MD, PhD

Blood (2005) 106 (11): 2979.

https://doi.org/10.1182/blood.V106.11.2979.2979

Published: 2005

Journal Articles

AT-101, a Small Molecule Inhibitor of Bcl-2 Family Proteins, Has Significant In Vitro Activity in Multiple Myeloma.

Shaji Kumar, MD, Michael Kline, PhD, Terry Kimlinger, BA, Michael Timm, Jessica Haug, Philip R. Greipp, MD, Dajun Yang, MD, PhD, S. Vincent Rajkumar, MD

Blood (2005) 106 (11): 1581.

https://doi.org/10.1182/blood.V106.11.1581.1581

Published: 2005

NARROW

Phase I/II Clinical Trial of Lenalidomide in Combination with AT101 for the Treatment of Relapsed B-Cell Chronic Lymphocytic Leukemia (B-CLL)

Targeting the Apoptotic Pathway by TW-37, a Novel Bcl-2 Family Small Molecule Inhibitor, In CLL Primary Samples

L-Gossypol Inhibits NF- κB, Down Regulates Mcl-1 and Induces Apoptosis of Primary Acute Myeloid Leukaemia Cells.

Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells

Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2–transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)

L-Gossypol Has Significant In Vitro Activity Against Primary Acute Myeloid Leukaemia Cells, Inducing Apoptosis through the Intrinsic Pathway.

Induction of Apoptosis and Anti-Tumor Effects of a Novel Pan Inhibitor of Bcl-2 and Mcl-1 Apogossypolone (ApoG2) in Multiple Myeloma Cells.

Bcl-2 Antagonist ApoGossypol (NSC736630) Displays Single-Agent Activity in Bcl-2 Transgenic Mice and Has Superior Efficacy and Pharmacology with Less Toxicity Compared to Gossypol (NSC19048).

Effects of Gossypol Acetate on Proliferation and Apoptosis in Lymphoblastoid Cell Line and Primary ALL and CLL Cells.

R-(−)-Gossypol (AT101) Binds to Bcl-2 Family Proteins and Induces Apoptosis in CLL.

AT 101, an Inhibitor of Bcl-2 Family Members Is Cytotoxic to a Heterogeneous Group of CLL Samples and Synergistic with Rituximab.

AT-101, a Small Molecule Inhibitor of Bcl-2 Family Proteins, Has Significant In Vitro Activity in Multiple Myeloma.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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