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Journal Articles

Clinical Profile of IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate (ADC), in Patients with Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Naval G. Daver, MD, Pau Montesinos, MD PhD, Daniel J. DeAngelo, MD, Eunice S. Wang, MD, Nikolaos Papadantonakis, MDPhDMSc, Eric Deconinck, MD PhD, Harry P. Erba, MD PhD, Naveen Pemmaraju, MD, Andrew A. Lane, MD PhD, David A. Rizzieri, MD, Kendra L. Sweet, MD, Giovanni Martinelli, Corrado Tarella, MD, Elisabetta Todisco, MD PhD, Marina Y Konopleva, MD PhD, Callum M. Sloss, PhD, Kerry Culm-Merdek, PhD, Patrick A. Zweidler-McKay, MD PhD, Hagop M. Kantarjian, MD

Blood (2019) 134 (Supplement_1): 734.

https://doi.org/10.1182/blood-2019-128648

Published: 2019

Journal Articles

Discovery of Novel IL3RA (CD123) Isoforms By Long Read Transcriptomics, Heterogeneous Expression Among AML Patient Cohorts and the Implications for Anti-CD123 Therapeutics

Jason G Underwood, PhD BA, Jenny L. Smith, MSc, MD, Lindsey F. Call, B.A., Elizabeth Tseng, PhD, Tiffany A. Hylkema, BS, Rhonda E. Ries, MA, Amanda R. Leonti, MS, Jason E. Farrar, MD, Timothy Junius Triche, Jr., PhD, Soheil Meshinchi, MD PhD

Blood (2019) 134 (Supplement_1): 4658.

https://doi.org/10.1182/blood-2019-131508

Published: 2019

Journal Articles

A Phase 1b/2 Study of the CD123-Targeting Antibody-Drug Conjugate IMGN632 As Monotherapy or in Combination with Venetoclax and/or Azacitidine for Patients with CD123-Positive Acute Myeloid Leukemia

Naval G. Daver, MD, Harry P. Erba, MD PhD, Nikolaos Papadantonakis, MDPhDMSc, Daniel J. DeAngelo, MD, Eunice S. Wang, MD, Marina Y Konopleva, MD PhD, Callum M. Sloss, PhD, Jiuzhou Wang, PhD, Kara E. Malcolm, RN, Patrick A. Zweidler-McKay, MD PhD, Hagop M. Kantarjian, MD

Blood (2019) 134 (Supplement_1): 2601.

https://doi.org/10.1182/blood-2019-128501

Published: 2019

Journal Articles

Palmitoylation of GNA13 Is Essential for Its Tumor Suppressor Function and Its Inhibition Confers Hypersensitivity of B-Cell Lymphoma to BCL2 Inhibitors

Zhizhou Xia, Xiuli Zhang, Ping Liu, MD PhD, Bo Jiao, PhD, Ruibao Ren, MD PhD

Blood (2019) 134 (Supplement_1): 3787.

https://doi.org/10.1182/blood-2019-126368

Published: 2019

Journal Articles

Pharmacokinetic and Pharmacodynamic Study of NKTR-255, a Polymer-Conjugated Human IL-15, in Cynomolgus Monkey

Takahiro Miyazaki, Peiwen Kuo, Mekhala Maiti, Palakshi Obalapur, Murali Addepalli, Werner Rubas, Paul Sims, Ping Zhang, Mario Q. Marcondes, MD PhD, Loui Madakamutil, Jonathan Zalevsky

Blood (2018) 132 (Supplement 1): 2952.

https://doi.org/10.1182/blood-2018-99-115638

Published: 2018

Journal Articles

A Phase I, First-in-Human Study Evaluating the Safety and Preliminary Antileukemia Activity of IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate, in Patients with Relapsed/Refractory Acute Myeloid Leukemia and Other CD123-Positive Hematologic Malignancies

Naval G. Daver, MD, Harry P. Erba, MDPhD, Nikolaos Papadantonakis, MDPhDMSc, Daniel J. DeAngelo, MD, Eunice S. Wang, MD, Marina Y. Konopleva, MD PhD, Callum M. Sloss, PhD, Kerry Culm-Merdek, Patrick A. Zweidler-McKay, MD PhD, Hagop M. Kantarjian, MD

Blood (2018) 132 (Supplement 1): 27.

https://doi.org/10.1182/blood-2018-99-112955

Published: 2018

Journal Articles

The Role of AMPK in Chemotherapy Response in AML

Lais P Ghiraldeli, MS, Rebecca G. Anderson, B.S., Kristin M. Pladna, M.S., Timothy Pardee, MD PhD

Blood (2018) 132 (Supplement 1): 2633.

https://doi.org/10.1182/blood-2018-99-119288

Published: 2018

Journal Articles

CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis

Daniel Teschner, MD, Anna Cholaszczyńska, Frederic Ries, Hendrik Beckert, Matthias Theobald, Stephan Grabbe, MD, Markus P. Radsak, MD, Matthias Bros, PhD

Blood (2018) 132 (Supplement 1): 3690.

https://doi.org/10.1182/blood-2018-99-111843

Published: 2018

Journal Articles

Direct-Acting Small Molecule Activators of PP2A (SMAPs) in Myeloid Malignancies: Understanding Mechanisms of Cytotoxicity to Inform Rational Combinatorial Therapeutic Strategies

Christopher B Ryder, Goutham Narla, MD PhD

Blood (2017) 130 (Supplement 1): 2517.

https://doi.org/10.1182/blood.V130.Suppl_1.2517.2517

Published: 2017

Journal Articles

CBFA2T3 Enhances Transcriptional Activity of RUNX1: Implication in Leukemia

Hélène Jakobczyk, Lydie Debaize, Anne-Gaëlle Rio, Jérémie Gaudichon, Aurélien Serandour, PhD, Stéphane Avner, PhD, Olivier Delalande, PhD, Gilles Salbert, PhD, Marie-Dominique Galibert, PharmD/PhD, Virginie Gandemer, MDPhD, Marie-Berengere Troadec, PhD

Blood (2017) 130 (Supplement 1): 3804.

https://doi.org/10.1182/blood.V130.Suppl_1.3804.3804

Published: 2017

Journal Articles

Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-1

Kei Nakajima, Keita Kirito, MD, Ichiro Kawashima, Megumi Koshiishi, Takuma Kumagai, Toru Mitsumori

Blood (2017) 130 (Supplement 1): 4025.

https://doi.org/10.1182/blood.V130.Suppl_1.4025.4025

Published: 2017

Journal Articles

Immunotoxin Targeting Cell-Bound MUC1 on Myelomonocytic and Monocytic Leukemic Cells

Thierry Guillaume, MD PhD, Virginie Dehame, MSc, Patrice Chevallier, MD, Pierre Peterlin, MD, Marc Gregoire, PhD, Daniel Rubinstein, MD, Eddy Pichinuk, PhD, Daniel H Wreschner, MD

Blood (2017) 130 (Supplement 1): 5060.

https://doi.org/10.1182/blood.V130.Suppl_1.5060.5060

Published: 2017

Journal Articles

IMGN632: A CD123-Targeting Antibody-Drug Conjugate (ADC) with a Novel DNA-Alkylating Payload, Is Highly Active and Prolongs Survival in Acute Myeloid Leukemia (AML) Xenograft Models

Sharlene Adams, PhD, Alan Wilhelm, Lauren Harvey, MS, Chen Bai, Nicholas Yoder, PhD, Yelena Kovtun, PhD, Thomas Chittenden, PhD, Jan Pinkas, PhD

Blood (2016) 128 (22): 2832.

https://doi.org/10.1182/blood.V128.22.2832.2832

Published: 2016

Journal Articles

The G-Protein Coupled Receptors and G-Proteins Alpha Expression in Mantle Cell Lymphoma

Agata M Wasik, PhD, Filip Mundt, PhD, Birger Christensson, MD PhD, Birgitta Sander, MD PhD

Blood (2016) 128 (22): 4137.

https://doi.org/10.1182/blood.V128.22.4137.4137

Published: 2016

Journal Articles

Endothelial Cell-Expressed α Hemoglobin and Its Molecular Chaperone Ahsp Modulate Arterial Vascular Reactivity

Christophe Lechauve, PhD, Joshua Butcher, PhD, Abdullah Freiwan, Miranda Good, PhD, Sharon Frase, PhD, Heather Tillman, PhD, Brant Isakson, PhD, Mitchell J. Weiss, MD PhD

Blood (2016) 128 (22): 557.

https://doi.org/10.1182/blood.V128.22.557.557

Published: 2016

Journal Articles

Unraveling the Efficacy and Safety Profiles of Anti-CD123 Chimeric Antigen Receptors (CARs) in a Model of Acute Myeloid Leukemia Immunotherapy By Investigating CAR Binding Affinity and Density Variables

Silvia Arcangeli, Marco Bardelli, Sarah Tettamanti, Maria Caterina Rotiroti, Luca Simonelli, Chiara F Magnani, Luca Varani, Andrea Biondi, Prof, MD, Ettore Biagi, MD

Blood (2015) 126 (23): 1359.

https://doi.org/10.1182/blood.V126.23.1359.1359

Published: 2015

Journal Articles

Spectrum of Mutations Associated with Hereditary Erythrocytosis

Jennifer L Oliveira, MD, Lori A Frederick, BS, Lea M Coon, MS, Molly Susan Hein, BS, Mrinal M Patnaik, MBBS, Ayalew Tefferi, MD, Animesh Pardanani, MBBS, PhD, Stefan K Grebe, MD, PhD, David S Viswanatha, MD, James D Hoyer, MD

Blood (2015) 126 (23): 2140.

https://doi.org/10.1182/blood.V126.23.2140.2140

Published: 2015

Journal Articles

SGN-CD123A, a Pyrrolobenzodiazepine Dimer Linked Anti-CD123 Antibody Drug Conjugate, Demonstrates Effective Anti-Leukemic Activity in Multiple Preclinical Models of AML

May S.K. Sutherland, PhD, Changpu Yu, Roland B. Walter, MD PhD, Lori Westendorf, John Valliere-Douglass, PhD, Lucy Pan, PhD, Django Sussman, PhD, Martha Anderson, Weiping Zeng, Ivan Stone, Kerry Klussman, Michelle Ulrich, Mechthild Jonas, PhD, Peter Senter, PhD, Jonathan G. Drachman, MD, Dennis Benjamin, PhD

Blood (2015) 126 (23): 330.

https://doi.org/10.1182/blood.V126.23.330.330

Published: 2015

Journal Articles

Targeting Cell-Bound MUC1 on Myelomonocytic and Monocytic Leukemias and Leukemic Stem Cells: Therapeutic Implications

Thierry Guillaume, MD PhD, Virginie Dehame, MSc, Patrice Chevallier, MD PhD, Pierre Peterlin, MD, Marc Grégoire, PhD, Philippe Moreau, Daniel B Rubinstein, MD, Eddy Pichinuk, PhD, Daniel H Wreschner, MD

Blood (2015) 126 (23): 2899.

https://doi.org/10.1182/blood.V126.23.2899.2899

Published: 2015

Journal Articles

Anti-Leukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody-Conjugate in Acute Myeloid Leukemia

Lina Han, PhD, Eric Rowinsky, MD, Christopher Brooks, PhD, Tomasz Zal, M. Anna Zal, Jared K Burks, PhD, Jin Zhou, MD PhD, Stefan O. Ciurea, MD, Gheath Alatrash, Jorge E. Cortes, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Farhad Ravandi, MD, Marina Konopleva, MD PhD

Blood (2014) 124 (21): 981.

https://doi.org/10.1182/blood.V124.21.981.981

Published: 2014

NARROW

Clinical Profile of IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate (ADC), in Patients with Relapsed/Refractory (R/R) Acute Myeloid Leukemia (AML) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Discovery of Novel IL3RA (CD123) Isoforms By Long Read Transcriptomics, Heterogeneous Expression Among AML Patient Cohorts and the Implications for Anti-CD123 Therapeutics

A Phase 1b/2 Study of the CD123-Targeting Antibody-Drug Conjugate IMGN632 As Monotherapy or in Combination with Venetoclax and/or Azacitidine for Patients with CD123-Positive Acute Myeloid Leukemia

Palmitoylation of GNA13 Is Essential for Its Tumor Suppressor Function and Its Inhibition Confers Hypersensitivity of B-Cell Lymphoma to BCL2 Inhibitors

Pharmacokinetic and Pharmacodynamic Study of NKTR-255, a Polymer-Conjugated Human IL-15, in Cynomolgus Monkey

A Phase I, First-in-Human Study Evaluating the Safety and Preliminary Antileukemia Activity of IMGN632, a Novel CD123-Targeting Antibody-Drug Conjugate, in Patients with Relapsed/Refractory Acute Myeloid Leukemia and Other CD123-Positive Hematologic Malignancies

The Role of AMPK in Chemotherapy Response in AML

CD11b Regulates Fungal Outgrowth but Not Neutrophil Recruitment in a Mouse Model of Invasive Pulmonary Aspergillosis

Direct-Acting Small Molecule Activators of PP2A (SMAPs) in Myeloid Malignancies: Understanding Mechanisms of Cytotoxicity to Inform Rational Combinatorial Therapeutic Strategies

CBFA2T3 Enhances Transcriptional Activity of RUNX1: Implication in Leukemia

Aberrant Activation of NF-κB and Hypoxia Enhances Glycolytic Enzyme Hexokinase II Expression in B-Cell Lymphoma through Activation of HIF-1

Immunotoxin Targeting Cell-Bound MUC1 on Myelomonocytic and Monocytic Leukemic Cells

IMGN632: A CD123-Targeting Antibody-Drug Conjugate (ADC) with a Novel DNA-Alkylating Payload, Is Highly Active and Prolongs Survival in Acute Myeloid Leukemia (AML) Xenograft Models

The G-Protein Coupled Receptors and G-Proteins Alpha Expression in Mantle Cell Lymphoma

Endothelial Cell-Expressed α Hemoglobin and Its Molecular Chaperone Ahsp Modulate Arterial Vascular Reactivity

Unraveling the Efficacy and Safety Profiles of Anti-CD123 Chimeric Antigen Receptors (CARs) in a Model of Acute Myeloid Leukemia Immunotherapy By Investigating CAR Binding Affinity and Density Variables

Spectrum of Mutations Associated with Hereditary Erythrocytosis

SGN-CD123A, a Pyrrolobenzodiazepine Dimer Linked Anti-CD123 Antibody Drug Conjugate, Demonstrates Effective Anti-Leukemic Activity in Multiple Preclinical Models of AML

Targeting Cell-Bound MUC1 on Myelomonocytic and Monocytic Leukemias and Leukemic Stem Cells: Therapeutic Implications

Anti-Leukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody-Conjugate in Acute Myeloid Leukemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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