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Journal Articles

Inhibition of Acute Leukemia By a Small Molecule KYA1797K Which Destabilize RAS and β-Catenin

Seungmin Hahn, MD, Mi Ra Lee, Jungwoo Han, MD PhD, Moon Kyu Kim, Seung-Hwan Oh, Chuhl Joo Lyu, MD PhD

Blood (2019) 134 (Supplement_1): 5758.

https://doi.org/10.1182/blood-2019-126374

Published: 2019

Journal Articles

LAM-003, a Novel Oral Heat Shock Protein 90 Inhibitor for Treatment of Acute Myeloid Leukemia, Including Wild-Type and FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Disease

Neil Beeharry, Sean Landrette, PhD, Jeff Grotzke, PhD, Sophia Gayle, PhD, Marylens Hernandez, PhD, Stephanie Halene, MD, Peter R Young, PhD, Langdon L Miller, MD, Tian Xu, PhD, Jonathan Rothberg, PhD, Henri Lichenstein, PhD

Blood (2019) 134 (Supplement_1): 2664.

https://doi.org/10.1182/blood-2019-125770

Published: 2019

Journal Articles

Diffuse Large B Cell Lymphoma (DLBCL) Expresses ROR1 and a ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Tumor Cells

Mohammad Hojjat-Farsangi, MSc,PhD, Amineh Ghaderi, MSc, AmirHossein Daneshmanesh, MD PhD, Jemina Lehto, MSc, Ali Moshfegh, MSc,PhD, Parviz Kokhaei, MSc,PhD, Jan Vågberg, MSc,PhD, Elisabeth Olsson, MSc,PhD, Charlotta Löfberg, MSc,PhD, Charlotta Carina Norström, MSc,PhD, Johan Schultz, MSc,PhD, Martin Norin, MSc,PhD, Thomas Olin, MSc,PhD, Elias Drakos, MD PhD Prof., George Z. Rassidakis, MD PhD Prof., Anders Österborg, MD PhD, Håkan Mellstedt, MD PhD Prof.

Blood (2019) 134 (Supplement_1): 2565.

https://doi.org/10.1182/blood-2019-126801

Published: 2019

Journal Articles

Direct Phosphorylation and Stabilization of MYC By Aurora B Kinase Promotes T Cell Leukemogenesis

Hudan Liu, PhD, Jue Jiang, PhD, Jingchao Wang, PhD, Ming Yue, PhD, Hui Feng, MD PhD, Guoliang Qing, PhD

Blood (2019) 134 (Supplement_1): 732.

https://doi.org/10.1182/blood-2019-130112

Published: 2019

Journal Articles

Pharmacological Targeting of Osteoblast-Induced MDS and AML

Ioanna Mosialou, PhD, Marta Galan-Diez, PhD, Andrew Vandenberg, Abdullah Mahmood Ali, PhD, Azra Raza, MD, Stavroula Kousteni, PhD

Blood (2018) 132 (Supplement 1): 5235.

https://doi.org/10.1182/blood-2018-99-119985

Published: 2018

Journal Articles

Dual Targeting of PI3Kdelta and BRD4 Sensitizes Acute Lymphoblastic Leukemia to Chemotherapy

Hye Na Kim, Cydney Nichols, Enzi Ji Jiang, MD PhD, Nour Abdel-Azim, Ariana Coba, DOnald L. Durden, MD PhD, Yong-Mi Kim, MD MPH, PhD

Blood (2018) 132 (Supplement 1): 1420.

https://doi.org/10.1182/blood-2018-99-116310

Published: 2018

Journal Articles

Changes in Subcellular Localization of GSK3β As a Novel Driver of AML

James ignatz-Hoover, Isaac Ghansah, Masumi Ueda, MD, Victoria Wang, Hillard M Lazarus, MD, Marcos de Lima, MD, David Wald, PhD MD

Blood (2017) 130 (Supplement 1): 1226.

https://doi.org/10.1182/blood.V130.Suppl_1.1226.1226

Published: 2017

Journal Articles

Creatine Kinase Pathway Inhibition Alters GSK3 and WNT Signaling in EVI1-Positive Acute Myeloid Leukemia

Lina Benajiba, Gabriela Alexe, Olivier Hermine, MD PhD, Michael Hemann, Alexandre Puissant, Kimberly Stegmaier, MD

Blood (2017) 130 (Supplement 1): 1191.

https://doi.org/10.1182/blood.V130.Suppl_1.1191.1191

Published: 2017

Journal Articles

Exploiting an Asp-Glu "Switch" in Glycogen Synthase Kinase 3 to Design Paralog Selective Inhibitors for Acute Myeloid Leukemia Treatment

Blood (2017) 130 (Supplement 1): 2075.

https://doi.org/10.1182/blood.V130.Suppl_1.2075.2075

Published: 2017

Journal Articles

Diagnostic and Prognostic Implications of Prohibitin Overexpression in Normal Karyotype Acute Myeloid Leukemia

Hye-Ran Kim, PhD, Jun Hyung Lee, MD, Min-Gu Kang, MD, Ra-Young Park, PhD, Moinul Md Hoque, B.S., Sol Jeong, B.S., Min-Seo Noh, B.S., Seok-Yong Choi, MD, PhD, Soo-Hyun Kim, MD, PhD, Jong-Hee Shin, MD, PhD, Soon-Pal Suh, MD, PhD, Myung-Geun Shin, MD, PhD

Blood (2016) 128 (22): 1714.

https://doi.org/10.1182/blood.V128.22.1714.1714

Published: 2016

Journal Articles

CCND1 Mutations Increase Protein Stability and Promote Ibrutinib Resistance in Mantle Cell Lymphoma

Atish Ranjan Mohanty, PhD, Natalie Sandoval, MSc, Manasi Das, PhD, Hesham M. Amin, MD, Guido Marcucci, MD, Raju Pillai, MD, Dennis D Weisenburger, MD, Steven T. Rosen, MD, Lan Pham, PhD, Vu N. Ngo, PhD

Blood (2016) 128 (22): 4094.

https://doi.org/10.1182/blood.V128.22.4094.4094

Published: 2016

Journal Articles

Inhibition of Casein Kinase 2 Impairs Wnt Signaling and Cell Survival in Chronic Lymphocytic Leukemia

Christina Wu, PhD, Fitzgerald S Lao, BS, Emily Nan, Hongying Li, PhD, Michael Y. Choi, MD, Karen Messer, PhD, Dennis A. Carson, MD

Blood (2016) 128 (22): 2050.

https://doi.org/10.1182/blood.V128.22.2050.2050

Published: 2016

Journal Articles

Foundation-One R -Heme Next Generation Sequencing of Hairy Cell Leukemia Variant Lymphocytes

John R. Pawloski, MD PhD, Brion Randolph, MD, Paulie Bajic, MD PhD

Blood (2016) 128 (22): 5289.

https://doi.org/10.1182/blood.V128.22.5289.5289

Published: 2016

Journal Articles

Transcriptome Analysis Identified Significant Differences in Gene Expression Variability Between WM and IgM-MGUS BM B Cell Clones

Alessandra Trojani, Milena Lodola, Alessandra Tedeschi, Antonino Greco, Barbara Di Camillo, Tiziana Sanavia, Anna Maria Frustaci, Maddalena Mazzucchelli, Chiara Villa, Daniela Boselli, Enrica Morra, MD, Roberto Cairoli, MD

Blood (2016) 128 (22): 5089.

https://doi.org/10.1182/blood.V128.22.5089.5089

Published: 2016

Journal Articles

Efficient Induction of Myleoid and Lymphoid Hematopoiesis from Nonhuman Primate Pluripotent Stem Cells Using GSK3b Inhibitor

Saritha D'Souza, PhD, John Maufort, PhD, Akhilesh Kumar, PhD, James Thomson, D.V.M., PhD, Igor Slukvin, MD PhD

Blood (2015) 126 (23): 2363.

https://doi.org/10.1182/blood.V126.23.2363.2363

Published: 2015

Journal Articles

Identification of CKMT1B As a New Target in EVI1-Positive AML

Alexandre Puissant, PhD, Nina Fenouille, PhD, Christopher F. Bassil, BA, Issam Ben-Sahra, PhD, Gabriela Alexe, PhD, Lina Benajiba, Azucena Ramos, Yana Pikman, MD, Michael R. Burgess, MD PhD, Ilene Galinsky, ANP, Daniel J. DeAngelo, MD PhD, Richard M. Stone, MD, Kevin Shannon, MD, Michael T. Hemann, PhD, Kimberly Stegmaier, MD

Blood (2015) 126 (23): 3674.

https://doi.org/10.1182/blood.V126.23.3674.3674

Published: 2015

Journal Articles

Aurora Kinase Is a Therapeutic Target in Ibrutinib-Resistant Waldenstrom Macroglobulinemia: In-Silico Target Identification and in-Vitro Validation

Aneel Paulus, MDMS, Kasyapa S. Chitta, PhD, Sharoon Akhtar, MPhil, Hassan Yousaf, Davitte Cogen, Shireen Vali, Ansu Kumar, Neeraj Kumar Singh, Taher Abbasi, James M. Foran, MD, Candido E. Rivera, MD, Taimur Sher, MD, Vivek Roy, MD, Sikander Ailawadhi, MD, Asher Alban Chanan-Khan, MD

Blood (2015) 126 (23): 2754.

https://doi.org/10.1182/blood.V126.23.2754.2754

Published: 2015

Journal Articles

All -Trans-Retinoic Acid (ATRA) Combined with Lithium As Treatment of Relapsed Non-Progranulocytic AML: Therapeutic Targeting Inhibition of the Glycogen Synthase Kinase 3-Beta (GSK3) Enzyme

Paolo Caimi, MD, Kalpana Gupta, PhD, Tammy Stefan, Brenda Cooper, MD, Basem M. William, MD, Erica L Campagnaro, MD, Richard J. Creger, Pharm D, Donna Kane, BSN, Stanton L. Gerson, Hillard M. Lazarus, MD, Marcos de Lima, MD, David N. Wald, MD PhD

Blood (2014) 124 (21): 5299.

https://doi.org/10.1182/blood.V124.21.5299.5299

Published: 2014

Journal Articles

Connective Tissue Growth Factor (Ctgf/Ccn2) Is a Novel Extrinsic Niche-Derived Regulator Of Hematopoietic Stem Cells

Baiba Vilne, MSc, Rouzanna Istvanffy, PhD, Christina Eckl, MSc, Franziska Bock, MSc, Sandra Grziwok, MSc, Prazeras da Costa Olivia, PhD, Matthias Schiemann, PhD, Christian Peschel, H. Werner Mewes, PhD, Robert A.J. Oostendorp, PhD

Blood (2013) 122 (21): 3688.

https://doi.org/10.1182/blood.V122.21.3688.3688

Published: 2013

Journal Articles

Differential Modulation Of cKIT Signaling By CD63 Dictates The Magnitude Of Response To Stem Cell Factor Of Erythroblasts From Adult Blood, Cord Blood and Polycythemia Vera

Ann Zeuner, PhD, Giulia Federici, MS, Paola Contavalli, PhD, Emanuel F. Petricoin, PhD, Valentina Tirelli, MS, Francesca Masiello, Gabriella Girelli, MD, Giuliana Alimena, Agostino Tafuri, Giovanni Migliaccio, Ph.D., Anna Rita F Migliaccio, PhD

Blood (2013) 122 (21): 2850.

https://doi.org/10.1182/blood.V122.21.2850.2850

Published: 2013

NARROW

Inhibition of Acute Leukemia By a Small Molecule KYA1797K Which Destabilize RAS and β-Catenin

LAM-003, a Novel Oral Heat Shock Protein 90 Inhibitor for Treatment of Acute Myeloid Leukemia, Including Wild-Type and FMS-like Tyrosine Kinase 3 (FLT3)-Mutant Disease

Diffuse Large B Cell Lymphoma (DLBCL) Expresses ROR1 and a ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Tumor Cells

Direct Phosphorylation and Stabilization of MYC By Aurora B Kinase Promotes T Cell Leukemogenesis

Pharmacological Targeting of Osteoblast-Induced MDS and AML

Dual Targeting of PI3Kdelta and BRD4 Sensitizes Acute Lymphoblastic Leukemia to Chemotherapy

Changes in Subcellular Localization of GSK3β As a Novel Driver of AML

Creatine Kinase Pathway Inhibition Alters GSK3 and WNT Signaling in EVI1-Positive Acute Myeloid Leukemia

Exploiting an Asp-Glu "Switch" in Glycogen Synthase Kinase 3 to Design Paralog Selective Inhibitors for Acute Myeloid Leukemia Treatment

Diagnostic and Prognostic Implications of Prohibitin Overexpression in Normal Karyotype Acute Myeloid Leukemia

CCND1 Mutations Increase Protein Stability and Promote Ibrutinib Resistance in Mantle Cell Lymphoma

Inhibition of Casein Kinase 2 Impairs Wnt Signaling and Cell Survival in Chronic Lymphocytic Leukemia

Foundation-One R -Heme Next Generation Sequencing of Hairy Cell Leukemia Variant Lymphocytes

Transcriptome Analysis Identified Significant Differences in Gene Expression Variability Between WM and IgM-MGUS BM B Cell Clones

Efficient Induction of Myleoid and Lymphoid Hematopoiesis from Nonhuman Primate Pluripotent Stem Cells Using GSK3b Inhibitor

Identification of CKMT1B As a New Target in EVI1-Positive AML

Aurora Kinase Is a Therapeutic Target in Ibrutinib-Resistant Waldenstrom Macroglobulinemia: In-Silico Target Identification and in-Vitro Validation

All -Trans-Retinoic Acid (ATRA) Combined with Lithium As Treatment of Relapsed Non-Progranulocytic AML: Therapeutic Targeting Inhibition of the Glycogen Synthase Kinase 3-Beta (GSK3) Enzyme

Connective Tissue Growth Factor (Ctgf/Ccn2) Is a Novel Extrinsic Niche-Derived Regulator Of Hematopoietic Stem Cells

Differential Modulation Of cKIT Signaling By CD63 Dictates The Magnitude Of Response To Stem Cell Factor Of Erythroblasts From Adult Blood, Cord Blood and Polycythemia Vera

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American Society of Hematology

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ASH Publications

American Society of Hematology

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