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Journal Articles

Hemophilia A Dogs Tolerant to Human Factor VIII Provide a Unique Model to Determine Efficacy and Safety of AAV Delivery of Novel Factor VIII Variants

Giang N. Nguyen, BS, Lauren E. Wimsey, DVM, Elizabeth P. Merricks, PhD, Katherine P. Ponder, MD, Timothy C. Nichols, MD, Denise E. Sabatino, PhD

Blood (2019) 134 (Supplement_1): 3628.

https://doi.org/10.1182/blood-2019-126085

Published: 2019

Journal Articles

FVIII Protein Is Not Detectable in Human PBMCs or Livers from Dogs with an Intron-22 Inversion Mutation: Implications for FVIII Immunogenicity and Tolerance

Devi Gunasekera, MBBS, Pooja Vir, PhD, Ahmad Faisal Karim, PhD, Margaret V. Ragni, MD MPH, Elizabeth P. Merricks, PhD, Timothy C. Nichols, MD, Kathleen P. Pratt, PhD

Blood (2019) 134 (Supplement_1): 630.

https://doi.org/10.1182/blood-2019-124880

Published: 2019

Journal Articles

Long-Term AAV-Mediated Factor VIII Expression in Nine Hemophilia A Dogs: A 10 Year Follow-up Analysis on Durability, Safety and Vector Integration

Giang N. Nguyen, BS, John K. Everett, PhD, Hayley Raymond, BA, Samita Kafle, BS, Elizabeth P. Merricks, PhD, Haig H. Kazazian, MD, Timothy C. Nichols, MD, Frederic D. Bushman, PhD, Denise E. Sabatino, PhD

Blood (2019) 134 (Supplement_1): 611.

https://doi.org/10.1182/blood-2019-126007

Published: 2019

Journal Articles

A Phase 1/1b Dose-Escalation Trial Evaluating Cpi-818, an Oral Interleukin-2-Inducible T-Cell Kinase Inhibitor, in Subjects with Relapsed/Refractory T-Cell Lymphoma

Mehrdad Mobasher, MD MPH, Richard A. Miller, MD, James W. Janc, PhD, Long Kwei, PhD, Joseph J. Buggy, PhD, Gabriel Luciano, Anahita Mohammady, PharmD, Won Seog Kim, MD PhD, Youn H. Kim, MD, Michael S. Khodadoust, MD PhD, Steven M. Horwitz, MD, Dejan Radeski, MBBS, FRACP, FRCPA

Blood (2019) 134 (Supplement_1): 4030.

https://doi.org/10.1182/blood-2019-124958

Published: 2019

Journal Articles

A Phase 1 a/b Dose Escalation Trial to Evaluate the Safety and Tolerability of CG-806 in Patients with Relapsed or Refractory CLL/SLL or Non-Hodgkin's Lymphomas

Stephen B Howell, MD, Hongying Zhang, MD PhD, William G Rice, PhD

Blood (2019) 134 (Supplement_1): 5477.

https://doi.org/10.1182/blood-2019-130784

Published: 2019

Journal Articles

ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells

Håkan Mellstedt, MD PhD Prof., Amineh Ghaderi, MSc, Johanna Aschan, MSc, Fariba Mozaffari, MSc,PhD, Ali Moshfegh, MSc,PhD, Birgitta Sander, MD PhD Prof., Johan Schultz, MSc,PhD, Martin Norin, MSc,PhD, Thomas Olin, MSc,PhD, Elias Drakos, MD PhD Prof., George Z. Rassidakis, MD PhD Prof., Anders Österborg, MD PhD, Mohammad Hojjat-Farsangi, MSc,PhD

Blood (2019) 134 (Supplement_1): 5312.

https://doi.org/10.1182/blood-2019-129773

Published: 2019

Journal Articles

Initial Characterization and Toxicology of an Nmt Inhibitor in Development for Hematologic Malignancies

Michael Weickert, John Dillberger, John R. Mackey, Paul Wyatt, David Gray, Kevin Read, Christian Li, Audrey Parenteau, Luc G. Berthiaume

Blood (2019) 134 (Supplement_1): 3362.

https://doi.org/10.1182/blood-2019-124934

Published: 2019

Journal Articles

Quantitative PK/PD Prediction of the Efficacious and Safe Dose Ranges of the LMP7 Inhibitor M3258 for Phase I Application in Relapsed/Refractory Multiple Myeloma Patients

Florian Lignet, Christina Esdar, Manja Friese-Hamim, Andreas Becker, Elise Drouin, Samer El Bawab, Samantha M. Goodstal, Claude Gimmi, Phlipp Haselmayer, Frank Jährling, Michael Sanderson, Willem Sloot, Sofia Stinchi, Anja Victor, Gina Walter, Felix Rohdich

Blood (2019) 134 (Supplement_1): 5582.

https://doi.org/10.1182/blood-2019-126972

Published: 2019

Journal Articles

Preliminary Clinical Data from a Phase 1 Trial with CPI-818, a Selective ITK Inhibitor That Preferentially Blocks the Growth of T Lymphoma Cells

Patrick P. Ng, PhD, Mehrdad Mobasher, MD MPH, Kitman S. Yeung, MS, Andrew N. Hotson, PhD, Craig M. Hill, PhD, Antonett Madriaga, MS, Trang P. Dao-Pick, MA, Erik Verner, PhD, Dejan Radeski, MBBS, FRACP, FRCPA, Michael S. Khodadoust, MD PhD, Youn H. Kim, MD, Richard A. Miller, MD, Joseph J. Buggy, PhD, James W. Janc, PhD

Blood (2019) 134 (Supplement_1): 1571.

https://doi.org/10.1182/blood-2019-127338

Published: 2019

Journal Articles

Purification Platelets from Mouse Blood with Sickle Cell Disease Using Iohexol Gradient Medium

Md Nasimuzzaman, PhD

Blood (2019) 134 (Supplement_1): 4888.

https://doi.org/10.1182/blood-2019-128459

Published: 2019

Journal Articles

A Novel RAD51 Inhibitor, CYT01B, Shows Anti-Cancer Activity in Preclinical Models of Aid Expressing Lymphomas

Muneer G Hasham, PhD, Darryl Patrick, Leanne Bedard, Joseph Vacca, Casey McComas, Alfredo Castro, Melinda Day, PhD, Kevin Mills, PhD

Blood (2018) 132 (Supplement 1): 2944.

https://doi.org/10.1182/blood-2018-99-119351

Published: 2018

Journal Articles

A Naturally Occurring Canine Model of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: IGHV Mutation Status, Gene Expression, and Clinical Outcome

Emily Rout, DVM, Robert Burnett, PhD, Julia Labadie, PhD, Janna Yoshimoto, BS, Anne Avery, VMD, PhD

Blood (2018) 132 (Supplement 1): 4103.

https://doi.org/10.1182/blood-2018-99-120102

Published: 2018

Journal Articles

A Naturally Occurring Canine Model of Peripheral T-Cell Lymphoma Not Otherwise Specified

Lauren Harris, VMD, Emily Rout, DVM, Janna Yoshimoto, BS, Anne Avery, VMD, PhD

Blood (2018) 132 (Supplement 1): 4105.

https://doi.org/10.1182/blood-2018-99-120034

Published: 2018

Journal Articles

Transcriptomic Systems Biology Analyses with Buparlisib (BKM120) Pan PI3K Inhibition in Canine B Cell Lymphoma (BCL): Leveraging Comparative Oncology for Cancer Therapeutics and Biomarker Discovery

Ravi Dashnamoorthy, PhD, Afshin Beheshti, PhD, Sarah Cass, BSVM, Athena Kritharis, MD, Kristine Burgess, DVM, MS, Cheryl London, DVM, PhD DACVIM, Andrew M. Evens, DO, MSc

Blood (2018) 132 (Supplement 1): 4114.

https://doi.org/10.1182/blood-2018-99-118548

Published: 2018

Journal Articles

Generation of a Unique Cohort of Hemophilia A Dogs Tolerant to Human FVIII for Evaluating the Safety and Efficacy of AAV Delivery of Wild Type and Variant Human FVIII

Giang N. Nguyen, Lauren Wimsey, Elizabeth Merricks, Katherine P. Ponder, MD, Timothy C. Nichols, MD, Denise E. Sabatino, PhD

Blood (2018) 132 (Supplement 1): 2453.

https://doi.org/10.1182/blood-2018-99-113492

Published: 2018

Journal Articles

The Severe Spontaneous Bleeding Phenotype in a Novel Hemophilia a Rat Model with an Inversion Mutation Is Rescued By Platelet-Targeted FVIII Expression

Qizhen Shi, MD, Jeremy G Mattson, Scot A Fahs, Robert R Montgomery, MD

Blood (2018) 132 (Supplement 1): 219.

https://doi.org/10.1182/blood-2018-99-112165

Published: 2018

Journal Articles

A Comparative Medicine Study of Platelet Biophysics Among Hemostasis Models of Different Species

Renee Copeland, BS, Oluwamayokun T. Oshinowo, Yumiko Sakurai, MSc, Meredith Ellen Fay, BS, Brian G. Petrich, PhD, Benjamin Brainard, VMD, Dipl ACVAA, ACVECC, Wilbur A Lam, MD PhD, David R. Myers, PhD

Blood (2018) 132 (Supplement 1): 869.

https://doi.org/10.1182/blood-2018-99-113107

Published: 2018

Journal Articles

Macrophage Recycling of Red Blood Cells and Iron Following Transfusion

Eldad A. Hod, MD

Blood (2018) 132 (Supplement 1): SCI-3.

https://doi.org/10.1182/blood-2018-99-109520

Published: 2018

Journal Articles

New Molecular and Therapeutic Insights into Canine Diffuse Large B Cell Lymphoma Elucidates the Role of the Dog As a Model for Human Disease

Blood (2018) 132 (Supplement 1): 4173.

https://doi.org/10.1182/blood-2018-99-112763

Published: 2018

Journal Articles

Exploring PRMT5 As a Potential Therapeutic Target in Canine Lymphomas

Kyle Renaldo, DVM, MS, Shelby Sloan, BS, JiHyun Chung, PhD, Lindsay Courtney, BS, Konstantin Shilo, MD, William Kisseberth, DVM, PhD, Robert A Baiocchi, MD PhD

Blood (2018) 132 (Supplement 1): 4182.

https://doi.org/10.1182/blood-2018-99-119115

Published: 2018

NARROW

Hemophilia A Dogs Tolerant to Human Factor VIII Provide a Unique Model to Determine Efficacy and Safety of AAV Delivery of Novel Factor VIII Variants

FVIII Protein Is Not Detectable in Human PBMCs or Livers from Dogs with an Intron-22 Inversion Mutation: Implications for FVIII Immunogenicity and Tolerance

Long-Term AAV-Mediated Factor VIII Expression in Nine Hemophilia A Dogs: A 10 Year Follow-up Analysis on Durability, Safety and Vector Integration

A Phase 1/1b Dose-Escalation Trial Evaluating Cpi-818, an Oral Interleukin-2-Inducible T-Cell Kinase Inhibitor, in Subjects with Relapsed/Refractory T-Cell Lymphoma

A Phase 1 a/b Dose Escalation Trial to Evaluate the Safety and Tolerability of CG-806 in Patients with Relapsed or Refractory CLL/SLL or Non-Hodgkin's Lymphomas

ROR1 Small Molecule Inhibitor (KAN0441571C) Induced Significant Apoptosis of Mantle Cell Lymphoma (MCL) Cells

Initial Characterization and Toxicology of an Nmt Inhibitor in Development for Hematologic Malignancies

Quantitative PK/PD Prediction of the Efficacious and Safe Dose Ranges of the LMP7 Inhibitor M3258 for Phase I Application in Relapsed/Refractory Multiple Myeloma Patients

Preliminary Clinical Data from a Phase 1 Trial with CPI-818, a Selective ITK Inhibitor That Preferentially Blocks the Growth of T Lymphoma Cells

Purification Platelets from Mouse Blood with Sickle Cell Disease Using Iohexol Gradient Medium

A Novel RAD51 Inhibitor, CYT01B, Shows Anti-Cancer Activity in Preclinical Models of Aid Expressing Lymphomas

A Naturally Occurring Canine Model of Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: IGHV Mutation Status, Gene Expression, and Clinical Outcome

A Naturally Occurring Canine Model of Peripheral T-Cell Lymphoma Not Otherwise Specified

Transcriptomic Systems Biology Analyses with Buparlisib (BKM120) Pan PI3K Inhibition in Canine B Cell Lymphoma (BCL): Leveraging Comparative Oncology for Cancer Therapeutics and Biomarker Discovery

Generation of a Unique Cohort of Hemophilia A Dogs Tolerant to Human FVIII for Evaluating the Safety and Efficacy of AAV Delivery of Wild Type and Variant Human FVIII

The Severe Spontaneous Bleeding Phenotype in a Novel Hemophilia a Rat Model with an Inversion Mutation Is Rescued By Platelet-Targeted FVIII Expression

A Comparative Medicine Study of Platelet Biophysics Among Hemostasis Models of Different Species

Macrophage Recycling of Red Blood Cells and Iron Following Transfusion

New Molecular and Therapeutic Insights into Canine Diffuse Large B Cell Lymphoma Elucidates the Role of the Dog As a Model for Human Disease

Exploring PRMT5 As a Potential Therapeutic Target in Canine Lymphomas

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American Society of Hematology

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ASH Publications

American Society of Hematology

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