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Giang N. Nguyen
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Journal Articles

Second Generation Adeno-Associated Viral Vector Using a Novel Factor VIII Variant with Improved Secretion Achieves Higher Factor VIII Expression in Non-Human Primates

Giang N. Nguyen, Maria C. Seleme, Jonathan R. Lindgren, Allysen C. Henriksen, Amy Muehlmatt, Melanie McFadden, Geary R. Smith, Denise E. Sabatino
Journal: Blood
Blood (2022) 140 (Supplement 1): 1902–1903.
https://doi.org/10.1182/blood-2022-168340
Published: 2022
Journal Articles

Sustained Factor VIII Activity Following Single Dose of Non-Viral Integrating Gene Therapy

Brian Truong, Giang N. Nguyen, Khal Hajj, Joseph Lucas, Johannes Schwerk, James Yen, Kevin Briseno, Michelle Burrascano, Daniel Smith, Johnnatan Tamayo, Fernando Lopez-Espinoza, Michael Bennett, Blair Madison, Denise E. Sabatino, Joshua Rychak
Journal: Blood
Blood (2022) 140 (Supplement 1): 969–970.
https://doi.org/10.1182/blood-2022-167919
Published: 2022
Journal Articles

Hemophilia A Dogs Tolerant to Human Factor VIII Provide a Unique Model to Determine Efficacy and Safety of AAV Delivery of Novel Factor VIII Variants

Giang N. Nguyen, BS, Lauren E. Wimsey, DVM, Elizabeth P. Merricks, PhD, Katherine P. Ponder, MD, Timothy C. Nichols, MD, Denise E. Sabatino, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3628.
https://doi.org/10.1182/blood-2019-126085
Published: 2019
Journal Articles

Long-Term AAV-Mediated Factor VIII Expression in Nine Hemophilia A Dogs: A 10 Year Follow-up Analysis on Durability, Safety and Vector Integration

Giang N. Nguyen, BS, John K. Everett, PhD, Hayley Raymond, BA, Samita Kafle, BS, Elizabeth P. Merricks, PhD, Haig H. Kazazian, MD, Timothy C. Nichols, MD, Frederic D. Bushman, PhD, Denise E. Sabatino, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 611.
https://doi.org/10.1182/blood-2019-126007
Published: 2019
Journal Articles

Generation of a Unique Cohort of Hemophilia A Dogs Tolerant to Human FVIII for Evaluating the Safety and Efficacy of AAV Delivery of Wild Type and Variant Human FVIII

Giang N. Nguyen, Lauren Wimsey, Elizabeth Merricks, Katherine P. Ponder, MD, Timothy C. Nichols, MD, Denise E. Sabatino, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2453.
https://doi.org/10.1182/blood-2018-99-113492
Published: 2018
Journal Articles

Novel Human Factor VIII Variant with Impaired Intracellular Processing Exhibits Enhanced In Vivo Efficacy

Giang N. Nguyen, B.S., Christian M. Wood, Tanner Dirstine, B.S., Robert J. Davidson, B.S., Denise E. Sabatino, PhD
Journal: Blood
Blood (2016) 128 (22): 256.
https://doi.org/10.1182/blood.V128.22.256.256
Published: 2016
Journal Articles

Human Factor VIII Variants with Diminished PACE-Furin Cleavage Exhibit Increased Biological Activity and Therapeutic Efficacy

Giang N. Nguyen, Joshua I. Siner, Robert J. Davidson, Valder R. Arruda, MD PhD, Rodney M. Camire, PhD, Denise E. Sabatino, PhD
Journal: Blood
Blood (2014) 124 (21): 104.
https://doi.org/10.1182/blood.V124.21.104.104
Published: 2014