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Journal Articles

Topoisomerase 2β mutation impairs early B-cell development

Olivier Papapietro, Anita Chandra, Davide Eletto, Sarah Inglott, Vincent Plagnol, James Curtis, Mailis Maes, Ali Alisaac, Adriana S. Albuquerque, Eugenie Basseres, Olivier Hermine, Capucine Picard, Alain Fischer, Anne Durandy, Sven Kracker, Siobhan O. Burns, Delphine Cuchet-Lourenco, Klaus Okkenhaug, Sergey Nejentsev

Blood (2020) 135 (17): 1497–1501.

https://doi.org/10.1182/blood.2019003299

Published: 2020

Includes: Supplemental data

Journal Articles

The Dual Cell Cycle Kinase Inhibitor JNJ-7706621 Reverses Resistance to CD37 Targeted Radioimmunotherapy in Activated B Cell like Diffuse Large B Cell Lymphoma Cell Lines

Gro Elise Rødland, PhD, Katrine Melhus, Roman Generalov, Sania Gilani, Francesco Bertoni, MD, Jostein Dahle, PhD, Randi Syljuåsen, PhD, Sebastian Patzke, PhD

Blood (2019) 134 (Supplement_1): 2574.

https://doi.org/10.1182/blood-2019-123287

Published: 2019

Journal Articles

The Identification of Novel Epigenetic Therapies for ALK-Driven Haematological Malignancies

Stephen P. Ducray, BSc, Ricky Trigg, PhD, Andrew J. Bannister, PhD, Raymond Lai, MD PhD FRCP, Gerda Egger, PhD, Olaf Merkel, PhD, Lukas Kenner, MD, Suzanne Turner, PhD

Blood (2019) 134 (Supplement_1): 1483.

https://doi.org/10.1182/blood-2019-125648

Published: 2019

Journal Articles

NSD2 Interacts with SMARCA2 and Regulates Expression of Oncogenes CCND1 and PRL3 in T(4;14) Multiple Myeloma

Jing Yuan Chooi, BSc, Zhigang Xie, PhD, Jayantha Gunaratne, PhD, Dennis Keppei, PhD, Wee Joo Chng, MB ChB, PhD FRCP(UK), FRCPath, FAMS

Blood (2018) 132 (Supplement 1): 4479.

https://doi.org/10.1182/blood-2018-99-110671

Published: 2018

Journal Articles

Topoisomerase I-DNA Covalent Complexes in Myeloid Malignancies: A Potential Biomarker for Topoisomerase I Inhibitor Sensitivity

Mira A. Kohorst, MD, Karen S. Flatten, Kevin L. Peterson, Paula A. Schneider, Cristina Correia, Keith W. Pratz, MD, B. Douglas Smith, MD, Scott H. Kaufmann, MD PhD

Blood (2018) 132 (Supplement 1): 5146.

https://doi.org/10.1182/blood-2018-99-115667

Published: 2018

Journal Articles

Cell Cycle Kinase Inhibitors Potentiate the Effect of 177 lu-Lilotomab Satetraxetan in Treatment of Aggressive Diffuse Large B-Cell Lymphoma Cell Lines

Gro Elise Rødland, PhD, Katrine Melhus, Jostein Dahle, PhD, Randi Syljuåsen, PhD, Sebastian Patzke, PhD

Blood (2018) 132 (Supplement 1): 1371.

https://doi.org/10.1182/blood-2018-99-110200

Published: 2018

Journal Articles

Concurrent Treatment with Pim Kinase Inhibitor Downregulates Alternative Non-Homologous End-Joining Repair and Decreases Genomic Instability in FLT3-ITD Cells Treated with Topoisomerase 2 Inhibitor Chemotherapy Drugs

Kshama A. Doshi, PhD, Shivani Kapoor, MS, Ying Zou, MD PhD, Xiang Li, PhD, Mario Scarpa, MS, Nidal Muvarak, PhD, Pratik Nagaria, PhD, Olga Goloubeva, PhD MSc, Adriana E. Tron, PhD, Charles J. Bieberich, PhD, Feyruz V. Rassool, BSc, PhD, Maria R. Baer, MD

Blood (2017) 130 (Supplement 1): 1243.

https://doi.org/10.1182/blood.V130.Suppl_1.1243.1243

Published: 2017

Journal Articles

A Novel Mutation Causing GATA2 Haploinsufficiency Activates a Cryptic Splice Site in Exon 3

Claudia Wehr, Katja Grotius, Dorothee Bleckmann, Emilia J Kozyra, Sebastian Bode, Björn C Frye, Marcin W. Wlodarski, MD PhD, Maximilian Seidl, Ulrich Salzer

Blood (2017) 130 (Supplement 1): 2467.

https://doi.org/10.1182/blood.V130.Suppl_1.2467.2467

Published: 2017

Journal Articles

TOP2A a New Predictive Marker of Response to Carfilzomib in Multiple Myeloma

Antonia Reale, MD Oncologist in training, Tiffany Khong, BSc, PhD, Sridurga Mithraprabhu, PhD, John Reynolds, Malarmathy Ramachandran, Ioanna Savvidou, MD PhD, Krystal Bergin, Jay Hocking, MD PhDstudent, Andrew Spencer

Blood (2016) 128 (22): 4461.

https://doi.org/10.1182/blood.V128.22.4461.4461

Published: 2016

Journal Articles

The Pim Kinase Inhibitor AZD1208 Enhances Topoisomerase-2 Inhibitor Induction of Apoptosis of Acute Myeloid Leukemia Cells with FLT3-ITD through Increased Oxidative Stress

Kshama A. Doshi, M.S., Karthika Natarajan, PhD, Feyruz V. Rassool, PhD, Dennis Huszar, PhD, Maria R. Baer, MD

Blood (2015) 126 (23): 1268.

https://doi.org/10.1182/blood.V126.23.1268.1268

Published: 2015

Journal Articles

Concomitant Acute Promyelocytic Leukemia and Chronic Lymphocytic Leukemia: Molecularly Two Distinct Diseases

Jingdong Su, MD, Hazem E. El-Osta, MD, Reinhold Munker, MD, Glenn M. Mills, MD, Srinivas S. Devarakonda, MD

Blood (2015) 126 (23): 4904.

https://doi.org/10.1182/blood.V126.23.4904.4904

Published: 2015

Journal Articles

Histone Deacetylation Inhibitor Sensitizes T-ALLs to Topoisomerase II Inhibitor By Attenuating G2 Cell Cycle Arrest and Blocking Nuclear Entry of Ctip during DNA Repair

Jin-Hwang Liu, MD PhD, Yu-Hern Lin, MS, Hon-Wen Liu, PhD, Jyh-Pyng Gau, MD

Blood (2015) 126 (23): 4862.

https://doi.org/10.1182/blood.V126.23.4862.4862

Published: 2015

Journal Articles

Stroma-Derived Factors Significantly Impact the Drug Response Profiles of Patient-Derived Primary AML Cells: Implications for Drug Sensitivity Testing

Riikka Karjalainen, MSc, Tea Pemovska, MSc, Muntasir Mamun Majumder, MSc, David Tamborero, PhD, Bhagwan Yadav, MSc, Mika Kontro, MD, Bjørn Gjertsen, MD PhD, Alun Parsons, MSc, Minna Suvela, BSc, Tero Aittokallio, PhD, Kimmo Porkka, MD PhD, Olli Kallioniemi, MD PhD, Krister Wennerberg, PhD, Caroline A Heckman, PhD

Blood (2014) 124 (21): 3505.

https://doi.org/10.1182/blood.V124.21.3505.3505

Published: 2014

Journal Articles

Targeting The Nuclear Export Signal In Multiple Myeloma

Joel G Turner, PhD, Thomas C Rowe, PhD, David Ostrov, PhD, Jana L Dawson, BS, Danielle Pernazza, PhD, Nicholas J Lawrence, Ph.D., Daniel M Sullivan, MD

Blood (2013) 122 (21): 1925.

https://doi.org/10.1182/blood.V122.21.1925.1925

Published: 2013

Journal Articles

Screening JAK2 V617F-Negative and MPL W515K/L-Negative Essential Thrombocythemia Patients For Mutations In SESN2, DNAJC17, ST13, TOP1MT , and NTRK1

Carla AL Assaf, Els Lierman, PhD, Timothy Devos, MD, PhD, Johan Billiet, MD, Carlos Graux, MD, PhD, Petros Papadopoulos, PhD, Peter Vandenberghe, MD, PhD

Blood (2013) 122 (21): 5264.

https://doi.org/10.1182/blood.V122.21.5264.5264

Published: 2013

Journal Articles

Profiling Of Polycyclic Aromatic Hydrocarbons-Induced Genotoxicity In Peripheral Blood Stem Cells and Bone Marrow Mesenchymal Stem Cells

Hwan-Young Kim, Hye-Ran Kim, PhD, Trang Nguyen Thi Dai, Hee-Jo Baek, MD, PhD, Jae-Dong Moon, MD, PhD, Jong-Hee Shin, MD, PhD, Soon-Pal Suh, MD, PhD, Hoon Kook, MD, PhD, Dong-Wook Ryang, MD, PhD, Myung-Geun Shin, MD, PhD

Blood (2013) 122 (21): 1221.

https://doi.org/10.1182/blood.V122.21.1221.1221

Published: 2013

Journal Articles

Multifunctionality of the FA pathway

Laura E. Hays

Blood (2013) 121 (1): 3–4.

https://doi.org/10.1182/blood-2012-11-464636

Published: 2013

Journal Articles

Acute Leukemias Following a Diagnosis of Colorectal Cancer: Are They Therapy-Related?

Eytan M. Stein, MD, Vipul Pareek, MD, David Kudlowitz, Dan Douer, MD, Martin S Tallman, MD

Blood (2012) 120 (21): 1453.

https://doi.org/10.1182/blood.V120.21.1453.1453

Published: 2012

Journal Articles

Harnessing Gene Expression Profiles for the Identification of Drug Resistance Genes in Pediatric AML

Costa Bachas, MSc, Gerrit Jan Schuurhuis, PhD, C. Michel Zwaan, MD, PhD, Marry M. van den Heuvel-Eibrink, Monique L. Den Boer, PhD, Zinia J. Kwidama, BSc, Evelina S. De Bont, MD, PhD, Dirk Reinhardt, MD, Ursula Creutzig, MD, PhD, Valérie de Haas, MD, PhD, Yehuda Assaraf, PhD, Gertjan J.L. Kaspers, MD, PhD, Jacqueline Cloos, PhD

Blood (2012) 120 (21): 283.

https://doi.org/10.1182/blood.V120.21.283.283

Published: 2012

Journal Articles

Gfi1 Is Repressed by p53 and Inhibits DNA Damage-Induced Apoptosis

Pei Du, Fangqiang Tang, Ph.D., Yaling Qiu, M.D., Fan Dong, M.D., Ph.D.

Blood (2012) 120 (21): 1228.

https://doi.org/10.1182/blood.V120.21.1228.1228

Published: 2012

NARROW

Topoisomerase 2β mutation impairs early B-cell development

The Dual Cell Cycle Kinase Inhibitor JNJ-7706621 Reverses Resistance to CD37 Targeted Radioimmunotherapy in Activated B Cell like Diffuse Large B Cell Lymphoma Cell Lines

The Identification of Novel Epigenetic Therapies for ALK-Driven Haematological Malignancies

NSD2 Interacts with SMARCA2 and Regulates Expression of Oncogenes CCND1 and PRL3 in T(4;14) Multiple Myeloma

Topoisomerase I-DNA Covalent Complexes in Myeloid Malignancies: A Potential Biomarker for Topoisomerase I Inhibitor Sensitivity

Cell Cycle Kinase Inhibitors Potentiate the Effect of 177 lu-Lilotomab Satetraxetan in Treatment of Aggressive Diffuse Large B-Cell Lymphoma Cell Lines

Concurrent Treatment with Pim Kinase Inhibitor Downregulates Alternative Non-Homologous End-Joining Repair and Decreases Genomic Instability in FLT3-ITD Cells Treated with Topoisomerase 2 Inhibitor Chemotherapy Drugs

A Novel Mutation Causing GATA2 Haploinsufficiency Activates a Cryptic Splice Site in Exon 3

TOP2A a New Predictive Marker of Response to Carfilzomib in Multiple Myeloma

The Pim Kinase Inhibitor AZD1208 Enhances Topoisomerase-2 Inhibitor Induction of Apoptosis of Acute Myeloid Leukemia Cells with FLT3-ITD through Increased Oxidative Stress

Concomitant Acute Promyelocytic Leukemia and Chronic Lymphocytic Leukemia: Molecularly Two Distinct Diseases

Histone Deacetylation Inhibitor Sensitizes T-ALLs to Topoisomerase II Inhibitor By Attenuating G2 Cell Cycle Arrest and Blocking Nuclear Entry of Ctip during DNA Repair

Stroma-Derived Factors Significantly Impact the Drug Response Profiles of Patient-Derived Primary AML Cells: Implications for Drug Sensitivity Testing

Targeting The Nuclear Export Signal In Multiple Myeloma

Screening JAK2 V617F-Negative and MPL W515K/L-Negative Essential Thrombocythemia Patients For Mutations In SESN2, DNAJC17, ST13, TOP1MT , and NTRK1

Profiling Of Polycyclic Aromatic Hydrocarbons-Induced Genotoxicity In Peripheral Blood Stem Cells and Bone Marrow Mesenchymal Stem Cells

Multifunctionality of the FA pathway

Acute Leukemias Following a Diagnosis of Colorectal Cancer: Are They Therapy-Related?

Harnessing Gene Expression Profiles for the Identification of Drug Resistance Genes in Pediatric AML

Gfi1 Is Repressed by p53 and Inhibits DNA Damage-Induced Apoptosis

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American Society of Hematology

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