Page 1 | Search Results | Blood | American Society of Hematology

1-20 of 82

Sort by

Sort Order Select

Journal Articles

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

Blood (2019) 134 (Supplement_1): 1692.

https://doi.org/10.1182/blood-2019-128573

Published: 2019

Journal Articles

Differentiation Therapy with Novel Epigenetic Inhibitors in Acute Myeloid Leukemia

Edurne San Jose, Naroa Gimenez-Camino, Obdulia Rabal, Estibaliz Miranda, Leire Garate, Fernando Garcia, Ana Alfonso Pierola, MD PhD, Sara Villar, Jose J. Rifon Roca, MD, Antonio Pineda-Lucena, Bruno Paiva, PhD, Javier Muñoz, Jesús San-Miguel, Julen Oyarzabal, PhD, Xabier Agirre, PhD, Felipe Prósper, MD PhD

Blood (2019) 134 (Supplement_1): 3762.

https://doi.org/10.1182/blood-2019-125578

Published: 2019

Journal Articles

Targeting DHODH with AG-636 Induces Apoptosis and Differentiation and Inhibits Mitochondrial Function in AML, Translating into Anti-Tumor Efficacy in Vitro and i n Vivo

Zhihong Zeng, Natalia Baran, PhDMD, Sergej Konoplev, Antonio Cavazos, Qi Zhang, Vinitha Mary Kuruvilla, MSc, Philip Lorenzi, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Courtney D. DiNardo, MDMSc, Joshua Murtie, Danielle Ulanet, Marina Y Konopleva, MD PhD

Blood (2019) 134 (Supplement_1): 3911.

https://doi.org/10.1182/blood-2019-125469

Published: 2019

Journal Articles

Loss of FLT3 Sensitizes Myeloid Cells to Differentiation Via DHODH Inhibition

Amy N Sexauer, MD PhD, Brian Do, David B Sykes, MD PhD

Blood (2019) 134 (Supplement_1): 2712.

https://doi.org/10.1182/blood-2019-128910

Published: 2019

Journal Articles

Reprogramming Leukemia Cells into Antigen Presenting Cells As a Novel Cancer Vaccination Immunotherapy

Miles Hamilton Linde, BS, BA, Christopher G Dove, Sarah F Gurev, Paul Phan, Feifei Zhao, MD, Lindsay P Miller, Ravindra Majeti, MD PhD

Blood (2019) 134 (Supplement_1): 3217.

https://doi.org/10.1182/blood-2019-128577

Published: 2019

Journal Articles

Elucidating the Non-Catalytic Function of Fatty Acid Synthase and Its Autophagy-Dependent Degradation in Acute Myelocytic Leukemia Differentiation Therapy

Magali Humbert, PhD, Severin Mosimann, Vreni Rentsch, Mario P. Tschan, PhD

Blood (2018) 132 (Supplement 1): 2624.

https://doi.org/10.1182/blood-2018-99-112068

Published: 2018

Journal Articles

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Peggy P. Hsu, MD PhD, Youmna Kfoury, PhD, Najihah Aziz, Jenna Elkhoury, Brittany Hallgren, David T. Scadden, MD, Matthew Vander Heiden, MD PhD, David B Sykes, MD PhD

Blood (2018) 132 (Supplement 1): 2716.

https://doi.org/10.1182/blood-2018-99-113387

Published: 2018

Journal Articles

Pharmacologic LSD1 Inhibition Preserves Human Granulocytic While Expanding Monocytic Progenitors

Karlotta E Kahmann, Stefanie Kesper, Marco Luciani, Michael Möllmann, Hugh Y. Rienhoff, Jr., MD, Ulrich Dührsen, Prof, MD PhD, Joachim R Göthert, MD

Blood (2018) 132 (Supplement 1): 2645.

https://doi.org/10.1182/blood-2018-99-113887

Published: 2018

Journal Articles

The Genes for Tissue Factor F3 and Nuclear Receptor 4A Are Down-Regulated in Early Death Acute Promyelocytic Leukemia Patients

Miriam Frech, PhD, Kathleen Stabla, Andrea Nist, PhD, Marco Mernberger, PhD, Heidi Altmann, PhD, Uwe Platzbecker, Christian Thiede, MD, Prema Erramsetti, Sabine Teichler, PhD, Cornelia Brendel, MD, Richard F. Schlenk, MD, Thorsten Stiewe, MD, Andreas Neubauer, MD

Blood (2018) 132 (Supplement 1): 3902.

https://doi.org/10.1182/blood-2018-99-112978

Published: 2018

Journal Articles

Anti-Leukemic Effect of Retinoic Acid in Non-APL AML Cells

Yasuhiko Harada, MD, Yuichi Ishikawa, MD PhD, Naomi Kawashima, MD, Hikaru Hattori, MS, Yohei Yamaguchi, MD, Yoshiya Adachi, MD, Yoko Ushijima, MD PhD, Hitoshi Kiyoi, MD PhD

Blood (2018) 132 (Supplement 1): 2805.

https://doi.org/10.1182/blood-2018-99-114298

Published: 2018

Journal Articles

ASLAN003, a Novel and Potent Dihydroorotate Dehydrogenase (DHODH) Inhibitor, Induces Differentiation of Acute Myeloid Leukemia

Jianbiao Zhou, MD,PhD, Jessie Yiying Quah, B.S., Jing Yuan Chooi, BSc, Sabrina Hui-Min Toh, B.S., Yvonne Ng, B.S., Baohong Lin, B.S., Motomi Osato, MD, PhD, Qihui Seet, B.S., PhD, A.G. Lisa Ooi, B.S., PhD, Bertil Lindmark, MD PhD, Mark McHale, B.S., PhD, Wee Joo Chng, MB ChB, PhD FRCP(UK), FRCPath, FAMS

Blood (2018) 132 (Supplement 1): 4047.

https://doi.org/10.1182/blood-2018-99-114392

Published: 2018

Journal Articles

The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

Xiaorong Gu, PhD, Quteba Ebrahem, MD, Reda Z. Mahfouz, MD PhD, Metis Hasipek, PhD, Francis Enane, PhD, Tomas Radivoyevitch, Nicolas Rapin, PhDMSc, Bartlomiej P. Przychodzen, MSc, Ramesh Balusu, PhD, Claudiu V Cotta, David Wald, MD PhD, Zhenbo Hu, MD PhD, Yosef Landesman, PhD, Maria Paola Martelli, MD PhD, Brunangelo Falini, MD, Hetty E. Carraway, MD MBA, Jaroslaw P. Maciejewski, PhD MD FACP, Babal K Jha, PhD, Yogenthiran Saunthararajah, MD

Blood (2017) 130 (Supplement 1): 878.

https://doi.org/10.1182/blood.V130.Suppl_1.878.878

Published: 2017

Journal Articles

Long Noncoding RNA Profiling Reveals an Abundant Crnde That Inhibits Granulocytic Differentiation in APL

Xuefei Ma, MS, Wen Jin, PhD, Ming Zhao, MS, Wei Zhang, MD, Jingming Li, BS, Kankan Wang, PhD

Blood (2017) 130 (Supplement 1): 3799.

https://doi.org/10.1182/blood.V130.Suppl_1.3799.3799

Published: 2017

Journal Articles

OSU-2S, a Novel PKC Activator, Mediates PKC Dependent Cell Death, Differentiation and Cell Cycle Arrest in Acute Myeloid Leukemia

Swagata Goswami, MS, Rajeswaran Mani, DVM,PhD, Xiaokui Mo, PhD MAS, Pearlly S. Yan, PhD, Michael B Broe, PhD, Ralf Bundschuh, PhD, Larry State Beaver, Kevan Zapolnik, BS, Zhiliang Xie, Donna Bucci, David M. Lucas, PhD, Allison R. Walker, MD MPH, Alice S. Mims, MD MSCR, Rebecca B. Klisovic, MD, Ching-Shih Chen, PhD, John C. Byrd, MD, Mitch A. Phelps, PhD, Sumithira Vasu, MDMBBS, Natarajan Muthusamy, DVM,PhD

Blood (2017) 130 (Supplement 1): 1247.

https://doi.org/10.1182/blood.V130.Suppl_1.1247.1247

Published: 2017

Journal Articles

Altered Enhancer Activity Represses CEBPE Expression in MLL -Rearranged Leukemia

Xianwen Yang, Yuk Man Lam, Wing Chi Lui, Ray K. Ng, PhD

Blood (2017) 130 (Supplement 1): 1207.

https://doi.org/10.1182/blood.V130.Suppl_1.1207.1207

Published: 2017

Journal Articles

Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

David B. Sykes, MD PhD, Youmna Sami Kfoury, PhD, Francois Mercier, MD, Mathias Wawer, PhD, Amir Schajnovitz, PhD, Hanna Meyer, PhD, Kerry A Pierce, PhD, Detlef Stoeckigt, PhD, Clary B Clish, PhD, Paul A Clemons, PhD, Andreas Janzer, PhD, David T. Scadden, MD

Blood (2016) 128 (22): 1656.

https://doi.org/10.1182/blood.V128.22.1656.1656

Published: 2016

Journal Articles

Non-Canonical Autophagy during APL Therapy

Jing Jin, PhD, Magali Humbert, PhD, Mario P. Tschan, PhD

Blood (2016) 128 (22): 1621.

https://doi.org/10.1182/blood.V128.22.1621.1621

Published: 2016

Journal Articles

Ex Vivo High-Throughput Flow Cytometry Screening Identifies Subsets of Responders to Differentiation Agents in Individual AML Patient Samples

Sacha L. Prashad, PhD, Leylah Drusbosky, PhD, Hassan Sibai, MD, Mark D. Minden, MD PhD, Stephen J. Western, Chris Biondi, MS, Reecha Shah, MS, Debra Liu, MS, Transon Nguyen, MS, Connor Warnock, BS, Pete Quinzio, BA, Matthew De Silva, BS, Elie Traer, MD, Christopher R. Cogle, MD, Aaron D. Schimmer, MD PhD, Diane Heiser, PhD

Blood (2016) 128 (22): 5206.

https://doi.org/10.1182/blood.V128.22.5206.5206

Published: 2016

Journal Articles

Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo

Q. Jeremy Wen, Brittany Woods, PhD, Qiong Yang, MD, Chiu Sophia, Gu Lillu, Franck Rapaport, PhD, Ross L. Levine, MD, John Crispino, PhD MBA

Blood (2016) 128 (22): 949.

https://doi.org/10.1182/blood.V128.22.949.949

Published: 2016

Journal Articles

Immunophenotypic-Defined Stage of Leukemia Differentiation Arrest Identifies Oncogenic and Metabolic Signatures in AML

Francois Vergez, DVM, PhD, Sarah Bertoli, MD PhD, Marina Bousquet, PhD, Marie-Laure Nicolau-Travers, Michael Peres, PharmD, Estelle Saland, Françoise Huguet, MD, Isabelle Luquet, MD, Veronique Mansat-de Mas, PharmD, PhD, Cecile Demur, MD, Eric Delabesse, MD PhD, Gwenn Danet-Desnoyers, PhD, Jean-Emmanuel Sarry, PhD, Christian Récher, MDPhD

Blood (2015) 126 (23): 90.

https://doi.org/10.1182/blood.V126.23.90.90

Published: 2015

NARROW

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

Differentiation Therapy with Novel Epigenetic Inhibitors in Acute Myeloid Leukemia

Targeting DHODH with AG-636 Induces Apoptosis and Differentiation and Inhibits Mitochondrial Function in AML, Translating into Anti-Tumor Efficacy in Vitro and i n Vivo

Loss of FLT3 Sensitizes Myeloid Cells to Differentiation Via DHODH Inhibition

Reprogramming Leukemia Cells into Antigen Presenting Cells As a Novel Cancer Vaccination Immunotherapy

Elucidating the Non-Catalytic Function of Fatty Acid Synthase and Its Autophagy-Dependent Degradation in Acute Myelocytic Leukemia Differentiation Therapy

DHODH Inhibitors in the Treatment of Acute Myeloid Leukemia: Defining the Mechanism of Action and the Basis of the Metabolic Therapeutic Window

Pharmacologic LSD1 Inhibition Preserves Human Granulocytic While Expanding Monocytic Progenitors

The Genes for Tissue Factor F3 and Nuclear Receptor 4A Are Down-Regulated in Early Death Acute Promyelocytic Leukemia Patients

Anti-Leukemic Effect of Retinoic Acid in Non-APL AML Cells

ASLAN003, a Novel and Potent Dihydroorotate Dehydrogenase (DHODH) Inhibitor, Induces Differentiation of Acute Myeloid Leukemia

The Mechanisms By Which Mutant-NPM1 Uncouples Differentiation from Proliferation Are Reversed By Several Drugs, Enabling Rational Multi-Component Non-Cytotoxic Differentiation Therapy

Long Noncoding RNA Profiling Reveals an Abundant Crnde That Inhibits Granulocytic Differentiation in APL

OSU-2S, a Novel PKC Activator, Mediates PKC Dependent Cell Death, Differentiation and Cell Cycle Arrest in Acute Myeloid Leukemia

Altered Enhancer Activity Represses CEBPE Expression in MLL -Rearranged Leukemia

Inhibition of the Enzyme Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia

Non-Canonical Autophagy during APL Therapy

Ex Vivo High-Throughput Flow Cytometry Screening Identifies Subsets of Responders to Differentiation Agents in Individual AML Patient Samples

Activation of JAK/STAT Signaling in Megakaryocytes Is Necessary and Sufficient for Myeloproliferation In Vivo

Immunophenotypic-Defined Stage of Leukemia Differentiation Arrest Identifies Oncogenic and Metabolic Signatures in AML

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only