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Journal Articles

Lyn Kinase Contributes to the Reprogramming of Fibroblasts Promoting Chronic Lymphocytic Leukemia Progression

Alexander Frederik Vom Stein, Maximilian Koch, Sebastian Reinarzt, Anna Lucas, Rocio Rebollido-Rios, PhD, Thomas Oellerich, MD, Phuong Hien Nguyen, PhD, Michael Hallek

Blood (2019) 134 (Supplement_1): 4283.

https://doi.org/10.1182/blood-2019-129299

Published: 2019

Journal Articles

Identification of Deubiquitinase OTUD1 As a Novel Player in Resistance of Multiple Myeloma to Bortezomib

Alexander Vdovin, Tomas Jelinek, MD, Matous Hrdinka, PhD, Juli R. Bago, PhD, Tereza Sevcikova, Roman Hajek, Prof, MD PhD, Michal Simicek, PhD

Blood (2019) 134 (Supplement_1): 5526.

https://doi.org/10.1182/blood-2019-127930

Published: 2019

Journal Articles

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

Mario Scarpa, PhD, Prerna Singh, MS, Shivani Kapoor, MS, Jonelle K. Lee, MS, Sandrine Niyongere, MD, Goutham Narla, MD PhD, Danilo Perrotti, MD PhD, Maria R. Baer, MD

Blood (2019) 134 (Supplement_1): 1276.

https://doi.org/10.1182/blood-2019-129011

Published: 2019

Journal Articles

The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination

Ryan Donaghy, Xu Han, Krasimira Rozenova, Kaosheng Lv, Qinqin Jiang, Miriam Doepner, Roger A. Greenberg, Wei Tong

Blood (2019) 133 (14): 1560–1571.

https://doi.org/10.1182/blood-2018-10-877563

Published: 2019

Includes: Supplemental data

Journal Articles

Deubiquitinase USP7 Regulates Erythroid Development Via Deubiquinating GATA1

Jing Liu, PhD, Long Liang, Mao Ye, Jieying Zhang, Yibin Zhang, Yijin Kuang, Zesen Zhu, Yuanliang Peng, Xiuli An, MD PhD

Blood (2017) 130 (Supplement 1): 10.

https://doi.org/10.1182/blood.V130.Suppl_1.10.10

Published: 2017

Journal Articles

Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells

Hiroki Akiyama, MD, Yoshihiro Umezawa, MD, Keigo Okada, MD, Shinya Ishida, MD, Ayako Nogami, MD, PhD, Osamu Miura, MD, PhD

Blood (2017) 130 (Supplement 1): 2531.

https://doi.org/10.1182/blood.V130.Suppl_1.2531.2531

Published: 2017

Journal Articles

Targeting deubiquitinases in CLL

Deepa Sampath

Blood (2017) 130 (2): 100–101.

https://doi.org/10.1182/blood-2017-06-786236

Published: 2017

Journal Articles

The Role of UAF1 in the Fanconi Anemia Pathway Regulation of Homologous Recombination-Mediated Genome Maintenance

Fengshan Liang, PhD, Simonne Longerich, PhD, Caroline Tang, MD, Olga Buzovestsky, Yong Xiong, PhD, David Maranon, PhD, Claudia Wiese, PhD, Adam Miller, PhD, Patrick Sung, PhD, Gary M. Kupfer, MD

Blood (2016) 128 (22): 1041.

https://doi.org/10.1182/blood.V128.22.1041.1041

Published: 2016

Journal Articles

Inhibition of USP10 Induces Degradation of Oncogenic FLT3: A Novel Approach to Therapy of Leukemia

Sara Buhrlage, PhD, Ellen Weisberg, MD, Nathan Schauer, Jing Yang, PhD, Ilaria Lamberto, PhD, Laura Doherty, Atsushi Nonami, MDPhD, Amanda L. Christie, BS, David M. Weinstock, MD, Richard M. Stone, MD, Nathanael Gray, PhD, James D Griffin, MD

Blood (2016) 128 (22): 524.

https://doi.org/10.1182/blood.V128.22.524.524

Published: 2016

Journal Articles

VLX1570, a First in Class Dub Inhibitor, Modulates BCR Signaling and CXCR4 Expression and Demonstrates Significant In Vivo Antitumor Activity in a Murine Model of Human Waldenstrom Macroglobulinemia

Blood (2015) 126 (23): 703.

https://doi.org/10.1182/blood.V126.23.703.703

Published: 2015

Journal Articles

Identification of USP14 and UCHL5 As Druggable Oncotargets in Ibrutinib-Resistant Mantle Cell Lymphoma

Aneel Paulus, MDMS, Sharoon Akhtar, MPhil, Kelara Samuel, Hassan Yousaf, Davitte Cogen, Pooja Advani, MBBS, Thomas E. Witzig, MD, George J Weiner, MD, Sikander Ailawadhi, MD, Joachim Gullbo, MD PhD, Stig Linder, PhD, Geraldo Otero-Colon, Kasyapa S. Chitta, PhD, Asher Alban Chanan-Khan, MD

Blood (2015) 126 (23): 1557.

https://doi.org/10.1182/blood.V126.23.1557.1557

Published: 2015

Journal Articles

Targeted Disruption of USP14 and UCHL5 with the Novel Deubiquitinase Enzyme (DUB) Inhibitor, VLX1570, Induces Immense Proteotoxicity and Cell Death in Malignant Plasma Cells

Aneel Paulus, MDMS, Sharoon Akhtar, MPhil, Maja Kuranz-Blake, B.S., Anne J. Novak, PhD, Stephen Ansell, MD, Morie A Gertz, MD, Robert A Kyle, MD, Peter Martin, MD, Morton Coleman, MD, Sikander Ailawadhi, MD, Stig Linder, MD PhD, Asher Chanan-Khan, MD, Kasyapa S. Chitta, PhD

Blood (2014) 124 (21): 3116.

https://doi.org/10.1182/blood.V124.21.3116.3116

Published: 2014

Journal Articles

Platelet FcγRIIA Signaling Results in Ubiquitination and Cellular Translocation of Activated Syk

Shaji Abraham, PhD, Leonard C. Edelstein, PhD, Chad A Shaw, PhD, Pierrette Andre, MS, Xianguo Kong, MD, Carol T Dangelmaier, Alexander Tsygankov, PhD, Paul F Bray, MD, Satya P. Kunapuli, PhD, Steven E. McKenzie, MD PhD

Blood (2014) 124 (21): 2761.

https://doi.org/10.1182/blood.V124.21.2761.2761

Published: 2014

Journal Articles

An Acquired Mutation in Deubiquitinating Enzyme USP11 Associated with Clonal Hematopoiesis in Diamond Blackfan Anemia

Nieves Perdigones, PhD, Daria V. Babushok, MD PhD, Lifeng Tian, PhD, Jonathan Bradfield, BS, Cecilia E Kim, Juan C. Perin, MS, Hakon Hakonarson, MD PhD, Monica Bessler, MDPhD, Philip J Mason, PhD

Blood (2014) 124 (21): 1596.

https://doi.org/10.1182/blood.V124.21.1596.1596

Published: 2014

Journal Articles

Characterization Of In Vitro Hdm2 E3 Ubiquitin Ligase-Mediated p53 Ubiquitination

Bradley B Brasher, Ph.D., Eduardo Guillen, Ph.D., Ivan Tomasic, Carsten Schwerdtfeger, Ph.D., Francesco D Melandri

Blood (2013) 122 (21): 4903.

https://doi.org/10.1182/blood.V122.21.4903.4903

Published: 2013

Journal Articles

The Deubiquitinating Enzymes Of The 19S Proteasome Offer Novel Therapeutic Opportunity In Bortezomib Resistant Waldenströms Macroglobulinemia

Aneel Paulus, MD, MS, Kasyapa S. Chitta, PhD, Sharoon Akhtar, Maja Kuranz, Vivek Roy, M.D., Stephen M Ansell, M.D.Ph.D., Anne J. Novak, PhD, Peter Martin, MD, Richard R. Furman, MD, Morton Coleman, MD, Stig Linder, MD, PhD, Asher Chanan-Khan, MD

Blood (2013) 122 (21): 4426.

https://doi.org/10.1182/blood.V122.21.4426.4426

Published: 2013

Journal Articles

Small Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells and Cause Cytotoxicity

Helena Mistry, Ph.D., Grace Hsieh, M.D., Sara Buhrlage, Ph.D, Min Huang, Ph.D., Eunmi Park, Ph.D., Gregory Cuny, Ph.D., Ilene Galinsky, ANP, Richard M. Stone, MD, Nathanael S Gray, PhD, Kalindi Parmar, PhD, Alan D. D'Andrea, MD

Blood (2013) 122 (21): 2906.

https://doi.org/10.1182/blood.V122.21.2906.2906

Published: 2013

Journal Articles

Inhibition Of The Deubiquitinating Enzymes UCHL5 and USP14 Is Lethal To Waldenströms Macroglobulinemia Cells

Kasyapa S. Chitta, PhD, Aneel Paulus, MD, MS, Sharoon Akhtar, Maja Kuranz, Vivek Roy, M.D., Stephen M Ansell, M.D.Ph.D., Anne J. Novak, PhD, Peter Martin, MD, Richard R. Furman, MD, Morton Coleman, MD, Stig Linder, MD, PhD, Asher Chanan-Khan, MD

Blood (2013) 122 (21): 1823.

https://doi.org/10.1182/blood.V122.21.1823.1823

Published: 2013

Journal Articles

Characterization Of Full-Length, Recombinant Amsh, USP9x, and USP1: Clinically-Relevant Deubiquitinases Involved In Hematological Malignancies

Nate Russell, Trevor Taylor, Kalindi Parmar, PhD, Alan D. D'Andrea, MD, Bradley B Brasher, Ph.D., Francesco D Melandri

Blood (2013) 122 (21): 4224.

https://doi.org/10.1182/blood.V122.21.4224.4224

Published: 2013

Journal Articles

Usp9x Silencing and Enzyme Inhibition Suppress Myeloma Cell Survival and in Vivo Tumor Growth.

Luke F. Peterson, PhD, Hanshi Sun, PhD, Yihong Liu, PhD, Malathi Kandarpa, PhD, Diane Giannola, Jessica Mercer, PhD, Hollis D. Showalter, Ph.D., Andrzej Jakubowiak, MD, PhD, Moshe Talpaz, MD, Nicholas J. Donato, PhD

Blood (2012) 120 (21): 2936.

https://doi.org/10.1182/blood.V120.21.2936.2936

Published: 2012

NARROW

Lyn Kinase Contributes to the Reprogramming of Fibroblasts Promoting Chronic Lymphocytic Leukemia Progression

Identification of Deubiquitinase OTUD1 As a Novel Player in Resistance of Multiple Myeloma to Bortezomib

PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation

The BRISC deubiquitinating enzyme complex limits hematopoietic stem cell expansion by regulating JAK2 K63-ubiquitination

Deubiquitinase USP7 Regulates Erythroid Development Via Deubiquinating GATA1

Deubiquitinase Inhibitor WP1130 Blocks FLT3-ITD to Induce Apoptosis in Leukemic Cells

Targeting deubiquitinases in CLL

The Role of UAF1 in the Fanconi Anemia Pathway Regulation of Homologous Recombination-Mediated Genome Maintenance

Inhibition of USP10 Induces Degradation of Oncogenic FLT3: A Novel Approach to Therapy of Leukemia

VLX1570, a First in Class Dub Inhibitor, Modulates BCR Signaling and CXCR4 Expression and Demonstrates Significant In Vivo Antitumor Activity in a Murine Model of Human Waldenstrom Macroglobulinemia

Identification of USP14 and UCHL5 As Druggable Oncotargets in Ibrutinib-Resistant Mantle Cell Lymphoma

Targeted Disruption of USP14 and UCHL5 with the Novel Deubiquitinase Enzyme (DUB) Inhibitor, VLX1570, Induces Immense Proteotoxicity and Cell Death in Malignant Plasma Cells

Platelet FcγRIIA Signaling Results in Ubiquitination and Cellular Translocation of Activated Syk

An Acquired Mutation in Deubiquitinating Enzyme USP11 Associated with Clonal Hematopoiesis in Diamond Blackfan Anemia

Characterization Of In Vitro Hdm2 E3 Ubiquitin Ligase-Mediated p53 Ubiquitination

The Deubiquitinating Enzymes Of The 19S Proteasome Offer Novel Therapeutic Opportunity In Bortezomib Resistant Waldenströms Macroglobulinemia

Small Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells and Cause Cytotoxicity

Inhibition Of The Deubiquitinating Enzymes UCHL5 and USP14 Is Lethal To Waldenströms Macroglobulinemia Cells

Characterization Of Full-Length, Recombinant Amsh, USP9x, and USP1: Clinically-Relevant Deubiquitinases Involved In Hematological Malignancies

Usp9x Silencing and Enzyme Inhibition Suppress Myeloma Cell Survival and in Vivo Tumor Growth.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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