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Journal Articles

Selectively Targeting Checkpoint Kinase By Prexasertib Had Potent Anti-Tumor Activity As Single Agent or Combined with Other Chemotherapeutic Drugs in Diffuse Large B-Cell Lymphoma, Especially Double Hit Lymphoma

Juan Gu, MD PhD, Dennis C Gaughan, Simran Gill, Cory Mavis, BSc, MSc, Francisco J. Hernandez-Ilizaliturri, MD

Blood (2018) 132 (Supplement 1): 5151.

https://doi.org/10.1182/blood-2018-99-110282

Published: 2018

Journal Articles

RSK Inhibition Induces Metaphase Arrest and Apoptosis in Acute Myeloid Leukemia Cells

Hee-Don Chae, PhD, Ritika Dutta, BS, Bruce Tiu, Kara L. Davis, DO, Norman J. Lacayo, MD, Kathleen M. Sakamoto, MD PhD

Blood (2017) 130 (Supplement 1): 2530.

https://doi.org/10.1182/blood.V130.Suppl_1.2530.2530

Published: 2017

Journal Articles

Pilot-Scale Production of Megakaryocytes/Platelets from Cord Blood CD34 + Cells in a Bottle Turning Device Culture System

Xin Guan, PhD Candidate, Lan Wang, M.S., Yu Zhang, PhD Candidate, Bin Shen, PhD Candidate, Zhihua Ren, MD PhD, Yupo Ma, MD PhD, Wei Dai, PhD, Yongping Jiang, PhD

Blood (2016) 128 (22): 819.

https://doi.org/10.1182/blood.V128.22.819.819

Published: 2016

Journal Articles

Elevated APEX1 Disrupts G2/M Checkpoint, Contributing to Evolution and Survival of Myeloma Cells

Subodh Kumar, PhD, Srikanth Talluri, PhD, Mariateresa Fulciniti, Masood A Shammas, PhD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 2997.

https://doi.org/10.1182/blood.V126.23.2997.2997

Published: 2015

Journal Articles

Notch Signaling In B-ALL Reveals PLK1 As A Potential Therapeutic Target In B-ALL: PLK1-Selective Inhibitor Poloxin Modulates Cyclin B and P53 Pathways, Leading To Growth Arrest and Apoptosis

Sankaranarayanan Kannan, PhD, Mandy A Hall, PhD, Leonard S Golfman, PhD, Patrick A Zweidler-McKay, MD, PhD

Blood (2013) 122 (21): 2912.

https://doi.org/10.1182/blood.V122.21.2912.2912

Published: 2013

Journal Articles

Dissecting Stem Cell Proliferation and Differentiation In Association With The Central Cell Cycle Regulator APC/C Cdh1 In Vitro and In Vivo

Daniel Ewerth, Andrea Schmidts, Birgit Kuegelgen, Dagmar Wider, Julia Schüler, Monika Engelhardt, MD, Ralph M. Waesch, MD

Blood (2013) 122 (21): 2446.

https://doi.org/10.1182/blood.V122.21.2446.2446

Published: 2013

Journal Articles

Aptamer TY04 Inhibits Multiple Myeloma Cell Growth Via Cell Cycle Arrest

Jing Liu, Hong-Juan Dai, Bian-Ying Ma, Jian-Hui Song, Hui-yong Chen, Jia-Jie Zhou, Shi-Jun Tang, Shan Yao, Mao Ye, Wei-Hong Tan

Blood (2013) 122 (21): 5390.

https://doi.org/10.1182/blood.V122.21.5390.5390

Published: 2013

Journal Articles

Integrative Whole Transcriptome and Exome Sequencing Reveals Reprogramming Of Mantle Cell Lymphoma In Prolonged Early G1 Arrest For Clinical Response To Selective Inhibition Of CDK4 In Combination Therapy

David Chiron, PhD, Peter Martin, MD, Maurizio Di Liberto, Ph.D., Xiangao Huang, PhD, Priyanka Vijay, B.A, Pedro Blecua, PhD, Scott A Ely, MD, MPH, Olivier Elemento, PhD, Christopher E Mason, PhD, John P. Leonard, MD, Selina Chen-Kiang, PhD

Blood (2013) 122 (21): 80.

https://doi.org/10.1182/blood.V122.21.80.80

Published: 2013

Journal Articles

Bortezomib (BTZ) Inhibits p21-Dependent Senescence and Triggers Mitotic Catastrophe in Rituximab-Chemotherapy Resistant Cell Lines (RRCL)

Juan Gu, PhD, Francisco Hernandez-Ilizaliturri, MD, Gregory P. Kaufman, Cory Mavis, BSc, MSc, Myron S. Czuczman, MD

Blood (2012) 120 (21): 1655.

https://doi.org/10.1182/blood.V120.21.1655.1655

Published: 2012

Journal Articles

Notch/HES1 Signaling Stabilizes p53 Expression Via a Novel PARP1-Chfr-PLK1-Mediated Mechanism in B-ALL

Sankaranarayanan Kannan, PhD, Patrick A Zweidler-McKay, MD, PhD

Blood (2012) 120 (21): 1292.

https://doi.org/10.1182/blood.V120.21.1292.1292

Published: 2012

Journal Articles

Dissecting Stem Cell Proliferation and Differentiation in Association with the Central Cell Cycle Regulator APC/C Cdh1

Daniel Ewerth, Andrea Schmidts, Birgit Kuegelgen, Dagmar Wider, Julia Schüler, Monika Engelhardt, Ralph Wäsch, MD

Blood (2012) 120 (21): 1236.

https://doi.org/10.1182/blood.V120.21.1236.1236

Published: 2012

Journal Articles

A Rationale to Enhance the Response to Antimitotic Therapy in Acute Myeloid Leukemia

Dominik Schnerch, MD, Julia Felthaus, Monika Engelhardt, Ralph Wäsch, MD

Blood (2012) 120 (21): 1332.

https://doi.org/10.1182/blood.V120.21.1332.1332

Published: 2012

Journal Articles

The Spindle Checkpoint Protein BubR1 Is Differentially Expressed in the Lymphatic and Myeloid Lineage and Is a Determinator of Response to Spindle Poisons

Dominik Schnerch, MD, Marie Follo, PhD, Andrea Schmidts, Julika Krohs, Julia Felthaus, Monika Engelhardt, MD, Ralph Wäsch

Blood (2011) 118 (21): 1407.

https://doi.org/10.1182/blood.V118.21.1407.1407

Published: 2011

Journal Articles

Apoptotic and Non-Apoptotic Cellular Pathways Executed by Bortezomib (BTZ) in Rituximab-Resistant Lymphomas

Juan Gu, PhD, Francisco J. Hernandez-Ilizaliturri, MD, Cory Mavis, BSc, MSc, Natalie M Czuczman, Karen E Thudium, George Deeb, MD, John Gibbs, MD, Myron S. Czuczman, MD

Blood (2011) 118 (21): 4967.

https://doi.org/10.1182/blood.V118.21.4967.4967

Published: 2011

Journal Articles

Targeting AKT Signaling in Pediatric Acute Lymphoblastic Leukemia with Sulforaphane

Koramit Suppipat, MD, Evelyn Zhu, Daniel Lacorazza, PhD

Blood (2011) 118 (21): 1521.

https://doi.org/10.1182/blood.V118.21.1521.1521

Published: 2011

Journal Articles

High Risk Acute Lymphoblastic Leukemia with Rapid NOD/SCID Engraftment Is Characterized by High Protein Expression of CYCLIN B, Beta-CATENIN, ANNEXIN I and Decreased PKC Alpha Activation

Felix Seyfried, Benedetta Accordi, PhD, Manon Queudeville, MD, Sarah Mirjam Eckhoff, MD, Gloria Milani, Luisa Galla, Marco Giordan, PhD, Johann M Kraus, Giuseppe Basso, MD PhD, Hans Armin Kestler, PhD, Geertruy te Kronnie, PhD, Klaus-Michael Debatin, MD, PhD, Lueder Hinrich Meyer, MD

Blood (2011) 118 (21): 1457.

https://doi.org/10.1182/blood.V118.21.1457.1457

Published: 2011

Journal Articles

Bim Is Required to Sensitize Mantle Cell Lymphoma Cells for Killing by Bortezomib, but Not Ara-C, by Selective Inhibition of CDK4/CDK6

Xiangao Huang, PhD, Maurizio Di Liberto, Ph.D., Jamieson Bretz, Ph.D., David Chiron, PhD, Peter Martin, MD, Morton Coleman, MD, Jia Ruan, MD, PhD, Mitchell R Smith, MD, PhD, Scott A Ely, M.D., Christopher E. Mason, PhD, Phoebe Joy Ho, MBBS, DPhil, John P. Leonard, MD, Selina Chen-Kiang, PhD

Blood (2011) 118 (21): 1655.

https://doi.org/10.1182/blood.V118.21.1655.1655

Published: 2011

Journal Articles

Analysis of Mitosis In Acute Myeloid Leukemia Using Live-Cell Imaging.

Dominik Schnerch, Julia Felthaus, Lara Mentlein, Monika Engelhardt, Ralph M. Waesch, MD

Blood (2010) 116 (21): 3363.

https://doi.org/10.1182/blood.V116.21.3363.3363

Published: 2010

Journal Articles

NIPA Checkpoint Control In Oncogenic Transformation Is Dependent on p53

Anna Lena Illert, MD, Hiroyuki Kawaguchi, MD, PhD, Corinna Albers, PhD, Melanie Sickinger, Ulrich Keller, MD, Stephan w. Morris, MD, PhD, Christian Peschel, MD, Justus Duyster, MD

Blood (2010) 116 (21): 4178.

https://doi.org/10.1182/blood.V116.21.4178.4178

Published: 2010

Journal Articles

Whole Transcriptome Resequencing of Paired Diagnosis-Relapse BCR-ABL1 -Positive Acute Lymphoblastic Leukemia (ALL) Samples Reveals the Loss of Cell Cycle Regulation as the Main Mechanism Responsible for Leukemia Progression.

Ilaria Iacobucci, Annalisa Lonetti, Alberto Ferrarini, Marco Sazzini, Anna Ferrari, Cristina Papayannidis, Simona Soverini, Enrico Giacomelli, Luciano Xumerle, Viviana Guadagnuolo, Antonella Vitale, Fabrizio Pane, MD, Michele Baccarani, Massimo Delledonne, Giovanni Martinelli

Blood (2010) 116 (21): 1024.

https://doi.org/10.1182/blood.V116.21.1024.1024

Published: 2010

NARROW

Selectively Targeting Checkpoint Kinase By Prexasertib Had Potent Anti-Tumor Activity As Single Agent or Combined with Other Chemotherapeutic Drugs in Diffuse Large B-Cell Lymphoma, Especially Double Hit Lymphoma

RSK Inhibition Induces Metaphase Arrest and Apoptosis in Acute Myeloid Leukemia Cells

Pilot-Scale Production of Megakaryocytes/Platelets from Cord Blood CD34 + Cells in a Bottle Turning Device Culture System

Elevated APEX1 Disrupts G2/M Checkpoint, Contributing to Evolution and Survival of Myeloma Cells

Notch Signaling In B-ALL Reveals PLK1 As A Potential Therapeutic Target In B-ALL: PLK1-Selective Inhibitor Poloxin Modulates Cyclin B and P53 Pathways, Leading To Growth Arrest and Apoptosis

Dissecting Stem Cell Proliferation and Differentiation In Association With The Central Cell Cycle Regulator APC/C Cdh1 In Vitro and In Vivo

Aptamer TY04 Inhibits Multiple Myeloma Cell Growth Via Cell Cycle Arrest

Integrative Whole Transcriptome and Exome Sequencing Reveals Reprogramming Of Mantle Cell Lymphoma In Prolonged Early G1 Arrest For Clinical Response To Selective Inhibition Of CDK4 In Combination Therapy

Bortezomib (BTZ) Inhibits p21-Dependent Senescence and Triggers Mitotic Catastrophe in Rituximab-Chemotherapy Resistant Cell Lines (RRCL)

Notch/HES1 Signaling Stabilizes p53 Expression Via a Novel PARP1-Chfr-PLK1-Mediated Mechanism in B-ALL

Dissecting Stem Cell Proliferation and Differentiation in Association with the Central Cell Cycle Regulator APC/C Cdh1

A Rationale to Enhance the Response to Antimitotic Therapy in Acute Myeloid Leukemia

The Spindle Checkpoint Protein BubR1 Is Differentially Expressed in the Lymphatic and Myeloid Lineage and Is a Determinator of Response to Spindle Poisons

Apoptotic and Non-Apoptotic Cellular Pathways Executed by Bortezomib (BTZ) in Rituximab-Resistant Lymphomas

Targeting AKT Signaling in Pediatric Acute Lymphoblastic Leukemia with Sulforaphane

High Risk Acute Lymphoblastic Leukemia with Rapid NOD/SCID Engraftment Is Characterized by High Protein Expression of CYCLIN B, Beta-CATENIN, ANNEXIN I and Decreased PKC Alpha Activation

Bim Is Required to Sensitize Mantle Cell Lymphoma Cells for Killing by Bortezomib, but Not Ara-C, by Selective Inhibition of CDK4/CDK6

Analysis of Mitosis In Acute Myeloid Leukemia Using Live-Cell Imaging.

NIPA Checkpoint Control In Oncogenic Transformation Is Dependent on p53

Whole Transcriptome Resequencing of Paired Diagnosis-Relapse BCR-ABL1 -Positive Acute Lymphoblastic Leukemia (ALL) Samples Reveals the Loss of Cell Cycle Regulation as the Main Mechanism Responsible for Leukemia Progression.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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