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Journal Articles

Differentiating between Hyperdiploidy and Pseudo-Hyperdiploidy in B-Lymphoblastic Leukemia Utilizing Low-Coverage Mate-Pair Sequencing

James B Smadbeck, Beth A Pitel, MA, Kathryn E. Pearce, Sarah H Johnson, MS, Nicole Hoppman, Rhett P. Ketterling, MD, Patricia Griepp, MD, Linda B Baughn, PhD, George Vasmatzis, PhD, Jess Peterson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5212.
https://doi.org/10.1182/blood-2019-122440
Published: 2019
Journal Articles

Analysis of CNV in the Genomes of the Marrow Cells of the Patients with AML Revealed That High Numbers of Aberrations Associate with Better Survival and Deletions with the Aberrant Expression of CD19 in the Leukemic Blasts

Emilia Jaskula, PhD, Janusz Lange, MD PhD, Monika Mordak-Domagala, MD, Mariola Sedzimirska, MD PhD, Marta Lemieszewska, Agnieszka Tarnowska, Helena Pakos, Anna Sobczynska-Konefal, Andrzej Lange, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5164.
https://doi.org/10.1182/blood-2019-130316
Published: 2019
Journal Articles

Involvement of RUNX1 Pathway Is a Common Event in the Leukemic Transformation of Chronic Myeloproliferative Neoplasms (MPNs)

Paola Guglielmelli, MD PhD, Niccolò Bartalucci, PhDBSc, Elisa Contini, PhD, Giada Rotunno, PhD, Annalisa Pacilli, PhD, Simone Romagnoli, BSc, Lara Mannelli, MD, Francesco Mannelli, MD, Giacomo Coltro, MD, Alessandro Pancrazzi, PhD, Valentina Ariu, BSci, Sara Fiaccabrino, Roberto Semeraro, Alberto Magi, PhD, Carmela Mannarelli, PhD, Francesca Gesullo, BSci, Chiara Paoli, PhD, Alessandro M. Vannucchi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2968.
https://doi.org/10.1182/blood-2019-129094
Published: 2019
Journal Articles

Transcriptional Profiling Reveals Strong Impact of Major Molecular Disease Subgroups and Mixed Epistasis in Chronic Lymphocytic Leukemia

Thorsten Zenz, MD, Almut Luetge, Junyan Lu, PhD, Huellein Jennifer, PhD, Sascha Dietrich, MD, Leopold Sellner, MD, Wolfgang Huber, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1742.
https://doi.org/10.1182/blood-2019-126388
Published: 2019
Journal Articles

Composite Copy Number Variation in CDK4 , CDKN2A and RB1 Predisposes Mantle Cell Lymphoma to Expansion of PD1+ Tumor Cells and Resistance to CDK4/6 Inhibitor Therapy as Revealed by Integrative Longitudinal scRNA-seq

Maurizio Di Liberto, PhD, Yang Hu, PhD, Xiangao Huang, PhD, Christina Y. Lee, MD, Kevin Wang, B.S., Nancy L. Bartlett, MD, LeAnn Ridling, Kristie A. Blum, MD, Kami J. Maddocks, MD, Steven I Park, MD, Jia Ruan, MD PhD, Kenneth Eng, B.S., Lorenzo Galluzzi, PhD, John P. Leonard, MD, Peter Martin, FRCPC, MD MS, Olivier Elemento, PhD, Selina Chen-Kiang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1492.
https://doi.org/10.1182/blood-2019-130944
Published: 2019
Journal Articles

Clinical Implications of Copy Number Variant Detection from Panel-Based Next-Generation Sequencing Data in Myelodysplastic Syndrome

Je-Hwan Lee, MD PhD, Yoo-Jin Kim, MD PhD, Seung-Hyun Jung, Eun-Hye Hur, Eun-Ji Choi, MD, Kyoo Hyung Lee, MD PhD, Seon-Hee Yim, Hye-Jung Kim, Yong-Rim Kwon, Young-Woo Jeon, MD PhD, Sug Hyung Lee, Yeun-Jun Chung
Journal: Blood
Blood (2019) 134 (Supplement_1): 4264.
https://doi.org/10.1182/blood-2019-131570
Published: 2019
Journal Articles

Can Monosomy 7 be Targeted By Next Generation Cereblon-Modulating Agents?

Vera Adema, PhD, Cassandra M Kerr, MS, Wencke Walter, PhD, Stephan Hutter, PhD, Yasunobu Nagata, MD PhD, Hassan Awada, MD, Sunisa Kongkiatkamon, Christina A. Snider, BA, Milo Co, Rainey Magdalena, Arda Durmaz, Manja Meggendorfer, PhD, Aziz Nazha, MD, Jacob Scott, MD, Hetty E. Carraway, MD MBA, Mikkael A. Sekeres, MD MS, Francesc Sole, PhD, Torsten Haferlach, MD, Valeria Visconte, PhD, Jaroslaw P. Maciejewski, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1270.
https://doi.org/10.1182/blood-2019-128967
Published: 2019
Journal Articles

Prognostic Impact of Clonal Diversity in Acute Myeloid Leukemia (AML) Treated with Intensive Chemotherapy (IC)

Marco Cerrano, MD, Marie Passet, PharmD, Loic Vasseur, MD, Pierre Hirsch, MD PhD, Xavier Thomas, MD PhD, Samuel Quentin, Justine Pasanisi, Florence Rabian, MD, Ramy Rahmé, MD, Etienne Lengline, MD, Emmanuel Raffoux, MD, Nathalie Dhedin, MD, Marie Sebert, MD, Odile Maarek, Anna Raimbault, PhD, Karine Celli-Lebras, CRA, Lionel Ades, MD PhD, Pierre Fenaux, MD PhD, Nicolas Boissel, MD PhD, Francois Delhommeau, MD PhD, Jean Soulier, MD PhD, Herve Dombret, MD PhD, Emmanuelle Clappier, PhD PharmD, Pierre Sujobert, MD PhD, Raphael Itzykson, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2700.
https://doi.org/10.1182/blood-2019-127475
Published: 2019
Journal Articles

Mutational Landscape and Temporal Evolution during Treatment of Relapsed Acute Lymphoblastic Leukemia

Benshang Li, Yongjin Li, PhD, Shuhong Shen, MD PhD, Yingchi Zhang, Samuel Brady, PhD, Xiaotu Ma, Yu Liu, PhD, Ningling Wang, Diane Flasch, Matthew Myers, Heather Mulder, BS, Yanling Liu, Liqing Tian, Kohei Hagiwara, MD, Hui Zhang, Ying Shao, Hongye Sun, Lele Sun, Ting-Nien Lin, Lijuan Du, Fan Yang, Michael Rusch, BS, Michael Edmonson, John Easton, PhD, Xiaofan Zhu, PhD, Jingliao Zhang, MD, Cheng Cheng, PhD, Benjamin Raphael, Jing-Yan Tang, James R. Downing, MD, Bin-Bing Zhou, Ching-Hon Pui, MD, Jun J. Yang, PhD, Jinghui Zhang
Journal: Blood
Blood (2018) 132 (Supplement 1): 917.
https://doi.org/10.1182/blood-2018-99-119144
Published: 2018
Journal Articles

Integrated Genomic and Proteomic Analysis of Murine CLL-like Cells Reveals SF3B1 Mutation to Impact DNA Damage Response and BCR Signaling

Lili Wang, MDPhD, Shanye Yin, PhD, Aina zurita Martinez, Fara Faye Regis, BS, Angela Brooks, PhD, Sarah E. M. Herman, PhD, Elisa Ten Hacken, PhD, Esther Obeng, MD PhD, Dean Campagna, BS, Mark D. Fleming, MD DPhil, Benjamin L. Ebert, MDPhD, Adrian Wiestner, MD, Ignaty Leshchiner, PhD, Gad Getz, PhD, Ruben D. Carrasco, MD PhD, Catherine J. Wu, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 947.
https://doi.org/10.1182/blood-2018-99-117691
Published: 2018
Journal Articles

Gene Aberrations in Adult Patients with Ph-Negative ALL in the Czech Republic

Zuzana Vrzalova, PhD, Hana Jelinkova, Stepan Hrabovsky, Frantisek Folber, MD PhD, Cyril Salek, Jan Horacek, Marketa Zaliova, Jiri Stika, Martina Slavikova, Sarka Pospisilova, Michael Doubek, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4090.
https://doi.org/10.1182/blood-2018-99-118308
Published: 2018
Journal Articles

Genetic Evidence for Involvement of Human Endogenous Retrovirus Herv-Fc1 in the Pathogenesis of MPNs

Vibe Skov, PhD, Katrine LM Schmidt, Kasper Mønsted Pedersen, MD, Bettina Hansen, Tobias Wirenfeldt Klausen, M.S., Torben A Kruse, Mads Thomassen, PhD, Lasse Kjær, PhD, Christina Ellervik, Associate Professor, MD PhD, Morten Holmstrøm, MD, Bjørn Nexø, Hans Carl Hasselbalch, Professor, dr.MD, Magdalena J Laska
Journal: Blood
Blood (2018) 132 (Supplement 1): 5488.
https://doi.org/10.1182/blood-2018-99-118080
Published: 2018
Journal Articles

Highly Comprehensive Genomic Testing for CLL: WGS, One Key to CLL Patient Stratification

Kate E Ridout, PhD, Pauline Robbe, MSc, PhD, Doriane Cavalieri, MSc, Jennifer Becq, PhD, Miao He, PhD, Ruth Clifford, FRCPath, PhD, Niamh Appleby, FRCPath, MD, Reem Alsolami, PhD, Adam Burns, BSc, PhD, Melanie Oates, PhD, Basile Stamatopoulos, PhD, Samantha Knight, PhD, Alona Sosinsky, PhD, Pavlos Antoniou, PhD, Mark Ross, PhD, David Bentley, PhD, Andrew Pettitt, FRCPath, PhD, Peter Hillmen, MB ChB, PhD FRCP, FRCPath, Mark Caulfield, PhD, Anna Schuh, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3115.
https://doi.org/10.1182/blood-2018-99-115935
Published: 2018
Journal Articles

Analysis of the Evolving MDS/AML Clones to Identify Resistance Mechanisms and Predict New Therapy Options at Relapse Using Computational Biology Modeling: Case-Studies from iCare1 Clinical Study

Shireen Vali, PhD, Taher Abbasi, MS, MBA, Neeraj Kumar Singh, B.Tech, Shahabuddin Usmani, M.Sc., Deepak Anil Lala, B.Tech, Poornachandra G, B.Tech, Saumya Radhakrishnan, B.Tech, Shivgonda C Birajdar, MCA, Ganesh Naga, B.Tech, Leylah M. Drusbosky, PhD, Christopher R. Cogle, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3086.
https://doi.org/10.1182/blood-2018-99-115821
Published: 2018
Journal Articles

Accurate Prediction of RH Genotypes Using Whole Genome Sequencing Data

Yan Zheng, MD PhD, Ti-Cheng Chang, PhD, Gang Wu, PhD, Jane S. Hankins, MD MS, Mitchell J. Weiss, MD PhD, Connie M. Westhoff, PhD, Stella T. Chou, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2332.
https://doi.org/10.1182/blood-2018-99-119681
Published: 2018
Journal Articles

Non-Ph variants in CML: guilty drivers?

Satu Mustjoki
Journal: Blood
Blood (2018) 132 (9): 880–881.
https://doi.org/10.1182/blood-2018-07-862698
Published: 2018
Journal Articles

Recurrent Copy Number Variants Are Highly Prevalent in Acute Myeloid Leukemia

Katherine Tarlock, MD, Yuting He, James Sun, Rhonda E. Ries, MA, Eric A Severson, MD PhD MMSc, Mark Bailey, MS, Samantha Morley, PhD, Sohail Balasubramanian, Rachel Erlich, PhD, Doron Lipson, PhD, Geoff Otto, PhD, Jo-Anne Vergillo, Jeffrey S Ross, MD, Tariq Mughal, FRCP, Phil Stephens, PhD, Vincent Miller, MD, Soheil Meshinchi, MD PhD, Jie He, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3800.
https://doi.org/10.1182/blood.V130.Suppl_1.3800.3800
Published: 2017
Journal Articles

Identification of Recurrent Non-Coding Driver Mutations in Non-Hodgkin Lymphomas through Integrative Genomic Analysis of 777 Patients

Aixiang Jiang, M.Sc., Bruno M. Grande, BSc, Sarah E Arthur, BSc, Miguel Alcaide, PhD, Daisuke Ennishi, MDPhD, Selin Jessa, Prasath Pararajalingam, B.Sc., Barbara Meissner, PhD, Merrill Boyle, BSc, Lauren Chong, MSc, Daniel Lai, Jordan Davidson, BSc, Anja Mottok, Kevin R Bushell, BSc, MSc, Laurie H. Sehn, MDMPH, Pedro Farinha, Sohrab P Shah, Andrew J. Mungall, PhD, Randy D. Gascoyne, MD, Marco A Marra, PhD, Christian Steidl, MD, Joseph M Connors, MD, David W. Scott, MD PhD FRACP, FRCPA, Ryan D. Morin, PhDBSc,MSc
Journal: Blood
Blood (2017) 130 (Supplement 1): 36.
https://doi.org/10.1182/blood.V130.Suppl_1.36.36
Published: 2017
Journal Articles

Icare 1: A Prospective Clinical Trial to Predict Treatment Response Based on Mutanome-Informed Computational Biology in Patients with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS)

Leylah M. Drusbosky, PhD, Kimberly E. Hawkins, PhD BS, Cesia Salan, Madeleine Turcotte, MS, Glenda G. Anderson, Neeraj Kumar Singh, B.Tech, Saumya Radhakrishnan, BT, Yashaswini Ullal, BE, Anay Talawdekar, MT, Huzaifa Sikora, BT, Prashant Nair, BT, Priyanka Bhowmick, MS, Taher Abbasi, MS, MBA, Shireen Vali, PhD, Fei Zou, PhD, Nosha Farhadfar, MD, Hemant S. Murthy, MD, Biljana N. Horn, MD, Helen L. Leather, Paul Castillo, MD, Barry Sawicki, BS, Randy A. Brown, MD, Maxim Norkin, MD, John W. Hiemenz, MD, Jack W. Hsu, MD, William Slayton, MD, John R. Wingard, MD, Christopher R. Cogle, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4277.
https://doi.org/10.1182/blood.V130.Suppl_1.4277.4277
Published: 2017
Journal Articles

Preferential In Vitro and In Vivo Induction of Endogenous Retrovirus Transcription from a Monoallelic Chromosome 7q in Decitabine (DAC) Treated AML Blasts

Gabriele Greve, Dietmar Pfeifer, Sina Bengel, Michael Lübbert
Journal: Blood
Blood (2017) 130 (Supplement 1): 2612.
https://doi.org/10.1182/blood.V130.Suppl_1.2612.2612
Published: 2017