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Journal Articles

How I treat paroxysmal nocturnal hemoglobinuria

Robert A. Brodsky
Journal: Blood
Blood (2021) 137 (10): 1304–1309.
https://doi.org/10.1182/blood.2019003812
Published: 2021
Journal Articles

A complementary new drug for PNH

Clinical Trials & Observations
Robert A. Brodsky
Journal: Blood
Blood (2020) 135 (12): 884–885.
https://doi.org/10.1182/blood.2020004959
Published: 2020
Journal Articles

Long Term Nomacopan Administration Results in Complete Transfusion Independence in Previously Transfusion-Dependent PNH Patients

Austin Kulasekararaj, MBBS MDMRCP FRCPath, Wynne Weston-Davies, Tadeusz Robak, MD, Miles Nunn, PhD, Agnieszka Piekarska, MD, Anna Szmigielska-Kaplon, MD, Anita Hill, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4797.
https://doi.org/10.1182/blood-2019-125263
Published: 2019
Journal Articles

Epidemiology of PNH and Real-World Treatment Patterns Following an Incident PNH Diagnosis in the US

Jessica J Jalbert, PhD, Umesh Chaudhari, MD, Haixin Zhang, MSc, Jonathan Weyne, MD, Jamile M. Shammo, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3407.
https://doi.org/10.1182/blood-2019-125867
Published: 2019
Journal Articles

Symptomatic Bilirubin Gallstones in Patients with PNH Treated with Eculizumab

David J. Araten, MD, H. Leon Pachter, Robert J Dring, Elliot Newman, Steven M Cohen
Journal: Blood
Blood (2019) 134 (Supplement_1): 4795.
https://doi.org/10.1182/blood-2019-124571
Published: 2019
Journal Articles

Plasmic and Plasic Αre Εxcellent Predictors of Severe ADAMTS13 Deficiency in Thrombotic Microangiopathy Patients without Secondary Causes

Eleni Gavriilaki, MD, Evdoxia Koravou, Thomas Chatziconstantinou, Christina Kalpadakis, Maria Ximeri, Anna Christoforidou, Nikoleta Printza, Georgios Karavalakis, Maria Kaliou, Vasiliki Kalaitzidou, SOFIA Chissan, SOFIA Vakalopoulou, MD, Tasoula Touloumenidou, Lila Papalexandri, MD, Maria Papathanassiou, Antonia Syrigou, Maria Topalidou, Maria Liga, Alexandros Spyridonidis, MD PhD, Anna Kioumi, Efthymia Vlachaki, MBBS, Eleni Papadaki, Prof, Panayiotis Panayiotidis, MD, Chrysavgi Lalayanni, Ioanna Sakellari, Achilles Anagnostopoulos
Journal: Blood
Blood (2019) 134 (Supplement_1): 4913.
https://doi.org/10.1182/blood-2019-125343
Published: 2019
Journal Articles

Comparative Evaluation of Complement Factor D, C3, and C5 Inhibitors on Serum Bactericidal Activity Against Neisseria Meningitidis Isolates

Yongsen Zhao, Dharaben Patel, MS, Jane A Thanassi, BS, Mingjun Huang, PhD, Steven D Podos, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5763.
https://doi.org/10.1182/blood-2019-132253
Published: 2019
Journal Articles

Ravulizumab: a complementary option for PNH

Clinical Trials & Observations
Nathan T. Connell
Journal: Blood
Blood (2019) 133 (6): 503–504.
https://doi.org/10.1182/blood-2018-12-891499
Published: 2019
Journal Articles

Ravulizumab (ALXN1210) vs eculizumab in adult patients with PNH naive to complement inhibitors: the 301 study

Clinical Trials & Observations
Jong Wook Lee, Flore Sicre de Fontbrune, Lily Wong Lee Lee, Viviani Pessoa, Sandra Gualandro, Wolfgang Füreder, Vadim Ptushkin, Scott T. Rottinghaus, Lori Volles, Lori Shafner, Rasha Aguzzi, Rajendra Pradhan, Hubert Schrezenmeier, Anita Hill
Journal: Blood
Blood (2019) 133 (6): 530–539.
https://doi.org/10.1182/blood-2018-09-876136
Published: 2019
Includes: Supplemental data
Journal Articles

Benefits and Limitations of Long-Term Eculizumab Treatment for Paroxysmal Nocturnal Hemoglobinuria (PNH): Real-World Data from Large Cohort Study in Russia

Aleksandr Kulagin, Olesya Klimova, Tatiana Rudakova, Irina Golubovskaya, Maria Ivanova, Anna Smirnova, Alexandra Lapina, Tatiana Bykova, Elena Babenko, Marina Popova, Vladimir Dobronravov, Boris Afanasyev
Journal: Blood
Blood (2018) 132 (Supplement 1): 2589.
https://doi.org/10.1182/blood-2018-99-120139
Published: 2018
Journal Articles

Thrombotic Microangiopathies Associated with Pregnancy: Diagnostic and Therapeutic Challenges

Maria Vinogradova, MD, Tatiana Kirsanova, MD, Roman Shmakov, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4810.
https://doi.org/10.1182/blood-2018-99-115220
Published: 2018
Journal Articles

Complement-Mediated Thrombotic Microangiopathy: A Murky Presentation of a Rare Disease Entity

Patrick Fleming, MD, Maggie Cheung, MD, David Sokol, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5005.
https://doi.org/10.1182/blood-2018-99-119893
Published: 2018
Journal Articles

Prognostic Value of Clone Size in Paroxysmal Nocturnal Hemoglobinuria (PNH) for Thrombotic Events in Untreated Patients in the International PNH Registry

Regis Peffault De Latour, Jaroslaw P. Maciejewski, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Loree Larratt, MD FRCP(C), Ronald S. Go, MD, David Dingli, MD PhD, Amanda Wilson, PhD, Philippe Gustovic, MD, Aleksandr Kulagin
Journal: Blood
Blood (2018) 132 (Supplement 1): 1038.
https://doi.org/10.1182/blood-2018-99-111324
Published: 2018
Journal Articles

Platelets Promote Activation of the Complement System in Ovarian Cancer

Omayra Gonzalez Pagan, MD, Min Soon Cho, PhD, Vahid Afshar-Kharghan, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4970.
https://doi.org/10.1182/blood-2018-99-116752
Published: 2018
Journal Articles

Current Status and Optimal Management of Eculizumab Poor-Responders Due to C5 Polymorphisms

Yasutaka Ueda, MD PhD, Hiroyuki Takamori, MD, Jun-Ho Jang, MD PhD, Chezi Ganzel, MD, Saskia Langemeijer, MD PhD, Makiko Osato, MS, Petra Muus, MD PhD, Jong-Wook Lee, MD PhD, Jun-Ichi Nishimura, MD PhD, Yuzuru Kanakura, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2323.
https://doi.org/10.1182/blood-2018-99-111230
Published: 2018
Journal Articles

Results from a Phase 3, Multicenter, Non-Inferiority Study of Ravulizumab (ALXN1210) Versus Eculizumab in Adult Patients with Paroxysmal Nocturnal Hemoglobinuria Currently Treated with Eculizumab

Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Anita Hill, MD PhS, Scott T. Rottinghaus, MD, Saskia Langemeijer, MD PhD, Richard A. Wells, MD DPhil, F. Ataulfo Gonzalez-Fernandez, Anna Gaya, Jong-Wook Lee, MD PhD, Emilio Ojeda Gutierrez, Caroline I. Piatek, Jeffrey Szer, MBBS, Antonio M. Risitano, MD PhD, Shinji Nakao, MD PhD, Eric Bachman, Lori Shafner, PhD, Andrew I. Damokosh, PhD, Stephan Ortiz, RPh, PhD, Alexander Röth, MD, Regis Peffault De Latour
Journal: Blood
Blood (2018) 132 (Supplement 1): 625.
https://doi.org/10.1182/blood-2018-99-119147
Published: 2018
Journal Articles

Ravulizumab (ALXN1210) Versus Eculizumab in Adults with Paroxysmal Nocturnal Hemoglobinuria: Pharmacokinetics and Pharmacodynamics Observed in Two Phase 3 Randomized, Multicenter Studies

Regis Peffault De Latour, Robert A. Brodsky, MD, Stephan Ortiz, RPh, PhD, Antonio M. Risitano, MD PhD, Jun-Ho Jang, MD PhD, Peter Hillmen, MB ChB, PhD FRCP, FRCPath, Aleksandr Kulagin, Rajendra Pradhan, PhD, Scott T. Rottinghaus, MD, Rasha Aguzzi, MS, Richard A. Wells, MD DPhil, Jeffrey Szer, MBBS
Journal: Blood
Blood (2018) 132 (Supplement 1): 626.
https://doi.org/10.1182/blood-2018-99-110858
Published: 2018
Journal Articles

A Phase 3 Study of Ravulizumab (ALXN1210) Versus Eculizumab in Adults with Paroxysmal Nocturnal Hemoglobinuria Naive to Complement Inhibitors: Results of a Subgroup Analysis with Patients Stratified By Baseline Hemolysis Level, Transfusion History, and Demographics

Ilene C. Weitz, MD, Aleksandr Kulagin, Shinji Nakao, MD PhD, Caroline I. Piatek, MD, Jeffrey Szer, MBBS, Scott T. Rottinghaus, MD, Lori Volles, MD, Andrew I. Damokosh, PhD, Rasha Aguzzi, MS, Loree Larratt, MD, Antonio M. Risitano, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 627.
https://doi.org/10.1182/blood-2018-99-110623
Published: 2018
Journal Articles

Coversin, a Novel C5 Complement Inhibitor, Is Safe and Effective in the Treatment of PNH: Results of a Phase II Clinical Trial

Anita Hill, MBChB (Hons), PhD, Wynne Weston-Davies, MB FRCS, Miles Nunn, PhD, Tadeusz Robak, MD PhD, Jerzy Windyga, MD, Andrzej Hellmann, MD PhD DSc, Austin G. Kulasekararaj, MBBS, MD MRCP, FRCPath, Agniezka Piekarska, Anna Szmigielska-Kaplon, Morag Griffin, Talha Munir
Journal: Blood
Blood (2017) 130 (Supplement 1): 4747.
https://doi.org/10.1182/blood.V130.Suppl_1.4747.4747
Published: 2017
Journal Articles

Evaluation of Clinical and Morphological Practices in the Diagnosis of Transplant-Associated Microangiopathy: A Study on Behalf of the Complications and Quality of Life Working Party of the EBMT

Ivan S Moiseev, MD PhD, Tatyana Tsvetkova, Mahmoud Aljurf, Randa M Alnounou, MD, Janet Bogardt, Yves Chalandon, MD PhD, Mikhail Yu. Drokov, MD PhD, Valentina Dvirnyk, Maura Faraci, Lone Smidstrup Friis, MD PhD, Fabio Giglio, MD, Hildegard T. Greinix, MD, Brian Thomas Kornblit, MD PhD, Christiane Külper, Krzysztof Lewandowski, Peter Neumeister, MD, Dietger Niederwieser, MD, Jakob R. Passweg, MDMS, Olaf Penack, MD, Zinaida Peric, MD PhD, Agnieszka Piekarska, Paola Erminia Ronchi, Alicia Rovó, MD, Piotr Rzepecki, Francesca Scuderi, Daniel Sigrist, Sanna M. Siitonen, MD PhD, Friedrich Stoelzel, MD, Kazimierz Sulek, Dimitrios A. Tsakiris, MD, Urszula Wilkowojska, Rafael F Duarte, MD PhD FRCP, Tapani Ruutu, MD PhD, Grzegorz W Basak, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1958.
https://doi.org/10.1182/blood.V130.Suppl_1.1958.1958
Published: 2017