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Journal Articles

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD

Blood (2019) 134 (Supplement_1): 2516.

https://doi.org/10.1182/blood-2019-129372

Published: 2019

Journal Articles

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

Blood (2019) 134 (Supplement_1): 4141.

https://doi.org/10.1182/blood-2019-131113

Published: 2019

Journal Articles

Leukemic Stem Cell Phenotype Is Associated with Mutational Profile in Acute Myeloid Leukemia

Ja Min Byun, MD, Dong-Yeop Shin, MD PhD, Youngil Koh, Sung-Soo Yoon, MD PhD, Junshik Hong, MD, Inho Kim, MD PhD

Blood (2019) 134 (Supplement_1): 3852.

https://doi.org/10.1182/blood-2019-126373

Published: 2019

Journal Articles

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

Blood (2019) 134 (Supplement_1): 4414.

https://doi.org/10.1182/blood-2019-122350

Published: 2019

Journal Articles

In silico Prediction Followed By in Vitro validation Identifies the Survivin Inhibitor YM155 As a Potent Secondary Drug Against Pi-Resistant Myeloma

Harish Kumar, PhD, Ujjal Kumar Mukherjee, PhD, Li Chen, PhD, Amit Kumar Mitra, PhD MSc, BSc

Blood (2019) 134 (Supplement_1): 5543.

https://doi.org/10.1182/blood-2019-131923

Published: 2019

Journal Articles

A Strong Correlation of the HIF1a mRNA Expression Level with the Total Expression of JAK2, As Well As a Decrease in Their Level Is Observed in Leukocytes of Patients with MPN and Lymphoproliferative Cancer

Igor A. Olkhovskiy, Aleksey S. Gorbenko, Marina A. Stolyar, Anna V. Komina, Evgeniy V. Vasiliev, Mikhail A. Mikhalev, Tatiana I. Olkhovik, Varvara I. Bakhtina

Blood (2019) 134 (Supplement_1): 5032.

https://doi.org/10.1182/blood-2019-122086

Published: 2019

Journal Articles

Unravelling Heterogeneity of Stem and Progenitor Cells in Myeloid Neoplasms Through Single Cell Multi-omics

Adam J. Mead, MD PhD

Blood (2019) 134 (Supplement_1): SCI-31.

https://doi.org/10.1182/blood-2019-121049

Published: 2019

Journal Articles

KLF4 Controls Leukemic Stem Cell Self-Renewal in MLL-AF9-Induced Acute Myeloid Leukemia

Andrew Lewis, BS, Chun Shik Park, PhD, Monica Puppi, H. Daniel Lacorazza, PhD

Blood (2019) 134 (Supplement_1): 1231.

https://doi.org/10.1182/blood-2019-129164

Published: 2019

Journal Articles

Role of HDAC8 Upregulation in Resistance of FLT3-ITD AML Stem Cells to FLT3 Inhibitors

Jun Long, Mingyuan Jia, Weiyue Fang, Xinjie Chen, Zhongyu Wang, Lili Mu, Rufang Xiang, Jun-Min LI, MD PhD, Dengli Hong, PhD, Aibin Liang, MD PhD, Jiong Hu, MD

Blood (2019) 134 (Supplement_1): 1268.

https://doi.org/10.1182/blood-2019-128394

Published: 2019

Journal Articles

Pharmacologic Targeting of LIN28/Let-7 in Acute Myeloid Leukemia

Martina M Roos, PhD PharmD, Michelle Li, Pang Amara, John P Chute, MD

Blood (2018) 132 (Supplement 1): 4072.

https://doi.org/10.1182/blood-2018-99-119982

Published: 2018

Journal Articles

Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies

Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Franziska Auer, PhD, Jaewoong Lee, PhD, Anthony Abarientos, BSc, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Muschen, MD

Blood (2018) 132 (Supplement 1): 547.

https://doi.org/10.1182/blood-2018-99-116956

Published: 2018

Journal Articles

Mcl-1/CDK9 Targeting By AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and In Vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions

Bing Z Carter, PhD, Po Yee Mak, Wenjing Tao, Mark Warmoes, Philip L Lorenzi, PhD, Duncan Mak, BSc, MPhil, Vivian Ruvolo, MS, Xiangmeng Wang, Huaxian Ma, MS, Hong Mu, MD PhD, Justin Cidado, PhD, Lisa Drew, PhD, Michael Andreeff, MD PhD

Blood (2018) 132 (Supplement 1): 768.

https://doi.org/10.1182/blood-2018-99-113491

Published: 2018

Journal Articles

Activated Leukocyte Cell Adhesion Molecule (ALCAM) Regulate Myeloma Cancer Stem Cell Mediated Myelomagenesis and Chemoresistance

Yuhuan Zheng, Hongmei Luo, Dan Zhang, Fangfang Wang

Blood (2018) 132 (Supplement 1): 3190.

https://doi.org/10.1182/blood-2018-99-111740

Published: 2018

Journal Articles

ZEB2 and LMO2 Drive Immature T-Cell Lymphoblastic Leukemia Via Distinct Oncogenic Mechanisms

Steven Goossens, PhD, Jueqiong Wang, PhD, Cedric Tremblay, PhD, Pieter Van Vlierberghe, PhD, Geert Berx, PhD, Tom Taghon, PhD, Jody J Haigh, PhD

Blood (2018) 132 (Supplement 1): 3916.

https://doi.org/10.1182/blood-2018-99-111104

Published: 2018

Journal Articles

Downregulation of BMI-1 By the Small Molecule PTC596 Induces Mitochondrial Apoptosis in Mantle Cell Lymphoma

Kensuke Kojima, MD PhD, Aya Maeda, Sho Okamoto, MD, Yuki Nishida, Cao Liangl, Marla Weetall, PhD, Art Branstrom, PhD, Shinya Kimura, MD, PhD

Blood (2017) 130 (Supplement 1): 1263.

https://doi.org/10.1182/blood.V130.Suppl_1.1263.1263

Published: 2017

Journal Articles

High Molecular Weight Kininogen Alters the Tumor Microenvironment and Reduces Tumor Stem Cell Content

Meenal Shukla, James Hale, PhD, Justin Lathia, PhD, Keith McCrae, MD

Blood (2017) 130 (Supplement 1): 2340.

https://doi.org/10.1182/blood.V130.Suppl_1.2340.2340

Published: 2017

Journal Articles

Inhibition of FLT3-ITD and Melk By Small Molecule Inhibitor OTS167 in FLT3 mutant Acute Myeloid Leukemia (AML)

Bartholomew Eisfelder, PhD, Houda Alachkar, PharmD, PhD, Margaret Colton, Noreen Fulton, BS, Olatoyosi Odenike, MD, Yusuke Nakamura, MD, Wendy Stock, MD

Blood (2017) 130 (Supplement 1): 2525.

https://doi.org/10.1182/blood.V130.Suppl_1.2525.2525

Published: 2017

Journal Articles

Bortezomib-Activated Macrophages Contribute to Multiple Myeloma Progression Via Cancer Stem Cell Enrichment

Ofrat Beyar Katz, MD, Ksenia Magidey Klein, M.Sc, Michael Timaner, PhD, Ziv Raviv, PhD, Noam Benyamini, MD, Benjamin Brenner, MD, Yuval Shaked, PhD

Blood (2017) 130 (Supplement 1): 2269.

https://doi.org/10.1182/blood.V130.Suppl_1.2269.2269

Published: 2017

Journal Articles

Canonical Wnt Pathway Is Activated in Myeloid Leukemia Stem Cells Via Hematopoietic Cell Kinase That Is Phosphorylated By an Autocrine TIM-3/Galectin-9 Signaling

Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD

Blood (2017) 130 (Supplement 1): 3919.

https://doi.org/10.1182/blood.V130.Suppl_1.3919.3919

Published: 2017

Journal Articles

Targeting Maternal Embryonic Leucine Zipper Kinase with OTSSP167 Displays Anti-Tumor Activities in Chronic Lymphocytic Leukemia through Down-Regulation of FoxM1

Ya Zhang, MD, Xiangxiang Zhou, MD, Ying Li, MD, Yangyang Xu, MD, Xin Wang, MD PhD

Blood (2017) 130 (Supplement 1): 801.

https://doi.org/10.1182/blood.V130.Suppl_1.801.801

Published: 2017

NARROW

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

Leukemic Stem Cell Phenotype Is Associated with Mutational Profile in Acute Myeloid Leukemia

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

In silico Prediction Followed By in Vitro validation Identifies the Survivin Inhibitor YM155 As a Potent Secondary Drug Against Pi-Resistant Myeloma

A Strong Correlation of the HIF1a mRNA Expression Level with the Total Expression of JAK2, As Well As a Decrease in Their Level Is Observed in Leukocytes of Patients with MPN and Lymphoproliferative Cancer

Unravelling Heterogeneity of Stem and Progenitor Cells in Myeloid Neoplasms Through Single Cell Multi-omics

KLF4 Controls Leukemic Stem Cell Self-Renewal in MLL-AF9-Induced Acute Myeloid Leukemia

Role of HDAC8 Upregulation in Resistance of FLT3-ITD AML Stem Cells to FLT3 Inhibitors

Pharmacologic Targeting of LIN28/Let-7 in Acute Myeloid Leukemia

Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies

Mcl-1/CDK9 Targeting By AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and In Vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions

Activated Leukocyte Cell Adhesion Molecule (ALCAM) Regulate Myeloma Cancer Stem Cell Mediated Myelomagenesis and Chemoresistance

ZEB2 and LMO2 Drive Immature T-Cell Lymphoblastic Leukemia Via Distinct Oncogenic Mechanisms

Downregulation of BMI-1 By the Small Molecule PTC596 Induces Mitochondrial Apoptosis in Mantle Cell Lymphoma

High Molecular Weight Kininogen Alters the Tumor Microenvironment and Reduces Tumor Stem Cell Content

Inhibition of FLT3-ITD and Melk By Small Molecule Inhibitor OTS167 in FLT3 mutant Acute Myeloid Leukemia (AML)

Bortezomib-Activated Macrophages Contribute to Multiple Myeloma Progression Via Cancer Stem Cell Enrichment

Canonical Wnt Pathway Is Activated in Myeloid Leukemia Stem Cells Via Hematopoietic Cell Kinase That Is Phosphorylated By an Autocrine TIM-3/Galectin-9 Signaling

Targeting Maternal Embryonic Leucine Zipper Kinase with OTSSP167 Displays Anti-Tumor Activities in Chronic Lymphocytic Leukemia through Down-Regulation of FoxM1

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American Society of Hematology

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ASH Publications

American Society of Hematology

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