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Journal Articles

In silico Prediction Followed By in Vitro validation Identifies the Survivin Inhibitor YM155 As a Potent Secondary Drug Against Pi-Resistant Myeloma

Free
Harish Kumar, PhD, Ujjal Kumar Mukherjee, PhD, Li Chen, PhD, Amit Kumar Mitra, PhD MSc, BSc
Journal: Blood
Blood (2019) 134 (Supplement_1): 5543.
https://doi.org/10.1182/blood-2019-131923
Published: 2019
Journal Articles

Unravelling Heterogeneity of Stem and Progenitor Cells in Myeloid Neoplasms Through Single Cell Multi-omics

Free
Adam J. Mead, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): SCI-31.
https://doi.org/10.1182/blood-2019-121049
Published: 2019
Journal Articles

Human Acute Leukemia Is Addicted to Branched-Chain Amino Acid Metabolism to Maintain Leukemia Stemness

Free
Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Takahiro Maeda, MD PhD, Koichi Akashi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2516.
https://doi.org/10.1182/blood-2019-129372
Published: 2019
Journal Articles

Leukemic Stem Cell Phenotype Is Associated with Mutational Profile in Acute Myeloid Leukemia

Free
Ja Min Byun, MD, Dong-Yeop Shin, MD PhD, Youngil Koh, Sung-Soo Yoon, MD PhD, Junshik Hong, MD, Inho Kim, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3852.
https://doi.org/10.1182/blood-2019-126373
Published: 2019
Journal Articles

A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity

Free
Giovannino Silvestri, PhD, Rossana Trotta, PhD, Lorenzo Stramucci, PhD, Shuzhen Wang, PhD, Ann-Kathrin Eisfeld, MD, Bin Zhang, PhD, Klara Srutova, PhD, Gabriel Pineda, PhD, Catriona Jamieson, MD PhD, Fabio Stagno, MD, Paolo Vigneri, MD PhD, Georgios Nteliopoulos, PhD, Martin Guimond, PhD, Peter Hokland, MD DMSc, Michael W. Deininger, Francesco Dazzi, PhD, Dragana Milojkovic, MBBS, MD, Jane Apperley, MB, ChB, MD, Guido Marcucci, MD, Xiaoxuan Fan, PhD, Maria R. Baer, MD, Bruno Calabretta, MD PhD, Danilo Perrotti, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4141.
https://doi.org/10.1182/blood-2019-131113
Published: 2019
Journal Articles

KLF4 Controls Leukemic Stem Cell Self-Renewal in MLL-AF9-Induced Acute Myeloid Leukemia

Free
Andrew Lewis, BS, Chun Shik Park, PhD, Monica Puppi, H. Daniel Lacorazza, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1231.
https://doi.org/10.1182/blood-2019-129164
Published: 2019
Journal Articles

Role of HDAC8 Upregulation in Resistance of FLT3-ITD AML Stem Cells to FLT3 Inhibitors

Free
Jun Long, Mingyuan Jia, Weiyue Fang, Xinjie Chen, Zhongyu Wang, Lili Mu, Rufang Xiang, Jun-Min LI, MD PhD, Dengli Hong, PhD, Aibin Liang, MD PhD, Jiong Hu, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1268.
https://doi.org/10.1182/blood-2019-128394
Published: 2019
Journal Articles

The Preclinical Activities of PTC596, a Novel Tubulin Binding Agent That Down-Regulates BMI1, Alone and in Combination with Bortezomib in Multiple Myeloma

Free
Yurie Nagai, MD, Naoya Mimura, MD PhD, Ola Rizq, MD PhD, Yusuke Isshiki, MD PhD, Motohiko Oshima, PhD, Mohamed Rizk, BSc, MSc, Atsunori Saraya, Shuhei Koide, PhD, Yaeko Nakajima-Takagi, PhD, Makiko Miyota, Nagisa Oshima-Hasegawa, MD PhD, Shokichi Tsukamoto, MD PhD, Shio Mitsukawa, MD PhD, Yusuke Takeda, MD PhD, Chikako Ohwada, MD PhD, Masahiro Takeuchi, MD PhD, Tohru Iseki, MD PhD, Chiaki Nakaseko, MD PhD, Josephine Sheedy, BS, MSc, Marla Weetall, PhD, Atsushi Iwama, MD PhD, Emiko Sakaida, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4414.
https://doi.org/10.1182/blood-2019-122350
Published: 2019
Journal Articles

A Strong Correlation of the HIF1a mRNA Expression Level with the Total Expression of JAK2, As Well As a Decrease in Their Level Is Observed in Leukocytes of Patients with MPN and Lymphoproliferative Cancer

Free
Igor A. Olkhovskiy, Aleksey S. Gorbenko, Marina A. Stolyar, Anna V. Komina, Evgeniy V. Vasiliev, Mikhail A. Mikhalev, Tatiana I. Olkhovik, Varvara I. Bakhtina
Journal: Blood
Blood (2019) 134 (Supplement_1): 5032.
https://doi.org/10.1182/blood-2019-122086
Published: 2019
Journal Articles

ZEB2 and LMO2 Drive Immature T-Cell Lymphoblastic Leukemia Via Distinct Oncogenic Mechanisms

Free
Steven Goossens, PhD, Jueqiong Wang, PhD, Cedric Tremblay, PhD, Pieter Van Vlierberghe, PhD, Geert Berx, PhD, Tom Taghon, PhD, Jody J Haigh, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3916.
https://doi.org/10.1182/blood-2018-99-111104
Published: 2018
Journal Articles

Pharmacologic Targeting of LIN28/Let-7 in Acute Myeloid Leukemia

Free
Martina M Roos, PhD PharmD, Michelle Li, Pang Amara, John P Chute, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4072.
https://doi.org/10.1182/blood-2018-99-119982
Published: 2018
Journal Articles

Lgr5 Enables Positive B-Cell Selection and Tumor-Initiation in B-Cell Malignancies

Free
Kadriye Nehir Cosgun, PhD, Gauri Deb, MS, PhD, Xin Yang, MD, Gang Xiao, PhD, Teresa Sadras, PhD, Franziska Auer, PhD, Jaewoong Lee, PhD, Anthony Abarientos, BSc, Maurizio Mangolini, PhD, Ali Aghajanirefah, PhD, Huimin Geng, PhD, Hassan Jumaa, PhD, Andrew G. Polson, PhD, Hans Clevers, MD PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 547.
https://doi.org/10.1182/blood-2018-99-116956
Published: 2018
Journal Articles

Mcl-1/CDK9 Targeting By AZD5991/AZD4573 Overcomes Intrinsic and Acquired Venetoclax Resistance in Vitro and In Vivo in PDX Model of AML through Modulation of Cell Death and Metabolic Functions

Free
Bing Z Carter, PhD, Po Yee Mak, Wenjing Tao, Mark Warmoes, Philip L Lorenzi, PhD, Duncan Mak, BSc, MPhil, Vivian Ruvolo, MS, Xiangmeng Wang, Huaxian Ma, MS, Hong Mu, MD PhD, Justin Cidado, PhD, Lisa Drew, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 768.
https://doi.org/10.1182/blood-2018-99-113491
Published: 2018
Journal Articles

Activated Leukocyte Cell Adhesion Molecule (ALCAM) Regulate Myeloma Cancer Stem Cell Mediated Myelomagenesis and Chemoresistance

Free
Yuhuan Zheng, Hongmei Luo, Dan Zhang, Fangfang Wang
Journal: Blood
Blood (2018) 132 (Supplement 1): 3190.
https://doi.org/10.1182/blood-2018-99-111740
Published: 2018
Journal Articles

Targeting Maternal Embryonic Leucine Zipper Kinase with OTSSP167 Displays Anti-Tumor Activities in Chronic Lymphocytic Leukemia through Down-Regulation of FoxM1

Free
Ya Zhang, MD, Xiangxiang Zhou, MD, Ying Li, MD, Yangyang Xu, MD, Xin Wang, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 801.
https://doi.org/10.1182/blood.V130.Suppl_1.801.801
Published: 2017
Journal Articles

Treatment with the Novel TOPK Inhibitor OTS514 Exhibits Potent Anti-Myeloma Activity in Pre-Clinical Models

Free
Andrew Stefka, MS, David Johnson, Shaun Rosebeck, PhD, Jae-Hyun Park, DVM, PhD, Yusuke Nakamura, MD, Andrzej J. Jakubowiak, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4415.
https://doi.org/10.1182/blood.V130.Suppl_1.4415.4415
Published: 2017
Journal Articles

Bortezomib-Activated Macrophages Contribute to Multiple Myeloma Progression Via Cancer Stem Cell Enrichment

Free
Ofrat Beyar Katz, MD, Ksenia Magidey Klein, M.Sc, Michael Timaner, PhD, Ziv Raviv, PhD, Noam Benyamini, MD, Benjamin Brenner, MD, Yuval Shaked, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2269.
https://doi.org/10.1182/blood.V130.Suppl_1.2269.2269
Published: 2017
Journal Articles

Canonical Wnt Pathway Is Activated in Myeloid Leukemia Stem Cells Via Hematopoietic Cell Kinase That Is Phosphorylated By an Autocrine TIM-3/Galectin-9 Signaling

Free
Teppei Sakoda, MD, Yoshikane Kikushige, MD PhD, Toshihiro Miyamoto, MD PhD, Koichi Akashi, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3919.
https://doi.org/10.1182/blood.V130.Suppl_1.3919.3919
Published: 2017
Journal Articles

ETO2 Regulates Cell-Fate Genes and Controls Relapse in Acute Myeloid Leukemia

Free
Nickolas Steinauer, BA, Chun Guo, MS, Chunfa Huang, PhD, Yifan Tu, MD PhD, Carl E. Freter, MD PhD, Jinsong Zhang, PhD MS
Journal: Blood
Blood (2017) 130 (Supplement 1): 3808.
https://doi.org/10.1182/blood.V130.Suppl_1.3808.3808
Published: 2017
Journal Articles

Branched Chain Amino Acid Catabolism Restricts Alpha-Ketoglutarate Levels Resembling IDH mut -Driven DNA Hypermethylation in AML Stem Cells

Free
Simon Raffel, MD, Mattia Falcone, Niclas Kneisel, Jenny Hansson, Wei Wang, Christoph Lutz, MD, Gernot Poschet, Yannic Nonnenmacher, Patrizia Jensen, Claudia Scholl, MD, Stefan Fröhling, MD, Sibylle Cocciardi, MSc, Patrick Wuchter, MD, Christian Thiede, MD, Anne Floercken, Joerg Westermann, MD, Gerhard Ehninger, Karsten Hiller, Rüdiger Hell, Carl Herrmann, Anthony D. Ho, Jeroen Krijgsveld, Bernhard Radlwimmer, Andreas Trumpp, Prof, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 472.
https://doi.org/10.1182/blood.V130.Suppl_1.472.472
Published: 2017