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Journal Articles

An Exploratory Analysis of Brentuximab Vedotin Plus CHP (A+CHP) in the Frontline Treatment of Patients with CD30+ Peripheral T-Cell Lymphomas (ECHELON-2): Impact of Consolidative Stem Cell Transplant

Kerry J Savage, BSc, MD MSc, Steven M. Horwitz, MD, Ranjana H Advani, MD, Jacob H. Christensen, MD, Eva Domingo-Domenech, MD, Giuseppe Rossi, Franck Morschhauser, MD, Onder Alpdogan, MD, Cheolwon Suh, Kensei Tobinai, MD PhD, Andrei R Shustov, MD, Marek Trneny, MD prof, Sam Yuen, MBBS,FRCPA,FRACP, Pier Luigi Zinzani, MD PhD, Lorenz Truemper, MD, Timothy Illidge, MD PhD, Owen O'Connor, MD PhD, Barbara Pro, MD, Meredith Little, MPH, Veronica Bunn, Keenan Fenton, Thomas Manley, MD, Swaminathan P. Iyer, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 464.
https://doi.org/10.1182/blood-2019-122781
Published: 2019
Journal Articles

Phase Ib Study of the Anti-TIM-3 Antibody MBG453 in Combination with Decitabine in Patients with High-Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Uma Borate, MD, Jordi Esteve, Kimmo Porkka, Steve Knapper, Norbert Vey, MD PhD, Sebastian Scholl, Guillermo Garcia-Manero, MD, Martin Wermke, MD, Jeroen Janssen, Elie Traer, Chong Chyn Chua, Rupa Narayan, Natalia Tovar, Mika Kontro, Oliver Ottmann, Prof, MD, Haiying Sun, Tyler Longmire, Sebastian Szpakowski, Serena Liao, Anuradha Patel, Mikael L Rinne, Andrew Brunner, MD, Andrew H. Wei, PhD FRACP, FRCPA, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 570.
https://doi.org/10.1182/blood-2019-128178
Published: 2019
Journal Articles

Abscopal Effect of Radiotherapy and Nivolumab in Relapsed or Refractory Hodgkin Lymphoma (AERN): An International Multicenter Single-Arm Two-Stage Phase II GHSG Trial

Paul J Bröckelmann, MD, Annette Plütschow, Richard Greil, MD, Josée M Zijlstra, MD PhD, Timothy Illidge, MD PhD, Alexander Fosså, MD PhD, Julia Meissner, MD, Andreas Zimmermann, MD, Stephan Mathas, MD, Felicitas Thol, MD, Michael Fuchs, MD, Andreas Engert, MD, Christian Baues, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1547.
https://doi.org/10.1182/blood-2019-124351
Published: 2019
Journal Articles

Dissecting the Immune Cell Progeny of CAR-Expressing Hematopoietic Stem Cells in a Humanized Mouse Model

Heng-Yi Liu, Nezia Rahman, Tzu-Ting Chiou, PhD, Satiro N. De Oliveira, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4640.
https://doi.org/10.1182/blood-2019-129746
Published: 2019
Journal Articles

Progression-Free Survival and Overall Survival Among a Patient Cohort of Relapsed/Refractory Mycosis Fungoides in France, Germany, Italy, Spain and the United Kingdom

Martine Bagot, MD PhD, Timothy Illidge, MD PhD, Nicola Pimpinelli, MD, Mehul Dalal, PhD, Athanasios Zomas, Chalid Assaf, MD, Nathalie Waser, PhD, Zhouqin He, MSc, Tina Li, MPH, Robert Sambrook, MSc, Fabrizio Trinchese, Meredith Little, Nawal Bent-Ennakhil, Pablo L. Ortiz-Romero, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5879.
https://doi.org/10.1182/blood-2019-126246
Published: 2019
Journal Articles

Lentiviral Gene Therapy with Autologous Hematopoietic Stem and Progenitor Cells (HSPCs) for the Treatment of Severe Combined Immune Deficiency Due to Adenosine Deaminase Deficiency (ADA-SCID): Results in an Expanded Cohort

Donald B. Kohn, MD, Kit L. Shaw, PhD, Elizabeth Garabedian, RN, MS, Denise Ann Carbonaro-Sarracino, PhD, Theodore B. Moore, MD, Satiro N. De Oliveira, MD, Gay M. Crooks, MD, John Tse, Sally Shupien, Dayna Terrazas, Alejandra Davila, Amalia Icreverzi, PhD, Allen Yu, Krista M. Chun, Christian E. Casas, Provaboti Barman, PhD, Maritess Coronel, Beatriz Campo Fernandez, PhD, Ruixue Zhang, Roger P. Hollis, PhD, Chilenwa Uzowuru, Hilory Ricketts, Jinhua Xu Bayford, Valentina Trevisan, Serena Arduini, PhD, Frances Lynn, Mahesh Kudari, MBBS, MA, Andrea Spezzi, MD MBBS, Lilith Reeves, MS, MT(ASCP), Kenneth Cornetta, Robert A. Sokolic, MD, Roberta Parrott, BS, Rebecca Buckley, MD, Claire Booth, Fabio Candotti, MD, Harry L. Malech, MD, Adrian J. Thrasher, MBBS, PhD FMedSci, H. Bobby Gaspar, MBBS, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3345.
https://doi.org/10.1182/blood-2019-123432
Published: 2019
Journal Articles

Downregulation of Morrbid in Tet2-Deficient Preleukemic Cells Overcomes Resistance to Inflammatory Stress and Mitigates Clonal Hematopoiesis

Zhigang Cai, PhD, Jonathan Kotzin, Baskar Ramdas, PhD, Sisi Chen, Sai Nelanuthala, Lakshmi Reddy Palam, PhD, Ruchi Pandey, Raghuveer Mali, PhD, Yan Liu, PhD, Mark R. Kelley, George Sandusky, DVM, PhD, Morvarid Mohseni, Adam Williams, Jorge Henao-Mejia, Reuben Kapur, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1288.
https://doi.org/10.1182/blood-2018-99-116703
Published: 2018
Journal Articles

Predictors of T Cell Expansion and Clinical Responses Following B-Cell Maturation Antigen-Specific Chimeric Antigen Receptor T Cell Therapy (CART-BCMA) for Relapsed/Refractory Multiple Myeloma (MM)

Adam D. Cohen, MD, J. Joseph Melenhorst, PhD, Alfred L. Garfall, MD, Simon F Lacey, PhD BS, Megan Davis, PhD, Dan T. Vogl, MD, Lifeng Tian, PhD, Vanessa Gonzalez, Iulian Pruteanu, PhD, Anne Marie Nelson, Gabriela Plesa, MD, Adam Waxman, MD, Regina M Young, PhD, Bruce L Levine, PhD, Carl H June, MD, Edward A. Stadtmauer, MD FACP, Michael C. Milone, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1974.
https://doi.org/10.1182/blood-2018-99-119665
Published: 2018
Journal Articles

Updated Analysis of the Efficacy and Safety of Tisagenlecleucel in Pediatric and Young Adult Patients with Relapsed/Refractory (r/r) Acute Lymphoblastic Leukemia

Stephan A. Grupp, MD PhD, Shannon L. Maude, MD PhD, Susana Rives, MD PhD, Andre Baruchel, MD, Michael W. Boyer, MD, Henrique Bittencourt, MD PhD, Peter Bader, MD PhD, Jochen Büchner, MDPhD, Theodore W. Laetsch, MD, Heather Stefanski, MDPhD, Gary Douglas Myers, MD, Muna Qayed, MD MSc, Michael A. Pulsipher, MD, Barbara De Moerloose, MD PhD, Gregory A. Yanik, MD, Kara L. Davis, DO, Paul L. Martin, MD PhD, Eneida R. Nemecek, MD, Christina Peters, MD, Joerg Krueger, MD, Adriana Balduzzi, MD, Nicolas Boissel, MD PhD, Francoise Marie Mechinaud, MD FRACP, Mimi Leung, Lamis K. Eldjerou, MD, Lan Yi, PhD, Karen Thudium Mueller, PharmD,MSc, Eric Bleickardt, MD, Hidefumi Hiramatsu, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 895.
https://doi.org/10.1182/blood-2018-99-112599
Published: 2018
Journal Articles

Evaluation of In Vivo CAR Transgene Levels in Relapsed/Refractory Pediatric and Young Adult ALL and Adult DLBCL Tisagenlecleucel-Treated Patients

Rakesh Awasthi, PhD, Karen Thudium Mueller, PharmD,MSc, Gregory A. Yanik, MD, Constantine S. Tam, MBBS (Hons), MD FRACP, FRCPA, Susana Rives, MD PhD, Joseph P. McGuirk, DO, Michael A. Pulsipher, MD, Michael W. Boyer, MD, Ulrich Jaeger, MD, Andre Baruchel, MD, Gary Douglas Myers, MD, Hyatt Balke-Want, MD, Stephen J. Schuster, MD, Heather Stefanski, MD PhD, Michael R. Bishop, MD, Edward R. Waldron, PhD MSc, BSc, Özlem Anak, MD, Abhijit Chakraborty, PhD, Eric Bleickardt, MD, Stephane Wong, PhD MBA, Lida Bubuteishvili Pacaud, MD, Edmund K. Waller, MD, Shannon L. Maude, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 899.
https://doi.org/10.1182/blood-2018-99-116385
Published: 2018
Journal Articles

Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NFkB Activation in Preclinical Patient-Derived Models of CNS Lymphoma

Huimin Geng, PhD, Brice Tiret, PhD, Hua-Xin Gao, PhD, Cigall Kadoch, PhD, Ming Lu, PhD, Lingjing Chen, PhD, Ilwoo Park, PhD, Gerd Melkus, PhD, Adam Elkhaled, PhD, John Kurhanewicz, PhD, Lisa Drew, PhD, Sebastien Degorce, PhD, Michele Mayo, PhD, Keith Dillman, PhD, Rana Anjum, PhD, Andrew Bloecher, PhD, Myriam Chaumeil, PhD, James Rubenstein, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2840.
https://doi.org/10.1182/blood-2018-99-117625
Published: 2018
Journal Articles

Prospective Clinical Trial of Anti-CD19 CAR T Cells in Combination with Ibrutinib for the Treatment of Chronic Lymphocytic Leukemia Shows a High Response Rate

Saar I. Gill, MDPhD, Vanessa Vides, BS, Noelle V. Frey, MD, Susan Metzger, BSN, Megan O'Brien, Elizabeth Hexner, MD, Anthony R. Mato, MDMSCE, Simon F Lacey, PhD BS, J. Joseph Melenhorst, PhD, Edward Pequignot, MSc, Whitney Lynn Gladney, PhD, Wei-Ting Hwang, PhD, Anne Lamontagne, Megan Davis, PhD, John C. Byrd, MD, Stephen J. Schuster, MD, Don L. Siegel, MD PhD, Randi E. Isaacs, MD, Carl H June, MD, David L. Porter, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 298.
https://doi.org/10.1182/blood-2018-99-115418
Published: 2018
Journal Articles

Safety and Efficacy of Tisagenlecleucel Treatment in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (r/r DLBCL) and No Evidence of Active Disease Following Bridging Chemotherapy in the JULIET Trial

Michael R. Bishop, MD, Richard Thomas T. Maziarz, MD, Edmund K. Waller, MD, Christopher del Corral, PharmD, Ranjan Tiwari, MSc, Özlem Anak, MD, Rakesh Awasthi, PhD, Vadim V. Romanov, MD MPhil, FFPM, Stephen J. Schuster, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2958.
https://doi.org/10.1182/blood-2018-99-115094
Published: 2018
Journal Articles

Identification of Long Non-Coding RNA Genes Important for Normal Hematopoiesis and Leukemogenesis Using Bioinformatics Tools

Sarah Zhao, Lana Chen, Shuiling Jin, PhD, Lele Zhang, Hairui Su, BS, PhD, Christopher Klug, PhD, Xinyang Zhao, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2693.
https://doi.org/10.1182/blood.V130.Suppl_1.2693.2693
Published: 2017
Journal Articles

Molecular Design and Characterization of a Novel, Vwf Independent Coagulation Factor VIII (LAFATE)

Eui-Cheol Jo, PhD, Injae Oh, MS, Seung-hoon Lee, PhD, Mee Sook Oh, MS, Jae Hwan Ryu, MS, Yong Jae Kim, PhD, Jin-hyeon Park, MS, So Ra Kim, MS, Myung Eun Jung, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2342.
https://doi.org/10.1182/blood.V130.Suppl_1.2342.2342
Published: 2017
Journal Articles

CTL019 Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor (CAR) T Cells to Characterize the Impact of Tocilizumab on Expansion and to Identify Correlates of Cytokine Release Syndrome Severity

Andrew M Stein, Stephan A Grupp, MD PhD, John E Levine, MD, Theodore W Laetsch, MD, Michael A Pulsipher, MD, Michael W Boyer, MD, Keith J August, MD MS, Bruce L Levine, PhD, Carl H June, MD, Lori Tomassian, MS, Sweta Shah, PharmD, Mimi Leung, MPH, Pai-Hsi Huang, Sebastien Jolivet, Rakesh Awasthi, PhD, Karen Thudium Mueller, PharmD,MSc, Patricia A Wood, MD PhD, Shannon L Maude, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2561.
https://doi.org/10.1182/blood.V130.Suppl_1.2561.2561
Published: 2017
Journal Articles

CRISPR/Cas9 Gene-Edited Hematopoietic Stem Cell Therapy for Sickle Cell Disease

Vionnie W. C. Yu, PhD, Yi Liu, PhD, Matthew Curran, Pu Zhang, MD, Jennifer Snead, PhD, Christian Schmedt, Yi Yang, PhD, Victor Guosheng Lin, William R Tschantz, PhD, Lisa Quinn, Carsten Russ, Scott Clarkson, Amy Janiak, Morag Stewart, PhD, Yanick Mulumba, Reynald Lescarbeau, Brad Murray, Jessica Seitzer, Walter Strapps, Hon-Ren Huang, Kevin Sloan, Craig S Mickanin, BS, Lloyd Klickstein, MD, Susan Stevenson
Journal: Blood
Blood (2017) 130 (Supplement 1): 535.
https://doi.org/10.1182/blood.V130.Suppl_1.535.535
Published: 2017
Journal Articles

Impact of Humoral Immunogenicity (Anti-mCAR19 Antibodies) on CTL019 Cellular Kinetics, Efficacy, and Safety

Karen Thudium Mueller, PharmD,MSc, Edward Waldron, PhD, Denise Sickert, PhD, Stephan A Grupp, MD PhD, Shannon L Maude, MD PhD, John E Levine, MD, Theodore W Laetsch, MD, Michael A Pulsipher, MD, Michael W Boyer, MD, Keith J August, MD MS, Rakesh Awasthi, PhD, Bruce L Levine, PhD, Carl H June, MD, Tetiana Taran, MD, Patricia A Wood, MD PhD, Gary Douglas Myers, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1281.
https://doi.org/10.1182/blood.V130.Suppl_1.1281.1281
Published: 2017
Journal Articles

BET Bromodomain Degradation As a Therapeutic Strategy in Multiple Myeloma

Geoffrey M. Matthews, PhD, Sara Gandolfi, MD, Johanna Bruggentheis, Ricardo De Matos Simoes, PhD, Dennis L Buckley, PhD, Yiguo Hu, MD PhD, Michal Sheffer, PhD, Hayley Poarch, James E. Bradner, MD, Constantine S Mitsiades, MD PhD
Journal: Blood
Blood (2016) 128 (22): 1062.
https://doi.org/10.1182/blood.V128.22.1062.1062
Published: 2016
Journal Articles

A Phase I Study of IDH305 in Patients with Advanced Malignancies Including Relapsed/Refractory AML and MDS That Harbor IDH1 R132 Mutations

Courtney D DiNardo, MD, Aaron D. Schimmer, MD PhD, Karen W.L. Yee, MD, Andreas Hochhaus, MD, Alwin Kraemer, MD, Richard D. Carvajal, MD, Filip Janku, MD PhD, Philippe Bedard, MD, Cecilia Carpio, MD, Antje Wick, MD, Gary K. Schwartz, MD, Patrick Schöffski, MD, Patrick Wen, MD, Martin J. van den Bent, MD, Mark Rosenthal, MD PhD, Jessica O'Keeffe, BS, Xueying Chen, PhD, Raymond Pagliarini, PhD, Virna Schuck, PhD, Andrea Myers, MD PhD, Andrew Wei
Journal: Blood
Blood (2016) 128 (22): 1073.
https://doi.org/10.1182/blood.V128.22.1073.1073
Published: 2016