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Journal Articles

Long-term outcomes of Sleeping Beauty–generated CD19-specific CAR T-cell therapy for relapsed-refractory B-cell lymphomas

Clinical Trials & Observations
S. A. Srour, H. Singh, J. McCarty, E. de Groot, H. Huls, G. Rondon, M. Qazilbash, S. Ciurea, G. Bardelli, J. Buck, A. Alousi, Y. Nieto, K. Rezvani, D. Marin, U. Popat, C. Hosing, E. J. Shpall, W. G. Wierda, H. Kantarjian, R. E. Champlin, L. J. Cooper, P. Kebriaei
Journal: Blood
Blood (2020) 135 (11): 862–865.
https://doi.org/10.1182/blood.2019002920
Published: 2020
Journal Articles

Donor-Derived CD19 CAR Cytokine Induced Killer (CIK) Cells Engineered with Sleeping Beauty Transposon for Relapsed B-Cell Acute Lymphoblastic Leukemia (B-ALL)

Chiara F Magnani, PhD, Giuseppe Gaipa, PhD, Daniela Belotti, Giada Matera, Sarah Tettamanti, PhD, Benedetta Cabiati, Chiara Buracchi, PhD, Grazia Fazio, Silvia Zaninelli, Silvia Rigamonti, Stefania Cesana, Valentina Colombo, Giovanni Cazzaniga, PhD, Attilio Rovelli, MD, Adriana Balduzzi, MD, Sara Napolitano, MD, Fabrizio Benedicenti, Eugenio Montini, PhD, Gian Maria Borleri, Silvia Ferrari, MD, Giuseppe Gritti, MD PhD, Federico Lussana, MD, Martino Introna, MD, Alessandro Rambaldi, MD, Giuseppe Dastoli, MD, Andrea Biondi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 200.
https://doi.org/10.1182/blood-2019-125894
Published: 2019
Journal Articles

Rapid Personalized Manufacture (RPM) of Sleeping Beauty System-Generated NY-ESO-1-Specific TCR-T Cells Co-Expressing Membrane-Bound IL-15 Yields Anti-Tumor Responses

Lenka V Hurton, PhD, Tiejuan Mi, Kirsten C Switzer, PhD, Ling Zhang, Cuiping Dai, Misun Kim, Karishma R Bavisi, Matthew J Figliola, Vazquez M Lydia, Sourindra N Maiti, Shihuang Su, Drew C Deniger, PhD, Simon Olivares, Laurence J N Cooper, MD PhD, Harjeet Singh, MSc, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3218.
https://doi.org/10.1182/blood-2019-131419
Published: 2019
Journal Articles

Clinical-Grade Transduction of Allogeneic Cytokine Induced Killer (CIK) Cells with CD19 Chimeric Antigen Receptor (CAR) Using Sleeping Beauty (SB) Transposon: Successful GMP-Compliant Manufacturing for Clinical Applications

Giuseppe Gaipa, PhD, Chiara Francesca Magnani, PhD, Daniela Belotti, Giada Matera, Sarah Tettamanti, PhD, Benedetta Cabiati, Stefania Cesana, Valentina Colombo, Giovanni Cazzaniga, PhD, Grazia Fazio, PhD, Chiara Buracchi, PhD, Silvia Rigamonti, Attilio Rovelli, MD, Adriana Balduzzi, MD, Sara Napolitano, MD, Eugenio Montini, Gian Maria Borleri, Giuseppe Gritti, MD PhD, Federico Lussana, MD PhD, Martino Introna, MD, Alessandro Rambaldi, MD, Giuseppe Dastoli, MD, Andrea Biondi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 196.
https://doi.org/10.1182/blood-2018-196
Published: 2018
Journal Articles

Long Term Follow up after Adoptive Transfer of CD19-Specific CAR + T Cells Genetically Modified Via Non-Viral Sleeping Beauty S ystem Following Hematopoietic Stem Cell Transplantation (HSCT)

Partow Kebriaei, MD, Helen Huls, Simon Olivares, Aaron F Orozco, Shihuang Su, Sourindra N Maiti, Elenanor De Groot, Amy Smith, Yijun Yang, PhD, Gabriela Rondon, MD, Muzaffar H. Qazilbash, MD, Stefan O. Ciurea, Amin M. Alousi, Yago Nieto, MD PhD, David Costa Marin, MD, Uday Popat, MD, Chitra Hosing, MD, Hagop M. Kantarjian, MD, Katayoun Rezvani, MD PhD, Elizabeth J Shpall, MD, Richard E Champlin, MD, Laurence J N Cooper, MDPhD, Harjeet Singh, MSc, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2059.
https://doi.org/10.1182/blood.V130.Suppl_1.2059.2059
Published: 2017
Journal Articles

Shortening the Time to Manufacture CAR + T Cells with Sleeping Beauty System Supports T-Cell Engraftment and Anti-Tumor Effects in Patients with Refractory CD19 + Tumors

Partow Kebriaei, MD, Helen Huls, Susan Lynn Neel, RN, OCN, Simon Olivares, Aaron F Orozco, Shihuang Su, Sourindra N Maiti, Amy Smith, Elenanor De Groot, Hagop M. Kantarjian, MD, Maro Ohanian, DO, Katy Rezvani, MD PhD, Elizabeth J Shpall, MD, Richard E Champlin, MD, Laurence J N Cooper, MDPhD, Harjeet Singh, MSc, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2060.
https://doi.org/10.1182/blood.V130.Suppl_1.2060.2060
Published: 2017
Journal Articles

CD19-Specific Chimeric Antigen Receptor-Modified T Cells with Safety Switch Produced Under "Point-of-Care" Using the Sleeping Beauty System for the Very Rapid Manufacture and Treatment of B-Cell Malignancies

Tim Chan, PhD, John Gallagher, Nai-Lin Cheng, PhD, Fernando Carvajal-Borda, DVM, Jacques Plummer, Adeline Govekung, John A Barrett, PhD, Pranay D. Khare, PhD, Laurence J N Cooper, MDPhD, Rutul R Shah
Journal: Blood
Blood (2017) 130 (Supplement 1): 1324.
https://doi.org/10.1182/blood.V130.Suppl_1.1324.1324
Published: 2017
Journal Articles

The beauty and the beast: lymphoma-like morphology of myeloid blast phase in CML

Anne Marie Asemissen, Judith Dierlamm
Journal: Blood
Blood (2017) 130 (10): 1274.
https://doi.org/10.1182/blood-2017-05-782714
Published: 2017
Journal Articles

Sleeping Beauty Modified CAR+ Lymphocytes Engraft and Exhibit Anti-Tumor Activity in Patient-Derived Xenograft Models of Acute Lymphoblastic Leukemia

Chiara F. Magnani, PhD, Claudia Mezzanotte, Claudia Cappuzzello, PhD, Fabrizio Benedicenti, Michela Bardini, PhD, Sarah Tettamanti, PhD, Grazia Fazio, PhD, Gianni Cazzaniga, PhD, Laurence J.N. Cooper, MD PhD, Eugenio Montini, PhD, Andrea Biondi, MD, Ettore Biagi, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4022.
https://doi.org/10.1182/blood.V128.22.4022.4022
Published: 2016
Journal Articles

Very Rapid Production of CAR + T-Cells upon Non-Viral Gene Transfer Using the Sleeping Beauty System

Lenka V. Hurton, PhD, Harjeet Singh, PhD, Kirsten C. Switzer, PhD, Tiejuan Mi, MS, Leo G. Flores, Aaron Orozco, Sourindra N. Maiti, PhD, Shihuang Su, MS, Amer Najjar, PhD, Mary Helen Huls, BS, Partow Kebriaei, MD, Richard E. Champlin, MD, Laurence J.N. Cooper, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2807.
https://doi.org/10.1182/blood.V128.22.2807.2807
Published: 2016
Journal Articles

Blood 's 70th anniversary: musings of a Blood editor, 2003-2007

Sanford J. Shattil
Journal: Blood
Blood (2016) 127 (22): 2649–2651.
https://doi.org/10.1182/blood-2015-11-635755
Published: 2016
Journal Articles

Mitochondrial Biomass As a Measure of Fitness for T Cells Expressing Chimeric Antigen Receptors

Bipulendu Jena, PhD, David Rushworth, MD PhD, George T McNamara, PhD, Laurence JN Cooper, MD PhD
Journal: Blood
Blood (2015) 126 (23): 3242.
https://doi.org/10.1182/blood.V126.23.3242.3242
Published: 2015
Journal Articles

Adoptive Therapy Using Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells to Manufacture T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Partow Kebriaei, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Sourindra Maiti, PhD, Su Shihuang, PhD, Pappanaicken R Kumar, BS, Bipulendu Jena, PhD, Marie Andree Forget, Sonny Ang, PhD, Jackson Rineka, BBA, Tingting Liu, BS, Ian K. McNiece, PhD, Gabriela Rondon, Perry Hackett, PhD, William G. Wierda, MD PhD, Susan O'Brien, MD, Michael J Keating, MBBS, Hagop M. Kantarjian, MD, Chitra M Hosing, MD, Elizabeth J Shpall, MD, Richard E. Champlin, Laurence JN Cooper, MD PhD
Journal: Blood
Blood (2014) 124 (21): 311.
https://doi.org/10.1182/blood.V124.21.311.311
Published: 2014
Journal Articles

Adoptive Immunotherapy Following Umbilical Cord Blood Transplantation Using The Sleeping Beauty System and Artificial Antigen Presenting Cells To Generate Donor-Derived T Cells Expressing a CD19-Specific Chimeric Antigen Receptor

Partow Kebriaei, MD, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Pappanaicken R Kumar, BS, Bipulendu Jena, PhD, Rineka N Jackson, BBA, Tingting Liu, BS, Ian K. McNiece, PhD, Gabriela Rondon, MD, Perry Hackett, PhD, Richard E Champlin, MD, Elizabeth J Shpall, MD, Laurence J N Cooper, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 4208.
https://doi.org/10.1182/blood.V122.21.4208.4208
Published: 2013
Journal Articles

Stable Expression Of Chimeric Antigen Receptors (CARs) By Sleeping Beauty-Mediated Gene Transfer and Efficient Expansion Of Leukemia-Specific Cytokine-Induced Killer (CIK) Cells

Chiara Francesca Magnani, PhD, Nice Turazzi, Fabrizio Benedicenti, Greta Maria Paola Giordano Attianese, PhD, Sarah Tettamanti, PhD, Eugenio Montini, PhD, Laurence J N Cooper, MD, PhD, Alessandro Aiuti, MD, PhD, Andrea Biondi, MD, Ettore Biagi, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1663.
https://doi.org/10.1182/blood.V122.21.1663.1663
Published: 2013
Journal Articles

First Clinical Trials Employing Sleeping Beauty Gene Transfer System and Artificial Antigen Presenting Cells To Generate and Infuse T Cells Expressing CD19-Specific Chimeric Antigen Receptor

Partow Kebriaei, MD, Helen Huls, BS, Harjeet Singh, PhD, Simon Olivares, BS, Matthew Figliola, BS, Pappanaicken R. Kumar, BS, Bipulendu Jena, PhD, Marie Andree Forget, Sonny Ang, PhD, Rineka N. Jackson, BBA, Tingting Liu, BS, Doyle Bosque, ADN, Ian K. McNiece, PhD, Gabriela Rondon, MD, Perry Hackett, PhD, Chitra M. Hosing, MD, Elizabeth J. Shpall, MD, Richard E. Champlin, MD, Laurence J N. Cooper, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 166.
https://doi.org/10.1182/blood.V122.21.166.166
Published: 2013
Journal Articles

Rook AH. The beauty of TLR agonists for CTCL. Blood . 2012;119(2): 321-322 .

Journal: Blood
Blood (2013) 122 (15): 2765.
https://doi.org/10.1182/blood-2013-09-525857
Published: 2013
Journal Articles

A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model

Brief Report
Nicola Zanesi, Veronica Balatti, Jesse Riordan, Aaron Burch, Lara Rizzotto, Alexey Palamarchuk, Luciano Cascione, Alessandro Lagana, Adam J. Dupuy, Carlo M. Croce, Yuri Pekarsky
Journal: Blood
Blood (2013) 121 (21): 4355–4358.
https://doi.org/10.1182/blood-2013-02-486035
Published: 2013
Includes: Supplemental data
Journal Articles

RUNX1c Expression Identifies an Enriched Subpopulation of Hematopoietic Progenitor Cells Derived From Human Pluripotent Stem Cells.

Patrick I Ferrell, B.S., Mitali Adlakha, B.S., Dan S. Kaufman, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2294.
https://doi.org/10.1182/blood.V120.21.2294.2294
Published: 2012
Journal Articles

Sleeping Beauty Transposon Insertional Mutagenesis Identifies Drivers of Erythroid Leukemia in Mice.

Keith R. Loeb, MD, PhD, Bridget T Hughes, Ph.D., Brian M. Fissel, Yongiae E. Choi, Galina Pogosov, Sue E Knoblaugh, DVM, Brent L. Wood, MD, PhD, Bruce E. Clurman, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 2407.
https://doi.org/10.1182/blood.V120.21.2407.2407
Published: 2012