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Journal Articles

Targeting the Plasma Cell Specific Purine Metabolic Enzyme, AMPD1, Induces Multiple Myeloma Cell Death Accompanying NAD Depletion

Yawara Kawano, MD PhD, Takayuki Sasano, Saki Kushima, Yuki Inada, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3097.
https://doi.org/10.1182/blood-2019-125756
Published: 2019
Journal Articles

PKR-like Endoplasmic Reticulum Kinase Mediates Apoptosis Induced By Pharmacological AMP-Activated Protein Kinase Activation in Acute Myeloid Leukemia

Laury Poulain, PhD, Adrien Grenier, MD PhD, Johanna Mondesir, MD, Arnaud Jacquel, PhD, Claudie Bosc, Lucille Stuani, PhD, Rudy Birsen, MD, Sarah Mouche, Justine Decroocq, MD, Fetta Mazed, PhD, Benoit Viollet, PhD, Patrick Auberger, PhD, Pierre Sujobert, MD PhD, Didier Bouscary, MD PhD, Jean-Emmanuel Sarry, PhD, Jerome Tamburini, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2552.
https://doi.org/10.1182/blood-2019-123364
Published: 2019
Journal Articles

Multicentre, Open Label, Randomized Phase III Study of Cpi-613 ® (devimistat) in Combination with High Dose Cytarabine and Mitoxantrone (CHAM) Compared to High Dose Cytarabine and Mitoxantrone (HAM) in Older Patients (≥ 60 years) with Relapsed / Refractory Acute Myeloid Leukemia (AML) - Armada 2000 (AML003) Trial

Timothy S. Pardee, MD PhD, Sanjeev Luther, MBA, Marc E. Buyse, ScD, Bayard L Powell, MD, Jorge E. Cortes, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2658.
https://doi.org/10.1182/blood-2019-129377
Published: 2019
Journal Articles

The Role of AMPK in Chemotherapy Response in AML

Lais P Ghiraldeli, MS, Rebecca G. Anderson, B.S., Kristin M. Pladna, M.S., Timothy Pardee, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2633.
https://doi.org/10.1182/blood-2018-99-119288
Published: 2018
Journal Articles

An Engineered Cell-Traceable Model of Reticular Dysgenesis in Human Hematopoietic Stem Cells Linking Metabolism and Differentiation

Wenqing Wang, PhD, Avni Awani, PhD, Lauren Reich, Yusuke Nakauchi, MD PhD, Daniel Thomas, MD PhD, Daniel P. Dever, PhD, Matthew Porteus, MD PhD, Katja G. Weinacht, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2558.
https://doi.org/10.1182/blood-2018-99-117926
Published: 2018
Journal Articles

The Role of Adenosine Monophosphate Activated Protein Kinase Alpha 1 (AMPK) in Gamma-Globin Regulation

Alicia Chang, MD, Yankai Zhang, PhD, Nelda Itzep, MD, Vivien A Sheehan, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 413.
https://doi.org/10.1182/blood-2018-99-117092
Published: 2018
Journal Articles

The Purine Metabolic Enzyme AMPD1 Is a Novel Therapeutic Target for Multiple Myeloma

Yawara Kawano, MD PhD, Yuki Inada, Takayuki Sasano, Nao Nishimura, MD, Hiroyuki Hata, MD PhD, Masao Matsuoka, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 5614.
https://doi.org/10.1182/blood-2018-99-118603
Published: 2018
Journal Articles

Interim Analysis of a Single Arm Phase II Study of Cpi-613 in Combination with High Dose Cytarabine and Mitoxantrone for Patients with Relapsed or Refractory AML

Timothy S Pardee, MD PhD, Scott Isom, M.S., Leslie Renee Ellis, MD, Dianna S. Howard, MD, Rupali Bhave, MD, Megan Manuel, M.S.N, Sarah Dralle, M.S.N., Susan Lyerly, P.A.-C., Bayard L. Powell, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2626.
https://doi.org/10.1182/blood.V130.Suppl_1.2626.2626
Published: 2017
Journal Articles

Phosphodiesterase 4 inhibitors have wide-ranging activity in B-cell malignancies

Clinical Trials & Observations
Jeffrey D. Cooney, Ricardo C. T. Aguiar
Journal: Blood
Blood (2016) 128 (25): 2886–2890.
https://doi.org/10.1182/blood-2016-09-737676
Published: 2016
Journal Articles

Metabolomic Profiling Defines Distinct Metabolic Signature Associated with FLT3/ITD AML

Bradley Stockard, Pharm.D, Timothy Garrett, Soheil Meshinchi, MD PhD, Jatinder K Lamba, PhD
Journal: Blood
Blood (2016) 128 (22): 1692.
https://doi.org/10.1182/blood.V128.22.1692.1692
Published: 2016
Journal Articles

TCA Cycle Inhibition By Cpi-613 Increases Sensitivity to Chemotherapy in Older and Poor Risk Acute Myeloid Leukemia (AML)

Timothy S Pardee, MD PhD, Lance D Miller, PhD, Kristin Pladna, MS, Scott Isom, MS, Leslie Renee Ellis, MD, Dmitriy Berenzon, MD, Dianna Howard, MD, Megan Manuel, MSN, Sarah Dralle, MSN, Susan Lyerly, PA-C, Bayard L Powell, MD
Journal: Blood
Blood (2016) 128 (22): 4062.
https://doi.org/10.1182/blood.V128.22.4062.4062
Published: 2016
Journal Articles

Calcium Calmodulin Dependent Kinase Kinase 2 Regulates Hematopoietic Stem Cell Regeneration and Quiescence

William Lento, PhD, Wei Huang, Phuong Doan, MD, Nelson J. Chao, MD, Luigi Racioppi, MDPhD
Journal: Blood
Blood (2014) 124 (21): 1571.
https://doi.org/10.1182/blood.V124.21.1571.1571
Published: 2014
Journal Articles

ODE-Adefovir As Potential Therapeutic Agent In AML

Haytham Khoury, MD, Hu Ruijuan, Aaron Schimmer, PhD, MD, Karl Hostetler, MD, Mark D Minden, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 3970.
https://doi.org/10.1182/blood.V122.21.3970.3970
Published: 2013
Journal Articles

Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation

Connie M. Krawczyk, Thomas Holowka, Jie Sun, Julianna Blagih, Eyal Amiel, Ralph J. DeBerardinis, Justin R. Cross, Euihye Jung, Craig B. Thompson, Russell G. Jones, Edward J. Pearce
Journal: Blood
Blood (2010) 115 (23): 4742–4749.
https://doi.org/10.1182/blood-2009-10-249540
Published: 2010
Includes: Supplemental data
Journal Articles

Myeloma Cell Proliferation Is Inhibitied by the Activation of Adenosine Monophosphate Activated Protein Kinase (AMPK).

Philipp Baumann, Sonja Mandl-Weber, Bertold Emmerich, Christian Straka, Daniel Franke, Ralf Schmidmaier
Journal: Blood
Blood (2006) 108 (11): 5045.
https://doi.org/10.1182/blood.V108.11.5045.5045
Published: 2006