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Journal Articles

Mechanistic Analysis of Prolonged Negative Impacts of Anti-CCR4 Antibody Mogamulizumab on Regulatory T Cell Homeostasis after Allogeneic Hematopoietic Stem Cell Transplantation

Yasuhisa Sando, MD, Ken-Ichi Matsuoka, MD PhD, Yusuke Meguri, MD, Takumi Kondo, MD, Shuntaro Ikegawa, MD, Hiroyuki Sugiura, MD, Makoto Nakamura, MD, Miki Iwamoto, Takeru Asano, Takanori Yoshioka, MD, Yoshinobu Maeda, MD PhD

Blood (2018) 132 (Supplement 1): 3400.

https://doi.org/10.1182/blood-2018-99-117548

Published: 2018

Journal Articles

Posttransplant Cyclophosphamide Promote Naïve-Subset Dominant B Cell Recovery Coordinated with Early Treg Expansion; Implication of Reduced Risk of Pathogenesis into Chronic Gvhd

Miki Iwamoto, Yusuke Meguri, MD, Takumi Kondo, MD, Hiroyuki Sugiura, MD, Shuntaro Ikegawa, MD, Yasuhisa Sando, MD, Makoto Nakamura, MD, Yoshinobu Maeda, MD PhD, Ken-Ichi Matsuoka, MD PhD

Blood (2018) 132 (Supplement 1): 4566.

https://doi.org/10.1182/blood-2018-99-120081

Published: 2018

Journal Articles

Post-Transplant Cyclophosphamide Ameliorates Lethal Thymic GVHD By Restoring Regulatory and Effector T Cell Homeostasis in Recipients with Prior PD-1 Blockade Therapy

Shuntaro Ikegawa, MD, Yusuke Meguri, MD, Takumi Kondo, MD, Hiroyuki Sugiura, MD, Yasuhisa Sando, MD, Makoto Nakamura, MD, Miki Iwamoto, Yoshinobu Maeda, MD PhD, Ken-Ichi Matsuoka, MD PhD

Blood (2018) 132 (Supplement 1): 479.

https://doi.org/10.1182/blood-2018-99-111142

Published: 2018

Journal Articles

Efficacy of HLA-Matched PLT Transfusions for Platelet Transfusion Refractoriness in HSCT Patients

Keisuke Seike, Nobuharu Fujii, MD PhD, Keiko Fujii, MD PhD, Yasuhisa Sando, MD, Makoto Nakamura, MD, Kyosuke Saeki, MD, Yusuke Meguri, MD, Noboru Asada, MD PhD, Daisuke Ennishi, MDPhD, Hisakazu Nishimori, MD PhD, Ken-Ichi Matsuoka, MD PhD, Yoshinobu Maeda, MDPhD

Blood (2018) 132 (Supplement 1): 1265.

https://doi.org/10.1182/blood-2018-99-112365

Published: 2018

Journal Articles

Granulocyte Transfusions for Neutropenic Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation

Shuntaro Ikegawa, MD, Nobuharu Fujii, MD PhD, Keiko Fujii, MD PhD, Yusuke Meguri, MD, Kyosuke Saeki, MD, Noboru Asada, MD PhD, Hisakazu Nishimori, MD PhD, Ken-ichi Matsuoka, MDPhD, Yoshinobu Maeda, MDPhD

Blood (2017) 130 (Supplement 1): 2410.

https://doi.org/10.1182/blood.V130.Suppl_1.2410.2410

Published: 2017

Journal Articles

Loss of the GVL Effect By Distinct Expression of Migration Markers As a Mechanism of Immune Escape in Adult T Cell Leukemia/Lymphoma (ATLL), a Malignant Counterpart of Regulatory T Cells

Yasuhisa Sando, MD, Ken-ichi Matsuoka, MDPhD, Yusuke Meguri, MD, Shuntaro Ikegawa, MD, Hiroyuki Sugiura, MD, Makoto Nakamura, MD, Iwamoto Miki, Takeru Asano, MD, Takanori Yoshioka, MD, Yoshinobu Maeda, MDPhD

Blood (2017) 130 (Supplement 1): 2760.

https://doi.org/10.1182/blood.V130.Suppl_1.2760.2760

Published: 2017

Journal Articles

Liposomal Alpha-Galactosylceramide Ameliorates Graft-Versus-Host Disease with Remaining Intensified GVL Gained By Dose-Reduction of Posttransplant Cyclophosphamaide after Haploidentical HSCT

Makoto Nakamura, MD, Ken-ichi Matsuoka, MDPhD, Yusuke Meguri, MD, Shuntaro Ikegawa, MD, Hiroyuki Sugiura, MD, Yasuhisa Sando, MD, Miki Iwamoto, Takeru Asano, MD, Yasuyuki Ishii, PhD, Yoshinobu Maeda, MDPhD

Blood (2017) 130 (Supplement 1): 1897.

https://doi.org/10.1182/blood.V130.Suppl_1.1897.1897

Published: 2017

Journal Articles

Essential Role of Regulatory T Cells on Early B Cell Reconstitution after Haploidentical BMT with Posttransplant Cyclophosphamide

Miki Iwamoto, Ken-ichi Matsuoka, MDPhD, Yusuke Meguri, MD, Shuntaro Ikegawa, MD, Hiroyuki Sugiura, MD, Yasuhisa Sando, MD, Makoto Nakamura, MD, Takeru Asano, MD, Yoshinobu Maeda, MDPhD

Blood (2017) 130 (Supplement 1): 4447.

https://doi.org/10.1182/blood.V130.Suppl_1.4447.4447

Published: 2017

Journal Articles

Early Administration of Low-Dose IL-2 Intensify Graft-Versus-Leukemia Effect without Worsening GVHD through Sequential Enhancement of Effector T Cell and CD62L+ Regulatory T Cell Subset

Yusuke Meguri, MD, Ken-ichi Matsuoka, MDPhD, Shuntaro Ikegawa, MD, Hiroyuki Sugiura, MD, Makoto Nakamura, MD, Yasuhisa Sando, MD, Iwamoto Miki, Takanori Yoshioka, MD, Takeru Asano, MD, Yoshinobu Maeda, MDPhD

Blood (2017) 130 (Supplement 1): 3192.

https://doi.org/10.1182/blood.V130.Suppl_1.3192.3192

Published: 2017

Journal Articles

PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy

Blood (2017) 129 (15): 2186–2197.

https://doi.org/10.1182/blood-2016-09-741629

Published: 2017

Includes: Supplemental data

Journal Articles

Very Early Dynamics of Regulatory T-Cell Chimerism Significantly Varies According to the Donor Sources: Implication for Basic Immune Pathogenesis of Engraftment Phase

Miki Iwamoto, Ken-ichi Matsuoka, MD PhD, Yusuke Meguri, MD, Takeru Asano, MD, Takanori Yoshioka, MD, Yuriko Kishi, Makoto Nakamura, MD, Yasuhisa Sando, MD, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD

Blood (2016) 128 (22): 4575.

https://doi.org/10.1182/blood.V128.22.4575.4575

Published: 2016

Journal Articles

Comprehensive Analyses of Early Lymphocyte Reconstitution after Haploidentical HSCT with Posttransplant Cyclophosphamide: Coordinated Treg-Dominant T-Cell Reconstitution and Stem Cell-Derived Mature B-Cell with Broad BCR-Repertoir Diversity

Miki Iwamoto, Ken-ichi Matsuoka, MD PhD, Yusuke Meguri, MD, Takeru Asano, MD, Takanori Yoshioka, MD, Yuriko Kishi, Makoto Nakamura, MD, Yasuhisa Sando, MD, Ryuji Suzuki, DVM, PhD, Kazutaka Kitaura, DVM, PhD, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD

Blood (2016) 128 (22): 4542.

https://doi.org/10.1182/blood.V128.22.4542.4542

Published: 2016

Journal Articles

Interval of IL-2 Administration Has a Major Impact on Treatment Efficacy for Regulatory T Cell Expansion and Homeostasis

Yuriko Kishi, Yusuke Meguri, MD, Miki Iwamoto, Takeru Asano, MD, Takanori Yoshioka, MD, Yoshinobu Maeda, MDPhD, Mitsune Tanimoto, MD PhD, John Koreth, MBBS, DPhil, Jerome Ritz, MD, Ken-Ichi Matsuoka, MDPhD

Blood (2015) 126 (23): 1928.

https://doi.org/10.1182/blood.V126.23.1928.1928

Published: 2015

Journal Articles

PD-1 Signaling Has a Critical Role in Maintaining Regulatory T Cell Homeostasis; Implication for Treg Depletion Therapy By PD-1 Blockade

Takeru Asano, MD, Yuriko Kishi, Yusuke Meguri, MD, Takanori Yoshioka, MD, Miki Iwamoto, Yoshinobu Maeda, MD PhD, Hideo Yagita, PhD, Mitsune Tanimoto, MD PhD, John Koreth, MBBS, DPhil, Jerome Ritz, MD, Ken-Ichi Matsuoka, MDPhD

Blood (2015) 126 (23): 848.

https://doi.org/10.1182/blood.V126.23.848.848

Published: 2015

Journal Articles

Acute Gvhd Induce the Critical Depletion of Naïve Pool in Regulatory T Cells: Implication for Linked Pathogenesis into Chronic Gvhd

Takanori Yoshioka, MD, Yusuke Meguri, MD, Takeru Asano, MD, Yuriko Kishi, Miki Iwamoto, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD, Ken-Ichi Matsuoka, MDPhD

Blood (2015) 126 (23): 923.

https://doi.org/10.1182/blood.V126.23.923.923

Published: 2015

Journal Articles

Host Immune Status Determines the Effects of Therapeutic Interleukin-2 Administration: Enhancement of GVL or Induction of Tolerance?

Yusuke Meguri, Takeru Asano, MD, Takanori Yoshioka, MD, Haruka Izumi, Yuriko Kishi, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD, Ken-ichi Matsuoka, MD PhD

Blood (2014) 124 (21): 2431.

https://doi.org/10.1182/blood.V124.21.2431.2431

Published: 2014

Journal Articles

Early Homeostatic Expansion of Regulatory T Cells with the Predominant Effector/Memory Phenotype May Stabilize Immune Recovery in the First Month after HSCT

Takanori Yoshioka, MD, Yusuke Meguri, MD, Takeru Asano, MD, Taro Masunari, MD PhD, Kumiko Kagawa, MD PhD, Koichi Nakase, MD PhD, Yoshinobu Maeda, MD PhD, Mitsune Tanimoto, MD PhD, Ken-ichi Matsuoka, MD PhD

Blood (2014) 124 (21): 2501.

https://doi.org/10.1182/blood.V124.21.2501.2501

Published: 2014

Journal Articles

Enhanced Expression of PD-1 Modulates CD4+Foxp3+ Regulatory T Cell Homeostasis during Low-Dose IL-2 Therapy in Patients with Chronic Graft-Versus-Host Disease

Takeru Asano, MD, Haesook T. Kim, PhD, John Koreth, MBBS, DPhil, Robert J Soiffer, MD, Yusuke Meguri, MD, Takanori Yoshioka, MD, Hideo Yagita, PhD, Mitsune Tanimoto, MD PhD, Jerome Ritz, MD, Ken-ichi Matsuoka, MD PhD

Blood (2014) 124 (21): 662.

https://doi.org/10.1182/blood.V124.21.662.662

Published: 2014

NARROW

Mechanistic Analysis of Prolonged Negative Impacts of Anti-CCR4 Antibody Mogamulizumab on Regulatory T Cell Homeostasis after Allogeneic Hematopoietic Stem Cell Transplantation

Posttransplant Cyclophosphamide Promote Naïve-Subset Dominant B Cell Recovery Coordinated with Early Treg Expansion; Implication of Reduced Risk of Pathogenesis into Chronic Gvhd

Post-Transplant Cyclophosphamide Ameliorates Lethal Thymic GVHD By Restoring Regulatory and Effector T Cell Homeostasis in Recipients with Prior PD-1 Blockade Therapy

Efficacy of HLA-Matched PLT Transfusions for Platelet Transfusion Refractoriness in HSCT Patients

Granulocyte Transfusions for Neutropenic Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation

Loss of the GVL Effect By Distinct Expression of Migration Markers As a Mechanism of Immune Escape in Adult T Cell Leukemia/Lymphoma (ATLL), a Malignant Counterpart of Regulatory T Cells

Liposomal Alpha-Galactosylceramide Ameliorates Graft-Versus-Host Disease with Remaining Intensified GVL Gained By Dose-Reduction of Posttransplant Cyclophosphamaide after Haploidentical HSCT

Essential Role of Regulatory T Cells on Early B Cell Reconstitution after Haploidentical BMT with Posttransplant Cyclophosphamide

Early Administration of Low-Dose IL-2 Intensify Graft-Versus-Leukemia Effect without Worsening GVHD through Sequential Enhancement of Effector T Cell and CD62L+ Regulatory T Cell Subset

PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy

Very Early Dynamics of Regulatory T-Cell Chimerism Significantly Varies According to the Donor Sources: Implication for Basic Immune Pathogenesis of Engraftment Phase

Comprehensive Analyses of Early Lymphocyte Reconstitution after Haploidentical HSCT with Posttransplant Cyclophosphamide: Coordinated Treg-Dominant T-Cell Reconstitution and Stem Cell-Derived Mature B-Cell with Broad BCR-Repertoir Diversity

Interval of IL-2 Administration Has a Major Impact on Treatment Efficacy for Regulatory T Cell Expansion and Homeostasis

PD-1 Signaling Has a Critical Role in Maintaining Regulatory T Cell Homeostasis; Implication for Treg Depletion Therapy By PD-1 Blockade

Acute Gvhd Induce the Critical Depletion of Naïve Pool in Regulatory T Cells: Implication for Linked Pathogenesis into Chronic Gvhd

Host Immune Status Determines the Effects of Therapeutic Interleukin-2 Administration: Enhancement of GVL or Induction of Tolerance?

Early Homeostatic Expansion of Regulatory T Cells with the Predominant Effector/Memory Phenotype May Stabilize Immune Recovery in the First Month after HSCT

Enhanced Expression of PD-1 Modulates CD4+Foxp3+ Regulatory T Cell Homeostasis during Low-Dose IL-2 Therapy in Patients with Chronic Graft-Versus-Host Disease

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American Society of Hematology

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American Society of Hematology

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