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Journal Articles

RUNX1 Mutation Leads to Megakaryocyte-Primed Hematopoietic Stem Cell Expansion and Familial Platelet Disorder

Chen Wang, MD, Weinan Wang, BS, Lei Huang, PhD, Yoshihiro Hayashi, MD PhD, Xiongwei Cai, PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2020) 136 (Supplement 1): 8–9.

https://doi.org/10.1182/blood-2020-140769

Published: 2020

Journal Articles

Autism-Associated Chromatin Remodeler CHD8 Governs the Survival and Differentiation of Hematopoietic Stem/Progenitor Cells

Zhaowei Tu, PhD, Chen Wang, MSc, Chuntao Zhao, PhD, Lei Huang, PhD, Nathan Salomonis, PhD, Richard Q Lu, PhD, Yi Zheng, PhD

Blood (2019) 134 (Supplement_1): 1191.

https://doi.org/10.1182/blood-2019-127313

Published: 2019

Journal Articles

RhoA Targeting Suppresses Cold-Induced Platelet Lesion and Allows Refrigerated Storage of Functional Human Platelets to Fourteen Days

Shailaja N Hegde, PhD, Huzoor Akbar, PhD, Shawnagay Nestheide, BS, Ashley M Wellendorf, B.S., Breanna Bohan, James F Johnson, Yi Zheng, PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 99.

https://doi.org/10.1182/blood-2019-125359

Published: 2019

Journal Articles

The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph + (BCR-ABL1) B-ALL

Nicolas Nassar, PhD, Shailaja N Hegde, PhD, Anjelika Gasilina, Mark Wunderlich, MS, Gurdat Premnauth, Edward Merino, PhD, Yuan Lin, PhD, Reza Ahmadian, PhD, Yi Zheng, PhD, Benjamin Mizukawa, Lisa Privette Vinnedge, PhD, Jose A Cancelas, MD

Blood (2019) 134 (Supplement_1): 4647.

https://doi.org/10.1182/blood-2019-130250

Published: 2019

Journal Articles

The Inherited MDS Gene DDX41 Is Required for Ribosome Biogenesis and Cell Viability

Timothy M Chlon, PhD, Emily Stepanchick, Kwangmin Choi, PhD, Yi Zheng, PhD, Kathleen Hueneman, Ashley Davis, Daniel T. Starczynowski, PhD

Blood (2019) 134 (Supplement_1): 773.

https://doi.org/10.1182/blood-2019-127471

Published: 2019

Journal Articles

Precision Assessment of on- and Off-Target Effects of mTOR Kinase Inhibitors in a Mouse Model

Cuiqing Fan, PhD, Xiongwei Cai, PhD, Feng Zhang, PhDcandidate, Cindy Hochstetler, PhDcandidate, Xiaoyi Chen, PhD, Fukun Guo, PhD, Weidong Tian, PhD, Yi Zheng, PhD

Blood (2018) 132 (Supplement 1): 2632.

https://doi.org/10.1182/blood-2018-99-115225

Published: 2018

Journal Articles

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Shailaja N Hegde, PhD, Mark J Althoff, BS, Ramesh C. Nayak, PhD, Ashley M Wellendorf, B.S., Fatima Mohmoud, B.S., Gang Huang, PhD, Yi Zheng, PhD, Maria T Diaz-Meco, PhD, Jorge Moscat, PhD, Jose A Cancelas, MD PhD

Blood (2018) 132 (Supplement 1): 551.

https://doi.org/10.1182/blood-2018-99-118919

Published: 2018

Journal Articles

Inducible Correction of a RUNX1 Mutation of Human AML Causes a Switch of AML to B-ALL

Chen Wang, PhDcandidate, Yoshihiro Hayashi, MD PhD, Xiongwei Cai, PhD, Xiaomei Yan, MD PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2018) 132 (Supplement 1): 1325.

https://doi.org/10.1182/blood-2018-99-116919

Published: 2018

Journal Articles

Targeted Inhibition of STAT/TET1 Axis As a Potent Therapeutic Strategy for Acute Myeloid Leukemia

Blood (2017) 130 (Supplement 1): 857.

https://doi.org/10.1182/blood.V130.Suppl_1.857.857

Published: 2017

Journal Articles

mTOR Restricts Chromatin Access and Genomic Activity to Maintain Hematopoietic Stem Cell Quiescence and Engraftment

Cuiqing Fan, PhD, Chuntao Zhao, PhD, Feng Zhang, Xiongwei Cai, PhD, Lingli Xu, Shan Lin, PhD, Xiaoyi Chen, PhD, Fukun Guo, PhD, Richard Q Lu, PhD, Weidong Tian, PhD, Yi Zheng, PhD

Blood (2017) 130 (Supplement 1): 2416.

https://doi.org/10.1182/blood.V130.Suppl_1.2416.2416

Published: 2017

Journal Articles

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Xiongwei Cai, PhD, Yoshihiro Hayashi, MD PhD, Mark Wunderlich, MS, Nancy A. Speck, PhD, James C. Mulloy, PhD, Gang Huang, PhD, Yi Zheng, PhD

Blood (2016) 128 (22): 3860.

https://doi.org/10.1182/blood.V128.22.3860.3860

Published: 2016

Journal Articles

mTOR Is Dispensable in Hematopoietic Stem Cells and GMP Progenitors, but Plays an Essential Role in the CMP Population, for Autophagy Regulation

Xiaoyi Chen, PhDcandidate, Yi Zheng, PhD, Cuiqing Fan, Song Chen, Jun-lin Guan

Blood (2016) 128 (22): 3864.

https://doi.org/10.1182/blood.V128.22.3864.3864

Published: 2016

Journal Articles

Reactive Oxygen Species Produced by NADPH Oxidase Contribute to Cardiac Pathology in a Mouse Model of Sickle Cell Disease

Georgios E Christakopoulos, MD, Satheesh Chonat, MD, Inigo Valiente-Alandi, PhD, Diamantis G Konstantinidis, BSc, PhD, Amanda Schleper, Nihal Bakeer, MD, Anastacia Loberg, Burns C Blaxall, PhD FAHA, FACC, FAPS, Yi Zheng, PhD, Jeanne James, MD, Punam Malik, MD, Theodosia A Kalfa, MD PhD

Blood (2016) 128 (22): 853.

https://doi.org/10.1182/blood.V128.22.853.853

Published: 2016

Journal Articles

An Altered Bone Marrow Vascular Niche Impacts Normal Hematopoiesis and Tilts the Balance Between Myelopoiesis and Lymphopoiesis

Cindy L Hochstetler, B.S., Yuxin Feng, PhD, Yi Zheng, PhD

Blood (2016) 128 (22): 174.

https://doi.org/10.1182/blood.V128.22.174.174

Published: 2016

Journal Articles

Susceptibility of AML to Chloroquine Therapy Is Independent of Autophagy

Xiaoyi Chen, PhDcandidate, Jason Clark, Jun-lin Guan, PhD, Ashish R Kumar, MBBS, PhD, Yi Zheng, PhD

Blood (2015) 126 (23): 1262.

https://doi.org/10.1182/blood.V126.23.1262.1262

Published: 2015

Journal Articles

Ubiquitin Editing of a Spliceosome Auxiliary Factor By TRAF6 Links Chronic TLR Signaling with Hematopoietic Defects and Myelodysplasia

Jing Fang, MD, PhD, Lyndsey Bolanos, BSc, Kwang-Min Choi, PhD, Xiaona Liu, Ms, Susanne Christie, Shailaja Akunuru, PhD, Rupali Kumar, PhD, Ken Greis, PhD, Peter Stoilov, PhD, Marie-Dominique Filippi, PhD, Jaroslaw P. Maciejewski, MD PhD, Guillermo Garcia-Manero, MD, Matthew Weirauch, PhD, Nathan Salomonis, PhD, Hartmut Geiger, PhD, Yi Zheng, PhD, Daniel Starczynowski, PhD

Blood (2015) 126 (23): 143.

https://doi.org/10.1182/blood.V126.23.143.143

Published: 2015

Journal Articles

RhoA and Rac1 Gtpases Differentially Regulate Agonist-Receptor Mediated ROS Generation in Platelets

Huzoor Akbar, PhD, Xin Duan, PhD, Saima Saleem, PhD, Ashley Kuenzi Davis, MS, Yi Zheng, PhD

Blood (2014) 124 (21): 2763.

https://doi.org/10.1182/blood.V124.21.2763.2763

Published: 2014

Journal Articles

Maintenance Of Bone Marrow Residency and Self-Renewal Of Leukemic Stem Cells By Cdc42 Gtpase

Benjamin Mizukawa, MD, Eric O'Brien, BS, Wei Liu, MD, PhD, Daniel Moriera Ridsdale, MD, Mark Wunderlich, MS, Yi Zheng, PhD, James C. Mulloy, PhD

Blood (2013) 122 (21): 2889.

https://doi.org/10.1182/blood.V122.21.2889.2889

Published: 2013

Journal Articles

Oncogenic Insult In Bone Marrow Endothelial Cells Causes Hematopoietic Abnormalities

Yuxin Feng, PhD, Yi Zheng, PhD

Blood (2013) 122 (21): 2461.

https://doi.org/10.1182/blood.V122.21.2461.2461

Published: 2013

Journal Articles

Identification Of Genes/Signaling Pathways That Predispose To Therapy Related MDS (t-MDS)

Shailaja Akunuru, PhD, Kimberly Seymore, Kalpana Nattamai, Yi Zheng, PhD, Hartmut Geiger

Blood (2013) 122 (21): 2817.

https://doi.org/10.1182/blood.V122.21.2817.2817

Published: 2013

NARROW

RUNX1 Mutation Leads to Megakaryocyte-Primed Hematopoietic Stem Cell Expansion and Familial Platelet Disorder

Autism-Associated Chromatin Remodeler CHD8 Governs the Survival and Differentiation of Hematopoietic Stem/Progenitor Cells

RhoA Targeting Suppresses Cold-Induced Platelet Lesion and Allows Refrigerated Storage of Functional Human Platelets to Fourteen Days

The Small Molecule IODVA1 Inhibits the Rac Guanine Nucleotide Exchange Factor Vav3 and Overcomes TKI-Resistance in Ph + (BCR-ABL1) B-ALL

The Inherited MDS Gene DDX41 Is Required for Ribosome Biogenesis and Cell Viability

Precision Assessment of on- and Off-Target Effects of mTOR Kinase Inhibitors in a Mouse Model

Basal Polarity Complex Scribble Is Required for Leukemic Initiation and Propagation through Negative Regulation of Apical Polarity Complex Activator Cdc42 and Hypoxia Inducing Factor-1α

Inducible Correction of a RUNX1 Mutation of Human AML Causes a Switch of AML to B-ALL

Targeted Inhibition of STAT/TET1 Axis As a Potent Therapeutic Strategy for Acute Myeloid Leukemia

mTOR Restricts Chromatin Access and Genomic Activity to Maintain Hematopoietic Stem Cell Quiescence and Engraftment

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

mTOR Is Dispensable in Hematopoietic Stem Cells and GMP Progenitors, but Plays an Essential Role in the CMP Population, for Autophagy Regulation

Reactive Oxygen Species Produced by NADPH Oxidase Contribute to Cardiac Pathology in a Mouse Model of Sickle Cell Disease

An Altered Bone Marrow Vascular Niche Impacts Normal Hematopoiesis and Tilts the Balance Between Myelopoiesis and Lymphopoiesis

Susceptibility of AML to Chloroquine Therapy Is Independent of Autophagy

Ubiquitin Editing of a Spliceosome Auxiliary Factor By TRAF6 Links Chronic TLR Signaling with Hematopoietic Defects and Myelodysplasia

RhoA and Rac1 Gtpases Differentially Regulate Agonist-Receptor Mediated ROS Generation in Platelets

Maintenance Of Bone Marrow Residency and Self-Renewal Of Leukemic Stem Cells By Cdc42 Gtpase

Oncogenic Insult In Bone Marrow Endothelial Cells Causes Hematopoietic Abnormalities

Identification Of Genes/Signaling Pathways That Predispose To Therapy Related MDS (t-MDS)

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American Society of Hematology

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ASH Publications

American Society of Hematology

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