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Yan Zhang, PhD
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Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM
Journal: Blood
Blood (2019) 134 (Supplement_1): 73.
https://doi.org/10.1182/blood-2019-128646
Published: 2019
Journal Articles

Vzhe-039, a Novel Structurally-Enhanced Allosteric Hemoglobin Effector Inhibits Sickling of SS Erythrocytes In Vitro , and Exhibits Improved Pharmacologic Properties In Vivo

Martin K. Safo, PhD, Guoyan Xu, PhD, Mohini Ghatge, PhD, Qiukan Chen, Carla Casu, PhD, David Tanya, PhD, Yan Zhang, PhD, Jurgen Venitz, MD PhD, Osheiza Abdulmalik, DVM, MS
Journal: Blood
Blood (2016) 128 (22): 3645.
https://doi.org/10.1182/blood.V128.22.3645.3645
Published: 2016
Journal Articles

LSD1 Inhibition Induces Fetal Hemoglobin Expression and Provides a Novel Therapeutic Approach to Sickle Cell Disease

Sang Hyun Lee, PhD, Maxim Soloviev, MDPhD, Yan Zhang, PhD, Valerie Roman, Gengjie Yang, Kevin Bowman, Krista Burke, Alexander Margulis, Sybil O'Connor, Yan-ou Yang, PhD, Liangxing Wu, PhD, Richard Wynn, PhD, Timothy Burn, PhD, Dana Shuey, PhD, Sharon Diamond, PhD, Wenqing Yao, PhD, Gregory Hollis, PhD, Swamy Yeleswaram, PhD, Alan Roberts, PhD, Reid Huber, PhD, Peggy Scherle, PhD, Bruce Ruggeri, PhD
Journal: Blood
Blood (2016) 128 (22): 2472.
https://doi.org/10.1182/blood.V128.22.2472.2472
Published: 2016
Journal Articles

In-Vivo Labelling Studies in Patients with Chronic Lymphocytic Leukemia Studies Demonstrate the Existence of Apparently Distinct Subpopulations That Differ in Phenotype and Proliferative Capacity

Kirsty Cuthill, FRCPath,MBBS,MRCP, Yan Zhang, PhD, Andrea Buggins, PhD MBA, Eve Coulter, PhD, Piers E. Patten, BSc, MRCP, MRCPath, PhD, Derek Macallan, PhD MBBS, Stephen Devereux, FRCP, FRCPath, PhD
Journal: Blood
Blood (2015) 126 (23): 615.
https://doi.org/10.1182/blood.V126.23.615.615
Published: 2015
Journal Articles

Aberrant Hematopoietic Stem Cell Function in Mice Haploinsufficient for a 2 Mb Deletion of Chromosome 5A3 Syntenic to a Region of Human 7q22 Frequently Deleted in Myelodysplastic Syndromes

Jasmine C. Wong, PhD, Kelley Weinfurtner, BA, Pilar Alzamora, Scott C. Kogan, MD, Michael R. Burgess, MD PhD, Yan Zhang, PhD, Joy Nakitandwe, PhD, Jing Ma, PhD, Jinjun Cheng, MB, MS, Shann-Ching Chen, PhD, Johanna Flach, Damien Reynaud, PhD, Emmanuelle Passegue, PhD, James R Downing, MD, Kevin Shannon, MD
Journal: Blood
Blood (2014) 124 (21): 3247.
https://doi.org/10.1182/blood.V124.21.3247.3247
Published: 2014
Journal Articles

Novel Structurally-Modified Allosteric Effectors of Hemoglobin Exhibit Superior Antisickling Properties

Osheiza Abdulmalik, DVM, MS, Tanvi Deshpande, MS, Mohini Ghatge, PhD, Yan Zhang, PhD, Jurgen Venitz, MDPhD, Apurvasena Parikh, PhD, Martin K. Safo, PhD
Journal: Blood
Blood (2014) 124 (21): 218.
https://doi.org/10.1182/blood.V124.21.218.218
Published: 2014
Journal Articles

Proplatelet Formation Is Regulated by the Rho/Rock Pathway.

Yunhua Chang, PhD, Frederic Aurade, PhD, Frederic Larbret, Jean Pierre Le Couedic, Laurence Momeux, Yan Yan Zhang, PhD, Jerome Larghero, MD, Fawzia Louache, PhD, Jacques Bertoglio, MD, Elisabeth Cramer, PhD, William Vainchenker, MD, PhD, Najet Debili, PhD
Journal: Blood
Blood (2005) 106 (11): 3147.
https://doi.org/10.1182/blood.V106.11.3147.3147
Published: 2005
Journal Articles

Increased Inflammatory State and Metabolic Activation in Neutrophils from Patients with Sickle Cell Disease: Comparison of Neutrophil Gene Expression Profiles with Controls.

Sule Bakanay, MD, Ferdane Kutlar, MD, Joshi Ratanmani, PhD, Betsy Clair, Leigh Wells, MSN, Lisa Daitch, PA-C, Yan Zhang, PhD, Jin-Xiong She, PhD, Abdullah Kutlar, MD
Journal: Blood
Blood (2004) 104 (11): 3571.
https://doi.org/10.1182/blood.V104.11.3571.3571
Published: 2004