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Journal Articles

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Stefania Gobessi, PhD, Luca Laurenti, MD, Fabiola Porro, MS, Claudio Martines, MS, Rosa Fazio, BS, Elena Xerxa, PhD, Idanna Innocenti, MD PhD, Antonella Zucchetto, Shih-Shih Chen, PhD, Xiao-Jie Yan, MD PhD, Nicholas Chiorazzi, MD, Valter Gattei, MD, Dimitar G Efremov, MD PhD

Blood (2018) 132 (Supplement 1): 4409.

https://doi.org/10.1182/blood-2018-99-118562

Published: 2018

Journal Articles

Musashi 2 Is Overexpressed in Poor Outcome CLL Patients and Their Proliferative Fraction and Silencing This Gene Induces Apoptosis and Increases Cell Adhesion and Movement

Florencia Palacios, PhD, Xiao-Jie Yan, MD PhD, Gerardo Ferrer, PhD, Jacqueline C Barrientos, MD MS, Jonathan E. Kolitz, MD, Steven L. Allen, Rai Kanti R., MD, Nicholas Chiorazzi, MD

Blood (2018) 132 (Supplement 1): 1837.

https://doi.org/10.1182/blood-2018-99-115060

Published: 2018

Journal Articles

In CLL, Myeloid-Derived Suppressor Cells and Their Monocytic and Granulocytic Varieties Differ in T-Cell Subset Association and Polarization Induction

Gerardo Ferrer, PhD, Brendan Franca, Pui Yan Chiu, MSc, Stefano Vergani, MS, Andrea Nicola Mazzarello, PhD, Florencia Palacios, PhD, Davide Bagnara, PhD, Shih-Shih Chen, PhD, Sophia Yancopoulos, PhD, Yun Liu, MS, Aliki Xochelli, MD PhD, Xiao-Jie Yan, MD PhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kostas Stamatopoulos, MD PhD, Kanti R. Rai, MD, Barbara Sherry, PhD, Nicholas Chiorazzi, MD

Blood (2016) 128 (22): 4350.

https://doi.org/10.1182/blood.V128.22.4350.4350

Published: 2016

Journal Articles

Reappraising Immunoglobulin Repertoire Restrictions in Chronic Lymphocytic Leukemia: Focus on Major Stereotyped Subsets and Closely Related Satellites

Andreas Agathangelidis, Anastasia Hadzidimitriou, Eva Minga, Lesley-Ann Sutton, Eleftheria Polychronidou, Tait D. Shanafelt, MD, Zadie Davis, Xiao-Jie Yan, MD PhD, Karla Plevova, Myriam Boudjoghra, Alba Navarro, Davide Rossi, Lone Bredo Pedersen, Vasilis Bikos, Panagiotis Baliakas, Lydia Scarfò, MD, Mattias Mattsson, Aliki Xochelli, MD PhD, Paola Francia di Celle, Krzysztof Giannopoulos, Katrina Vanura, Ludo Evers, Silvio Veronese, Monica Facco, Panagiotis Moschonas, Vojtech Bystry, Teodora Karan-Djurasevic, Maria Roumelioti, Sonja Pavlovic, Larry Mansouri, Charles Chu, Evangelia Stalika, Veronique Giudicelli, Panagiotis Panagiotidis, Andrey Sudarikov, Achilles Anagnostopoulos, Livio Trentin, MD, Mark Catherwood, Marco Montillo, MD, Niki Stavroyianni, MD, Gianluca Gaidano, Elias Campo, Carsten Utoft Niemann, Anton W. Langerak, Sarka Pospisilova, Marie-Paule Lefranc, Ulrich Jaeger, Arnon Kater, MD PhD, Christiane Pott, Nicholas Chiorazzi, MD, David Oscier, Diane F. Jelinek, Stephan Stilgenbauer, Michael Hallek, Dimitrios Tzovaras, Nikos Darzentas, Chrysoula Belessi, Frederic Davi, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos, MD PhD

Blood (2016) 128 (22): 4376.

https://doi.org/10.1182/blood.V128.22.4376.4376

Published: 2016

Journal Articles

B Cells of the Proliferative Fraction of CLL Clones Exhibit Activated B-Cell and Myeloid-Cell Signatures Suggesting Enhanced Antigen-Presentation, Integrin Responsiveness, and IL-4 Receptiveness: Additional Targets for CLL Therapy

Xiao-Jie Yan, MD PhD, Florencia Palacios, PhD, Wentian Li, PhD, Sophia Yancopoulos, PhD, Carlo Calissano, MD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Kanti Rai, MD, Nicholas Chiorazzi, MD

Blood (2016) 128 (22): 302.

https://doi.org/10.1182/blood.V128.22.302.302

Published: 2016

Journal Articles

Comparative Density Analyses of B Cell Receptor-Complex Components (Membrane IgM, Membrane IgD, and Stimulatory/Inhibitory Co-Receptors) on Intraclonal Subpopulations of CLL B Cells, before and during Ibrutinib Therapy

Andrea Nicola Mazzarello, PhD, Stefano Vergani, MS, Gerardo Ferrer, PhD, Yun Liu, MS, Shih-Shih Chen, PhD, Sophia Yancopoulos, PhD, Xiao-Jie Yan, MD PhD, Jacqueline C. Barrientos, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2016) 128 (22): 4356.

https://doi.org/10.1182/blood.V128.22.4356.4356

Published: 2016

Journal Articles

Automated Clustering Analysis of Immunoglobulin Sequences in Chronic Lymphocytic Leukemia Based on 3D Structural Descriptors

Paolo Marcatili, Konstantinos Mochament, Andreas Agathangelidis, Panagiotis Moschonas, Lesley-Ann Sutton, Xiao-Jie Yan, MD PhD, Vasilis Bikos, Anna Vardi, Anna Chailyan, Niki Stavroyianni, MD, Kamilla Kjærgaard Jensen, Achilles Anagnostopoulos, Nicholas Chiorazzi, Chrysoula Belessi, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos, MD PhD, Anastasia Hadzidimitriou, Dimitrios Tzovaras

Blood (2016) 128 (22): 4365.

https://doi.org/10.1182/blood.V128.22.4365.4365

Published: 2016

Journal Articles

Chronic Lymphocytic Leukemia Patients and Eµ- TCL1 Mice Share a Phenotype of Functional Granulocyte-like and Dysfunctional Monocyte-like Myeloid Derived Suppressor Cells

Gerardo Ferrer, PhD, Xiao-Jie Yan, MD PhD, Brendan Franca, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L Allen, MD, Kanti R Rai, MD, Nicholas Chiorazzi, MD

Blood (2015) 126 (23): 614.

https://doi.org/10.1182/blood.V126.23.614.614

Published: 2015

Journal Articles

The Correlation of APOBEC Gene Family Member Expression with Worse CLL Patient Outcome Suggests a Role in CLL Mutational Evolution

Charles C Chu, Xiao-Jie Yan, MD PhD, Arvind Dhayalan, Piers E. Patten, BSc, MRCP, MRCPath, PhD, Thomas MacCarthy, PhD, Chaohui Yuan, MS, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2015) 126 (23): 363.

https://doi.org/10.1182/blood.V126.23.363.363

Published: 2015

Journal Articles

The RNA Binding Protein Musashi 2 Is up-Regulated in the Proliferative B-Cell Fraction of Chronic Lymphocytic Leukemia Clones

Florencia Palacios, PhD, Xiao-Jie Yan, MD PhD, Jaqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2015) 126 (23): 4149.

https://doi.org/10.1182/blood.V126.23.4149.4149

Published: 2015

Journal Articles

Overexpression of Activation-Induced Deaminase in TCL1 Mice Leads to the Development of IGHV -Mutated and -Unmutated CLL Clones That Resemble Unique Subsets of Human CLL

Xiao-Jie Yan, MD PhD, Pablo Morande, PhD, Ezra B Kolitz, BS, Crystal D Grant, BS, Gautam Nayyar, Pablo Oppezzo, PhD, Nicholas Chiorazzi, MD

Blood (2015) 126 (23): 1710.

https://doi.org/10.1182/blood.V126.23.1710.1710

Published: 2015

Journal Articles

Recurrent Mutations within the Nfkbie gene: A Novel Mechanism for NF-κB Deregulation in Aggressive Chronic Lymphocytic Leukemia

Blood (2014) 124 (21): 297.

https://doi.org/10.1182/blood.V124.21.297.297

Published: 2014

Journal Articles

IGHV4-34 B-Cell Receptor Immunoglobulins from CLL Stereotyped Subset 4 React with Influenza A Virus: Requirement for IGHV-D-J/Iglv-J Rearrangement and Isotype Switching to IgG

Yun Liu, M.S., Rosa Catera, PhD, Florian Krammer, PhD, Chao Gao, Xiao-Jie Yan, MD PhD, Kanti R. Rai, MD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Jonathan E. Kolitz, MD, Adolfo García-Sastre, PhD, Ten Feizi, MD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 299.

https://doi.org/10.1182/blood.V124.21.299.299

Published: 2014

Journal Articles

IGHV-D-J Ultra-Deep Sequencing Reveals APOBEC and AID Targeted Mutations during Clonal Evolution of CLL in a Xenograft Mouse Model

Charles C. Chu, PhD, Piers E.M. Patten, BSc, MRCP, MRCPath, PhD, Thomas MacCarthy, PhD, Chaohui Yuan, MS, Xiao-Jie Yan, MD PhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 300.

https://doi.org/10.1182/blood.V124.21.300.300

Published: 2014

Journal Articles

Functional Evidence from Deuterated Water Labeling That the Bruton Tyrosine Kinase Inhibitor Ibrutinib Blocks Leukemia Cell Proliferation and Trafficking and Promotes Leukemia Cell Death in Patients with Chronic Lymphocytic Leukemia and small Lymphocytic Lymphoma

Jan A. Burger, MD PhD, Kelvin Li, PhD, Michael Keating, MBBS, Mariela Sivina, PhD, Alessandra Ferrajoli, MD, Annette Jalayer, RN, Xuelin Huang, Hagop M. Kantarjian, MD, William G. Wierda, MD PhD, Susan O'Brien, MD, Marc Hellerstein, MD PhD, Scott Turner, PhD, Claire Emson, PhD, Shih-Shih Chen, PhD, Xiao-Jie Yan, MD PhD, Nicholas Chiorazzi, MD

Blood (2014) 124 (21): 326.

https://doi.org/10.1182/blood.V124.21.326.326

Published: 2014

Journal Articles

Subset-Specific Spectra of Recurrent Gene Mutations in Chronic Lymphocytic Leukemia with Stereotyped B-Cell Receptors

Blood (2014) 124 (21): 3320.

https://doi.org/10.1182/blood.V124.21.3320.3320

Published: 2014

Journal Articles

Apparent Involvement Of The Interferon, RNA Processing, and Wnt Signaling Pathways In Monoclonal B Lymphocytosis

Xiao-Jie Yan, MD PhD, Claudia Fazi, PhD, Scarfo Lydia, MD, Wentian Li, Ph.D., Jonathan E. Kolitz, MD, Jacqueline C. Barrientos, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Paolo Ghia, MD, PhD, Nicholas Chiorazzi, MD

Blood (2013) 122 (21): 4157.

https://doi.org/10.1182/blood.V122.21.4157.4157

Published: 2013

Journal Articles

Intraclonal Complexity Of CLL Fractions In Cell Proliferation Rates, Gene Expression Signatures, and Responses To Autologous T-Cell Help In Peripheral blood and Secondary Lymphoid Tissues

Shih-Shih Chen, Thomas M. Herndon, MD, Claire Emson, PhD, John C. Riches, MD, Fabienne McClanahan, MD, Timothy Tong, Xiao-Jie Yan, MD PhD, Piers E.M. Patten, MD, PhD, John Gribben, MD, DSc, Adrian Wiestner, MD, PhD, Nicholas Chiorazzi, MD

Blood (2013) 122 (21): 115.

https://doi.org/10.1182/blood.V122.21.115.115

Published: 2013

Journal Articles

Evaluation of IGHV Ultra-Deep Sequences for Activation-Induced Deaminase Characteristics in CLL Cells after T Cell Stimulation

Charles C. Chu, PhD, Piers E.M. Patten, MD, PhD, Thomas MacCarthy, PhD, Xiao-Jie Yan, MD PhD, Jacqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Steven L. Allen, MD, Kanti R. Rai, MD, Nicholas Chiorazzi, MD

Blood (2013) 122 (21): 2583.

https://doi.org/10.1182/blood.V122.21.2583.2583

Published: 2013

Journal Articles

A Systematic Search Into The Role Of IGHV Gene Replacement In Shaping The Immunoglobulin Repertoire Of Chronic Lymphocytic Leukemia

Sophia Yancopoulos, PhD, Xiao-Jie Yan, MD PhD, Andreas Agathangelidis, Wentian Li, Ph.D., Chrysoula Belessi, Paolo Ghia, MD, PhD, Richard Rosenquist, MD, PhD, Frederic Davi, MD, PhD, David Graham Oscier, MD, Sarka Pospisilova, Panagiotis Panagiotidis, MD, Lin Huang, PhD, Zhixin Zhang, PhD, Steven L. Allen, MD, Jaqueline C. Barrientos, MD, Jonathan E. Kolitz, MD, Kanti R. Rai, MD, Kostas Stamatopoulos, MD, Nicholas Chiorazzi, MD

Blood (2013) 122 (21): 4129.

https://doi.org/10.1182/blood.V122.21.4129.4129

Published: 2013

NARROW

Serum IgM/Fcmr Interactions Inhibit BCR Signaling and Influence the Cinical Course of CLL

Musashi 2 Is Overexpressed in Poor Outcome CLL Patients and Their Proliferative Fraction and Silencing This Gene Induces Apoptosis and Increases Cell Adhesion and Movement

In CLL, Myeloid-Derived Suppressor Cells and Their Monocytic and Granulocytic Varieties Differ in T-Cell Subset Association and Polarization Induction

Reappraising Immunoglobulin Repertoire Restrictions in Chronic Lymphocytic Leukemia: Focus on Major Stereotyped Subsets and Closely Related Satellites

B Cells of the Proliferative Fraction of CLL Clones Exhibit Activated B-Cell and Myeloid-Cell Signatures Suggesting Enhanced Antigen-Presentation, Integrin Responsiveness, and IL-4 Receptiveness: Additional Targets for CLL Therapy

Comparative Density Analyses of B Cell Receptor-Complex Components (Membrane IgM, Membrane IgD, and Stimulatory/Inhibitory Co-Receptors) on Intraclonal Subpopulations of CLL B Cells, before and during Ibrutinib Therapy

Automated Clustering Analysis of Immunoglobulin Sequences in Chronic Lymphocytic Leukemia Based on 3D Structural Descriptors

Chronic Lymphocytic Leukemia Patients and Eµ- TCL1 Mice Share a Phenotype of Functional Granulocyte-like and Dysfunctional Monocyte-like Myeloid Derived Suppressor Cells

The Correlation of APOBEC Gene Family Member Expression with Worse CLL Patient Outcome Suggests a Role in CLL Mutational Evolution

The RNA Binding Protein Musashi 2 Is up-Regulated in the Proliferative B-Cell Fraction of Chronic Lymphocytic Leukemia Clones

Overexpression of Activation-Induced Deaminase in TCL1 Mice Leads to the Development of IGHV -Mutated and -Unmutated CLL Clones That Resemble Unique Subsets of Human CLL

Recurrent Mutations within the Nfkbie gene: A Novel Mechanism for NF-κB Deregulation in Aggressive Chronic Lymphocytic Leukemia

IGHV4-34 B-Cell Receptor Immunoglobulins from CLL Stereotyped Subset 4 React with Influenza A Virus: Requirement for IGHV-D-J/Iglv-J Rearrangement and Isotype Switching to IgG

IGHV-D-J Ultra-Deep Sequencing Reveals APOBEC and AID Targeted Mutations during Clonal Evolution of CLL in a Xenograft Mouse Model

Functional Evidence from Deuterated Water Labeling That the Bruton Tyrosine Kinase Inhibitor Ibrutinib Blocks Leukemia Cell Proliferation and Trafficking and Promotes Leukemia Cell Death in Patients with Chronic Lymphocytic Leukemia and small Lymphocytic Lymphoma

Subset-Specific Spectra of Recurrent Gene Mutations in Chronic Lymphocytic Leukemia with Stereotyped B-Cell Receptors

Apparent Involvement Of The Interferon, RNA Processing, and Wnt Signaling Pathways In Monoclonal B Lymphocytosis

Intraclonal Complexity Of CLL Fractions In Cell Proliferation Rates, Gene Expression Signatures, and Responses To Autologous T-Cell Help In Peripheral blood and Secondary Lymphoid Tissues

Evaluation of IGHV Ultra-Deep Sequences for Activation-Induced Deaminase Characteristics in CLL Cells after T Cell Stimulation

A Systematic Search Into The Role Of IGHV Gene Replacement In Shaping The Immunoglobulin Repertoire Of Chronic Lymphocytic Leukemia

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American Society of Hematology

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American Society of Hematology

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