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Journal Articles

Clinical Validation of a NGS Capture Panel to Identify Mutations, Copy Number Variations and Translocations in Patients with Multiple Myeloma

Isabel Cuenca, MSc, Alejandro Medina, MD, Laura Rosinol, MD PhD, Iria Vazquez, PhD BSc, Ricardo Sanchez, Norma C. Gutierrez, MD PhD, Yanira Ruiz-Heredia, Santiago Barrio, Albert Oriol, MD, Maria Luisa Martin-Ramos, Manuela Fernández-Guijarro, María Jesús Blanchard, Rafael Rios, MD PhD, Anna Sureda Balari, MD PhD, Miguel T Hernández, Javier de la Rubia, Gorka Alkorta, Xabier Agirre, PhD, Gonzalo R Ordóñez, Rafael Valdés-Mas, Maria-Victoria Mateos, MD PhD, Joan Blade Creixenti, Juan Jose Lahuerta, MD PhD, Jesus F. San-Miguel, MD PhD, Maria Jose Calasanz, PhD BSc, Ramon Garcia-Sanz, Joaquin Martinez-Lopez, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 13–14.
https://doi.org/10.1182/blood-2020-140711
Published: 2020
Journal Articles

Characterization of Complete Lncrnas Transcriptome Reveals Expression of Lncrnas As a Prognostic Factor and Linc-Smilo As a Potential Therapeutic Target in Multiple Myeloma

Arantxa Carrasco, Teresa Ezponda, Cem Meydan, PhD, Luis Vitores Valcárcel, MSc, Raquel Ordoñez, PhD, Marta Kulis, PhD, Leire Garate, Estíbaliz Miranda, Victor Segura, PhD, Elizabeth Guruceaga, Amaia Vilas-Zornoza, PhD, Diego Alignani, PhD, Laura Castro, Marien Pascual, PhD, Ane Amundarain, Halima El Omri, Ruba Yasin, MBBS, MRCP, Maria Jose Calasanz, PhD BSc, Francisco J Planes, Bruno Paiva, PhD, Christopher Mason, PhD, Jesús San-Miguel, Inaki Martin Subero, PhD, Ari M Melnick, MD, Felipe Prosper, MD PhD, Xabier Agirre, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4323.
https://doi.org/10.1182/blood-2019-123008
Published: 2019
Journal Articles

Lncrnas As New Partners of Novel Chimeric Transcripts in Multiple Myeloma

Ane Amundarain, Luis Vitores Valcárcel, MSc, Raquel Ordoñez, PhD, Leire Garate, Estíbaliz Miranda, Xabier Cendoya, Maria Jose Calasanz, PhD BSc, Bruno Paiva, PhD, Jesús San-Miguel, Francisco J Planes, Felipe Prósper, MD PhD, Xabier Agirre, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4356.
https://doi.org/10.1182/blood-2019-122568
Published: 2019
Journal Articles

Computational Systems Biology Models for the Identification of Metabolic Vulnerabilities in Multiple Myeloma

Luis Vitores V. Valcárcel, MSc, Raquel Ordoñez, PhD, Iñigo Apaolaza, MSc, Ana Valcárcel, Leire Garate, Cem Meydan, PhD, Bruno Paiva, PhD, Ari M Melnick, MD, Jesús San-Miguel, Francisco J. Planes, Xabier Agirre, PhD, Felipe Prosper, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3084.
https://doi.org/10.1182/blood-2019-123970
Published: 2019
Journal Articles

Circulating Tumor Cells (CTCs) for Comprehensive and Multiregional Non-Invasive Genetic Characterization of Multiple Myeloma (MM)

Juan José Garcés, Gabriel Bretones, Leire Burgos, Rafael Valdes-Mas, Diego Alignani, PhD, Diana Álvarez Puente, Ibai Goicoechea, PhD, Miguel García Álvarez, Sonia Garate, Idoia Rodriguez, Maria Jose Calasanz, PhD BSc, Paula Rodriguez, MD, Rafael Rios, MD PhD, Joaquin Martinez-Lopez, MD PhD, Pamela Millacoy, Luis Palomera, MD PhD, Rafael Del Orbe, MD PhD, Albert Pérez, MD, Xabier Agirre, PhD, Juan Flores-Montero, Luzalba Sanoja-Flores, Alberto Orfao, MD PhD, Halima El Omri, Felipe Prosper, MD PhD, Carlos Lopez-Otin, Jesús San-Miguel, Bruno Paiva, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3064.
https://doi.org/10.1182/blood-2019-126527
Published: 2019
Journal Articles

Differentiation Therapy with Novel Epigenetic Inhibitors in Acute Myeloid Leukemia

Edurne San Jose, Naroa Gimenez-Camino, Obdulia Rabal, Estibaliz Miranda, Leire Garate, Fernando Garcia, Ana Alfonso Pierola, MD PhD, Sara Villar, Jose J. Rifon Roca, MD, Antonio Pineda-Lucena, Bruno Paiva, PhD, Javier Muñoz, Jesús San-Miguel, Julen Oyarzabal, PhD, Xabier Agirre, PhD, Felipe Prósper, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3762.
https://doi.org/10.1182/blood-2019-125578
Published: 2019
Journal Articles

A Computational Based Approach for Identification and Validation of Gene Mutations As Surrogate Markers of Gene Essentiality in Acute Myeloid Leukemia

Fernando Carazo, Edurne San Jose, Leire Garate, Estibaliz Miranda, Ana Alfonso Pierola, MD PhD, Sara Villar, Jose J. Rifon Roca, MD, Bruno Paiva, PhD, Jesús San-Miguel, Xabier Agirre, PhD, Felipe Prósper, MD PhD, Angel Rubio
Journal: Blood
Blood (2019) 134 (Supplement_1): 1414.
https://doi.org/10.1182/blood-2019-126506
Published: 2019
Journal Articles

Transcriptomic Profiling of Circulating Tumor Cells (CTCs) in Multiple Myeloma (MM): A New Model to Understand Disease Dissemination

Juan José Garcés, Michal Šimíček, Marco Vicari, Lucie Brozova, MSc, Leire Burgos, Renata Bezděková, MSc., Diego Alignani, PhD, Maria Jose Calasanz, BSc, PhD, Katerina Growkova, Ludek Pour, MD, Rafael Rios, MD PhD, Joaquin Martinez-Lopez, MD PhD, Pamela Millacoy, Luis Palomera, MD PhD, Rafael Del Orbe, Sonia Garate, Laura Blanco, Patricia Maiso, PhD, Zuzana Chyra, Alexander Vdovin, Tomas Jelinek, Cirino Botta, MD, Halima El Omri, Xabier Agirre, PhD, Felipe Prosper, MD PhD, Roman Hajek, MD PhD, Jesus F San-Miguel, MD PhD, Bruno Paiva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 245.
https://doi.org/10.1182/blood-2018-99-113331
Published: 2018
Journal Articles

ZFP36L1, a Novel Potential Tumor Supressor Gene in Myelofibrosis, Epigenetically Deregulated By Methylation of the Enhancer Region

Nicolas Martinez-Calle, MD MSc, Marien Pascual, PhD, Raquel Ordoñez, MSc, Edurne San Jose Eneriz, PhD, Victor Segura, PhD, Giancarlo Castellano, PhD, Jose J. Rifon, MD, Maria Jose Calasanz, BSc, PhD, José I. Martin-Subero, PhD, Xabier Agirre, PhD, Felipe Prosper, MDPhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2936.
https://doi.org/10.1182/blood.V130.Suppl_1.2936.2936
Published: 2017
Journal Articles

Whole-Genome Analysis of the Chromatin Structure in Multiple Myeloma

Marta Kulis, Raquel Ordoñez, Nuria Russiñol, Renée Beekman, Núria Verdaguer-Dot, Teresa Ezponda, Arantxa Carrasco, Joost H.A. Martens, Hendrik G. Stunnenberg, Bruno Paiva, PhD, Jesus San Miguel, MDPhD, Elias Campo, Felipe Prosper, MD, Xabier Agirre, PhD, José I. Martin-Subero
Journal: Blood
Blood (2016) 128 (22): 118.
https://doi.org/10.1182/blood.V128.22.118.118
Published: 2016
Journal Articles

The Presence of MDS-like Phenotypic Abnormalities (MDS-PA) Identifies Newly Diagnosed Multiple Myeloma (MM) Patients with MDS/AML-Related Somatic Mutations and Inferior Survival

Bruno Paiva, PhD, Noemi Puig, MD PhD, Maria Teresa Cedena, Iria Vazquez, PhD, Carmen Chillon, Yanira Ruiz, Joaquin Martinez-Lopez, Ramon Garcia-Sanz, Marcos González, MD PhD, Xabier Agirre, PhD, Maria-Jose Calasanz, Leire Burgos, Diego Alignani, Felipe Prosper, MD, Sergio Matarraz, Alberto Orfao, MD PhD, Albert Oriol, MD, Ana Isabel Teruel, MD, M Asuncion Echeveste, Raquel De Paz, PhD, Felipe De Arriba, Miguel-T Hernandez, Gemma Azaceta, MD PhD, Rafael Martinez, MD, Maria-Victoria Mateos, MD PhD, Joan Bladé, Juan José Lahuerta, MD PhD, Jesus San Miguel, MDPhD
Journal: Blood
Blood (2016) 128 (22): 375.
https://doi.org/10.1182/blood.V128.22.375.375
Published: 2016
Journal Articles

Targeting ß -Catenin Signaling in DLBCL with ICG-001 and PAM-1 Suppresses Cell Proliferation and Induces Apoptosis

Angela A. Fachel, PhD, Ashlesha Shrikant Muley, MS, Cem Meydan, PhD, Xabier Agirre, PhD, Leandro Cerchietti, MD, Ari Melnick, MD, Kristy L. Richards, PhD MD
Journal: Blood
Blood (2016) 128 (22): 5382.
https://doi.org/10.1182/blood.V128.22.5382.5382
Published: 2016
Journal Articles

Non-Invasive Genetic Profiling Is Highly Applicable in Multiple Myeloma (MM) through Characterization of Circulating Tumor Cells (CTCs)

Leire Burgos, Diego Alignani, Juan-Jose Garces, Lourdes Ortiz, Tomas Jelinek, MD, Victor Segura, PhD, Luzalba Sanoja, Maria-Jose Calasanz, Xabier Agirre, PhD, Felipe Prosper, MD, Paula Rodriguez-Otero, MD PhD, Rafael Rios, Joaquin Martinez-Lopez, Luis Palomera, MD PhD, Maria Teresa Zudaire, Rafael Del Orbe, MD, Jacques J.M. van Dongen, MD PhD, Alberto Orfao, MD PhD, Bruno Paiva, PhD, Jesus San Miguel, MD PhD
Journal: Blood
Blood (2016) 128 (22): 801.
https://doi.org/10.1182/blood.V128.22.801.801
Published: 2016
Journal Articles

Long Non-Coding RNAs Annotation and Their Involvement in Multiple Myeloma

Arantxa Carrasco, Teresa Ezponda, Cem Meydan, PhD, Marta Kulis, Raquel Ordoñez, Leire Garate, Victor Segura, PhD, Diego Alignani, Bruno Paiva, PhD, Jesus San Miguel, MD PhD, José I. Martin Subero, PhD, Ari Melnick, MD, Felipe Prosper, MD, Xabier Agirre, PhD
Journal: Blood
Blood (2016) 128 (22): 4420.
https://doi.org/10.1182/blood.V128.22.4420.4420
Published: 2016
Journal Articles

Genomic Profiles of Bone Marrow (BM) Clonal Plasma Cells (PCs) Vs Circulating Tumor Cells (CTCs) and Extramedullary (EM) Plasmacytomas in Multiple Myeloma (MM)

Gabriel Bretones, Bruno Paiva, PhD, Rafael Valdes-Mas, Diego Alignani, Miguel Garcia, Leire Burgos, Diana Alvarez Puente, Xabier Agirre, PhD, Felipe Prosper, MD, Carlos Lopez-Otin, Jesus San Miguel, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4442.
https://doi.org/10.1182/blood.V128.22.4442.4442
Published: 2016
Journal Articles

Crebbp Mutations Disrupt Dynamic Enhancer Acetylation in B-Cells, Enabling HDAC3 to Drive Lymphomagenesis

Hsia-Yuan Ying, PhD, Yanwen Jiang, PhD, Ana Ortega-Molina, PhD, Huimin Geng, PhD, Dylan McNally, B.S., Ling Wang, M.S., Ashley Doane, B.S., Xabier Agirre, PhD, Haiying Ju, MS, David Poloway, B.S., Matt Teater, M.S., Sara Parsa, PhD, Daisuke Ennishi, David W Scott, MBChB, PhD, Rita Shaknovich, MD PhD, Randy D. Gascoyne, Wayne Tam, MD PhD, Olivier Elemento, PhD, Hans-Guido Wendel, MD, Ari Melnick, MD
Journal: Blood
Blood (2016) 128 (22): 735.
https://doi.org/10.1182/blood.V128.22.735.735
Published: 2016
Journal Articles

Characterization of DLBCL-Derived Exosomes and Investigation of Their Biological Properties

Sarah C. Rutherford, MD, Seema Sawh, Ashish Saxena, MD PhD, Jennifer Ishii, Maria D. Dominguez, PhD, Nyasha Chambwe, PhD, Eloisi Caldas Lopes, PhD, Xabier Agirre, PhD, Doron Betel, PhD, Rita Shaknovich, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3021.
https://doi.org/10.1182/blood.V124.21.3021.3021
Published: 2014
Journal Articles

Inhibition of the Methyltransferase G9a with Small Molecules As a New Therapeutic Strategy for Treatment of Hematological Malignancies

Edurne San José-Enériz, PhD, Xabier Agirre, PhD, Obdulia Rabal, PhD, Sergio Roa, PhD, Amaia Vilas-Zornoza, PhD, Estíbaliz Miranda, Ana Ugarte, PhD, Juan Antonio Sanchez-Arias, PhD, Bruno Paiva, PhD, Jesus F. San Miguel, Jose A. Martinez-Climent, MD PhD, Julen Oyarzabal, PhD, Felipe Prosper, MD
Journal: Blood
Blood (2014) 124 (21): 3532.
https://doi.org/10.1182/blood.V124.21.3532.3532
Published: 2014
Journal Articles

Whole-Genome Epigenomic Analysis in Multiple Myeloma Reveals DNA Hypermethylation of B-Cell Specific Enhancers

Xabier Agirre, PhD, Giancarlo Castellano, Marien Pascual, Simon Health, Marta Kulis, Victor Segura, PhD, Anke Bergmann, Anna Esteve, Angelika Merkel, Emanuele Raineri, Lidia Agueda, Julie Blanc, David Richardson, Laura Clarke, Nuria Russiñol, Ana C. Queirós, Renée Beekman, Juan R. Rodriguez-Madoz, Edurne San José-Enériz, PhD, Fang Fang, Norma Carmen Gutierrez, PhD MD, José M García-Verdugo, Michael I. Robson, Eric C. Schirmer, Elisabeth Guruceaga, Joost H.A. Martens, Marta Gut, María José Calasanz, PhD, Paul Flicek, Reiner Siebert, Elias Campo, MD PhD, Jesus F. San Miguel, Ari M Melnick, MD, Hendrik G. Stunnenberg, Ivo G. Gut, Felipe Prosper, MD, Jose Ignacio Martín-Subero
Journal: Blood
Blood (2014) 124 (21): 2032.
https://doi.org/10.1182/blood.V124.21.2032.2032
Published: 2014
Journal Articles

Preclinical Activity of LBH589 Alone or in Combination with Chemotherapy in a Xenogeneic Mouse Model of Human Acute Lymphoblastic Leukemia

Xabier Agirre, PhD, Amaia Vilas-Zornoza, PhD, Gloria Abizanda, Cristina Moreno, Victor Segura, PhD, Alba De Martino Rodriguez, Edurne San José-Enériz, Estíbaliz Miranda, José Ignacio Martín-Subero, Leire Garate, María J. Blanco-Prieto, José A. García de Jalón, Jose J. Rifon, MD, Jose A Martinez-Climent, MD, PhD, Juan Cruz Cigudosa, José Román-Gómez, Maria José Calasanz, PhD, Josep-Maria Ribera, MD, PhD, Felipe Prosper, MD
Journal: Blood
Blood (2011) 118 (21): 1520.
https://doi.org/10.1182/blood.V118.21.1520.1520
Published: 2011