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Wolfgang Jahnke
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Journal Articles

Structural and Biochemical Studies Confirming the Mechanism of Action of Asciminib, an Agent Specifically Targeting the ABL Myristoyl Pocket (STAMP)

Peter Schuld, PhD, Stephan Grzesiek, PhD, Johannes Schlotte, Judith M Habazettl, PhD, Wolfgang Jahnke, PhD, Louise Barys, MS, Sandra W Cowan-Jacob, PhD, Alice Loo, MS, Andrea Wiget, Paul W. Manley, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 34–35.
https://doi.org/10.1182/blood-2020-140968
Published: 2020
Journal Articles

ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myeloid Leukemia

Andrew Wylie, PhD, Joseph Schoepfer, Giuliano Berellini, Hongbo Cai, Giorgio Caravatti, Simona Cotesta, Stephanie Dodd, Jerry Donovan, Bernhard Erb, Pascal Furet, Geeti Gangal, Robert Grotzfeld, Quamrul Hassan, Tami Hood, Varsha Iyer, Sandra Jacob, Wolfgang Jahnke, Franco Lombardo, Alice Loo, Paul W. Manley, Ph. D., Andreas Marzinzik, Michael Palmer, Xavier Pelle, Bahaa Salem, Sreenath Sharma, Sanjeev Thohan, Suzanne Zhu, Nicholas Keen, Lilli Petruzzelli, MDPhD, K. Gary Vanasse, MD, William R Sellers, MD
Journal: Blood
Blood (2014) 124 (21): 398.
https://doi.org/10.1182/blood.V124.21.398.398
Published: 2014
Journal Articles

Nilotinib, in Comparison to Both Dasatinib and Imatinib, Possesses a Greatly Prolonged Residence Time When Bound to the BCR-ABL Kinase SH1 Domain

Paul W. Manley, Ph. D., Sandra W. Cowan-Jacob, Gabriele Fendrich, Wolfgang Jahnke, Doriano Fabbro
Journal: Blood
Blood (2011) 118 (21): 1674.
https://doi.org/10.1182/blood.V118.21.1674.1674
Published: 2011
Journal Articles

Fingolimod (FTY720) Inhibits BCR-ABL Signaling Allosterically by Binding to the Myristate Binding Site

Paul W. Manley, Ph. D., Sandra W. Cowan-Jacob, Robert Cozens, Gabriele Fendrich, Wolfgang Jahnke, Johannes L Roesel, Doriano Fabbro
Journal: Blood
Blood (2011) 118 (21): 2746.
https://doi.org/10.1182/blood.V118.21.2746.2746
Published: 2011
Journal Articles

Bcr-Abl Binding Modes of Dasatinib, Imatinib and Nilotinib: An NMR Study.

Paul W. Manley, Sandra W. Cowan-Jacob, Gabriele Fendrich, André Strauss, Navratna Vapai, Stephan Grzesiek, Wolfgang Jahnke
Journal: Blood
Blood (2006) 108 (11): 747.
https://doi.org/10.1182/blood.V108.11.747.747
Published: 2006