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Journal Articles

Downregulating Notch Counteracts Kras G12D -Induced ERK Activation and Oxidative Phosphorylation in Myeloproliferative Neoplasm

Guangyao Kong, PhD, Yuan-I Chang, PhD, Jingfang Zhang, PhD, Erik A. Ranheim, MD, Xinmin Zhang, Yun Zhou, Yangang Liu, Lan Zhou, MD PhD, Warren S. Pear, MD PhD, Jing Zhang, PhD

Blood (2016) 128 (22): 1565.

https://doi.org/10.1182/blood.V128.22.1565.1565

Published: 2016

Journal Articles

Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling

Russell J.H. Ryan, MD, Jelena Petrovic, PhD, Dylan Rausch, BS, Caleb Lareau, BS, Winston Lee, MD PhD, Laura Donohue, BS, Amanda L. Christie, BS, Shawn Gillespie, BS, Michael J. Kluk, MD PhD, Valentina Nardi, MD, Robert B. Faryabi, PhD, Ephraim P. Hochberg, MD, David M. Weinstock, MD, Bradley E. Bernstein, MD PhD, Jon C. Aster, MD PhD, Warren S. Pear, MD PhD

Blood (2016) 128 (22): 457.

https://doi.org/10.1182/blood.V128.22.457.457

Published: 2016

Journal Articles

Modular Domains within a Super Enhancer Determine Drug Resistance in Leukemia

Yumi Ohtani, PhD, Shuquan Xu, MSc, Jelena Petrovic, Lanwei Xu, MD, Jon C Aster, MDPhD, Warren S. Pear, MD PhD

Blood (2015) 126 (23): 44.

https://doi.org/10.1182/blood.V126.23.44.44

Published: 2015

Journal Articles

Downregulating Notch Signaling in Kras G12D/+ Mice Inhibits Both T-Cell Leukemia and Myeloproliferative Neoplasm in a Cell-Autonomous Manner

Guangyao Kong, PhD, Yuan-I Chang, PhD, Erik A. Ranheim, MD, Yun Zhou, Yangang Liu, Paul Lambert, PhD, Lan Zhou, MD PhD, Pamela Stanley, PhD, Warren S. Pear, MD PhD, Jing Zhang, PhD

Blood (2014) 124 (21): 261.

https://doi.org/10.1182/blood.V124.21.261.261

Published: 2014

Journal Articles

Alternative Super-Enhancer States Determine MYC Sensitivity to Notch and Brd4 Inhibitors in T Lymphoblastic Leukemia/Lymphoma

Hongfang Wang, PhD, Yumi Yashiro-Ohtani, PhD, Chongzhi Zang, PhD, Yinling Joey Wong, MS, Will Bailis, PhD, Birgit Knoechel, MD PhD, Bradley Bernstein, MD PhD, Steve Blacklow, MD PhD, X. Shirley Liu, PhD, Warren S. Pear, MD PhD, Jon C Aster, MD PhD

Blood (2014) 124 (21): 863.

https://doi.org/10.1182/blood.V124.21.863.863

Published: 2014

Journal Articles

Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones

Monique Dail, PhD, Jason Wong, Jessica Lawrence, Daniel O'Connor, Joy Nakitandwe, PhD., Shann-Ching Chen, PhD, Keiko Akagi, Leslie Lee, Jon C. Aster, MD, PhD, Warren S. Pear, MD, PhD, Deepak Sampath, PhD, James R. Downing, MD, Kevin Shannon, MD

Blood (2013) 122 (21): 2677.

https://doi.org/10.1182/blood.V122.21.2677.2677

Published: 2013

Journal Articles

Genome-Wide Analysis of NOTCH1, ETS Family Factors, and RUNX1 Binding in Human T Lymphoblastic Leukemia Cells Reveals Distinct Regulatory Elements

Hongfang Wang, PhD, Chongzhi Zang, Ph.D, Len Taing, Hoifung Wong, Yumi Yashiro-Ohtani, Ph.D., Stephen Blacklow, MD. PhD., Warren S. Pear, MD, PhD, X. Shirley Liu, Ph.D, Jon C Aster, MD, PhD

Blood (2012) 120 (21): 1277.

https://doi.org/10.1182/blood.V120.21.1277.1277

Published: 2012

Journal Articles

Genome-Wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells

Jon C Aster, MD, PhD, Hongfang Wang, Ph.D., James Zou, Yumi Yashiro-Ohtani, Ph.D., Bo Zhao, Ph.D., Eric Johannsen, MD, Jonathan Schug, Ph.D., Stephen C. Blacklow, MD, PhD, Elliott Kieff, MD, PhD, Warren S. Pear, MD, PhD

Blood (2011) 118 (21): 5236.

https://doi.org/10.1182/blood.V118.21.5236.5236

Published: 2011

Journal Articles

Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies

Giovanni Roti, MD.Ph.D, Annie Carlton, B.S., Kenneth N. Ross, Ph.D, Michele Markstein, Ph.D, Kostandin Pajcini, Ph.D, Norbert Perrimon, Ph.D, Andrew L. Kung, MD, PhD, Warren S. Pear, MD, PhD, Stephen C. Blacklow, MD, PhD, Jon C Aster, MD, PhD, Kimberly Stegmaier, MD

Blood (2011) 118 (21): 555.

https://doi.org/10.1182/blood.V118.21.555.555

Published: 2011

Journal Articles

Critical Functions for Notch Dimerization In T Cell Transformation.

Hudan Liu, Ph.D., Anthony Chi, Kelly Arnett, Ph.D., Mark Chiang, MD, PhD, Lanwei Xu, M.D., Olga Shestova, Ph.D., Hongfang Wang, Ph.D., Avinash Bhandoola, M.D., Ph.D., Jon C Aster, MD, PhD, Stephen C. Blacklow, MD, PhD, Warren S. Pear, MD, PhD

Blood (2010) 116 (21): 3647.

https://doi.org/10.1182/blood.V116.21.3647.3647

Published: 2010

Journal Articles

Deletion-Based Mechanisms of Notch1 Activation In T-ALL: Key Roles for RAG Recombinase and A Conserved Internal Translational Start Site In Notch1 .

Jon C Aster, MD, PhD, Todd D Ashworth, Mark Chiang, MD, PhD, Warren S. Pear, MD, PhD, Stephen Blacklow, Michelle Kelliher, Philippe Kastner, Susan Chan

Blood (2010) 116 (21): 3367.

https://doi.org/10.1182/blood.V116.21.3367.3367

Published: 2010

Journal Articles

Essential Role for Mir-181a1/b1 In T-Cell Acute Lymphoblastic Leukemia

Ana Rita Fragoso, PhD, Tin Mao, Song Wang, Steven Schaffert, Hyeyoung Min, Warren S. Pear, MD, PhD, Chang-Zheng Chen

Blood (2010) 116 (21): 470.

https://doi.org/10.1182/blood.V116.21.470.470

Published: 2010

Journal Articles

Notch Signaling Is a Critical Regulator of Allogeneic T Cell Responses Mediating Graft-Versus-Host Disease.

Yi Zhang, MD, PhD, Ashley R Sandy, BS, Jina Wang, Koji Kato, MD, Shan He, Ivy Tran, Gloria Tran Shan, Ann Friedman, Elizabeth Hexner, MD, Stephen G. Emerson, MD, PhD, Warren S. Pear, MD, PhD, Ivan Maillard, MD, PhD

Blood (2009) 114 (22): 230.

https://doi.org/10.1182/blood.V114.22.230.230

Published: 2009

Journal Articles

Divergent Effects of Notch Signaling On Leukemia Stem Cells and Hematopoietic Stem Cells.

Mark Y Chiang, MD, PhD, Olga Shestova, Ph.D., M. Eden Childs, B.A., Candice Romany, Jon Aster, MD, PhD, Warren S. Pear, MD, PhD

Blood (2009) 114 (22): 395.

https://doi.org/10.1182/blood.V114.22.395.395

Published: 2009

Journal Articles

C-Myc, but Not Akt, Can Substitute for Notch in Lymphomagenesis.

Mark Y Chiang, MD, PhD, M. Eden Childs, B.A., Candice Romany, Olga Shestova, Ph.D., Jon Aster, MD, PhD, Warren S. Pear, MD, PhD

Blood (2009) 114 (22): 7.

https://doi.org/10.1182/blood.V114.22.7.7

Published: 2009

Journal Articles

Trib1 and Trib2 but Not Trib3 Degrade C/EBPá and Induce Acute Myelogenous Leukemia

Priya Dedhia, Karen Keeshan, Maria Vega, Sacha Uljon, M.D., Ph.D., Lanwei Xu, Olga Shestova, Candice Romany, Stephen C Blacklow, M.D., Ph.D., Warren S. Pear, MD, PhD

Blood (2008) 112 (11): 2950.

https://doi.org/10.1182/blood.V112.11.2950.2950

Published: 2008

Journal Articles

Runx1 Is Required for Notch-Induced Specification of Megakaryocyte Development from Early Hematopoietic Stem and Progenitor Cells

Melanie G Cornejo, Thomas Mercher, Ph.D, Joseph D. Growney, PhD, Jonathan Jesneck, Ivan Maillard, MD, PhD, Warren S. Pear, MD, PhD, Jon Aster, MD, PhD, D. Gary Gilliland, MD, PhD

Blood (2008) 112 (11): 1370.

https://doi.org/10.1182/blood.V112.11.1370.1370

Published: 2008

Journal Articles

Notch and Leukemia: Lessons from Mouse Models.

Warren S. Pear, MD, PhD

Blood (2008) 112 (11): sci-31.

https://doi.org/10.1182/blood.V112.11.sci-31.sci-31

Published: 2008

Journal Articles

Menin Regulates the Function of Lymphoid Progenitors and Hematopoietic Stem Cells.

Ivan Maillard, MD, PhD, Ya-Xiong Chen, PhD, Anthony T. Tubbs, Olga Shestova, PhD, Warren S. Pear, MD-PhD, Xianxin Hua, MD-PhD

Blood (2007) 110 (11): 1257.

https://doi.org/10.1182/blood.V110.11.1257.1257

Published: 2007

Journal Articles

Notch Signaling Regulates Hematopoietic Stem Cell Homeostasis in the Fetal Liver through a Non-Cell-Autonomous Mechanism.

Ivan Maillard, MD, PhD, Frances High, Olga Shestova, Priya Dedhia, Jonathan A. Epstein, MD, Warren S. Pear, MD-PhD

Blood (2006) 108 (11): 440.

https://doi.org/10.1182/blood.V108.11.440.440

Published: 2006

NARROW

Downregulating Notch Counteracts Kras G12D -Induced ERK Activation and Oxidative Phosphorylation in Myeloproliferative Neoplasm

Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling

Modular Domains within a Super Enhancer Determine Drug Resistance in Leukemia

Downregulating Notch Signaling in Kras G12D/+ Mice Inhibits Both T-Cell Leukemia and Myeloproliferative Neoplasm in a Cell-Autonomous Manner

Alternative Super-Enhancer States Determine MYC Sensitivity to Notch and Brd4 Inhibitors in T Lymphoblastic Leukemia/Lymphoma

Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones

Genome-Wide Analysis of NOTCH1, ETS Family Factors, and RUNX1 Binding in Human T Lymphoblastic Leukemia Cells Reveals Distinct Regulatory Elements

Genome-Wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells

Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies

Critical Functions for Notch Dimerization In T Cell Transformation.

Deletion-Based Mechanisms of Notch1 Activation In T-ALL: Key Roles for RAG Recombinase and A Conserved Internal Translational Start Site In Notch1 .

Essential Role for Mir-181a1/b1 In T-Cell Acute Lymphoblastic Leukemia

Notch Signaling Is a Critical Regulator of Allogeneic T Cell Responses Mediating Graft-Versus-Host Disease.

Divergent Effects of Notch Signaling On Leukemia Stem Cells and Hematopoietic Stem Cells.

C-Myc, but Not Akt, Can Substitute for Notch in Lymphomagenesis.

Trib1 and Trib2 but Not Trib3 Degrade C/EBPá and Induce Acute Myelogenous Leukemia

Runx1 Is Required for Notch-Induced Specification of Megakaryocyte Development from Early Hematopoietic Stem and Progenitor Cells

Notch and Leukemia: Lessons from Mouse Models.

Menin Regulates the Function of Lymphoid Progenitors and Hematopoietic Stem Cells.

Notch Signaling Regulates Hematopoietic Stem Cell Homeostasis in the Fetal Liver through a Non-Cell-Autonomous Mechanism.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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