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Journal Articles

Validation of the Bioequivalence of USP Potency Adjusted Porcine, Ovine, and Bovine Heparins

Nausheen Baig, Ahmed Kouta, Walter Jeske, PhD, Debra Hoppensteadt, PhD, Jeanine Walenga, PhD, Omer Iqbal, MD, Fakiha Siddiqui, Mamdouh Bakhos, MD, Jawed Fareed, PhD

Blood (2020) 136 (Supplement 1): 6.

https://doi.org/10.1182/blood-2020-142861

Published: 2020

Journal Articles

Assay Dependent Reversal of the Oral and Parenteral Anti-Xa Agents By Andexanet Alfa

Fakiha Siddiqui, Debra Hoppensteadt, PhD, Jeanine Walenga, PhD, Walter Jeske, PhD, Alfonso J Tafur, MD MS, Eduardo Ramacciotti, PhD MD, Jawed Fareed, PhD

Blood (2020) 136 (Supplement 1): 39–40.

https://doi.org/10.1182/blood-2020-142653

Published: 2020

Journal Articles

Andexanet Alpha Differentially Neutralizes the Anticoagulant, Antiprotease and Thrombin Generation Inhibitory Effects of Unfractionated Heparin, Enoxaparin and Fondaparinux

Fakiha Siddiqui, Alfonso J Tafur, MD MS, Debra Hoppensteadt, PhD, Jeanine Walenga, PhD, Walter Jeske, PhD, Emily Bontekoe, Ahmed Kouta, Jawed Fareed, PhD

Blood (2019) 134 (Supplement_1): 1158.

https://doi.org/10.1182/blood-2019-127072

Published: 2019

Journal Articles

Differential Neutralization of Apixaban, Betrixaban, Edoxaban, and Rivaroxaban By Andexanet Alfa As Measured By Whole Blood Thromboelastographic Analysis

Siddharth Mehrotra, Debra Hoppensteadt, PhD, Walter Jeske, PhD, Omer Iqbal, MD, Alfonso J Tafur, MD MS, Bruce Lewis, Jawed Fareed, PhD

Blood (2019) 134 (Supplement_1): 1155.

https://doi.org/10.1182/blood-2019-131907

Published: 2019

Journal Articles

Potency Equated Porcine and Bovine Mucosal Heparin Are Bioequivalent in Terms of Biochemical and Pharmacological Effects

Nausheen Baig, Ahmed Kouta, Fakiha Siddiqui, Ambar Farooqui, Debra Hoppensteadt, PhD, Walter Jeske, PhD, Omer Iqbal, MD, Cassie Bacher, Sharan Krishnappan, Jawed Fareed, PhD

Blood (2019) 134 (Supplement_1): 3665.

https://doi.org/10.1182/blood-2019-126075

Published: 2019

Journal Articles

Prothrombinase Induced Clotting Time Is More Sensitive then aPTT and PT and Can be Used for the Monitoring of Anti-Xa Agents in Whole Blood and Plasma

Debra Hoppensteadt, PhD, Emily Bontekoe, Fakiha Siddiqui, Ambar Farooqui, Omer Iqbal, MD, Walter Jeske, PhD, Jeanine Walenga, PhD, Alfonso J Tafur, MD MS, Jawed Fareed, PhD

Blood (2019) 134 (Supplement_1): 3374.

https://doi.org/10.1182/blood-2019-131221

Published: 2019

Journal Articles

Bovine Heparin Demonstrates the Same Interaction with HIT Antibodies As Porcine Heparin

Jeanine Walenga, PhD, Walter Jeske, PhD, Sabrina Bertini, Giulia Risi, Michelle Sung, BS, Ambar Farooqui, Cassie Bacher, Debra Hoppensteadt, PhD, Omer Iqbal, MD, Bruce Lewis, Mamdouh Bakhos, MD

Blood (2019) 134 (Supplement_1): 2351.

https://doi.org/10.1182/blood-2019-127304

Published: 2019

Journal Articles

Comparative Studies on the Interaction of Unfractionated Heparin and Sulodexide with Functional Anti-Heparin Platelet Factor 4 Antibodies

Ambar Farooqui, Debra Hoppensteadt, PhD, Omer Iqbal, MD, Cassie Bacher, Jeanine Walenga, PhD, Ahmed Kouta, Walter Jeske, PhD, Bruce Lewis, Jawed Fareed, PhD

Blood (2019) 134 (Supplement_1): 2446.

https://doi.org/10.1182/blood-2019-131825

Published: 2019

Journal Articles

USP Potency Adjusted Bovine Mucosal Heparins (BMH) Are Comparable to Porcine Mucosal Heparin (PMH) at Equivalent Levels

Ahmed Kouta, Walter Jeske, PhD, Rick Duff, Debra Hoppensteadt, PhD, Omer Iqbal, MD, Jawed Fareed, PhD

Blood (2019) 134 (Supplement_1): 165.

https://doi.org/10.1182/blood-2019-131943

Published: 2019

Journal Articles

Factor Xa Inhibitory Profile of Apixaban, Betrixaban, Edoxaban and Rivaroxaban Does Not Fully Reflect Their Biologic Spectrum

Fakiha Siddiqui, Siddharth Mehrotra, Vishnu Venkitasubramony, Rithik Raina, Lorenzo Storino Ramacciotti, Jack Bontekoe, BS, Omer Iqbal, MD, Debra Hoppensteadt, PhD, Walter Jeske, PhD, Jawed Fareed, PhD

Blood (2018) 132 (Supplement 1): 2520.

https://doi.org/10.1182/blood-2018-99-116993

Published: 2018

Journal Articles

Comparing a New Bovine Source Heparin to the Clinically Used Porcine Heparin for Platelet Function Effects and Heparin-Induced Thrombocytopenia Potential

Michelle Sung, BS, Jeanine Walenga, PhD, Walter Jeske, PhD, Omer Iqbal, MD, Mamdouh Bakhos, MD

Blood (2018) 132 (Supplement 1): 2540.

https://doi.org/10.1182/blood-2018-99-118781

Published: 2018

Journal Articles

Bovine Heparin Compared to Porcine Heparin to Demonstrate Bioequivalence

Marco Khiella, Walter Jeske, PhD, Jeanine Walenga, PhD, Omer Iqbal, MD, Rajan Laddu, Fakiha Siddiqui, Mamdouh Bakhos, MD

Blood (2018) 132 (Supplement 1): 1253.

https://doi.org/10.1182/blood-2018-99-118809

Published: 2018

Journal Articles

Comparison of Ufh and Enoxaparin Originated from Bovine, Ovine and Porcine Mucosa with Functional Coagulation Assays

Grigorios T. Gerotziafas, MD PhD, Patrick Van Dreden, PhD, Walter Jeske, PhD, Jeanine M. Walenga, PhD, Debra Hoppensteadt, PhD, Annette Larsen, Ismail Elalamy, MD PhD, Yiming Yao, Jawed Fareed, PhD

Blood (2016) 128 (22): 5020.

https://doi.org/10.1182/blood.V128.22.5020.5020

Published: 2016

Journal Articles

Porcine and Ovine Mucosal Heparins and Their Depolymerized Derivatives Are Comparable in Contrast to Their Bovine Equivalents

Olivia Bouchard, Debra Hoppensteadt, PhD, Paula Maia, Alice Silva de Castro, Emmanuele Kumar, Nil Guler, MD, Walter Jeske, PhD, Daniel Kahn, BS, Jeanine M. Walenga, PhD, Erwin Coyne, Yimng Yao, Jawed Fareed, PhD

Blood (2016) 128 (22): 5027.

https://doi.org/10.1182/blood.V128.22.5027.5027

Published: 2016

Journal Articles

Down-Regulation of Protein C Pathway Associated with Increased Inflammation in Patients with Implanted Ventricular Assist Devices As a Potential Cause of Pump Thrombosis

Tania Torres, MS, BA, Jeanine M. Walenga, PhD, Walter Jeske, PhD, Vicki Escalante, BS, Erin Coglianese, MD, Jeffrey Schwartz, MD, Mamdouh Bakhos, MD

Blood (2016) 128 (22): 4995.

https://doi.org/10.1182/blood.V128.22.4995.4995

Published: 2016

Journal Articles

Identification & Characterization of Novel Hemostatic Biomarkers of Adverse Clinical Events in Patients with Continuous Flow Left Ventricular Assist Device Implants

Nathan McClane, Walter Jeske, PhD, Jeanine M. Walenga, PhD, Vicki Escalante, BS, Erin Coglianese, MD, Debra Hoppensteadt, PhD, Jeffrey Schwartz, MD, Mamdouh Bakhos, MD

Blood (2016) 128 (22): 4997.

https://doi.org/10.1182/blood.V128.22.4997.4997

Published: 2016

Journal Articles

Activated Immune Response in Ventricular Assist Device Implanted Patients Identified through a Platelet Activation Biomarker

Walter Jeske, PhD, Jeanine M. Walenga, PhD, Tania Torres, MS, BA, Vicki Escalante, BS, Jeffrey Schwartz, MD, Mamdouh Bakhos, MD

Blood (2016) 128 (22): 5001.

https://doi.org/10.1182/blood.V128.22.5001.5001

Published: 2016

Journal Articles

Comparative Studies on the Anticoagulant Actions of Recombinant Thrombomodulin and Heparin and Their Neutralization By FEIBA As Measured By Thromboelastography

Parul Aggarwal, Zafar Siddiqui, Omer Iqbal, MD, Walter Jeske, PhD, Debra Hoppensteadt, PhD, Kazuhisa Tsuruta, PhD, Jawed Fareed, PhD, Mary Lewis

Blood (2016) 128 (22): 2608.

https://doi.org/10.1182/blood.V128.22.2608.2608

Published: 2016

Journal Articles

Idarucizumab, a Specific Antidote for Dabigatran, Cross-Reacts with Melagatran and May Also Interact with Other Benzamidine-Containing Compounds

Jawed Fareed, PhD, Larissa Reikensmeyer, Amanda Walborn, BS, Debra Hoppensteadt, PhD, Jeanine M. Walenga, PhD, Eduardo Ramacciotti, MD, Schuharazad Abro, MD, Walter Jeske, PhD, Olivia Bouchard, Ismail Elalamy, MD PhD

Blood (2016) 128 (22): 3836.

https://doi.org/10.1182/blood.V128.22.3836.3836

Published: 2016

Journal Articles

Cellular and Functional Characterization of Microparticles in Sepsis-Associated Coagulopathy

A. Kathleen Hesselton, Michael Mosier, Debra Hoppensteadt, PhD, Walter Jeske, PhD, Jawed Fareed, PhD

Blood (2015) 126 (23): 2297.

https://doi.org/10.1182/blood.V126.23.2297.2297

Published: 2015

NARROW

Validation of the Bioequivalence of USP Potency Adjusted Porcine, Ovine, and Bovine Heparins

Assay Dependent Reversal of the Oral and Parenteral Anti-Xa Agents By Andexanet Alfa

Andexanet Alpha Differentially Neutralizes the Anticoagulant, Antiprotease and Thrombin Generation Inhibitory Effects of Unfractionated Heparin, Enoxaparin and Fondaparinux

Differential Neutralization of Apixaban, Betrixaban, Edoxaban, and Rivaroxaban By Andexanet Alfa As Measured By Whole Blood Thromboelastographic Analysis

Potency Equated Porcine and Bovine Mucosal Heparin Are Bioequivalent in Terms of Biochemical and Pharmacological Effects

Prothrombinase Induced Clotting Time Is More Sensitive then aPTT and PT and Can be Used for the Monitoring of Anti-Xa Agents in Whole Blood and Plasma

Bovine Heparin Demonstrates the Same Interaction with HIT Antibodies As Porcine Heparin

Comparative Studies on the Interaction of Unfractionated Heparin and Sulodexide with Functional Anti-Heparin Platelet Factor 4 Antibodies

USP Potency Adjusted Bovine Mucosal Heparins (BMH) Are Comparable to Porcine Mucosal Heparin (PMH) at Equivalent Levels

Factor Xa Inhibitory Profile of Apixaban, Betrixaban, Edoxaban and Rivaroxaban Does Not Fully Reflect Their Biologic Spectrum

Comparing a New Bovine Source Heparin to the Clinically Used Porcine Heparin for Platelet Function Effects and Heparin-Induced Thrombocytopenia Potential

Bovine Heparin Compared to Porcine Heparin to Demonstrate Bioequivalence

Comparison of Ufh and Enoxaparin Originated from Bovine, Ovine and Porcine Mucosa with Functional Coagulation Assays

Porcine and Ovine Mucosal Heparins and Their Depolymerized Derivatives Are Comparable in Contrast to Their Bovine Equivalents

Down-Regulation of Protein C Pathway Associated with Increased Inflammation in Patients with Implanted Ventricular Assist Devices As a Potential Cause of Pump Thrombosis

Identification & Characterization of Novel Hemostatic Biomarkers of Adverse Clinical Events in Patients with Continuous Flow Left Ventricular Assist Device Implants

Activated Immune Response in Ventricular Assist Device Implanted Patients Identified through a Platelet Activation Biomarker

Comparative Studies on the Anticoagulant Actions of Recombinant Thrombomodulin and Heparin and Their Neutralization By FEIBA As Measured By Thromboelastography

Idarucizumab, a Specific Antidote for Dabigatran, Cross-Reacts with Melagatran and May Also Interact with Other Benzamidine-Containing Compounds

Cellular and Functional Characterization of Microparticles in Sepsis-Associated Coagulopathy

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American Society of Hematology

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American Society of Hematology

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