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Vivian Ruvolo, PhD
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Journal Articles

Inhibition of Translation Initiation and Heat Shock Factor 1 (HSF1): A Novel Strategy Targeting FLT3 Double Mutant and Non-FLT3 Mutant AML Progenitor/Stem Cells

Jo Ishizawa, MD PhD, Ran Zhao, Lauren Heese, Alex Jaeger, PhD, Yuki Nishida, Rodrigo Jacamo, PhD, Kensuke Kojima, MD PhD, Man Chun John MA, PhD, Vivian Ruvolo, PhD, Dhruv Chachad, R. Eric Davis, MD, William Devine, PhD, John A Porco, Jr., PhD, Luke Whitesell, MD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2637.
https://doi.org/10.1182/blood.V130.Suppl_1.2637.2637
Published: 2017
Journal Articles

Galectin 3 Protein Network Analysis By Reverse Protein Arrays Demonstrates Regulation of MCL-1, PKC Delta and CD74 Associated with Poor Survival in Patients with AML

Peter P. Ruvolo, PhD, Chenyue Hu, Yihua Qiu, Vivian Ruvolo, PhD, Kevin R Coombes, Amina Qutub, Michael Andreeff, MD PhD, Steven Kornblau, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1395.
https://doi.org/10.1182/blood.V130.Suppl_1.1395.1395
Published: 2017
Journal Articles

Robust Bioinformatics Approach for Identifying Novel AML LSC Targets: Putative Role of Galectin-1 in the Immune-Microenvironment

Shelley Herbrich, MS, Peter P. Ruvolo, PhD, Vivian Ruvolo, PhD, Keith Baggerly, PhD, Gheath Alatrash, DO, PhD, Michael Andreeff, MD PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3962.
https://doi.org/10.1182/blood.V130.Suppl_1.3962.3962
Published: 2017
Journal Articles

Novel Oxidative Phosphorylation Inhibitor IACS-010759 Induces AMPK-Dependent Apoptosis of AML Cells

Haeun Yang, Yoko Tabe, MD PhD, Kazumasa Sekihara, PhD, Kaori Saito, Helen Ma, MS, Vivian Ruvolo, PhD, Junichi Imoto, Kazuho Ikeo, PhD, Kaoru Mogushi, PhD, Masaki Hosoya, Yoshihide Hayashizaki, MD PhD, Yasunari Yamanaka, MD PhD, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Joseph R Marszalek, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1245.
https://doi.org/10.1182/blood.V130.Suppl_1.1245.1245
Published: 2017
Journal Articles

Bone Marrow Stromal Cells Induce ALDH+ Stem Cell Phenotype and Chemotherapy Resistance in AML Cells through TGF-β1 Mediated Signaling: Reversal By TGFβ Inhibitor Galunisertib

Ximin Zhou, Bin Yuan, Yuanqing Yan, Khoa Nguyen, Vivian Ruvolo, PhD, Hong Mu, MD PhD, Teresa McQueen, MS, Elizabeth J Shpall, MD, Kim-Ann Do, Marina Konopleva, MD PhD, Michael Andreeff, MD PhD, Venkata Lokesh Battula, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1163.
https://doi.org/10.1182/blood.V130.Suppl_1.1163.1163
Published: 2017
Journal Articles

BRD4 Proteolysis Targeting Chimera (PROTAC) ARV-825 Targets Both NOTCH1-MYC Regulatory Circuit and Leukemia-Microenvironment in T-ALL

Sujan Piya, PhD, Hong Mu, MD PhD, Seemana Bhattacharya, PhD, Teresa McQueen, MS, Richard E Davis, BSPharm, MS, Vivian Ruvolo, PhD, Natalia Baran, PhD MD, Yimin Qian, PhD, Kanak Raina, PhD, Craig M Crews, PhD, M. James You, MD PhD, Patrick Zweider McKay, MDPhD, Marina Konopleva, MD PhD, Hagop M. Kantarjian, MD, Michael Andreeff, MD PhD, Gautam Borthakur, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 716.
https://doi.org/10.1182/blood.V130.Suppl_1.716.716
Published: 2017
Journal Articles

Novel ARC//IL1β/PGE2/β-Catenin/ARC Circuit Regulates Leukemia and Leukemia Microenvironment and Drug Resistance in AML

Bing Z Carter, PhD, Po Yee Mak, Xiangmeng Wang, PhD, Hong Mu, MD PhD, Wenjing Tao, PhD, Vivian Ruvolo, PhD, Michael Andreeff, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3776.
https://doi.org/10.1182/blood.V130.Suppl_1.3776.3776
Published: 2017
Journal Articles

Inhibition of FAO in AML Co-Cultured with BM Adipocytes: Mechanisms of Survival and Chemosensitization to Cytarabine

Yoko Tabe, MD PhD, Kazumasa Sekihara, PhD, Haeun Yang, Kaori Saito, Vivian Ruvolo, PhD, Hikari Taka, Naoko Kaga, Takashi Miida, MD PhD, Michael Andreeff, MD PhD, Paul A. Spagnuolo, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3832.
https://doi.org/10.1182/blood.V130.Suppl_1.3832.3832
Published: 2017
Journal Articles

The Novel Imipridone ONC212 Induces Pronounced Anti-Leukemia Effects in Vitro and In Vivo and Is Highly Synergistic with the BCL-2 Inhibitor ABT-199

Takenobu Nii, PhD, Jo Ishizawa, MD PhD, Varun Vijay Prabhu, BPharm, MS, PhD, Vivian Ruvolo, PhD, Neel Madhukar, Ran Zhao, Hong Mu, MD PhD, Lauren Heese, Kensuke Kojima, MD PhD, Mathew Garnett, Ultan McDermott, Cyril H Benes, Neil Charter, Sean Deacon, Olivier Elemento, PhD, Joshua E. Allen, PhD, Wolfgang Oster, MD, Martin Stogniew, Michael Andreeff, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2616.
https://doi.org/10.1182/blood.V130.Suppl_1.2616.2616
Published: 2017