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Toshihiko Imamura, MD PhD
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Journal Articles

NUTM1 -Rearranged Infant and Pediatric B Cell Precursor Acute Lymphoblastic Leukemia: A Good Prognostic Subtype Identified in a Collaborative International Study

Judith M. Boer, PhD, Maria Grazia Valsecchi, PhD, Femke M. Hormann, MSc, Zeljko Antic, MD, Marketa Zaliova, MD PhD, Claire Schwab, PhD, Giovanni Cazzaniga, PhD, Chloé Arfeuille, MD, Hélène Cavé, PharmD, PhD, Andishe Attarbaschi, MD, Sabine Strehl, PhD, Gabriele Escherich, MD, Toshihiko Imamura, MD PhD, Kentaro Ohki, MD PhD, Tanja A. Gruber, MD PhD, Rosemary Sutton, BSc MSc PhD, Agata Pastorczak, Tim Lammens, PhD, Frederic Lambert, MD, Chi Kong Li, MD, Enrique Carrillo de Santa Pau, PhD, Steve Hoffmann, MD PhD, Anja Möricke, MD, Christine J. Harrison, PhD FRCPath, Monique L. Den Boer, PhD, Paola De Lorenzo, Ronald W. Stam, PhD, Anke K. Bergmann, MD PhD, Rob Pieters, MDPhDMSc
Journal: Blood
Blood (2020) 136 (Supplement 1): 25–26.
https://doi.org/10.1182/blood-2020-139376
Published: 2020
Journal Articles

Comprehensive Genetic Analysis Revealed Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia As a Novel Distinctive Leukemia Entity

Akira Nishimura, MD, Kazuaki Yokoyama, MD PhD, Chika Yamagishi, MD, Toshihiko Imamura, MD PhD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Yukie Tanaka, PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Naoko Higuchi, MD, Akiko Takada, MD, Haruna Okuno, MD, Shoji Saito, MD PhD, Shuhei Karakawa, MD PhD, Shogo Kobayashi, MD, Daisuke Hasegawa, MD PhD, Hiroyuki Fujisaki, MD PhD, Daiichiro Hasegawa, MD PhD, Kazutoshi Koike, MD PhD, Takashi Koike, MD, Shinya Rai, MD PhD, Katsutsugu Umeda, MD PhD, Hideki Sano, MD, Yujin Sekinaka, MD PhD, Atsushi Ogawa, MD PhD, Akitoshi Kinoshita, MD PhD, Norio Shiba, MD PhD, Mizuka Miki, MD, Fumihiko Kimura, MD PhD, Hideki Nakayama, MD, Yozo Nakazawa, MD PhD, Takashi Taga, MD PhD, Tomohiko Taki, MD PhD, Souichi Adachi, MD PhD, Atsushi Manabe, MD PhD, Katsuyoshi Koh, MD, Yasushi Ishida, MD PhD, Arinobu Tojo, MD PhD, Masatoshi Takagi, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 14–15.
https://doi.org/10.1182/blood-2020-139312
Published: 2020
Journal Articles

Acute Lymphoblastic Leukemia with Zinc-Finger Protein 384 (ZNF384)-Related Rearrangements: A Retrospective Analysis from the Ponte Di Legno Childhood ALL Working Group

Shinsuke Hirabayashi, Ellie Butler, Kentaro Ohki, MD PhD, Nobutaka Kiyokawa, MD PhD, Anke K. Bergmann, Judith M. Boer, PhD, Hélène Cavé, PharmD, PhD, Giovanni Cazzaniga, Allen Eng Juh Yeoh, Toshihiko Imamura, MD PhD, Hiroto Inaba, MD, Mignon L. Loh, MD, Ulrika Norén-Nyström, MD PhD, Agata Pastorczak, Lee-Yung Shih, MD, Marketa Zaliova, MD PhD, Oskar A Haas, Christine J. Harrison, PhD FRCPath, Anthony V. Moorman, Atsushi Manabe, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 652.
https://doi.org/10.1182/blood-2019-123236
Published: 2019
Journal Articles

Leukemic Cell with a Novel Kinase Fusion Gene SPAG9-JAK2 Exhibits High Sensitivity to Ruxolitinib

Azusa Mayumi, MD, Toshihiro Tomii, MD, Toshihiko Imamura, MD PhD, Machiko Kawamura, MD, Hajime Hosoi, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5044.
https://doi.org/10.1182/blood-2019-126592
Published: 2019
Journal Articles

Clinical Features of Children with Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis in Japan: Retrospective Nationwide Survey

Hisashi Ishida, MD PhD, Takeo Sarashina, MD PhD, Risa Matsumura, Katsutsugu Umeda, MD, PhD, Tetsuo Mitsui, MD PhD, Naoto Fujita, MD PhD, Daisuke Tomizawa, MD PhD, Kevin Y Urayama, PhD MPH, Yasushi Ishida, MD PhD, Takashi Taga, MD PhD, Masatoshi Takagi, MD PhD, Souichi Adachi, MD PhD, Atsushi Manabe, MD PhD, Toshihiko Imamura, MD PhD, Katsuyoshi Koh, MD, Akira Shimada, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2958.
https://doi.org/10.1182/blood-2019-123429
Published: 2019
Journal Articles

NUDT15 Variants Confer High Incidence of Secondary Malignancies of ALL in Children

Masanori Yoshida, MD, Kazuhiko Nakabayashi, PhD, Aiko Sato-Otsubo, PhD, Shinichi Tsujimoto, MD PhD, Kaoru Yoshida, MD, Ryota Shirai, MD, Tomoo Osumi, MD, Yuki Yuza, MD PhD, Masatoshi Takagi, MD PhD, Hiroyuki Takahashi, MD PhD, Katsuyoshi Koh, MD, Akitoshi Kinoshita, MD PhD, Moeko Hino, MD, Toshihiko Imamura, MD PhD, Yozo Nakazawa, MD PhD, Okuya Mayuko, MD PhD, Harumi Kakuda, MD PhD, Masashi Sanada, MD, Kimikazu Matsumoto, MD, PhD, Daisuke Tomizawa, MD PhD, Nobutaka Kiyokawa, MD PhD, Akira Ohara, MD PhD, Atsushi Manabe, MD PhD, Kenichiro Hata, MD PhD, Jun J. Yang, PhD, Motohiro Kato, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2751.
https://doi.org/10.1182/blood-2019-125713
Published: 2019
Journal Articles

Intensive Chemotherapy Along with Aggressive Supportive Care Can Spare Stem Cell Transplantation in a Subset of Patients without Compromising an Outcome in Infants with Acute Lymphoblastic Leukemia; A Report from the Japanese Pediatric Leukemia/Lymphoma Study Group (JPLSG) Trial MLL-10

Daisuke Tomizawa, MD PhD, Takako Miyamura, MD PhD, Toshihiko Imamura, MD PhD, Tomoyuki Watanabe, PhD, Akiko Moriya Saito, MD PhD, Atsushi Ogawa, MD PhD, Yoshihiro Takahashi, MD PhD, Masahiro Hirayama, MD PhD, Yuki Arakawa, MD, Tomohiko Taki, MD PhD, Takao Deguchi, MD PhD, Toshinori Hori, MD PhD, Sakae Omori, PhD, Masami Haba, PhD, Akihiro Iguchi, MD PhD, Yuuki Koga, MD PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Eiichi Ishii, MD PhD, Katsuyoshi Koh, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2626.
https://doi.org/10.1182/blood-2019-121328
Published: 2019
Journal Articles

Outcome of Hematopoietic Stem Cell Transplantation in the Patients with Pediatric Acute Lymphoblastic Leukemia Enrolled in the Japan Association of Childhood Leukemia Study (JACLS) ALL-02

Mio Yano, MD, Hisashi Ishida, MD PhD, Yoshiko Hashii, MD PhD, Asahito Hama, MD PhD, Yoshiyuki Kosaka, MD PhD, Tsukasa Hori, MD PhD, Junichi Hara, MD, PhD, Hiroshi Kawaguchi, MD PhD, Etsuro Ito, MD PhD, Akiko M Saito, MD PhD, Atsushi Sato, MD PhD, Hiroki Hori, MD PhD, Keizo Horibe, MD PhD, Toshihiko Imamura, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4605.
https://doi.org/10.1182/blood-2019-122224
Published: 2019
Journal Articles

Leukemic Cell Expressing a Novel Kinase Fusion Protein NCOR1-LYN Exhibits High Sensitivity to Dasatinib and Rapamycin

Toshihiro Tomii, MD, Toshihiko Imamura, MD PhD, Mio Yano, MD, Kenichi Sakamoto, MD PhD, Itaru Kato, Kuniaki Tanaka, MD, Takashi Mikami, MD, Makiko Morita, PhD, Souichi Adachi, MD PhD, Junko Takita, MD, PhD, Nobutaka Kiyokawa, MD PhD, Keizo Horibe, MD PhD, Hajime Hosoi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1557.
https://doi.org/10.1182/blood-2018-99-111612
Published: 2018
Journal Articles

A Novel PAX5-KIDINS220 Fusion Protein Activates Multiple Signals Associated with Therapeutic Resistance

Takuyo Kanayama, MD, Toshihiko Imamura, MD PhD, Kenichi Sakamoto, MD PhD, Fumihiko Hayakawa, MD, PhD, Akihiko Tanizawa, MD PhD, Nobutaka Kiyokawa, MD PhD, Hajime Hosoi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3928.
https://doi.org/10.1182/blood-2018-99-116022
Published: 2018
Journal Articles

Coagulation and Fibrinolysis Imbalance Demonstrated By Novel Simultaneous Thrombin and Plasmin Generation Assay during L-Asparaginase Treatment Phase of Induction Therapy in Pediatric Acute Lymphoblastic Leukemia

Takashi Ishihara, MD, Keiji Nogami, MD PhD, Satoshi Ochi, MD, Toshiaki Ishida, MD PhD, Yoshiyuki Kosaka, MD PhD, Akihisa Sawada, MD PhD, Masami Inoue, MD, Shinya Osone, MD PhD, Toshihiko Imamura, MD PhD, Hajime Hosoi, MD PhD, Midori Shima, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3972.
https://doi.org/10.1182/blood-2018-99-110411
Published: 2018
Journal Articles

The Prognostic Value of TP53 Mutations Depends on Clinical Backgrounds in Pediatric Patients with Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yusuke Shiozawa, MD, PhD, Yasuhito Nannya, MD PhD, Yuka Iijima-Yamashita, PhD, Nobutaka Kiyokawa, MD PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, PhD, Hiroko Tanaka, BA, Tomoya Isobe, MD, Masafumi Seki, MD,PhD, Shunsuke Kimura, MD, Hideki Makishima, MD PhD, Nobuyuki Kakiuchi, MD, Keisuke Kataoka, MD PhD, Tetsuichi Yoshizato, MD PhD, Hiroyuki Tsukamoto, MD PhD, Dai Nishijima, PhD, Takao Deguchi, MD PhD, Kentaro Ohki, MD PhD, Atsushi Sato, MD, Hiroyuki Takahashi, Yoshiko Hashii, MD, PhD, Sadao Tokimasa, MD, PhD, Junichi Hara, MD, PhD, Yoshiyuki Kosaka, MD PhD, Koji Kato, MD PhD, Takeshi Inukai, MD, Junko Takita, MD, PhD, Toshihiko Imamura, MD PhD, Satoru Miyano, PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Seishi Ogawa, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4077.
https://doi.org/10.1182/blood-2018-99-115617
Published: 2018
Journal Articles

Distribution and Clinical Features of NOTCH1 Signaling Activating Alterations in Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Shunsuke Kimura, MD, Masafumi Seki, MD, PhD, Kenichi Yoshida, MD PhD, Hiroo Ueno, MD, Yasuhito Nannya, MD PhD, Kentaro Ohki, MD PhD, Motohiro Kato, MD PhD, Katsuyoshi Koh, MD, Ryoji Kobayashi, MD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD PhD, Toshihiko Imamura, MD PhD, Atsushi Sato, MD, Nobutaka Kiyokawa, MD PhD, Atsushi Manabe, MD PhD, Keizo Horibe, MD PhD, Akira Ohara, MD, Masashi Sanada, MD PhD, Mitsuteru Hiwatari, MD PhD, Masao Kobayashi, MD PhD, Akira Oka, MD PhD, Satoru Miyano, PhD, Seishi Ogawa, MD PhD, Junko Takita, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4089.
https://doi.org/10.1182/blood-2018-99-111092
Published: 2018
Journal Articles

Negative CD19 Expression Is Associated with Inferior Relapse-Free Survival in RUNX1-RUNX1T1 -Positive Acute Myeloid Leukemia; The Japanese Pediatric Leukemia/Lymphoma Study Group Experience from the AML-05 Study

Toshihiko Imamura, MD PhD, Kenichi Sakamoto, MD PhD, Norio Shiba, MD PhD, Takao Deguchi, MD PhD, Nobutaka Kiyokawa, MD PhD, Yoshiko Hashii, MD, PhD, Akiko Saito, MD, Daisuke Tomizawa, MD PhD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2810.
https://doi.org/10.1182/blood-2018-99-115553
Published: 2018
Journal Articles

Clinical Feature and Genetic Alterations in Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia and Myeloid/NK Cell Acute Leukemia

Akira Nishimura, MD, Kazuaki Yokoyama, MD PhD, Chika Yamagishi, MD, Takuya Naruto, MD PhD, Tomohiro Morio, MD PhD, Akinori Kanai, PhD, Hirotaka Matsui, MD PhD, Naoko Higuchi, MD, Akiko Takada, MD, Haruna Okuno, MD, Shoji Saito, MD, Shuhei Karakawa, MD, Shogo Kobayashi, MD, Hideki Sano, MD, Takashi Koike, MD, Daisuke Hasegawa, MD PhD, Hiroyuki Fujisaki, MD, PhD, Daiichiro Hasegawa, MD PhD, Kazutoshi Koike, MD, Atsushi Ogawa, MD PhD, Akitoshi Kinoshita, MD PhD, Norio Shiba, MD PhD, Mizuka Miki, MD, Hideki Nakayama, MD, Yozo Nakazawa, MD, PhD, Toshihiko Imamura, MD PhD, Takashi Taga, MD PhD, Souichi Adachi, MD PhD, Katsuyoshi Koh, MD, Atsushi Manabe, MD PhD, Tomohiko Taki, MD PhD, Yasushi Ishida, MD PhD, Arinobu Tojo, MD PhD, Masatoshi Takagi, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2824.
https://doi.org/10.1182/blood-2018-99-118627
Published: 2018
Journal Articles

Hematopoietic Stem Cell Transplantation in Children with Refractory Langerhans Cell Histiocytosis

Kazuko Kudo, MD PhD, Miho Maeda, MD, Nobuhiro Suzuki, MD PhD, Hirokazu Kanegane, MD PhD, Shouichi Ohga, MD PhD, Eiichi Ishii, MD PhD, Yoko Shioda, MD, Toshihiko Imamura, MD PhD, Shinsaku Imashuku, MD PhD, Yukiko Tsunematsu, MD, Mikiya Endo, MD, Akira Shimada, MD PhD, Yuuki Koga, MD PhD, Yoshiko Hashii, MD PhD, Jiro Inagaki, MD, Masami Inoue, MD, Ken Tabuchi, MD, Akira Morimoto, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4657.
https://doi.org/10.1182/blood-2018-99-110711
Published: 2018
Journal Articles

Clinical Effect of Genetic Alterations in Pediatric Patients with B-Progenitor Acute Lymphoblastic Leukemia

Hiroo Ueno, MD, Kenichi Yoshida, MD PhD, Yasuhito Nannya, MD PhD, Yuka Iijima-Yamashita, M.S., Yusuke Shiozawa, MD , PhD, Yuichi Shiraishi, PhD, Tomomi Ishida, Keisuke Kataoka, MD PhD, Tetsuichi Yoshizato, MD,PhD, Hideki Makishima, MD PhD, Nobuyuki Kakiuchi, MD, Masafumi Seki, MD,PhD, Hiroko Tanaka, B.A., Kenichi Chiba, B.A., Takao Deguchi, MD PhD, Atsushi Sato, MD, Yoshiko Hashii, MD, PhD, Sadao Tokimasa, MD, PhD, Junichi Hara, MD, PhD, Yoshiyuki Kosaka, MD, PhD, Koji Kato, MD, PhD, Toshihiko Imamura, MD, PhD, Satoru Miyano, PhD, Keizo Horibe, Seishi Ogawa, MD PhD, Masashi Sanada, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3979.
https://doi.org/10.1182/blood.V130.Suppl_1.3979.3979
Published: 2017
Journal Articles

Nationwide Survey of Pediatric Hypodiploid Acute Lymphoblastic Leukemia in Japan

Sae Ishimaru, MD, Yasuhiro Okamoto, MD, Chihaya Imai, MD PhD, Hirotoshi Sakaguchi, MD PhD, Tomohiko Taki, MD PhD, Daisuke Hasegawa, MD PhD, Yuko Cho, MD, Harumi Kakuda, MD PhD, Hideki Sano, MD, Atushi Manabe, MD PhD, Toshihiko Imamura, MD, PhD, Motohiro Kato, MD, Yuki Arakawa, MD, Hidemi Shimonodan, MD, Atsushi Sato, MD, So-ichi Suenobu, MD PhD, Takeshi Inukai, MD, Arata Watanabe, MD, Yoshifumi Kawano, MD PhD, Atsushi Kikuta, MD, Keizo Horibe, Akira Ohara, MD, Katsuyoshi Koh, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5121.
https://doi.org/10.1182/blood.V130.Suppl_1.5121.5121
Published: 2017
Journal Articles

The Epigenetic and Genetic Landscapes of Pediatric T-Cell Acute Lymphoblastic Leukemia (T-ALL)

Shunsuke Kimura, Masafumi Seki, MD,PhD, Tomoko Kawai, PhD, Kenichi Yoshida, MD PhD, Tomoya Isobe, Hiroo Ueno, MD, Yusuke Shiozawa, MD , PhD, Hiromichi Suzuki, MD , PhD, Yuichi Shiraishi, PhD, Kenichi Chiba, B.A., Hiroko Tanaka, B.A., Kentaro Ohki, MD PhD, Motohiro Kato, MD, Katsuyoshi Koh, MD, Ryoji Hanada, MD, Ryoji Kobayashi, MD, Takao Deguchi, MD PhD, Yoshiko Hashii, MD, PhD, Toshihiko Imamura, MD, PhD, Atsushi Sato, MD, Nobutaka Kiyokawa, MD PhD, Atushi Manabe, MD PhD, Keizo Horibe, Akira Ohara, MD, Masashi Sanada, MD PhD, Masao Kobayashi, MD PhD, Akira Oka, MD PhD, Yasuhide Hayashi, MD PhD, Satoru Miyano, PhD, Kenichiro Hata, MD PhD, Seishi Ogawa, MD PhD, Junko Takita, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1444.
https://doi.org/10.1182/blood.V130.Suppl_1.1444.1444
Published: 2017
Journal Articles

The Outcome of Childhood B-Cell Precursor ALL with ETV6-RUNX1 Treated with Japan Association of Childhood Leukemia Study (JACLS) ALL-02 Trial

Ikuya Usami, Toshihiko Imamura, MD, PhD, Yoshihiro Takahashi, MD PhD, So-ichi Suenobu, MD PhD, Daiichiro Hasegawa, MD PhD, Yoshiko Hashii, MD, PhD, Takao Deguchi, MD PhD, Tsukasa Hori, MD PhD, Akira Shimada, MDPhD, Koji Kato, MD, PhD, Etsuro Ito, MD PhD, Akiko Moriya Saito, MD PhD, Hirohide Kawasaki, MD, Hiroki Hori, MD PhD, Keiko Yumura Yagi, MD PhD, Jun-ichi Hara, MD PhD, Atsushi Sato, MD, Keizo Horibe
Journal: Blood
Blood (2017) 130 (Supplement 1): 2565.
https://doi.org/10.1182/blood.V130.Suppl_1.2565.2565
Published: 2017