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Thomas J. Kipps, M.D.
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Journal Articles

Agelastatin A (AgA), a Marine Sponge Derived Alkaloid, Inhibits Wnt/Beta-Catenin Signaling and Selectively Induces Apoptosis in Chronic Lymphocytic Leukemia Independently of p53

Michael Y. Choi, MD, Johanna Melo Cardenas, BSc, Desheng Lu, MD, PhD, Jian Yu, PhD, E. Paige Stout, PhD, Raymond P. Wu, Ph.D., John M Horton, B.S., Allison Gomez, Julio A. Diaz-Perez, M.D., M.S., Dennis A. Carson, M.D., Tadeusz F. Molinski, PhD, Thomas J. Kipps, M.D., Ph.D, Januario E. Castro, M.D.
Journal: Blood
Blood (2011) 118 (21): 1786.
https://doi.org/10.1182/blood.V118.21.1786.1786
Published: 2011
Journal Articles

Ad-ISF35-Transduced Autologous Cells In Combination with Fludarabine, Cyclophosphamide, Rituximab (FCR) Induces Complete and Partial Responses In a Phase 1b Study for Patients with Fludarabine-Refractory and/or Del(17p)/p53-Defective Chronic Lymphocytic Leukemia (CLL)

Januario E. Castro, M.D., Lee Schwartzberg, MD, FACP, Javier Pinilla-Ibarz, MD, PhD, Johanna Melo-Cardenas, B.Sc, Juan S. Barajas-Gamboa, M.D., Mark J. Cantwell, PhD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 168.
https://doi.org/10.1182/blood.V118.21.168.168
Published: 2011
Journal Articles

Lenalidomide Inhibits Proliferation of Chronic Lymphocytic Leukemia Cells in Vitro

Jessie-Farah Fecteau, Ph.D., Diahnn Futalan, Ila Bharati, BS, Emanuela M. Ghia, PhD, Laura G Corral, Senior, Thomas J. Kipps, M.D., Ph.D, Davorka Messmer, PhD
Journal: Blood
Blood (2011) 118 (21): 1775.
https://doi.org/10.1182/blood.V118.21.1775.1775
Published: 2011
Journal Articles

Correlations Between Ofatumumab Exposure and Treatment Outcomes for Patients with Chronic Lymphocytic Leukemia (CLL) Treated with Frontline Ofatumumab, Fludarabine, and Cyclophosphamide Chemoimmunotherapy

William G. Wierda, MD, PhD, Roxanne C. Jewell, PhD, Thomas J. Kipps, M.D., Ph.D, Jan Dürig, MD, Laimonas Griskevicius, Stephan Stilgenbauer, MD, Lukas Smolej, M.D., Ph.D., Georg Hess, Francisco J. Hernandez-Ilizaliturri, MD, Swaminathan Padmanabhan, MBBS, MD, Lei Fang, Michele M. Gorczyca, MS, Geoffrey W. Chan, MD, Ira V. Gupta, MD, Steen Lisby
Journal: Blood
Blood (2011) 118 (21): 1793.
https://doi.org/10.1182/blood.V118.21.1793.1793
Published: 2011
Journal Articles

Mir-155 Contributed to Chronic Lymphocytic Leukemia Survival by Modulation of BCR-Signalling

Liguang Chen, MD, PhD, Bing Cui, PhD, George Chen, B.S., Michelle Salcedo, BS, Carlo M. Croce, MD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 620.
https://doi.org/10.1182/blood.V118.21.620.620
Published: 2011
Journal Articles

A Monoclonal Antibody Specifically Targeting CD44 Inhibits B-Cell Chronic Lymphocytic Leukemia Cell Survival In Vitro and In Vivo

Suping Zhang, PhD, Christina C.N. Wu, Ph.D., Jessie-Farah Fecteau, Ph.D., Bing Cui, PhD, Rongrong Wu, Laura Z. Rassenti, Ph.D., Fitzgerald S. Lao, B.S., Rommel Tawatao, B.S., Stefan Weigland, PhD, Charles Prussak, PhD, Dennis A. Carson, MD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 927.
https://doi.org/10.1182/blood.V118.21.927.927
Published: 2011
Journal Articles

Targeting of Chronic Lymphocytic Leukemia B Cells with a Novel Monoclonal Antibody to ROR1

Bing CUi, PhD, George F. Widhopf, II, PhD, Jian Yu, PhD, Daniel Martinez, BS, Esther Avery, B.S., Suping Zhang, PhD, Liguang Chen, MD, PhD, Rongrong Wu, Christina C.N. Wu, Ph.D., Charles Prussak, PhD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 984.
https://doi.org/10.1182/blood.V118.21.984.984
Published: 2011
Journal Articles

Eradication of Minimal Residual Disease Using Alemtuzumab Consolidation After High-Dose Methyl-Prednisolone Plus Rituximab (HDMP-R) Is Safe, Effective and Induces Long Term Remission in Chronic Lymphocytic Leukemia

Januario E. Castro, M.D., Lina M. Ariza-Serrano, M.D. (c), Juan S. Barajas-Gamboa, M.D., Julio A. Diaz-Perez, M.D., M.S., Danelle F. James, M.D., Amine Ale-Ali, Pharm.D., Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 2866.
https://doi.org/10.1182/blood.V118.21.2866.2866
Published: 2011
Journal Articles

Lenalidomide and Rituximab for the Initial Treatment of Patients with Chronic Lymphocytic Leukemia (CLL) A Multicenter Study of the CLL Research Consortium

Danelle F. James, M.D., Jennifer R. Brown, MD, PhD, Lillian Werner, William G. Wierda, MD, PhD, Jaqueline C. Barrientos, MD, Januario Castro, MD, Andrew Greaves, Laura Z. Rassenti, Ph.D., Kanti R. Rai, MD, Donna Neuberg, ScD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 291.
https://doi.org/10.1182/blood.V118.21.291.291
Published: 2011
Journal Articles

Chronic Lymphocytic Leukemia Patients with IGHV Genes Carrying Only Silent Mutations Have A Longer Time From Diagnosis to Initial Therapy Than Patients Expressing B-Cell Receptors with No Somatic Mutations

Matthew Kaufman, MD, Xiao J. Yan, MD, PhD, Emanuela M. Ghia, PhD, Donna Neuberg, ScD, Laura Z. Rassenti, Ph.D., Kostas Stamatopoulos, MD, Paolo Ghia, MD, PhD, David G Oscier, MD, Frederic Davi, MD, PhD, Richard Rosenquist, MD, PhD, Chrysoula Belessi, MD, Zadie Davis, PhD, Andreas Agathangelidis, Neil Kay, MD, John C. Byrd, MD, Jennifer R Brown, MD, PhD, Kanti R. Rai, M.D., Thomas J. Kipps, M.D., Ph.D, Nicholas Chiorazzi, M.D.
Journal: Blood
Blood (2011) 118 (21): 288.
https://doi.org/10.1182/blood.V118.21.288.288
Published: 2011
Journal Articles

In Vitro Propagation of Mesenchymal Stromal Cells From Marrow Aspirates of Patients with Chronic Lymphocytic Leukemia Is Dependent Upon Physiologic Oxygen Tension

Jessie-Farah Fecteau, Ph.D., Davorka Messmer, PhD, Suping Zhang, PhD, Bing Cui, PhD, Liguang Chen, MD, PhD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 2839.
https://doi.org/10.1182/blood.V118.21.2839.2839
Published: 2011
Journal Articles

MicroRNA Profiling in Patients with CLL B Cells Expressing the Unmutated IGHV1-69 Gene

Laura Z. Rassenti, Ph.D., Emanuela M. Ghia, PhD, Lillian Werner, Donna Neuberg, ScD, Muller Fabbri, MD, Stefano Volinia, PhD, George F. Widhopf, II, PhD, Carlo M. Croce, MD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 2846.
https://doi.org/10.1182/blood.V118.21.2846.2846
Published: 2011
Journal Articles

Heat Shock Protein 90 (Hsp90) Activity Status Is An Independent Prognostic Marker in Chronic Lymphocytic Leukemia (CLL) and Correlates with IgV H Mutational Status, ZAP-70 Expression and Time to First Treatment

Januario E. Castro, M.D., Juan S. Barajas-Gamboa, M.D., Julio A. Diaz-Perez, M.D., M.S., Lina M. Ariza-Serrano, M.D. (c), Johanna Melo-Cardenas, B.Sc, Mauricio Rodriguez, D.D.S., M.S., Mauricio Urquiza, Ph.D., Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 2544.
https://doi.org/10.1182/blood.V118.21.2544.2544
Published: 2011
Journal Articles

Increased Activity of Aldehyde Dehydrogenase, a Stem/Progenitor Cell Marker, in Chronic Lymphocytic Leukemia,

Raymond P. Wu, Ph.D., Christina C.N. Wu, Ph.D., Tomoko Hayashi, M.D., Ph.D., Laura Z. Rassenti, Ph.D., Thomas J. Kipps, M.D., Ph.D, Dennis A. Carson, M.D.
Journal: Blood
Blood (2011) 118 (21): 3867.
https://doi.org/10.1182/blood.V118.21.3867.3867
Published: 2011
Journal Articles

Treatment of Chronic Lymphocytic Leukemia Patients with Lenalidomide Induces Down-Regulation of miR342-3p Associated with Over-Expression of Tumor Suppressor RASSF4,

Emanuela M. Ghia, PhD, Lillian Werner, Danelle F. James, M.D., Donna Neuberg, ScD, Laura G Corral, Senior, Scientist, Laura Z. Rassenti, Ph.D., Carlo M. Croce, MD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 3885.
https://doi.org/10.1182/blood.V118.21.3885.3885
Published: 2011
Journal Articles

Relative Prognostic Significance of ZAP-70 and IGHV1-69 Expression in Chronic Lymphocytic Leukemia,

Laura Z. Rassenti, Ph.D., Emanuela M. Ghia, PhD, Lillian Werner, Donna Neuberg, ScD, George F. Widhopf, II, PhD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 3891.
https://doi.org/10.1182/blood.V118.21.3891.3891
Published: 2011
Journal Articles

Variation in Health-Related Quality of Life by Age Among Patients with Chronic Lymphocytic Leukemia

Chris L. Pashos, PhD, Christopher R Flowers, MD, Mark Weiss, MD, Nicole Lamanna, MD, Charles M Farber, MD, PhD, Thomas J. Kipps, M.D., Ph.D, Susan Lerner, MS, BA, Neil Kay, MD, Jeff Porte Sharman, MD, David L. Grinblatt, MD, Ian W. Flinn, MD, PhD, Mark Kozloff, MD, Arlene S Swern, PhD, Zeba M. Kahn, Ph.D, Thomas K. Street, RPh, Kristen A Sullivan, MBA, Gale Harding, MA, Michael J Keating, MD
Journal: Blood
Blood (2011) 118 (21): 2085.
https://doi.org/10.1182/blood.V118.21.2085.2085
Published: 2011
Journal Articles

Navitoclax (ABT-263) Plus Fludarabine/Cyclophosphamide/Rituximab (FCR) or Bendamustine/Rituximab (BR): A Phase 1 Study in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL),

Thomas J. Kipps, M.D., Ph.D, Lode J. Swinnen, MD, William G. Wierda, MD, PhD, Jeffrey Alan Jones, MD, MPH, Steven E. Coutre, MD, Mitchell R Smith, MD, PhD, Jianning Yang, PhD, Yue Cui, PhD, Todd Busman, MS, Sari Enschede, MD, Rod Humerickhouse, MD
Journal: Blood
Blood (2011) 118 (21): 3904.
https://doi.org/10.1182/blood.V118.21.3904.3904
Published: 2011
Journal Articles

ROR1 Expression Accelerates Leukemia Development in RORxTCL1 Transgenic Mice,

George F. Widhopf, II, PhD, Bing Cui, Ph.D., Esther Avery, B.S., George Chen, B.S., Masato Obara, MD, PhD, Karen Messer, PhD, Thomas J. Kipps, M.D., Ph.D
Journal: Blood
Blood (2011) 118 (21): 3905.
https://doi.org/10.1182/blood.V118.21.3905.3905
Published: 2011
Journal Articles

Improved Outcome in Unrelated Donor Recipients After Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Advanced Relapse / Refractory Chronic Lymphocytic Leukemia

Januario E. Castro, M.D., Juan S. Barajas-Gamboa, M.D., Julio A. Diaz-Perez, M.D., M.S., Lina M. Ariza-Serrano, M.D. (c), Sue Corringham, R.N., Thomas J. Kipps, M.D., Ph.D, Edward D. Ball, M.D.
Journal: Blood
Blood (2011) 118 (21): 4474.
https://doi.org/10.1182/blood.V118.21.4474.4474
Published: 2011