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Journal Articles

Comprehensive Genomic Profiling of Pediatric Therapy-Related Myeloid Neoplasms Identifies Mecom Dysregulation to be Associated with Poor Outcome

Jason R Schwartz, MD PhD, Jing Ma, PhD, Michael P Walsh, PhD, Xiaolong Chen, PhD, Tamara Lamprecht, BS, Jennifer Kamens, MD, Scott Newman, PhD, Jinghui Zhang, PhD, Tanja A. Gruber, MD PhD, Xiaotu Ma, Jeffery M. Klco, MD PhD

Blood (2019) 134 (Supplement_1): 1394.

https://doi.org/10.1182/blood-2019-128665

Published: 2019

Journal Articles

NUP98-KDM5A Fusion Induces Hematopoietic Cell Proliferation and Alters Myelo-Erythropoietic Differentiation

Jonathan Miller, MD PhD, Ryan Hiltenbrand, MS, Tamara Lamprecht, BS, Aman Seth, MS, Sherif Abdelhamed, PhD, Ilaria Iacobucci, PhD, Charles G. Mullighan, MBBS, MD, Jeffery M. Klco, MD PhD

Blood (2019) 134 (Supplement_1): 3775.

https://doi.org/10.1182/blood-2019-130768

Published: 2019

Journal Articles

Integrative Analysis of Pediatric Acute Leukemia Identifies Immature Subtypes That Span a T Lineage and Myeloid Continuum with Distinct Prognoses

Blood (2019) 134 (Supplement_1): 918.

https://doi.org/10.1182/blood-2019-127411

Published: 2019

Journal Articles

The Mutational Profile of Pediatric Therapy-Related Myeloid Neoplasms

Jason R Schwartz, MD PhD, Michael P Walsh, PhD, Jing Ma, PhD, Tamara Lamprecht, B.S., Raul C Ribeiro, MD, Jeffery M. Klco, MD PhD

Blood (2018) 132 (Supplement 1): 2775.

https://doi.org/10.1182/blood-2018-99-118995

Published: 2018

Journal Articles

The Genomic Landscape of Pediatric Myelodysplastic Syndromes

Jason R. Schwartz, MD PhD, Michael P. Walsh, PhD, Jing Ma, PhD, Tamara Lamprecht, B.S., Shuoguo Wang, PhD, Gang Wu, PhD, John Easton, PhD, Raul C. Ribeiro, MD, Jeffery M. Klco, MD PhD

Blood (2016) 128 (22): 956.

https://doi.org/10.1182/blood.V128.22.956.956

Published: 2016

Journal Articles

Whole Genome Bisulfite Sequencing of Purified Mouse Promyelocytes Reveals Differentially Methylated Regions in Cells Expressing PML-Rara

Shamika Ketkar-Kulkarni, MS, Christopher B Cole, David H. Spencer, MDPhD, Angela M. Verdoni, PhD, Nichole Havey, Tamara Lamprecht, Vincent Magrini, PhD, Ryan T Demeter, Richard K. Wilson, PhD, Timothy J Ley, MD

Blood (2014) 124 (21): 3531.

https://doi.org/10.1182/blood.V124.21.3531.3531

Published: 2014

Journal Articles

Whole-Genome Bisulfite Sequencing of Primary AML Cells with the DNMT3A R882H Mutation Identifies Regions of Focal Hypomethylation That Are Associated with Open Chromatin

David H. Spencer, MDPhD, Bilal Al-Khalil, David Russler-Germain, Tamara Lamprecht, Nicole Havey, Robert S. Fulton, Michelle O'Laughlin, BS, Catrina Fronick, Richard K. Wilson, PhD, Timothy J. Ley, MD

Blood (2014) 124 (21): 608.

https://doi.org/10.1182/blood.V124.21.608.608

Published: 2014

Journal Articles

DNMT3A R882H Overexpression Acts in a Dominant Negative Manner to Cause DNA Hypomethylation and Increased Susceptibility to Hematopoietic Malignancies in Transgenic Mice

Angela M. Verdoni, PhD, Christopher B Cole, Shamika Ketkar-Kulkarni, MS, Tamara Lamprecht, Nichole Havey, David H. Spencer, MDPhD, Timothy J. Ley, MD

Blood (2014) 124 (21): 609.

https://doi.org/10.1182/blood.V124.21.609.609

Published: 2014

Journal Articles

R882H DNMT3A Causes Dominant-Negative Inhibition Of WT DNMT3A

David A. Russler-Germain, B.S., David H Spencer, MD/PhD, Margaret A. Young, MD/PhD, Tamara Lamprecht, B.S., Chris Miller, PhD, Robert S. Fulton, Petra Gilmore, PhD, Reid Townsend, MD, PhD, Timothy J. Ley, MD

Blood (2013) 122 (21): 3812.

https://doi.org/10.1182/blood.V122.21.3812.3812

Published: 2013

Journal Articles

Subclonal “skewing” Of De Novo AML Samples After Engraftment In Immunodeficient Mice

Jeffery M. Klco, MD/PhD, David H Spencer, MD/PhD, Christopher A Miller, PhD, Tamara Lamprecht, Dan George, Robert S. Fulton, Richard K Wilson, PhD, Timothy J. Ley, MD

Blood (2013) 122 (21): 609.

https://doi.org/10.1182/blood.V122.21.609.609

Published: 2013

Journal Articles

The Role Of Early TP53 Mutations On The Evolution Of Therapy-Related AML

Terrence Neal Wong, MD PhD, Giridharan Ramsingh, M.D, Andrew Young, Dong Shen, Chris Miller, PhD, Tamara Lamprecht, B.S., Sharon Heath, Robert S. Fulton, Elaine R. Mardis, PhD, Li Ding, Peter Westervelt, MD, PhD, John Welch, PhD/MD, Matthew J. Walter, MD, Timothy Graubert, MD, John F. DiPersio, MD, PhD, Timothy J. Ley, MD, Todd E Druley, MD, PhD, Richard K Wilson, PhD, Daniel C. Link, MD

Blood (2013) 122 (21): 5.

https://doi.org/10.1182/blood.V122.21.5.5

Published: 2013

Journal Articles

The De Novo DNA Methylation Activity of WT DNMT3A Is Inhibited by R882H DNMT3A and DNMT3B3 in Vitro

David A. Germain, B.S., Tamara Lamprecht, B.S., Margaret Young, B.S., Timothy J. Ley, MD

Blood (2012) 120 (21): 1329.

https://doi.org/10.1182/blood.V120.21.1329.1329

Published: 2012

Journal Articles

Deep Digital Sequencing Identifies an AML Subclone with Enhanced in Vitro and in Vivo Growth Properties Associated with Disease Relapse

Jeffery M. Klco, MD/PhD, David H Spencer, MD/PhD, Chris Miller, PhD, Tamara Lamprecht, Robert S. Fulton, John S. Welch, MD/PhD, Li Ding, Richard K Wilson, Timothy J. Ley, MD

Blood (2012) 120 (21): 407.

https://doi.org/10.1182/blood.V120.21.407.407

Published: 2012

Journal Articles

Whole Genome Sequencing of Therapy-Related Acute Myeloid Leukemia

Giridharan Ramsingh, Dong Shen, Tamara Lamprecht, B.S., Sharon Heath, Robert S. Fulton, Elaine R. Mardis, PhD, Li Ding, Peter Westervelt, John S. Welch, Matthew J. Walter, MD, Timothy Graubert, John F. DiPersio, MD, PhD, Timothy J. Ley, MD, Richard K Wilson, Daniel C. Link

Blood (2012) 120 (21): 784.

https://doi.org/10.1182/blood.V120.21.784.784

Published: 2012

Journal Articles

In Vitro Decitabine Treatment Demonstrates Heterogeneous Changes in Methylation and Gene Expression in Primary AML Samples.

David H Spencer, MD/PhD, Jeffery M. Klco, MD/PhD, Tamara Lamprecht, Todd Wylie, BS, Vincent Magrini, PhD, Jasreet Hundal, MS, Jason Walker, BA, BS, Nobish Varghese, MS, Matthew R Meyer, PhD, Petra Gilmore, PhD, Reid Townsend, MD, PhD, Elaine R. Mardis, PhD, Timothy J. Ley, MD

Blood (2012) 120 (21): 2527.

https://doi.org/10.1182/blood.V120.21.2527.2527

Published: 2012

Journal Articles

Complete Sequencing and Comparison of 12 Normal Karyotype M1 AML Genomes with 12 t(15;17) Positive M3-APL Genomes

Blood (2011) 118 (21): 404.

https://doi.org/10.1182/blood.V118.21.404.404

Published: 2011

Journal Articles

Mutations In the DNA Methyltransferase Gene DNMT3A Are Highly Recurrent In Patients with Intermediate Risk Acute Myeloid Leukemia, and Predict Poor Outcomes

Timothy J Ley, MD, Li Ding, PhD, Matthew J. Walter, MD, Michael D. McLellan, BS, Tamara Lamprecht, BS, David E. Larson, PhD, Cyriac Kandoth, PhD, Jacqueline E. Payton, MD, PhD, Jack Baty, BA, John S. Welch, MD, PhD, Christopher C. Harris, BS, Cheryl F. Lichti, PhD, R. Reid Townsend, MD, Robert S. Fulton, MS, David J. Dooling, PhD, Daniel C. Koboldt, MS, Heather Schmidt, BS, Qunyuan Zhang, PhD, John R. Osborne, BS, Ling Lin, MS, Michelle O'Laughlin, BS, Joshua F. McMichael, BS, Kim D. Delehaunty, BA, Sean D. McGrath, MS, Lucinda A. Fulton, MS, Vincent J. Magrini, PhD, Tammi L. Vickery, BS, Jasreet Hundal, MS, Lisa L. Cook, Joshua J. Conyers, Gary W. Swift, BS, Jerry P. Reed, MS, Patricia A. Alldredge, MS, Todd Wylie, BS, Jason Walker, BA, BS, Joelle Kalicki-Veizer, BS, Mark A. Watson, MD, PhD, Sharon Heath, William D. Shannon, PhD, Nobish Varghese, MS, Rakesh Nagarajan, MD, PhD, Peter Westervelt, MD, PhD, Michael H. Tomasson, MD, Daniel C. Link, MD, Timothy A. Graubert, MD, John F. DiPersio, MD, PhD, Elaine R. Mardis, PhD, Richard K. Wilson, PhD

Blood (2010) 116 (21): 99.

https://doi.org/10.1182/blood.V116.21.99.99

Published: 2010

NARROW

Comprehensive Genomic Profiling of Pediatric Therapy-Related Myeloid Neoplasms Identifies Mecom Dysregulation to be Associated with Poor Outcome

NUP98-KDM5A Fusion Induces Hematopoietic Cell Proliferation and Alters Myelo-Erythropoietic Differentiation

Integrative Analysis of Pediatric Acute Leukemia Identifies Immature Subtypes That Span a T Lineage and Myeloid Continuum with Distinct Prognoses

The Mutational Profile of Pediatric Therapy-Related Myeloid Neoplasms

The Genomic Landscape of Pediatric Myelodysplastic Syndromes

Whole Genome Bisulfite Sequencing of Purified Mouse Promyelocytes Reveals Differentially Methylated Regions in Cells Expressing PML-Rara

Whole-Genome Bisulfite Sequencing of Primary AML Cells with the DNMT3A R882H Mutation Identifies Regions of Focal Hypomethylation That Are Associated with Open Chromatin

DNMT3A R882H Overexpression Acts in a Dominant Negative Manner to Cause DNA Hypomethylation and Increased Susceptibility to Hematopoietic Malignancies in Transgenic Mice

R882H DNMT3A Causes Dominant-Negative Inhibition Of WT DNMT3A

Subclonal “skewing” Of De Novo AML Samples After Engraftment In Immunodeficient Mice

The Role Of Early TP53 Mutations On The Evolution Of Therapy-Related AML

The De Novo DNA Methylation Activity of WT DNMT3A Is Inhibited by R882H DNMT3A and DNMT3B3 in Vitro

Deep Digital Sequencing Identifies an AML Subclone with Enhanced in Vitro and in Vivo Growth Properties Associated with Disease Relapse

Whole Genome Sequencing of Therapy-Related Acute Myeloid Leukemia

In Vitro Decitabine Treatment Demonstrates Heterogeneous Changes in Methylation and Gene Expression in Primary AML Samples.

Complete Sequencing and Comparison of 12 Normal Karyotype M1 AML Genomes with 12 t(15;17) Positive M3-APL Genomes

Mutations In the DNA Methyltransferase Gene DNMT3A Are Highly Recurrent In Patients with Intermediate Risk Acute Myeloid Leukemia, and Predict Poor Outcomes

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American Society of Hematology

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American Society of Hematology

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