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Journal Articles

First-in-Human Study of the EZH1/2 Dual Inhibitor Valemetostat in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) - Updated Results Focusing on Adult T-Cell Leukemia-Lymphoma (ATL)

Satoko Morishima, MD PhD, Kenji Ishitsuka, MD PhD, Koji Izutsu, MD PhD, Shigeru Kusumoto, MD PhD, Junya Makiyama, MD PhD, Atae Utsunomiya, MD, Kisato Nosaka, MD PhD, Takashi Ishida, MD PhD, Yoshitaka Imaizumi, MD PhD, Nobuhiko Yamauchi, MD, Kazushi Araki, DVM, PhD, Nobuaki Adachi, PhD, Tomonari Yamashita, Ryo Atsumi, PhD, Kunihiro Tsukasaki, MD PhD, Kensei Tobinai, MD PhD

Blood (2019) 134 (Supplement_1): 4025.

https://doi.org/10.1182/blood-2019-125507

Published: 2019

Journal Articles

Tax-Targeting Dendritic Cell Therapy for ATL: A Phase Ia/Ib Clinical Study

Motoaki Shiratsuchi, MDPhD, Tetsuya Fukuda, MD PhD, Tadafumi Iino, MD PhD, Atsuhiko Hasegawa, PhD, Jun-ichirou Yasunaga, MD PhD, Ken Watanabe, MD PhD, Akie Hirata, MD PhD, Hayato Utsunomiya, MD, Hirofumi Ohno, MD, Takashi Ishida, MD PhD, Koichi Akashi, MD PhD, Masao Matsuoka, MDPhD, Mari Kannagi, MD PhD, Youko Suehiro, MDPhD

Blood (2018) 132 (Supplement 1): 1649.

https://doi.org/10.1182/blood-2018-99-113315

Published: 2018

Journal Articles

DS-3201, a Potent EZH1/2 Dual Inhibitor, Demonstrates Antitumor Activity Against Non-Hodgkin Lymphoma (NHL) Regardless of EZH2 Mutation

Blood (2018) 132 (Supplement 1): 2217.

https://doi.org/10.1182/blood-2018-99-113379

Published: 2018

Journal Articles

First-in-Human Study of the EZH1/2 Dual Inhibitor DS-3201b in Patients with Relapsed or Refractory Non-Hodgkin Lymphomas — Preliminary Results

Dai Maruyama, MD PhD, Kensei Tobinai, MD PhD, Shinichi Makita, MD, PhD, Takashi Ishida, MD PhD, Shigeru Kusumoto, MD, Kenji Ishitsuka, MD PhD, Makoto Yoshimitsu, MD PhD, Yoshitaka Imaizumi, MD PhD, Yasushi Sawayama, MD, PhD, Shogo Takeuchi, MD, Atae Utsunomiya, MD, PhD, Kunihiro Tsukasaki, MD PhD, Sumiaki Fujitani, MSc, Kazushi Araki, D.V.M., PhD

Blood (2017) 130 (Supplement 1): 4070.

https://doi.org/10.1182/blood.V130.Suppl_1.4070.4070

Published: 2017

Journal Articles

Population Pharmacokinetic and Exposure-Response Modeling for the EZH1/2 Dual Inhibitor DS-3201b in Patients with Non-Hodgkin Lymphomas

Ryo Atsumi, PhD, Satoshi Yoshiba, Dai Maruyama, MD PhD, Kensei Tobinai, MD PhD, Takashi Ishida, MD PhD, Kenji Ishitsuka, MD PhD, Yoshitaka Imaizumi, MD PhD, Shogo Takeuchi, MD, Kunihiro Tsukasaki, MD PhD, Nobuaki Adachi, PhD, Sumiaki Fujitani, MSc, Masaya Tachibana, PhD, Kazutaka Yoshihara, Hitoshi Ishizuka, PhD

Blood (2017) 130 (Supplement 1): 2544.

https://doi.org/10.1182/blood.V130.Suppl_1.2544.2544

Published: 2017

Journal Articles

Identification of Super-Enhancer-Associated Cancer Genes Provides Novel Therapeutic Targets in Adult T-Cell Leukemia/Lymphoma

Regina Wan Ju Wong, BSc, Phuong Thi Ngoc Cao, PhD, Wei Zhong Leong, BSc, Alice Wei Yee Yam, Bsc, Tinghu Zhang, PhD, Shinsuke Iida, MD PhD, Takashi Okamoto, MD PhD, Ryuzo Ueda, MD PhD, Nathanael S. Grey, PhD, Takashi Ishida, MD PhD, Takaomi Sanda, MD PhD

Blood (2016) 128 (22): 2720.

https://doi.org/10.1182/blood.V128.22.2720.2720

Published: 2016

Journal Articles

Phase I/II Multicenter Study of Romidepsin in Japanese Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma

Blood (2016) 128 (22): 3012.

https://doi.org/10.1182/blood.V128.22.3012.3012

Published: 2016

Journal Articles

Anti-Myeloma Activity of a Syringolin Analog: A Dual 20S Proteasome Inhibitor of Beta 2 and 5 Subunits

Takashi Yoshida, MD, Masaki Ri, MD PhD, Shiori Kinoshita, MD, Tomoko Narita, MD PhD, Haruhito Totani, MD, Reham Ashour, MD, Ayako Masaki, MD PhD, Asahi Ito, MD PhD, Shigeru Kusumoto, MD PhD, Takashi Ishida, MD PhD, Hirokazu Komatsu, MD PhD, Satoshi Ichikawa, Ph, PhD, Shinsuke Iida, MD PhD

Blood (2016) 128 (22): 4473.

https://doi.org/10.1182/blood.V128.22.4473.4473

Published: 2016

Journal Articles

Identification of Circulating Serum microRNAs As Novel Biomarkers Predicting Disease Progression and Sensitivity to Bortezomib Treatment in Multiple Myeloma

Tomoko Narita, MD PhD, Masaki Ri, MD PhD, Shiori Kinoshita, MD, Takashi Yoshida, MD, Haruhito Totani, MD, Reham Ashour, MD, Ayako Masaki, MD PhD, Asahi Ito, MD PhD, Shigeru Kusumoto, MD PhD, Takashi Ishida, MD PhD, Hirokazu Komatsu, MD PhD, Makoto Osabe, PhD, Masahiro Tohkin, PhD, Shinsuke Iida, MD PhD

Blood (2016) 128 (22): 4408.

https://doi.org/10.1182/blood.V128.22.4408.4408

Published: 2016

Journal Articles

Monitoring of Adult T-Cell Leukemia-Lymphoma Cells in Patients Receiving Mogamulizumab, a Humanized Anti-CCR4 Monoclonal Antibody, Using T-Cell Receptor Repertoire Analysis

Masato Saito, Takashi Ishida, MD PhD, Itaru Urakawa, PhD, Toshihiko Ishii, Asahi Ito, MD PhD, Ayako Masaki, MD PhD, Susumu Suzuki, PhD, Shigeru Kusumoto, MD PhD, Hirokazu Komatsu, MD PhD, Hiroshi Inagaki, MD PhD, Takeshi Takahashi, PhD, Ryuzo Ueda, MD PhD, Shinsuke Iida, MD PhD

Blood (2016) 128 (22): 1744.

https://doi.org/10.1182/blood.V128.22.1744.1744

Published: 2016

Journal Articles

Oral HDAC Inhibitor HBI8000 in Japanese Patients with Non-Hodgkin Lymphoma (NHL): Phase I Safety and Efficacy Results

Makoto Onizuka, MD PhD, Kiyoshi Ando, MD PhD, Makoto Yoshimitsu, MD, PhD, Takashi Ishida, MD PhD, S Yoshida, MD, Ilseung Choi, MD, Michihiro Hidaka, MD, Yasushi Takamatsu, MD PhD, Midori Nagashima, Akira Miyazato, MD PhD, Joachim P Schupp, MD, Alain Rolland, PharmD, PhD, Mireille Gillings, PhD, Gloria T. Lee, MD PhD, Kensei Tobinai, MD PhD

Blood (2016) 128 (22): 1827.

https://doi.org/10.1182/blood.V128.22.1827.1827

Published: 2016

Journal Articles

Protection of Transplanted Hematopoietic Stem Cells from Inflammatory Recipient Marrow Environment through Specific TNF-α Signal Blockade

Takashi Ishida, MD, Sachie Suzuki, MD, Chen-Yi Lai, PhD, Masaaki Higashihara, MD, PhD, Hiromitsu Nakauchi, MD PhD, Makoto Otsu, MD, PhD

Blood (2015) 126 (23): 1867.

https://doi.org/10.1182/blood.V126.23.1867.1867

Published: 2015

Journal Articles

Current Clinico-Epidemiological Characteristics of Adult T-Cell Leukemia-Lymphoma (ATL) Based on the 11th Nationwide Survey in Japan

Kisato Nosaka, MD PhD, Masako Iwanaga, MD, PhD, Kenichi Ishizawa, MD, PhD, Yoji Ishida, MD, PhD, Kaoru Uchimaru, MD, PhD, Kenji Ishitsuka, MD, PhD, Masahiro Amano, MD,PhD, Takashi Ishida, MD PhD, Yoshitaka Imaizumi, MD, Naokuni Uike, MD, PhD, Atae Utsunomiya, MD, PhD, Koichi Ohshima, MD PhD, Kazuhiro Kawai, MD, PhD, Junji Tanaka, MD, PhD, Yoshiki Tokura, MD, PhD, Kensei Tobinai, MD PhD, Toshiki Watanabe, MD, PhD, Kunihiro Tsukasaki, MD, PhD

Blood (2015) 126 (23): 5034.

https://doi.org/10.1182/blood.V126.23.5034.5034

Published: 2015

Journal Articles

Proof of Benefit in Multiple-Cord Blood Transplantation Evidenced By Early Hematopoietic Reconstitution

Takashi Ishida, MD, Satoshi Takahashi, MD,PhD, Chen-Yi Lai, PhD, Masaaki Higashihara, MD, PhD, Hiromitsu Nakauchi, MD PhD, Makoto Otsu, MD, PhD

Blood (2015) 126 (23): 3071.

https://doi.org/10.1182/blood.V126.23.3071.3071

Published: 2015

Journal Articles

Multicenter Phase II Study of Lenalidomide in Patients with Relapsed Adult T-Cell Leukemia-Lymphoma

Hiroshi Fujiwara, MD PhD, Takashi Ishida, MD PhD, Kisato Nosaka, MD PhD, Naoya Taira, MD, Yasunobu Abe, MD PhD, Yoshitaka Imaizumi, MD PhD, Yukiyoshi Moriuchi, MD, Tatsuro Jo, MD PhD, Kenichi Ishizawa, MD, PhD, Kensei Tobinai, MD PhD, Kunihiro Tsukasaki, MD PhD, Shigeki Ito, MD PhD, Makoto Yoshimitsu, Maki Otsuka, Michinori Ogura, MD, Shuichi Midorikawa, PhD, Wanda Ruiz, PhD, Tomoko Ohtsu, MD

Blood (2015) 126 (23): 181.

https://doi.org/10.1182/blood.V126.23.181.181

Published: 2015

Journal Articles

A New Strategy to Overcome the Cell Dose Barrier to Umbilical Cord Blood Transplants: A Proof of Early Hematopoietic Reconstitution By Combined Multiple Units of Allogeneic Stem/Progenitor Cells

Takashi Ishida, MD, Makoto Otsu, MD PhD, Satoshi Takahashi, MD PhD, Masaaki Higashihara, MD PhD, Hiromitsu Nakauchi, MD PhD

Blood (2014) 124 (21): 3810.

https://doi.org/10.1182/blood.V124.21.3810.3810

Published: 2014

Journal Articles

Multicenter Phase II Study of Mogamulizumab (KW-0761), a Defucosylated Anti-CCR4 Antibody, in Patients with Relapsed Peripheral and Cutaneous T-Cell Lymphoma

Takashi Ishida, MD, PhD, Michinori Ogura, MD, PhD, Kiyohiko Hatake, Masafumi Taniwaki, MD, PhD, Kiyoshi Ando, MD, PhD, Kensei Tobinai, MD, PhD, Katsuya Fujimoto, MD, PhD, Kazuhito Yamamoto, M.D., Ph.D., Toshihiro Miyamoto, MD, PhD, Naokuni Uike, MD, PhD, Mitsune Tanimoto, MD, PhD, Kunihiro Tsukasaki, MD, PhD, Kenichi Ishizawa, MD, PhD, Junji Suzumiya, MD, PhD, Hiroshi Inagaki, MD, PhD, Kazuo Tamura, MD, PhD, Shiro Akinaga, PhD, Masao Tomonaga, MD, PhD, Ryuzo Ueda, MD, PhD

Blood (2012) 120 (21): 795.

https://doi.org/10.1182/blood.V120.21.795.795

Published: 2012

Journal Articles

Human Telomerase Reverse Transcriptase–specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Hiroshi Fujiwara, MD, PhD, Fumihiro Ochi, Yukihiro Miyazaki, MD, Hiroaki Asai, MD, Takashi Ishida, MD, PhD, Sachiko Okamoto, PhD, Junichi Mineno, PhD, Kiyotaka Kuzushima, MD, PhD, Hiroshi Shiku, MD, PhD, Masaki Yasukawa, MD, PhD

Blood (2012) 120 (21): 1902.

https://doi.org/10.1182/blood.V120.21.1902.1902

Published: 2012

Journal Articles

Identification of Toyocamycin, an Agent Cytotoxic for Multiple Myeloma Cells, As a Potent Inhibitor of ER Stress-Induced XBP1 mRNA Splicing

Blood (2012) 120 (21): 5034.

https://doi.org/10.1182/blood.V120.21.5034.5034

Published: 2012

Journal Articles

Reduced Expression of HDAC3 Contributes to the Resistance Against HDAC Inhibitor, Vorinostat (SAHA) in Mature Lymphoid Malignancies

Jianming (Diane) Ding, MD, PhD, Masaki Ri, MD, PhD, Tomoko Narita, MD, Ayako Masaki, MD, Fumiko Mori, MD, Asahi Ito, MD, PhD, Shigeru Kusumoto, MD, PhD, Takashi Ishida, MD, PhD, Hirokazu Komatsu, MD, PhD, Yukimasa Shiotsu, PhD, Akio Niimi, MD, PhD, Shinsuke Iida, MD, PhD

Blood (2012) 120 (21): 1342.

https://doi.org/10.1182/blood.V120.21.1342.1342

Published: 2012

NARROW

First-in-Human Study of the EZH1/2 Dual Inhibitor Valemetostat in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) - Updated Results Focusing on Adult T-Cell Leukemia-Lymphoma (ATL)

Tax-Targeting Dendritic Cell Therapy for ATL: A Phase Ia/Ib Clinical Study

DS-3201, a Potent EZH1/2 Dual Inhibitor, Demonstrates Antitumor Activity Against Non-Hodgkin Lymphoma (NHL) Regardless of EZH2 Mutation

First-in-Human Study of the EZH1/2 Dual Inhibitor DS-3201b in Patients with Relapsed or Refractory Non-Hodgkin Lymphomas — Preliminary Results

Population Pharmacokinetic and Exposure-Response Modeling for the EZH1/2 Dual Inhibitor DS-3201b in Patients with Non-Hodgkin Lymphomas

Identification of Super-Enhancer-Associated Cancer Genes Provides Novel Therapeutic Targets in Adult T-Cell Leukemia/Lymphoma

Phase I/II Multicenter Study of Romidepsin in Japanese Patients with Relapsed or Refractory Peripheral T-Cell Lymphoma

Anti-Myeloma Activity of a Syringolin Analog: A Dual 20S Proteasome Inhibitor of Beta 2 and 5 Subunits

Identification of Circulating Serum microRNAs As Novel Biomarkers Predicting Disease Progression and Sensitivity to Bortezomib Treatment in Multiple Myeloma

Monitoring of Adult T-Cell Leukemia-Lymphoma Cells in Patients Receiving Mogamulizumab, a Humanized Anti-CCR4 Monoclonal Antibody, Using T-Cell Receptor Repertoire Analysis

Oral HDAC Inhibitor HBI8000 in Japanese Patients with Non-Hodgkin Lymphoma (NHL): Phase I Safety and Efficacy Results

Protection of Transplanted Hematopoietic Stem Cells from Inflammatory Recipient Marrow Environment through Specific TNF-α Signal Blockade

Current Clinico-Epidemiological Characteristics of Adult T-Cell Leukemia-Lymphoma (ATL) Based on the 11th Nationwide Survey in Japan

Proof of Benefit in Multiple-Cord Blood Transplantation Evidenced By Early Hematopoietic Reconstitution

Multicenter Phase II Study of Lenalidomide in Patients with Relapsed Adult T-Cell Leukemia-Lymphoma

A New Strategy to Overcome the Cell Dose Barrier to Umbilical Cord Blood Transplants: A Proof of Early Hematopoietic Reconstitution By Combined Multiple Units of Allogeneic Stem/Progenitor Cells

Multicenter Phase II Study of Mogamulizumab (KW-0761), a Defucosylated Anti-CCR4 Antibody, in Patients with Relapsed Peripheral and Cutaneous T-Cell Lymphoma

Human Telomerase Reverse Transcriptase–specific T-Cell Receptor Gene Transfer Redirects T Cells to Display an Effective Antitumor Reactivity Against Adult T-Cell Leukemia

Identification of Toyocamycin, an Agent Cytotoxic for Multiple Myeloma Cells, As a Potent Inhibitor of ER Stress-Induced XBP1 mRNA Splicing

Reduced Expression of HDAC3 Contributes to the Resistance Against HDAC Inhibitor, Vorinostat (SAHA) in Mature Lymphoid Malignancies

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American Society of Hematology

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American Society of Hematology

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