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Journal Articles

Base Excision Repair and Homologous Recombination Pathway Intermediates Drive Genomic Instability and Evolution in Myeloma

Chengcheng Liao, PhD MD, Srikanth Talluri, PhD, Subodh Kumar, PhD, Leutz Buon, Jiangning Zhao, PhD MD, Lakshmi B. Potluri, MBBS, Rao Prabhala, Masood A. Shammas, PhD, Nikhil C. Munshi, MD

Blood (2020) 136 (Supplement 1): 27–28.

https://doi.org/10.1182/blood-2020-141042

Published: 2020

Journal Articles

ABL1 Kinase Plays an Important Role in Spontaneous and Melphalan-Induced Genomic Instability in Multiple Myeloma: Potential Therapeutic Application

Subodh Kumar, PhD, Srikanth Talluri, PhD, Jiangning Zhao, PhD MD, Chengcheng Liao, PhD MD, Lakshmi B. Potluri, MBBS, Leutz Buon, Shidai Mu, Jialan Shi, MDPhD, Mychell Neptune-Buon, Chandraditya Chakraborty, PhD, Yu-Tzu Tai, PhD, Mehmet K. Samur, PhD, Mariateresa Fulciniti, PhD, Rao Prabhala, Masood A. Shammas, PhD, Nikhil C. Munshi, MD

Blood (2020) 136 (Supplement 1): 51.

https://doi.org/10.1182/blood-2020-142793

Published: 2020

Journal Articles

Atpase Family AAA Domain-Containing Protein 2 (ATAD2) As a Novel Target in Multiple Myeloma

Lakshmi B. Potluri, MBBS, Srikanth Talluri, PhD, Leutz Buon, Mehmet K. Samur, PhD, Anil Aktas-Samur, PhD, Jialan Shi, MDPhD, Chandraditya Chakraborty, PhD, Subodh Kumar, PhD, Rao Prabhala, Masood A. Shammas, PhD, Nikhil C. Munshi, MD

Blood (2020) 136 (Supplement 1): 50.

https://doi.org/10.1182/blood-2020-140466

Published: 2020

Journal Articles

A High Throughput Functional Screen Identifies a Novel Apex Inhibitor: Augments Cytotoxicity While Significantly Decreasing Genomic Evolution in Myeloma

Srikanth Talluri, PhD, Jialan Shi, MDPhD, Mychell Neptune-Buon, Subodh Kumar, PhD, Lakshmi B. Potluri, MBBS, Nikhil C. Munshi, MD, Masood A. Shammas, PhD

Blood (2020) 136 (Supplement 1): 10–11.

https://doi.org/10.1182/blood-2020-139945

Published: 2020

Journal Articles

Integrated Genomics and Functional Validation Identifies a Global Kinase Gene Signature Impacting Genome Stability in Myeloma

Subodh Kumar, PhD, Leutz Buon, Srikanth Talluri, PhD, Chengcheng Liao, MD PhD, Jialan Shi, MD PhD, Mychell Neptune, Chandraditya Chakraborty, PhD, Mehmet Kemal Samur, PhD, Rao Prabhala, Masood A. Shammas, PhD, Nikhil C. Munshi, MD

Blood (2019) 134 (Supplement_1): 363.

https://doi.org/10.1182/blood-2019-129069

Published: 2019

Journal Articles

Ongoing Spontaneous DNA Damage Creates Synthetic Lethality Targeted By Novel RAD51 Inhibitors in Multiple Myeloma

Subodh Kumar, PhD, Maria Gkotzamanidou, MD PhD, Srikanth Talluri, PhD, Melinda Day, PhD, Mychell Neptune, Lakshmi B. Potluri, Chandraditya Chakraborty, PhD, Kevin Mills, PhD, Masood A. Shammas, PhD, Nikhil C. Munshi, MD

Blood (2019) 134 (Supplement_1): 4378.

https://doi.org/10.1182/blood-2019-129121

Published: 2019

Journal Articles

Interleukin-6 Adversely Impacts Genomic Stability Via Targeting Multiple Pathways in Multiple Myeloma

Chaitanya Yenumula, MD, Srikanth Talluri, PhD, Tommaso Perini, MD, Subodh Kumar, PhD, Jialan Shi, MD PhD, Rao Prabhala, PhD, Masood A. Shammas, PhD, Nikhil Munshi, MD

Blood (2018) 132 (Supplement 1): 4467.

https://doi.org/10.1182/blood-2018-99-119346

Published: 2018

Journal Articles

PDZ Binding Kinase (PBK) - a Novel Gene Driving Genomic Evolution in Multiple Myeloma

Subodh Kumar, PhD, Leutz Buon, Srikanth Talluri, PhD, Jialan Shi, MD PhD, Hervé Avet-Loiseau, MD PhD, Mehmet Kemal Samur, PhD, Masood A. Shammas, PhD, Nikhil Munshi, MD

Blood (2018) 132 (Supplement 1): 4474.

https://doi.org/10.1182/blood-2018-99-119186

Published: 2018

Journal Articles

PAK4 Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldestrostom Macroglobulinemia

Na Li, MD, Mariateresa Fulciniti, PhD, Michael A Lopez, BS, Tommaso Perini, MD, Raphael Szalat, MD, Subodh Kumar, PhD, Mehmet Kemal Samur, PhD, Lian Xu, Yan Xu, MD, William Senapedis, PhD, Erkan Baloglu, Stefania Oliva, MD, Masood A. Shammas, PhD, Zachary Hunter, PhD, Kenneth C Anderson, MD, Steven P Treon, MDPhDFRCP, Nikhil Munshi, MD

Blood (2017) 130 (Supplement 1): 648.

https://doi.org/10.1182/blood.V130.Suppl_1.648.648

Published: 2017

Journal Articles

Identifying Novel Genes Involved in Dysregulation of Homologous Recombination and Genomic Integrity in Myeloma

Subodh Kumar, PhD, Leutz Buon, Mehmet Kemal Samur, PhD, Puru Nanjappa, Srikanth Talluri, PhD, Masood A. Shammas, PhD, Nikhil Munshi, MD

Blood (2017) 130 (Supplement 1): 3050.

https://doi.org/10.1182/blood.V130.Suppl_1.3050.3050

Published: 2017

Journal Articles

Targeting Homologous Recombination Increases Cytotoxicity While Reducing Genomic Instability Induced By Melphalan in Myeloma

Subodh Kumar, PhD, Srikanth Talluri, PhD, Puru Nanjappa, Masood A. Shammas, PhD, Nikhil Munshi, MD

Blood (2017) 130 (Supplement 1): 4388.

https://doi.org/10.1182/blood.V130.Suppl_1.4388.4388

Published: 2017

Journal Articles

ABL Tyrosine Kinase Plays an Important Role in Mechanisms Involved in Genomic Instability in Multiple Myeloma

Subodh Kumar, PhD, Purushothama Nanjappa, Srikanth Talluri, PhD, Masood A Shammas, PhD, Nikhil C Munshi, MD

Blood (2016) 128 (22): 2087.

https://doi.org/10.1182/blood.V128.22.2087.2087

Published: 2016

Journal Articles

Flap Structure-Specific Endonuclease 1 (FEN1) May be a Key Mediator of Genome Instability in Myeloma: A Cellular Vulnerability with Potential Therapeutic Significance

Masood A Shammas, PhD, Leutz Buon, Subodh Kumar, PhD, Mehmet K. Samur, PhD, David Alagpulinsa, PhD, Purushothama Nanjappa, Nikhil C Munshi, MD

Blood (2016) 128 (22): 4440.

https://doi.org/10.1182/blood.V128.22.4440.4440

Published: 2016

Journal Articles

Elevated APEX1 Disrupts G2/M Checkpoint, Contributing to Evolution and Survival of Myeloma Cells

Subodh Kumar, PhD, Srikanth Talluri, PhD, Mariateresa Fulciniti, Masood A Shammas, PhD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 2997.

https://doi.org/10.1182/blood.V126.23.2997.2997

Published: 2015

Journal Articles

XRCC5 Plays an Important Role in Homologous Recombination, Genome Stability and Survival of Myeloma Cells

Edward Laane, MD PhD, Purushothama Nanjappa, Subodh Kumar, PhD, Florence Magrangeas, Stephane Minvielle, Hele Everaus, MD PhD, Kenneth C Anderson, MD, Herve Avet-Loiseau, Masood A Shammas, PhD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 1218.

https://doi.org/10.1182/blood.V126.23.1218.1218

Published: 2015

Journal Articles

Nuclease Activity Is Associated with Genomic Instability As Well As Survival in Myeloma; Underlying Mechanisms and Significance

Masood A Shammas, PhD, Leutz Buon, Jianhong Lin, MD M.Sc, Mehmet K Samur, PhD, Jaymin M. Patel, MD, Ankit Vahia, Purushothama Nanjappa, Subodh Kumar, PhD, Ahsun Bajwa, Humza Ahmad, David Alagpulinsa, BPham, Giovanni Parmigiani, PhD, Florence Magrangeas, Stephane Minvielle, Herve Avet-Loiseau, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 2420.

https://doi.org/10.1182/blood.V126.23.2420.2420

Published: 2015

Journal Articles

Critical Role of Split Hand/Foot Malformation Type 1 (SHFM1) in Homologous Recombination and Cell Survival in Multiple Myeloma (MM)

Purushothama Nanjappa, Subodh Kumar, PhD, Srikanth Talluri, PhD, Humza Ahmad, Ahsun Bajwa, Jialan Shi, MD PhD, Gabriel Gonzalez, PhD, Florence Magrangeas, Stephane Minvielle, Kenneth C Anderson, Herve Avet-Loiseau, Masood Shammas, PhD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 3625.

https://doi.org/10.1182/blood.V126.23.3625.3625

Published: 2015

Journal Articles

Functional and Genomic Signatures of Homologous Recombination (HR) Predict for Clinical Outcome in Multiple Myeloma (MM)

Masood A Shammas, PhD, Subodh Kumar, PhD, Purushothama Nanjappa, Mehmet K Samur, PhD, Srikanth Talluri, PhD, Jianhong Lin, MD M.Sc, Florence Magrangeas, Stephane Minvielle, Hervé Avet-Loiseau, MD, Nikhil C. Munshi, MD

Blood (2015) 126 (23): 3626.

https://doi.org/10.1182/blood.V126.23.3626.3626

Published: 2015

Journal Articles

Dysregulation of SHFM1, a Novel Target for Prevention of Genomic Instability in Myeloma, Is Associated with Epigenetic Changes at Specific CpG Sites

Masood Shammas, PhD, Subodh Kumar, PhD, Jagannath Pal, PhD, Puru Nanjappa, MS, Mehmat Samur, PhD, Maria Gkotzamanidou, MD PhD, Jialan Shi, MD PhD, Nikhil C. Munshi, MD

Blood (2014) 124 (21): 862.

https://doi.org/10.1182/blood.V124.21.862.862

Published: 2014

Journal Articles

Telomerase-Mediated Repair of Induced DNA Breaks Leads to Increased Genomic Instability in Multiple Myeloma Cells: Possible Mechanism and Translational Significance

Jagannath Pal, PhD, Masood Shammas, PhD, Subodh Kumar, PhD, Maria Gkotzamanidou, MD PhD, Puru Nanjappa, MS, Leutz Buon, Nikhil C. Munshi, MD

Blood (2014) 124 (21): 5170.

https://doi.org/10.1182/blood.V124.21.5170.5170

Published: 2014

NARROW

Base Excision Repair and Homologous Recombination Pathway Intermediates Drive Genomic Instability and Evolution in Myeloma

ABL1 Kinase Plays an Important Role in Spontaneous and Melphalan-Induced Genomic Instability in Multiple Myeloma: Potential Therapeutic Application

Atpase Family AAA Domain-Containing Protein 2 (ATAD2) As a Novel Target in Multiple Myeloma

A High Throughput Functional Screen Identifies a Novel Apex Inhibitor: Augments Cytotoxicity While Significantly Decreasing Genomic Evolution in Myeloma

Integrated Genomics and Functional Validation Identifies a Global Kinase Gene Signature Impacting Genome Stability in Myeloma

Ongoing Spontaneous DNA Damage Creates Synthetic Lethality Targeted By Novel RAD51 Inhibitors in Multiple Myeloma

Interleukin-6 Adversely Impacts Genomic Stability Via Targeting Multiple Pathways in Multiple Myeloma

PDZ Binding Kinase (PBK) - a Novel Gene Driving Genomic Evolution in Multiple Myeloma

PAK4 Inhibition Impacts Growth and Survival, and Increases Sensitivity to DNA-Damaging Agents in Waldestrostom Macroglobulinemia

Identifying Novel Genes Involved in Dysregulation of Homologous Recombination and Genomic Integrity in Myeloma

Targeting Homologous Recombination Increases Cytotoxicity While Reducing Genomic Instability Induced By Melphalan in Myeloma

ABL Tyrosine Kinase Plays an Important Role in Mechanisms Involved in Genomic Instability in Multiple Myeloma

Flap Structure-Specific Endonuclease 1 (FEN1) May be a Key Mediator of Genome Instability in Myeloma: A Cellular Vulnerability with Potential Therapeutic Significance

Elevated APEX1 Disrupts G2/M Checkpoint, Contributing to Evolution and Survival of Myeloma Cells

XRCC5 Plays an Important Role in Homologous Recombination, Genome Stability and Survival of Myeloma Cells

Nuclease Activity Is Associated with Genomic Instability As Well As Survival in Myeloma; Underlying Mechanisms and Significance

Critical Role of Split Hand/Foot Malformation Type 1 (SHFM1) in Homologous Recombination and Cell Survival in Multiple Myeloma (MM)

Functional and Genomic Signatures of Homologous Recombination (HR) Predict for Clinical Outcome in Multiple Myeloma (MM)

Dysregulation of SHFM1, a Novel Target for Prevention of Genomic Instability in Myeloma, Is Associated with Epigenetic Changes at Specific CpG Sites

Telomerase-Mediated Repair of Induced DNA Breaks Leads to Increased Genomic Instability in Multiple Myeloma Cells: Possible Mechanism and Translational Significance

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American Society of Hematology

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ASH Publications

American Society of Hematology

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