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Journal Articles

Elevated P21 (CDKN1a) Mediates Apoptosis of Beta-Thalassemic Erythroid Cells in Mice but Its Ablation Doesn't Improve Erythroid Maturation

Miao Lin, Vijay Menon, PhD, Raymond Liang, PhD, Tasleem Arif, PhD, Laura Breda, PhD, Stefano Rivella, PhD, Saghi Ghaffari, MDPhD

Blood (2020) 136 (Supplement 1): 19.

https://doi.org/10.1182/blood-2020-143384

Published: 2020

Journal Articles

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Martin K. Safo, PhD, Piyusha P Pagare, PhD, Mohini Ghatge, PhD, Carla Casu, PhD, Valentina Ghiaccio, PhD, Nancy Anabaraonye, Xiaomeng Xu, MS, Stefano Rivella, PhD, Patrick C. Hines, MD PhD, Ke Liu, PhD, Yan Zhang, PhD, Jürgen Venitz, MD PhD, Osheiza Abdulmalik, DVM

Blood (2019) 134 (Supplement_1): 73.

https://doi.org/10.1182/blood-2019-128646

Published: 2019

Journal Articles

Preclinical Evaluation of ALS20, a New and Improved Lentiviral Vector for Beta-Globinopathies

Laura Breda, PhD, Valentina Ghiaccio, PhD, Silvia Pires Lourenco, MSc, Danuta Jadwiga Jarocha, PhD, Yasuhiro Ikawa, MD PhD, Naoto Tanaka, PhD, Virginia Guzikowski, Carla Casu, PhD, Kim Smith-Whitley, MD, Janet L. Kwiatkowski, MD MSCE, Stefano Rivella, PhD

Blood (2019) 134 (Supplement_1): 2242.

https://doi.org/10.1182/blood-2019-124043

Published: 2019

Journal Articles

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Blood (2019) 134 (Supplement_1): 2244.

https://doi.org/10.1182/blood-2019-127017

Published: 2019

Journal Articles

Erythroferrone Regulates Bone Remodeling in β-Thalassemia

Melanie Castro-Mollo, MD, Marc Ruiz Martinez, PhD, Maria Feola, PhD, Anisa Azatovna Gumerova, MD, Carla Casu, PhD, Robert E Fleming, MD, Stefano Rivella, PhD, Tony Yuen, PhD, Mone Zaidi, MD PhD, Yelena Ginzburg, MD

Blood (2019) 134 (Supplement_1): 2.

https://doi.org/10.1182/blood-2019-125822

Published: 2019

Journal Articles

Elucidating the Role of IL6 in Stress Erythropoiesis and in the Development of Anemia Under Inflammatory Conditions

Sayantani Sinha, PhD, Ritama Gupta, PhD, Jianbing Zhang, PhD, Amaliris Guerra, PhD, Ping La, Sara Gardenghi, PhD, Stefano Rivella, PhD

Blood (2019) 134 (Supplement_1): 940.

https://doi.org/10.1182/blood-2019-128826

Published: 2019

Journal Articles

Improved Lentiviral Vectors for the Cure of Hemoglobinopathies

Laura Breda, PhD, Valentina Ghiaccio, PhD, Hanyia Zaidi, Silvia Pires Lourenco, MSc, Carla Casu, Kim Smith-Whitley, MD, Janet L. Kwiatkowski, MD, Vanessa Carrion, RN, CPN, Virginia Guzikowski, RN, MSN, CRNP, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Stefano Rivella, PhD

Blood (2018) 132 (Supplement 1): 3477.

https://doi.org/10.1182/blood-2018-99-111319

Published: 2018

Journal Articles

Generation of New Cell Models to Screen Improved Vectors for Functional Hemoglobin Expression

Silvia Pires Lourenco, MSc, Amaliris Gonzalez, PhD, Tobias Raabe, PhD, Ryo Kurita, PhD, Yukio Nakamura, MD PhD, Laura Breda, PhD, Stefano Rivella, PhD

Blood (2017) 130 (Supplement 1): 5563.

https://doi.org/10.1182/blood.V130.Suppl_1.5563.5563

Published: 2017

Journal Articles

Absence of Interleukin-6 Protects Murine Bone Marrow Erythropoiesis Under Inflammation, in a Process Reversible By Iron Mediated Reactive Oxygen Species Upregulation

Ritama Gupta, PhD, Roberta Chessa, PhD, La Ping, PhD, Vania Lo Presti, Sara Gardenghi, PhD, Stefano Rivella, PhD

Blood (2017) 130 (Supplement 1): 2195.

https://doi.org/10.1182/blood.V130.Suppl_1.2195.2195

Published: 2017

Journal Articles

Influential Role of Macrophages in Hepcidin Regulation in Apo-Transferrin Treated β-Thalassemic Mice

Daniel Moskop, Shuming Sun, PhD, Maria Feola, PhD, Marc Ruiz Martinez, PhD, Huiyong Chen, PhD, Jing Liu, PhD, Nathan Brinkman, PhD, Robert E Fleming, MD, Stefano Rivella, PhD, Yelena Ginzburg, MD

Blood (2017) 130 (Supplement 1): 172.

https://doi.org/10.1182/blood.V130.Suppl_1.172.172

Published: 2017

Journal Articles

Iron Binding to Specific Lobes of Transferrin Differentially Affects Erythropoiesis and Hepcidin Signaling

Nermi Parrow, PhD, Amaliris Gonzalez, PhD, Yihang Li, PhD, Princy Prasad, Luke Mammen, Faris Ali, Edvinas Vaicikauskas, Maria Feola, PhD, Yelena Ginzburg, MD, Stefano Rivella, PhD, Robert E Fleming, MD

Blood (2017) 130 (Supplement 1): 173.

https://doi.org/10.1182/blood.V130.Suppl_1.173.173

Published: 2017

Journal Articles

Absence of TNF-α Promotes Anemia of Inflammation and Inflammatory Bowel Disease

Ritama Gupta, PhD, Lo Presti Vania, Carla Casu, PhD, Rea Oikonomidou, MD, Emir OHara, Stefano Rivella, PhD

Blood (2017) 130 (Supplement 1): 3577.

https://doi.org/10.1182/blood.V130.Suppl_1.3577.3577

Published: 2017

Journal Articles

A Novel Dual Monoclonal Sandwich ELISA for Human Erythroferrone

Huiling Han, MD, Keith Westerman, BS, Vaughn Ostland, PhD, Patrick Gutschow, MS, Gordana Olbina, PhD, Jacqueline da Silva Guimarães, PhD, Juçara Gastaldi Cominal, M.Sc, Ana Maria de Souza, PhD, Ana Cristina Silva Pinto, MD, Stefano Rivella, PhD, Yelena Ginzburg, MD, Mark D. Fleming, MD DPhil, Mark Westerman, PhD

Blood (2016) 128 (22): 1272.

https://doi.org/10.1182/blood.V128.22.1272.1272

Published: 2016

Journal Articles

Potential Therapeutic Applications of Jak2 Inhibitors and Hif2a-ASO for the Treatment of β-Thalassemia Intermedia and Major

Carla Casu, Paraskevi Rea Oikonomidou, MD, Vania Lo Presti, Mariam Aghajan, PhD, Shuling Guo, PhD, Abdulmalik Osheiza, Luca Melchiori, Pedro Ramos, Stefano Rivella, PhD

Blood (2016) 128 (22): 1012.

https://doi.org/10.1182/blood.V128.22.1012.1012

Published: 2016

Journal Articles

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

Mariam Aghajan, PhD, Carla Casu, PhD, Vania lo Presti, Sheri Booten, Brett P. Monia, PhD, Stefano Rivella, PhD, Shuling Guo, PhD

Blood (2016) 128 (22): 1013.

https://doi.org/10.1182/blood.V128.22.1013.1013

Published: 2016

Journal Articles

Adult Hemoglobin Production, Chain Rebalance, and Splice Correction in IVS2-745 Beta-Thalassemia Patient Cells Using 2'-O-Methoxyethyl Splice-Switching Oligos

Alisa Cheung Dong, Valentina Ghiaccio, Irene Motta, MD, Shuling Guo, PhD, Raechel Peralta, MS, Coralea Stephanou, PhD, Paola Delbini, PhD, Connie Chen, Soteroula Christou, Marina Kleanthous, PhD, Maria Domenica Cappellini, MD, Osheiza Abdulmalik, DVM, MS, Laura Breda, PhD, Stefano Rivella, PhD

Blood (2016) 128 (22): 1014.

https://doi.org/10.1182/blood.V128.22.1014.1014

Published: 2016

Journal Articles

Administration of Minihepcidins to Animals Affected By β-Thalassemia Major Reduces Anemia and Splenomegaly

Roberta Chessa, PhD, Ritama Gupta, MSc, Carla Casu, PhD, Robert E Fleming, MD, Yelena Ginzburg, Brian MacDonald, MB, ChB, PhD, Stefano Rivella, PhD

Blood (2016) 128 (22): 259.

https://doi.org/10.1182/blood.V128.22.259.259

Published: 2016

Journal Articles

Ex Vivo Gene Therapy Approach By Targt Technology for the Treatment of β-Thalassemia Intermedia

Carla Casu, Vania Lo Presti, Emir M O'Hara, Garry Neil, Reem Miari, Nir Shapir, Stefano Rivella, PhD

Blood (2016) 128 (22): 2467.

https://doi.org/10.1182/blood.V128.22.2467.2467

Published: 2016

Journal Articles

Genetic Investigation of the Role of GDF11 in the Treatment of β-Thalassemia and MDS

Paraskevi Rea Oikonomidou, MD, Ping La, PhD, Ritama Gupta, MSc, Vania Lo Presti, Carla Casu, PhD, Laura Breda, PhD, Deborah Watson, PhD, Rajasekhar NVS Suragani, PhD, Ravindra Kumar, PhD, Stefano Rivella, PhD

Blood (2016) 128 (22): 2439.

https://doi.org/10.1182/blood.V128.22.2439.2439

Published: 2016

Journal Articles

Lack of Beta-1 Integrin Limits Stress Erythropoiesis and Splenomegaly in Beta-Thalassemia

Roberta Chessa, PhD, Ritama Gupta, MSc, Bart J Crielaard, MD PhD, Carla Casu, PhD, Rick Feldman, PhD, Stefano Rivella, PhD

Blood (2015) 126 (23): 2196.

https://doi.org/10.1182/blood.V126.23.2196.2196

Published: 2015

NARROW

Elevated P21 (CDKN1a) Mediates Apoptosis of Beta-Thalassemic Erythroid Cells in Mice but Its Ablation Doesn't Improve Erythroid Maturation

PP-14, a Novel Structurally-Enhanced Antisickling Allosteric Hemoglobin Effector, Increases Oxygen Affinity and Disrupts Hemoglobin S Polymer Formation

Preclinical Evaluation of ALS20, a New and Improved Lentiviral Vector for Beta-Globinopathies

2'-O-Methoxyethyl Splice-Switching Oligos to Reverse Splicing from IVS2-745 β-Thalassemia Patient Cells: A Foundation for Potential Therapies

Erythroferrone Regulates Bone Remodeling in β-Thalassemia

Elucidating the Role of IL6 in Stress Erythropoiesis and in the Development of Anemia Under Inflammatory Conditions

Improved Lentiviral Vectors for the Cure of Hemoglobinopathies

Generation of New Cell Models to Screen Improved Vectors for Functional Hemoglobin Expression

Absence of Interleukin-6 Protects Murine Bone Marrow Erythropoiesis Under Inflammation, in a Process Reversible By Iron Mediated Reactive Oxygen Species Upregulation

Influential Role of Macrophages in Hepcidin Regulation in Apo-Transferrin Treated β-Thalassemic Mice

Iron Binding to Specific Lobes of Transferrin Differentially Affects Erythropoiesis and Hepcidin Signaling

Absence of TNF-α Promotes Anemia of Inflammation and Inflammatory Bowel Disease

A Novel Dual Monoclonal Sandwich ELISA for Human Erythroferrone

Potential Therapeutic Applications of Jak2 Inhibitors and Hif2a-ASO for the Treatment of β-Thalassemia Intermedia and Major

Developing a Galnac-Conjugated TMPRSS6 Antisense Therapy for the Treatment of β-Thalassemia

Adult Hemoglobin Production, Chain Rebalance, and Splice Correction in IVS2-745 Beta-Thalassemia Patient Cells Using 2'-O-Methoxyethyl Splice-Switching Oligos

Administration of Minihepcidins to Animals Affected By β-Thalassemia Major Reduces Anemia and Splenomegaly

Ex Vivo Gene Therapy Approach By Targt Technology for the Treatment of β-Thalassemia Intermedia

Genetic Investigation of the Role of GDF11 in the Treatment of β-Thalassemia and MDS

Lack of Beta-1 Integrin Limits Stress Erythropoiesis and Splenomegaly in Beta-Thalassemia

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American Society of Hematology

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American Society of Hematology

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