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Journal Articles

Phase 1/2 Study of AUTO3 the First Bicistronic Chimeric Antigen Receptor (CAR) Targeting CD19 and CD22 Followed By an Anti-PD1 in Patients with Relapsed/Refractory (r/r) Diffuse Large B Cell Lymphoma (DLBCL): Results of Cohort 1 and 2 of the Alexander Study

Kirit M. Ardeshna, MBBChir, Maria A V Marzolini, Jane Norman, MD, Muhammad Al-Hajj, Simon Thomas, PhD, Jim Faulkner, Ekaterini Kotsopoulou, Martin Pule, MD, Vijay G R Peddareddigari, Nushmia Z Khokhar, Maud Jonnaert, PhD, Robert Chen, MD, Wendy Osborne, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 246.
https://doi.org/10.1182/blood-2019-122724
Published: 2019
Journal Articles

Generation of a Highly Sensitive CD22 CAR

Evangelia K Kokalaki, Biao Ma, PhD, Thomas Grothier, MSc, Warren Hazelton, MSc, Eren Costu, BSc, Somayya Manzoor, MSc, Ram Jha, MSc, Simon Thomas, PhD, Shimobi Onuoha, PhD, Shaun P Cordoba, PhD, Martin Pule, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5747.
https://doi.org/10.1182/blood-2019-128002
Published: 2019
Journal Articles

Phase 1 First-in-Human Study of AUTO2, the First Chimeric Antigen Receptor (CAR) T Cell Targeting APRIL for Patients with Relapsed/Refractory Multiple Myeloma (RRMM)

Rakesh Popat, Sonja Zweegman, MD PhD, Jim Cavet, FRCPath, Kwee Yong, Lydia Lee, Jim Faulkner, Ekaterini Kotsopoulou, Muhammad Al-Hajj, Simon Thomas, PhD, Shaun P Cordoba, PhD, Martin Pule, MD, Virginie Cerec, PhD, Vijay G R Peddareddigari, Nushmia Z Khokhar, MD, Tobias F Menne, MD PhD FRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 3112.
https://doi.org/10.1182/blood-2019-126689
Published: 2019
Journal Articles

Study of AUTO3, the First Bicistronic Chimeric Antigen Receptor (CAR) Targeting CD19 and CD22, Followed By Anti-PD1 Consolidation in Patients with Relapsed/Refractory (r/r) Diffuse Large B Cell Lymphoma (DLBCL): Alexander Study

Kirit Ardeshna, Maria A V Marzolini, Wendy Osborne, MD, Muhammad Al-Hajj, Simon Thomas, PhD, Jim Faulkner, Martin Pule, PhD, Vijay G R Peddareddigari, Nushmia Z Khokhar
Journal: Blood
Blood (2018) 132 (Supplement 1): 1679.
https://doi.org/10.1182/blood-2018-99-119197
Published: 2018
Journal Articles

Structure Guided Engineering of Highly Specific Chimeric Antigen Receptors for the Treatment of T Cell Lymphomas

Shimobi Onuoha, PhD, Mathieu Ferrari, Anna Bulek, Reyisa Bughda, Somayya Manzoor, Saket Srivastava, Biao Ma, Rajesh Karattil, Alex Kinna, PhD, Patrycja Wawrzyniecka, Simon Thomas, PhD, Shaun P Cordoba, PhD, Paul Maciocia, BSc, MBChB, MRCP, Martin Pule, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1661.
https://doi.org/10.1182/blood-2018-99-119564
Published: 2018
Journal Articles

A Dominant Negative SHP-2 Which Abrogates PD-1 Signalling Pathways and Restores Function of Cytotoxic CAR T Cells

Vania Baldan, PhD, Priyanka Ghongane, MSc, Evangelia Kokalaki, PhD, Wen Chean Lim, PhD, Shimobi Onuoha, PhD, Shaun Paul Cordoba, PhD, Simon Thomas, PhD, Martin Pule, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3190.
https://doi.org/10.1182/blood.V130.Suppl_1.3190.3190
Published: 2017
Journal Articles

An APRIL Based Chimeric Antigen Receptor to Simultaneously Target BCMA and TACI in Multiple Myeloma (MM) Has Potent Activity in Vitro and in Vivo

Lydia Sarah Hui Lee, MBBS, MRCP, MRCPath, BSc, Benjamin Owen Draper, BSc, MSc, Neil Chaplin, BSc, MSc, Brian Philip, PhD, Melody Chin, BSc, MSc, Daria Galas-Filipowicz, BSc, MSc, Simon Thomas, PhD, Evangelia Kokalaki, BSc, MSc, James Francis, PhD, Kwee L Yong, Martin A Pule, MD PhD
Journal: Blood
Blood (2016) 128 (22): 379.
https://doi.org/10.1182/blood.V128.22.379.379
Published: 2016
Journal Articles

CMV~IMPACT: Results of a Randomized Controlled Trial of Immuno-Prophylactic Adoptive Cellular Therapy following Sibling Donor Allogeneic HSCT

Karl S Peggs, Eleni Tholouli, Ronjon Chakraverty, PhD, Emmanouil Nikolousis, PhD, Adrian Bloor, PhD FRCPath, Stephen Devereux, MD PhD FRCPath, Kim H. Orchard, PhD, Charles Crawley, Anne Parker, Stephen P Robinson, PhD, Frederick Chen, MDPhD, Gordon Cook, MD, Richard E Clark, MBBS MD, Kirsty Thomson, Matthew Cobb, Katy Newton, PhD, Simon Thomas, PhD, Paul Moss, PhD
Journal: Blood
Blood (2014) 124 (21): 1109.
https://doi.org/10.1182/blood.V124.21.1109.1109
Published: 2014
Journal Articles

The Impact of Donor HLA Type on Characteristics of CMV-Specific T Cell Products: Experience from Two UK Randomized Trials

Amanda Skulte, BSc, MClinTRes, Arindam Mitra, BSc, Simon Thomas, PhD, Matthew Cobb, Alka Stansfield, Karl S Peggs, Katy Newton, PhD
Journal: Blood
Blood (2014) 124 (21): 1124.
https://doi.org/10.1182/blood.V124.21.1124.1124
Published: 2014
Journal Articles

Cytomegalovirus Drives Mixed Chimerism Following T-Cell Depleted Allogeneic HSCT, Providing Protective Immunity In The Absence Of GvHD

Rob S Sellar, MBBS, Frederick Arce Vargas, PhD, Jake Henry, Simon Thomas, PhD, Alka Stansfield, Stephanie Verfuerth, PhD, Sarah C Charrot, MBBS, Rachael E Hough, MD, Sergio A Quezada, PhD, Kirsty J Thomson, MD, Stephen Mackinnon, MD, Karl S Peggs, MD
Journal: Blood
Blood (2013) 122 (21): 4524.
https://doi.org/10.1182/blood.V122.21.4524.4524
Published: 2013
Journal Articles

A Highly Compact Epitope-Based Marker-Suicide Gene for More Convenient and Safer T-Cell Adoptive Immunotherapy.

Brian Philip, BSc, Simon Thomas, PhD, Virna Marin, PhD, Amit Jathoul, PhD, Alicja Kopec, David C Linch, MD, FMedSci, Martin Pule
Journal: Blood
Blood (2010) 116 (21): 1473.
https://doi.org/10.1182/blood.V116.21.1473.1473
Published: 2010