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Journal Articles

Foxo 3a Signaling Mediates Apoptosis in Lymphoma Cells By the Diterpenoid Lactone Andrographolide (Andro), the Active Component of Andrographis Paniculata

Shuo Yang, Bo Ding, Fei Ying, Jana Svetlichnaya, Austin Tom, Sheila Prachand, Yanzhuang Wang, Leo I Gordon, MD FACP

Blood (2015) 126 (23): 2760.

https://doi.org/10.1182/blood.V126.23.2760.2760

Published: 2015

Journal Articles

The Diterpenoid Lactone Andrographolide Induces Reactive Oxygen Species (ROS) Dependent Apoptosis in ATRA Sensitive and Resistant APL Cell Lines.

Shuo Yang, PhD, Jessica K. Altman, MD, Sheila Prachand, MS, Austin Tom, BS, Bo Ding, BS, Brent Wu, Leonidas C. Platanias, MD, PhD, Leo I. Gordon, MD

Blood (2012) 120 (21): 2446.

https://doi.org/10.1182/blood.V120.21.2446.2446

Published: 2012

Journal Articles

The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma

Savita Bhalla, Andrew M. Evens, Bojie Dai, Sheila Prachand, Leo I. Gordon, Ronald B. Gartenhaus

Blood (2011) 118 (4): 1052–1061.

https://doi.org/10.1182/blood-2011-03-340109

Published: 2011

Includes: Supplemental data

Journal Articles

The Novel Organic Arsenical, Darinaparsin (ZIO-101), Induces Apoptosis through AKT and MEK/ERK Pathways In Hodgkin Lymphoma (HL) and T-Cell Lymphoma (TCL) Cell Lines

Savita Bhalla, PhD, Sheila Prachand, MS, Leo I Gordon, MD, FACP, Andrew M Evens, DO, MSc

Blood (2010) 116 (21): 2840.

https://doi.org/10.1182/blood.V116.21.2840.2840

Published: 2010

Journal Articles

Hypoxia Inducible Factor 1á (HIF-1á) Regulates CD20 Expression in Lymphoma Cells: Possible Implications for Rituximab Based Therapy in Diffuse Large B Cell Lymphoma (DLBCL).

Sairah Ahmed, MD, Andrew M. Evens, DO, MSc, Savita Bhalla, PhD, Amareshwar Singh, PhD, Crystal James, Shuo Yang, PhD, Sheila Prachand, Danijela Dokic, MD, Randy D. Gascoyne, MD, Jane N. Winter, MD, Paul T Schumacker, PhD, Leo I. Gordon, MD

Blood (2009) 114 (22): 1698.

https://doi.org/10.1182/blood.V114.22.1698.1698

Published: 2009

Journal Articles

Glutathione Depletion Enhances Arsenic Trioxide-Induced Apoptosis in Lymphoma Cells through Mitochondrial and Caspase-Independent Mechanisms.

Savita Bhalla, PhD, Leo I. Gordon, MD, Amareshwar Singh, PhD, Sheila Prachand, M.S., Shuo Yang, PhD, Jane N. Winter, MD, Dongsheng Guo, PhD, Thomas O'Halloran, PhD, Leonidas C Platanias, Andrew M. Evens, DO, MSc

Blood (2009) 114 (22): 2708.

https://doi.org/10.1182/blood.V114.22.2708.2708

Published: 2009

Journal Articles

Mitochondrial-Mediated Apoptosis in Lymphoma by the Diterpenoid Lactone Andrographolide (Andro), the Active Component of Andrographolis Paniculata.

Shuo Yang, PhD, Andrew M Evens, DO, MSc, Savita Bhalla, PhD, Sheila Prachand, M.S., Amareshwar Singh, PhD, Leo I. Gordon, MD

Blood (2009) 114 (22): 2710.

https://doi.org/10.1182/blood.V114.22.2710.2710

Published: 2009

Journal Articles

The Novel 2 nd Generation Small Molecule MEK Inhibitor, AZD-6244, Induces Cell Death in Lymphoma Cells Lines, Primary Cells, and in a Human Lymphoma Xenograft Model.

Savita Bhalla, PhD, Ron Gartenhaus, MD, Bojie Dai, PhD, Sheila Prachand, Arindam Mukherjee, Rebecca L Elstrom, MD, Leo I. Gordon, MD, Andrew M. Evens, DO, MSc

Blood (2009) 114 (22): 285.

https://doi.org/10.1182/blood.V114.22.285.285

Published: 2009

Journal Articles

Inhibition of Autophagy with 3-Methyladenine Synergistically Enhances Cellular Apoptosis Induced by the Histone Deacetylase Inhibitor PCI 24781 in Non-Hodgkin’s Lymphoma Cells

Kevin A Davi, MD, Savita Bhalla, PhD, Sheila Prachand, M.S., Andrew M Evens, DO, MS, Leo I. Gordon, MD

Blood (2008) 112 (11): 3625.

https://doi.org/10.1182/blood.V112.11.3625.3625

Published: 2008

Journal Articles

The Diterpenoid Lactone Andrographolide (ANDRO) Stimulates Autophagy and Induces Reactive Oxygen Species (ROS)-Dependent Apoptosis in Lymphoma Cell Lines

Shuo Yang, PhD, Andrew M. Evens, DO, MS, Sheila Prachand, MS, Leo I. Gordon, MD

Blood (2008) 112 (11): 4991.

https://doi.org/10.1182/blood.V112.11.4991.4991

Published: 2008

Journal Articles

Arsenic Trioxide (As 2 O 3 ) Mediated Cell Death in Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL): Investigation of Reactive Oxygen Species (ROS), Caspase, and MAP Kinase Signaling Pathways.

Savita Bhalla, PhD, Amareshwar T.K Singh, PhD, Sheila Prachand, MS, Qudsia Haque, BS, Thomas V. O’Halloran, PhD, Jane N. Winter, MD, Paul T. Schumacker, PhD, Leonidas C. Platanias, MD, Leo I. Gordon, MD, Andrew M. Evens, DO, MS

Blood (2007) 110 (11): 2576.

https://doi.org/10.1182/blood.V110.11.2576.2576

Published: 2007

Journal Articles

Histone Deacetylase Inhibitor (HDACi) PCI-24781 and Bortezomib Result in Synergistic Apoptosis in Hodgkin Lymphoma (HL) and Non-Hodgkin’s Lymphoma (NHL) Cell Lines: Investigation of Cell Death and NFKB-Mediated Pathways.

Savita Bhalla, PhD, Kevin David, MD, Lauren Mauro, MD, Sheila Prachand, MS, Mint Sirisawad, Sriram Balasubramanian, PhD, Richard A. Miller, MD, Joseph Buggy, PhD, Leo I. Gordon, MD, Andrew M. Evens, DO, MS

Blood (2007) 110 (11): 3589.

https://doi.org/10.1182/blood.V110.11.3589.3589

Published: 2007

Journal Articles

Motexafin Gadolinium (Mgd), a Redox Stress Inducer, Lowers p53 Protein but Not Message in Lymphoma Cell Lines: Mechanisms of Reactive Oxygen Species (ROS)-Mediated Apoptosis in Lymphoma.

Amareshwar Singh, PhD, Sheila Prachand, Andrew M. Evens, DO,MS, Paul Schumacker, PhD, Leo I. Gordon, MD

Blood (2006) 108 (11): 2393.

https://doi.org/10.1182/blood.V108.11.2393.2393

Published: 2006

Journal Articles

Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells

Andrew M. Evens, Philip Lecane, Darren Magda, Sheila Prachand, Seema Singhal, Jeff Nelson, Richard A. Miller, Ronald B. Gartenhaus, Leo I. Gordon

Blood (2005) 105 (3): 1265–1273.

https://doi.org/10.1182/blood-2004-03-0964

Published: 2005

NARROW

Foxo 3a Signaling Mediates Apoptosis in Lymphoma Cells By the Diterpenoid Lactone Andrographolide (Andro), the Active Component of Andrographis Paniculata

The Diterpenoid Lactone Andrographolide Induces Reactive Oxygen Species (ROS) Dependent Apoptosis in ATRA Sensitive and Resistant APL Cell Lines.

The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma

The Novel Organic Arsenical, Darinaparsin (ZIO-101), Induces Apoptosis through AKT and MEK/ERK Pathways In Hodgkin Lymphoma (HL) and T-Cell Lymphoma (TCL) Cell Lines

Hypoxia Inducible Factor 1á (HIF-1á) Regulates CD20 Expression in Lymphoma Cells: Possible Implications for Rituximab Based Therapy in Diffuse Large B Cell Lymphoma (DLBCL).

Glutathione Depletion Enhances Arsenic Trioxide-Induced Apoptosis in Lymphoma Cells through Mitochondrial and Caspase-Independent Mechanisms.

Mitochondrial-Mediated Apoptosis in Lymphoma by the Diterpenoid Lactone Andrographolide (Andro), the Active Component of Andrographolis Paniculata.

The Novel 2 nd Generation Small Molecule MEK Inhibitor, AZD-6244, Induces Cell Death in Lymphoma Cells Lines, Primary Cells, and in a Human Lymphoma Xenograft Model.

Inhibition of Autophagy with 3-Methyladenine Synergistically Enhances Cellular Apoptosis Induced by the Histone Deacetylase Inhibitor PCI 24781 in Non-Hodgkin’s Lymphoma Cells

The Diterpenoid Lactone Andrographolide (ANDRO) Stimulates Autophagy and Induces Reactive Oxygen Species (ROS)-Dependent Apoptosis in Lymphoma Cell Lines

Arsenic Trioxide (As 2 O 3 ) Mediated Cell Death in Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL): Investigation of Reactive Oxygen Species (ROS), Caspase, and MAP Kinase Signaling Pathways.

Histone Deacetylase Inhibitor (HDACi) PCI-24781 and Bortezomib Result in Synergistic Apoptosis in Hodgkin Lymphoma (HL) and Non-Hodgkin’s Lymphoma (NHL) Cell Lines: Investigation of Cell Death and NFKB-Mediated Pathways.

Motexafin Gadolinium (Mgd), a Redox Stress Inducer, Lowers p53 Protein but Not Message in Lymphoma Cell Lines: Mechanisms of Reactive Oxygen Species (ROS)-Mediated Apoptosis in Lymphoma.

Motexafin gadolinium generates reactive oxygen species and induces apoptosis in sensitive and highly resistant multiple myeloma cells

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American Society of Hematology

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American Society of Hematology

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