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Seyedmehdi Shojaee, PhD
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Journal Articles

Signaling Input from Divergent Pathways Subverts Malignant B-Cell Transformation

Lai N Chan, PhD, Mark A. Murakami, MDMA,MMSc, Rebecca Caesar, Christian Hurtz, PhD, Kohei Kume, PhD, Teresa Sadras, PhD, Seyedmehdi Shojaee, PhD, Petri Pölönen, MSc, Amol Ugale, PhD, Jaewoong Lee, PhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Merja Heinäniemi, PhD, Olli Lohi, MD PhD, Arun P. Wiita, MD PhD, Shai Izraeli, MD, David M Weinstock, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3944.
https://doi.org/10.1182/blood-2019-130774
Published: 2019
Journal Articles

Divergent Evolutionary Trajectories of Erk- and Stat5-Activating Lesions in Acute Lymphoblastic Leukemia

Lai N Chan, Seyedmehdi Shojaee, PhD, Christian Hurtz, PhD, Franziska Auer, PhD, Zhengshan Chen, MDPhD, Kadriye Nehir Cosgun, PhD, Huimin Geng, PhD, Teresa Sadras, PhD, Deborah L White, PhD, Markus Muschen, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 568.
https://doi.org/10.1182/blood-2018-99-115536
Published: 2018
Journal Articles

BCL6 Enables RAS-Driven Pre-B Cell Transformation in Acute Lymphoblastic Leukemia

Lai N Chan, Christian Hurtz, PhD, Rebecca Caesar, Seyedmehdi Shojaee, PhD, Gang Xiao, PhD, Huimin Geng, PhD, Mignon L. Loh, MD, B. Hilda Ye, PhD, Steven Kornblau, MD, Markus Muschen, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1211.
https://doi.org/10.1182/blood.V130.Suppl_1.1211.1211
Published: 2017
Journal Articles

BCL6 Is Critical to Overcome Oncogene-Induced Senescence in RAS-Mediated B Cell Transformation

Lai N Chan, PhD, Christian Hurtz, PhD, Gang Xiao, PhD, Seyedmehdi Shojaee, PhD, Rebecca Caeser, Huimin Geng, PhD, Ari Melnick, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2016) 128 (22): 438.
https://doi.org/10.1182/blood.V128.22.438.438
Published: 2016
Journal Articles

B-Lymphoid Transcription Factors Restrict Glycolytic Energy Supply for Oncogenic Signaling

Lai N Chan, PhD, Zhengshan Chen, PhDMD, Daniel Braas, PhD, Huimin Geng, PhD, Christian Hurtz, PhD, Seyedmehdi Shojaee, PhD, Valeria Cazzaniga, PhD, Carina Ng, Thomas Ernst, MD, Andreas Hochhaus, MD, Steven M Kornblau, PhD, Giovanni Cazzaniga, PhD, Grace Liu, PhD, Thomas Milne, PhD, H. Phillip Koeffler, MD, Scott A. Armstrong, MD PhD, Ross Alexander Dickins, PhD, Keith R Yamamoto, PhD, Thomas G Graeber, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2015) 126 (23): 1255.
https://doi.org/10.1182/blood.V126.23.1255.1255
Published: 2015
Journal Articles

Identification of BCL6 As a Therapeutic Target in RAS -Driven Acute Lymphoblastic Leukemia

Qiang Li, PhD, Christian Hurtz, PhD, Seyedmehdi Shojaee, PhD, Zhengshan Chen, MDPhD, Huimin Geng, PhD, Gang Xiao, PhD, Mignon L. Loh, MD, B. Hilda Ye, PhD, Ari Melnick, MD, Markus Muschen, MDPhD
Journal: Blood
Blood (2015) 126 (23): 556.
https://doi.org/10.1182/blood.V126.23.556.556
Published: 2015
Journal Articles

Harnessing Negative B Cell Selection to Overcome Drug-Resistance in Acute Lymphoblastic Leukemia

Zhengshan Chen, MD PhD, Seyedmehdi Shojaee, PhD, Huimin Geng, PhD, Jae-Woong Lee, PhD, Maike Buchner, PhD, Lars Klemm, Clifford A. Lowell, MD PhD, Elisabeth Paietta, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Ari Melnick, MD, Jae U. Jung, PhD, Hassan Jumaa, PhD, John E. Coligan, PhD, Silvia Bolland, PhD, Tak W. Mak, OC, PhD DSc, FRSC, FRS, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 792.
https://doi.org/10.1182/blood.V124.21.792.792
Published: 2014
Journal Articles

Lineage-Specific Metabolic Reprogramming Reveals LKB1 as Therapeutic Target in Acute Lymphoblastic Leukemia

Lai N Chan, PhD, Daniel Braas, Christian Hurtz, PhD, Seyedmehdi Shojaee, PhD, Behzad Kharabi Masouleh, MD, Huimin Geng, PhD, Thomas Ernst, MD, Andreas Hochhaus, MD, Thomas Graeber, PhD, Markus Muschen, MDPhD
Journal: Blood
Blood (2014) 124 (21): 783.
https://doi.org/10.1182/blood.V124.21.783.783
Published: 2014
Journal Articles

Self-Enforcing Feedback Activation Between BCL6 and Tonic Pre-B Cell Receptor Signaling in Acute Lymphoblastic Leukemia

Huimin Geng, PhD, Christian Hurtz, PhD, Dirk Baumjohann, PhD, Zhengshan Chen, MD PhD, Wei-Yi Chen, PhD, Erica Ballabio, PhD, Gang Xiao, PhD, Jae-Woong Lee, PhD, Anne Deucher, MDPhD, Zhongxia Qi, PhD, Chuanxin Huang, PhD, Rahul Nahar, PhD, Soo-mi Kweon, PhD, Seyedmehdi Shojaee, PhD, Lai N Chan, PhD, Jingwei Yu, PhD, Jeffrey W. Tyner, PhD, Bill H Chang, MD PhD, Steven M. Kornblau, MD, Janetta Jacoba Bijl, PhD, B. Hilda Ye, PhD, Elisabeth Paietta, PhD, Ari Melnick, MD, Robert Roeder, PhD, Stephen Hunger, MD, Mignon Loh, MD, Thomas Milne, PhD, Markus Muschen, MD PhD
Journal: Blood
Blood (2014) 124 (21): 284.
https://doi.org/10.1182/blood.V124.21.284.284
Published: 2014
Journal Articles

PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells

Seyedmehdi Shojaee, PhD, Valeria Cazzaniga, Hilde Schjerven, PhD, Maike Buchner, PhD, Christian Hurtz, PhD, Huimin Geng, PhD, Andreas Hochhaus, MD, Giovanni Cazzaniga, PhD, Ari M Melnick, MD, Steven M. Kornblau, MD, Thomas G Graeber, PhD, Markus Muschen, MD PhD
Journal: Blood
Blood (2014) 124 (21): 262.
https://doi.org/10.1182/blood.V124.21.262.262
Published: 2014
Journal Articles

Inhibitory Receptors and Phosphatases Enable Oncogenic Tyrosine Kinase Signaling In B Cell Lineage Leukemia

Zhengshan Chen, MD, PhD, Seyedmehdi Shojaee, PhD, Huimin Geng, PhD, Jaewoong Lee, PhD, Maike Buchner, PhD, Lars Klemm, Clifford A. Lowell, MD, PhD, Elisabeth Paietta, PhD, Cheryl L. Willman, MD, William L. Carroll, MD, Ari M. Melnick, MD, Jae U. Jung, PhD, Hassan Jumaa, PhD, John E. Coligan, PhD, Silvia Bolland, PhD, Tak W. Mak, Markus Muschen, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 229.
https://doi.org/10.1182/blood.V122.21.229.229
Published: 2013