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Satoshi Iyama, MD, PhD
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Journal Articles

Interim Analysis of Hematologic Malignancies (HM)-Screen-Japan 01: A Mutation Profiling Multicenter Study of Patients with AML

Kenichi Miyamoto, MD, Kentaro Fukushima, MD PhD, SungGi Chi, MD PhD, Hirohiko Shibayama, MD PhD, Naoko Hosono, MD PhD, Takahiro Yamauchi, MD PhD, Seiichiro Katagiri, MDPhD, Akihiko Gotoh, MD PhD, Takanobu Morishita, MD, PhD, Masamitsu Yanada, MD PhD, Kazuhito Yamamoto, MD PhD, Naohito Fujishima, MD PhD, Naoto Takahashi, MD PhD, Reiki Ogasawara, MDPhD, Takeshi Kondo, MD PhD, Yoshikazu Utsu, MD PhD, Nobuyuki Aotsuka, MD PhD, Kensuke Usuki, MD PhD, Takaaki ONO, MD PhD, Tsutomu Kobayashi, MD PhD, Junya Kuroda, MD PhD, Hiroto Horiguchi, MDPhD, Satoshi Iyama, MD PhD, Suguru Fukuhara, MD PhD, Koji Izutsu, MD PhD, Makoto Nakamura, MD PhD, Kensuke Kojima, MD PhD, Yosuke Minami, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-139147
Published: 2020
Journal Articles

Genetic Features of AML with MLL-Rearrangement and NPM1 Mutation: An Interim-Analysis of HM-Screen-Japan 01

SungGi Chi, MD PhD, Naoko Hosono, MD PhD, Takahiro Yamauchi, MD PhD, Kentaro Fukushima, MD, Hirohiko Shibayama, MD PhD, Seiichiro Katagiri, MDPhD, Akihiko Gotoh, MD PhD, Motohito Okabe, MD, Takanobu Morishita, MD, PhD, Masamitsu Yanada, MD PhD, Kazuhito Yamamoto, MD PhD, Naohito Fujishima, MD PhD, Naoto Takahashi, MD PhD, Reiki Ogasawara, MDPhD, Takeshi Kondo, MD PhD, Yoshikazu Utsu, MD PhD, Nobuyuki Aotsuka, MD, Yoshimasa Kamoda, MD, Kensuke Usuki, MD PhD, Kanenari Takemura, MD, Yasuyuki Nagata, MD PhD, Takaaki Ono, MD PhD, Tsutomu Kobayashi, MD PhD, Junya Kuroda, MD PhD, Hiroto Horiguchi, MDPhD, Satoshi Iyama, MD PhD, Suguru Fukuhara, MD PhD, Koji Izutsu, MD PhD, Makoto Nakamura, MD PhD, Kazuto Togitani, MD, Kensuke Kojima, MD PhD, Kaoru Yamamoto, MD, Yukinori Nakamura, MD, Makoto Yoshimitsu, MD PhD, Kenji Ishitsuka, MD PhD, Kenichi Miyamoto, MD, Yosuke Minami, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 35–36.
https://doi.org/10.1182/blood-2020-139240
Published: 2020
Journal Articles

CD34+ Positive Myelodysplastic Cells with Ring Sideroblasts or SF3B1 Mutation Produce High Erythroferrone and GDF15

Hiroto Horiguchi, MDPhD, Masayoshi Kobune, MD PhD, Kento Ono, MD, Saori Shimoyama, MD, Chisa Fujita, MD, Akari Goto, MDPhD, Hiroshi Ikeda, MDPhD, Satoshi Iyama, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 28–29.
https://doi.org/10.1182/blood-2020-134861
Published: 2020
Journal Articles

Genomic Analysis of FLT3 Mutations in a Comprehensive NGS Multicenter Study of AML: HM-Screen-Japan 01

Kentaro Fukushima, MD PhD, SungGi Chi, MD PhD, Hirohiko Shibayama, MD PhD, Naoko Hosono, MD PhD, Takahiro Yamauchi, MD PhD, Seiichiro Katagiri, MDPhD, Akihiko Gotoh, MD PhD, Takanobu Morishita, MD, PhD, Masamitsu Yanada, MD PhD, Kazuhito Yamamoto, MD PhD, Naohito Fujishima, MD PhD, Naoto Takahashi, MD PhD, Reiki Ogasawara, MDPhD, Takeshi Kondo, MD PhD, Yoshikazu Utsu, MD PhD, Nobuyuki Aotsuka, MD, Kensuke Usuki, MD PhD, Takaaki ONO, MD PhD, Tsutomu Kobayashi, MD PhD, Junya Kuroda, MD PhD, Hiroto Horiguchi, MDPhD, Satoshi Iyama, MD PhD, Suguru Fukuhara, MD PhD, Koji Izutsu, MD PhD, Makoto Nakamura, MD PhD, Kensuke Kojima, MD PhD, Kenichi Miyamoto, MD, Yosuke Minami, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–34.
https://doi.org/10.1182/blood-2020-137343
Published: 2020
Journal Articles

Prospective Comparison of Azacitidine Treatment between 7-Days and 5-Days Schedules for Patients with Higher-Risk Myelodysplastic Syndromes; Results of Japan Adult Leukemia Study Group MDS212 Trial

Toru Kiguchi, MD PhD, Shinya Sato, MD, Kensuke Usuki, MD PhD, Ken Ishiyama, Yoshikazu Ito, MD PhD, Takahiro Suzuki, MD PhD, Jun Taguchi, MD PhD, Shigeru Chiba, MD PhD, Nobuaki Dobashi, MD, Akihiro Tomita, MD PhD, Hironori Harada, MD PhD, Hiroshi Handa, MD PhD, Shigeo Horiike, MD PhD, Tomoya Maeda, MD PhD, Mitsuhiro Matsuda, MD PhD, Motoshi Ichikawa, MD, Tomoko Hata, MD, PhD, Sumihisa Honda, Satoshi Iyama, MD PhD, Hitoshi Suzushima, MD PhD, Yukiyoshi Moriuchi, MD, Toshiro Kurokawa, MD PhD, Takahiro Yamauchi, MD PhD, Hitoshi Kiyoi, MD PhD, Tomoki Naoe, MD PhD, Yasushi Miyazaki, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 845.
https://doi.org/10.1182/blood-2019-122802
Published: 2019
Journal Articles

Prospective Evaluation of Alternative Donor from Unrelated Volunteer Donor and Cord Blood in Adult Acute Leukemia and Myelodysplastic Syndrome: No Difference between Unrelated Donor and Cord Blood

Seitaro Terakura, MD PhD, Tetsuya Nishida, MD PhD, Masashi Sawa, MD PhD, Tomonori Kato, MD PhD, Kotaro Miyao, MD PhD, Yukiyasu Ozawa, MD PhD, Tatsunori Goto, MD, Akio Kohno, MD, Kazutaka Ozeki, MD PhD, Yasushi Onishi, MD PhD, Noriko Fukuhara, MD PhD, Nobuharu Fujii, MD PhD, Hisayuki Yokoyama, MD PhD, Masanobu Kasai, MD PhD, Hiroatsu Iida, MD PhD, Nobuhiro Kanemura, MD PhD, Tomoyuki Endo, MD PhD, Hiroatsu Ago, MD, Makoto Onizuka, MD PhD, Satoshi Iyama, MD PhD, Yuichiro Nawa, MD, Mika Nakamae, MD PhD, Yasuyuki Nagata, MD PhD, Shingo Kurahashi, MD PhD, Yasuo Tomiya, MD, Atsumi Yanagisawa, Ritsuro Suzuki, MD PhD, Yachiyo Kuwatsuka, MD PhD, Yoshiko Atsuta, MD PhD, Koichi Miyamura, MD PhD, Makoto Murata, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4587.
https://doi.org/10.1182/blood-2019-124634
Published: 2019
Journal Articles

Extravesicular Mir-7977 Released from Leukemic Cells Inhibites the PCBP1-Mediated mRNA Stabilization and Hippo-YAP Signaling Pathway in Bone Marrow Mesenchymal Stromal Cells

Masahiro Yoshida, MD PhD, Satoshi Iyama, MD PhD, Hiroto Horiguchi, MD PhD, Akari Goto, MD PhD, Shohei Kikuchi, MD PhD, Kazuyuki Murase, MD PhD, Kohichi Takada, MD PhD, Koji Miyanishi, MD PhD, Hiroshi Ikeda, MD PhD, Masahiro Maeda, MD PhD, Junji Kato, MD PhD, Masayoshi Kobune, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1519.
https://doi.org/10.1182/blood-2018-99-111124
Published: 2018
Journal Articles

Extracellular Vesicle microRNAs from Acute Myeloid Leukemia Are Involved in the Regulation of Adherence Junction in Bone Marrow Microenvironment.

Masahiro Yoshida, MD, Masayoshi Kobune, MD PhD, Shogo Miura, MD, Soushi Ibata, MD PhD, Satoshi Iyama, MD PhD, Tsutomu Sato, MD PhD, Kazuyuki Murase, MD PhD, Kohichi Takada, MD PhD, Kaoru Ono, MD PhD, Akari Hashimoto, MD, Ayumi Tatekoshi, MD, Yusuke Kamihara, MD PhD, Yusuke Sugama, MD, Shohei Kikuchi, MD PhD, Hiroshi Ikeda, MD PhD, Hiroto Horiguchi, MD PhD, Yutaka Kawano, MD PhD, Koji Miyanishi, MD PhD, Hiroyuki Kuroda, MD PhD, Masahiro Maeda, MD PhD, Junji Kato, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2863.
https://doi.org/10.1182/blood.V128.22.2863.2863
Published: 2016
Journal Articles

Next Generation Sequencing of CD138+ Myeloma Cells Could Predict Response Rate and Appropriate Therapy at Diagnosis

Hiroshi Ikeda, MD PhD, Yasushi Sasaki, MDPhD, Soushi Ibata, MD PhD, Masahiro Yoshida, MD, Ayumi Tatekoshi, Satoshi Iyama, MD PhD, Kazuyuki Murase, MD PhD, Kohichi Takada, MD PhD, Shohei Kikuchi, MD PhD, Tsutomu Sato, MD PhD, Masayoshi Kobune, MD PhD, Junji Kato, MD PhD
Journal: Blood
Blood (2016) 128 (22): 5609.
https://doi.org/10.1182/blood.V128.22.5609.5609
Published: 2016
Journal Articles

CD34/EPO-R Double Positive MDS Cells Produce Erythroferrone in Response to Erythropoietin

Shogo Miura, MD, Masayoshi Kobune, MD PhD, Soushi Ibata, MD PhD, Masahiro Yoshida, MD, Satoshi Iyama, MD PhD, Tsutomu Sato, MD PhD, Kazuyuki Murase, MD PhD, Kohichi Takada, MD PhD, Kaoru Ono, MD PhD, Akari Hashimoto, MD, Ayumi Tatekoshi, MD, Yusuke Kamihara, MD PhD, Yusuke Sugama, MD, Wataru Jomen, MD, Shohei Kikuchi, MD PhD, Hiroshi Ikeda, MD PhD, Hiroto Horiguchi, MDPhD, Yutaka Kawano, MD PhD, Koji Miyanishi, MD PhD, Hiroyuki Kuroda, MD PhD, Masahiro Maeda, MD PhD, Junji Kato, MD PhD
Journal: Blood
Blood (2016) 128 (22): 2455.
https://doi.org/10.1182/blood.V128.22.2455.2455
Published: 2016
Journal Articles

Exosomes Derived from AML/MDS Cells Is Involved in Stromal Dysfunction and Bone Marrow Failure

Hiroto Horiguchi, MD, Masayoshi Kobune, MD PhD, Shohei Kikuchi, MD PhD, Wataru Jomen, MD, Kazuyuki Murase, MD PhD, Soushi Ibata, MD, Satoshi Iyama, MD PhD, Tsutomu Sato, MD PhD, Yusuke Kamihara, MD, Koji Miyanishi, MD PhD, Yasushi Sato, MD PhD, Tsuyoshi Hayashi, MD PhD, Rishu Takimoto, MD PhD, Junji Kato, MD PhD
Journal: Blood
Blood (2014) 124 (21): 4627.
https://doi.org/10.1182/blood.V124.21.4627.4627
Published: 2014
Journal Articles

Myelodysplastic Syndrome-Derived Stromal Cells Support Leukemia-Initiating Cells and Contradirectly Eliminate Normal CD34+ Clonogenic Cells

Hiroto Horiguchi, MD, Masayoshi Kobune, MD, PhD, Shohei Kikuchi, MD, PhD, Satoshi Iyama, MD, PhD, Kohichi Takada, MD, PhD, Kazuyuki Murase, MD, PhD, Kaoru Ono, MD, Yusuke Kamihara, MD, Akari Hashimoto, MD, Ayumi Tatekoshi, MD, Tsuyoshi Hayashi, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1219.
https://doi.org/10.1182/blood.V122.21.1219.1219
Published: 2013
Journal Articles

Iron Chelation Therapy Could Rapidly Reduce Oxidative DNA Damage In CD34+ Hematopoietic Cells Before Decrease Of Serum Ferritin Level

Masayoshi Kobune, MD, PhD, Shohei Kikuchi, MD, PhD, Satoshi Iyama, MD, PhD, Kohichi Takada, MD, PhD, Kazuyuki Murase, MD, PhD, Kaoru Ono, MD, Hiroto Horiguchi, MD, Yusuke Kamihara, MD, Akari Hashimoto, MD, Ayumi Tatekoshi, MD, Tsuyoshi Hayashi, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 959.
https://doi.org/10.1182/blood.V122.21.959.959
Published: 2013
Journal Articles

Role of Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia in an HTLV-1 Non-Endemic Area of Japan.

Akio Shigematsu, MD, PhD, Junji Tanaka, MD, PhD, Naoki Kobayashi, MD, PhD, Hiroshi Yasui, MD, PhD, Motohiro Shindo, MD, PhD, Yasutaka Kakinoki, MD, PhD, Kakinoki Yasutaka, MD, PhD, Satoshi Iyama, MD, PhD, Kuroda HIroyuki, MD, PhD, Tsutsumi Yutaka, MD.PhD, Satoshi Hashino, MD, PhD, Masahiro Imamura, MD, PhD, Takanori Teshima, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3089.
https://doi.org/10.1182/blood.V120.21.3089.3089
Published: 2012
Journal Articles

Stromal Cells Expressing Hedgehog-Interacting Protein Are One of the Main Regulators of the Hedgehog Signaling System in Myeloid Neoplasms

Masayoshi Kobune, MD, PhD, Hiroto Horiguchi, MD, Shohei Kikuchi, MD, PhD, Satoshi Iyama, MD, PhD, Kohichi Takada, MD, PhD, Kazuyuki Murase, MD, PhD, Kaoru Ono, MD, Yusuke Kamihara, MD, Yutaka Kawano, MD, PhD, Tsuyoshi Hayashi, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 3840.
https://doi.org/10.1182/blood.V120.21.3840.3840
Published: 2012
Journal Articles

Long-Term Production System of Red Blood Cells Using Human Cord Blood and Stromal Cells

Masayoshi Kobune, MD, PhD, Shohei Kikuchi, MD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 3211.
https://doi.org/10.1182/blood.V116.21.3211.3211
Published: 2010
Journal Articles

CD34+ Cobblestone Area-Forming Cells Are a Valuable Indicator to Screen the Soluble Inhibitors of Hematopoiesis in the Serum of Aplastic Anemia and MDS Patients.

Shohei Kikuchi, MD., Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Yutaka Kawano, MD, PhD, Koji Miyanishi, MD, PhD, Yasushi Sato, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 1439.
https://doi.org/10.1182/blood.V114.22.1439.1439
Published: 2009
Journal Articles

Cyclopamine Induced Apoptosis in Primary CD34+ Acute Leukemic Cells.

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Rishu Takimoto, MD, PhD, Yutaka Kawano, MD, PhD, Shohei Kikuchi, MD., Koji Miyanishi, MD, PhD, Yasushi Sato, MD, PhD, Junji Kato, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 3768.
https://doi.org/10.1182/blood.V114.22.3768.3768
Published: 2009
Journal Articles

Hedgehog Inhibitors Reduce the Survival and Drug Resistance in CD34+ Leukemic Cells.

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Yutaka Kawano, MD, PhD, Shohei Kikuchi, MD, PhD, Koji Miyanishi, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1611.
https://doi.org/10.1182/blood.V112.11.1611.1611
Published: 2008
Journal Articles

Wnt3 Signaling Augments integrinβ1-Dependent Adhesion-Mediated Drug Resistance of Multiple Myeloma in Autocrine and Paracrine Manner.

Masayoshi Kobune, MD, PhD, Kazuyuki Murase, MD, PhD, Satoshi Iyama, MD, PhD, Tsutomu Sato, MD, PhD, Yutaka Kawano, MD, PhD, Shohei Kikuchi, MD, PhD, Koji Miyanishi, MD, PhD, Rishu Takimoto, MD, PhD, Junji Kato, MD, PhD
Journal: Blood
Blood (2008) 112 (11): 1698.
https://doi.org/10.1182/blood.V112.11.1698.1698
Published: 2008