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Journal Articles

FT-4202, an Allosteric Activator of Pyruvate Kinase-R, Demonstrates Proof of Mechanism and Proof of Concept after a Single Dose and after Multiple Daily Doses in a Phase 1 Study of Patients with Sickle Cell Disease

R. Clark Brown, MD PhD, Kimberly Cruz, MD MS, Theodosia A. Kalfa, MD PhD, Frans A. Kuypers, PhD, Santosh L. Saraf, MD, Jeremie H. Estepp, MD, Luke R. Smart, MD, Punam Malik, MD, Mark Lerman, MD, Renae Mayer, MD, Maria D. Ribadeneira, PhD, Sanjeev Forsyth, MS, Patricia Schroeder, PhD, Eric Wu, PhD, Patrick Kelly, MD, Marilyn J. Telen, MD

Blood (2020) 136 (Supplement 1): 19–20.

https://doi.org/10.1182/blood-2020-134269

Published: 2020

Journal Articles

Mass-Spectrometry Analysis of Urinary Biomarkers of Endothelial Injury in Sickle Cell Anemia Patients

Harold Girum Dorsey, BS, Tatiana Ammosova, PhD, Santosh L. Saraf, MD, Victor R. Gordeuk, MD, Sergei Nekhai, PhD, Marina Jerebtsova, PhD

Blood (2020) 136 (Supplement 1): 28–29.

https://doi.org/10.1182/blood-2020-138446

Published: 2020

Journal Articles

The Effect of Crizanlizumab on the Number of Days Requiring Opioid Use for Management of Pain Associated with Vaso-Occlusive Crises in Patients with Sickle Cell Disease: Results from the Sustain Trial

Wally R Smith, MD, Kenneth I. Ataga, MD, Santosh L. Saraf, MD, Olufolake A. Adisa, MDMSc, Miranda Bailey, Nicholas Ramscar, MBBS, Ashley Bonner, PhD, Stephen Brown, PhD, Laura Pastor, MSc

Blood (2020) 136 (Supplement 1): 32–33.

https://doi.org/10.1182/blood-2020-140428

Published: 2020

Journal Articles

Lower Apache II Score and Exchange Transfusions Predict Better Outcomes in the Intensive Care Unit for Patients with Sickle Cell Disease

Renee Cheng, MD, Andrew Srisuwananukorn, MD, Jin Han, Michel Gowhari, DO, Franklin Njoku, MD, Faiz Ahmed Hussain, MD, Robert E. Molokie, MD, Victor R. Gordeuk, MD, Santosh L. Saraf, MD

Blood (2020) 136 (Supplement 1): 18–19.

https://doi.org/10.1182/blood-2020-137272

Published: 2020

Journal Articles

Use of Multiple Urinary Biomarkers for Early Detection of Chronic Kidney Disease in Sickle Cell Anemia Patients

Yagahira E. Castro-Sesquen, PhD, Santosh L. Saraf, MD, Victor R. Gordeuk, MD, Sergei Nekhai, PhD, Marina Jerebtsova, PhD

Blood (2020) 136 (Supplement 1): 30.

https://doi.org/10.1182/blood-2020-139500

Published: 2020

Journal Articles

Correction of Point-of-Care International Normalized Ratio (INR) Values in Patients with Sickle Cell Disease

Syeda Rahman, Andrew Srisuwananukorn, MD, Robert E. Molokie, MD, Michel Gowhari, DO, Franklin Njoku, MD, Faiz Ahmed Hussain, MD, Edith A. Nutescu, PharmD., MS, FCCP, Victor R. Gordeuk, MD, Santosh L. Saraf, MD, Jin Han

Blood (2020) 136 (Supplement 1): 34–35.

https://doi.org/10.1182/blood-2020-137166

Published: 2020

Journal Articles

Effects of Hydroxyurea and Renin-Angiotensin Blockade on Kidney Function in Sickle Cell Disease

Jin Han, Andrew Srisuwananukorn, MD, Michel Gowhari, DO, Faiz Ahmed Hussain, MD, Franklin Njoku, MD, Robert E. Molokie, MD, Victor R. Gordeuk, MD, Santosh L. Saraf, MD

Blood (2020) 136 (Supplement 1): 21–22.

https://doi.org/10.1182/blood-2020-138753

Published: 2020

Journal Articles

Cancer Incidence and Chemotherapy Tolerance in Patients with Sickle Cell Disease

Mahir Khan, MD, Andrew Srisuwananukorn, MD, Santosh L. Saraf, MD, Faiz Ahmed Hussain, MD, Robert E. Molokie, MD, Michel Gowhari, DO, Victor R. Gordeuk, MD, Franklin Njoku, MD

Blood (2020) 136 (Supplement 1): 24–25.

https://doi.org/10.1182/blood-2020-139653

Published: 2020

Journal Articles

Real World Outcomes of Sars-Cov-2 Thrombosis Rates across Three University Health Systems in the Chicago Metropolitan Area

Blood (2020) 136 (Supplement 1): 58–59.

https://doi.org/10.1182/blood-2020-135929

Published: 2020

Journal Articles

Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, in Healthy and Sickle Cell Disease Subjects

Theodosia A. Kalfa, MD PhD, Frans A Kuypers, PhD, Marilyn J. Telen, MD, Punam Malik, MD, Diamantis G. Konstantinidis, PhD BSc, Jeremy H. Estepp, MD, Hyon J. Kim, MD PhD, Santosh L. Saraf, MD, Lindsey Wilson, Maria D Ribadeneira, PhD, Sanjeev Forsyth, Patricia Schroeder, Adam Drake, Olga Polyanskaya, Patrick Kelly, MD, Lukasz Biernat, MD

Blood (2019) 134 (Supplement_1): 616.

https://doi.org/10.1182/blood-2019-121889

Published: 2019

Journal Articles

Thrombomodulin and Endothelial Dysfunction in Sickle Cell Anemia

Maria Armila Ruiz, MS, Binal N. Shah, Jin Han, PharmD, PhD, Rasha Raslan, MD, Victor R Gordeuk, MD, Santosh L. Saraf, MD

Blood (2019) 134 (Supplement_1): 3558.

https://doi.org/10.1182/blood-2019-123862

Published: 2019

Journal Articles

Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia

Santosh L. Saraf, MD, Vimal K. Derebail, MD, Xu Zhang, PhD, Mark T Gladwin, MD, Victor R Gordeuk, MD, Jane A. Little, MD

Blood (2019) 134 (Supplement_1): 2268.

https://doi.org/10.1182/blood-2019-124737

Published: 2019

Journal Articles

Risk Factors for Kidney Disease in Hb SC and Hb Sβ + -Thalassemia Sickle Cell Disease

Mandella Mensah, Binal N. Shah, Xu Zhang, PhD, Jin Han, PharmD, PhD, Michel Gowhari, DO, Robert E. Molokie, MD, Mark T Gladwin, MD, Victor R Gordeuk, MD, Santosh L. Saraf, MD

Blood (2019) 134 (Supplement_1): 2299.

https://doi.org/10.1182/blood-2019-128668

Published: 2019

Journal Articles

The Effect of Crizanlizumab Plus Standard of Care (SoC) Versus Soc Alone on Renal Function in Patients with Sickle Cell Disease and Chronic Kidney Disease: A Randomized, Multicenter, Open-Label, Phase II Study (STEADFAST)

Kenneth I. Ataga, MD, Santosh L. Saraf, MD, Vimal K. Derebail, MD, Claire C. Sharpe, Adlette Inati, MD, Jeffrey D. Lebensburger, DO, MSPH, Laurie DeBonnett, MD, Shirong Zhang, Pablo Bartolucci, MD PhD

Blood (2019) 134 (Supplement_1): 1018.

https://doi.org/10.1182/blood-2019-124823

Published: 2019

Journal Articles

Biomarkers of Cardiopulmonary, Renal, and Liver Dysfunction in an Adult Sickle Cell Disease Cohort

Xu Zhang, PhD, Binal N. Shah, Roberto Machado, MD, Santosh L. Saraf, MD, Victor R Gordeuk, MD

Blood (2019) 134 (Supplement_1): 3574.

https://doi.org/10.1182/blood-2019-131813

Published: 2019

Journal Articles

Impact of Intravenous Opioid Shortage on Managing Pain Crisis in Sickle Cell Disease

Jin Han, PharmD, PhD, Santosh L. Saraf, MD, Michel Gowhari, DO, Faiz Ahmed Hussain, MD, Shivi Jain, MD, Laura Kavoliunaite, APN, Robert E. Molokie, MD, Victor R Gordeuk, MD

Blood (2019) 134 (Supplement_1): 3390.

https://doi.org/10.1182/blood-2019-122249

Published: 2019

Journal Articles

Progression of Albuminuria in Sickle Cell Anemia: A Multicenter, Longitudinal Study

Omar Niss, MD, Adam Lane, PhD, Monika Asnani, PhD, Marianne McPherson Yee, MD MSc, Ashok Raj, Susan E Creary, MD, Courtney D. Fitzhugh, MD, Prasad V. Bodas, MD, Santosh L. Saraf, MD, Sharada Sarnaik, MD, Charles T. Quinn, MD, Prasad Devarajan, MD, Punam Malik, MD

Blood (2019) 134 (Supplement_1): 1004.

https://doi.org/10.1182/blood-2019-125860

Published: 2019

Journal Articles

Maximum Tolerated Dose Versus Fixed Low-Dose Hydroxyurea for Treatment of Adults with Sickle Cell Anemia - Retrospective Comparison of Two Studies

Titilola S. Akingbola, MBBS, FWACP, Bamidele Tayo, PhD, Chinedu A Ezekekwu, MBBS, Omowunmi Sonubi, MBBS, Santosh L. Saraf, MD, Lewis L. Hsu, Jin Han, PharmD, PhD, Richard S. Cooper, MD, Victor R. Gordeuk, MD

Blood (2018) 132 (Supplement 1): 3656.

https://doi.org/10.1182/blood-2018-99-114990

Published: 2018

Journal Articles

Kidney Ultrasound Findings in Sickle Cell Anemia According to Kidney Disease and the APOL1 G1/G2 Risk Variants

Sandra Kang, MD, Rishi Patel, MD, Ali Kord Valeshabad, MD, Binal N. Shah, PhD, Rishabh Choudhari, Dallas De La Vara, Jin Han, PharmD, PhD, Michel Gowhari, DO, Shivi Jain, MD, Robert E. Molokie, MD, Karen Xie, MD, James P. Lash, MD, Victor R. Gordeuk, MD, Santosh L. Saraf, MD

Blood (2018) 132 (Supplement 1): 3663.

https://doi.org/10.1182/blood-2018-99-113637

Published: 2018

Journal Articles

Pulmonary Function Abnormalities in Adults with Sickle Cell Anemia

Adam Rock, MD, Binal N. Shah, PhD, Jin Han, PharmD, PhD, Rasha Raslan, MD, Michel Gowhari, DO, Shivi Jain, MD, Xu Zhang, PhD, Robert E. Molokie, MD, Victor R. Gordeuk, MD, Santosh L. Saraf, MD

Blood (2018) 132 (Supplement 1): 3664.

https://doi.org/10.1182/blood-2018-99-114820

Published: 2018

NARROW

FT-4202, an Allosteric Activator of Pyruvate Kinase-R, Demonstrates Proof of Mechanism and Proof of Concept after a Single Dose and after Multiple Daily Doses in a Phase 1 Study of Patients with Sickle Cell Disease

Mass-Spectrometry Analysis of Urinary Biomarkers of Endothelial Injury in Sickle Cell Anemia Patients

The Effect of Crizanlizumab on the Number of Days Requiring Opioid Use for Management of Pain Associated with Vaso-Occlusive Crises in Patients with Sickle Cell Disease: Results from the Sustain Trial

Lower Apache II Score and Exchange Transfusions Predict Better Outcomes in the Intensive Care Unit for Patients with Sickle Cell Disease

Use of Multiple Urinary Biomarkers for Early Detection of Chronic Kidney Disease in Sickle Cell Anemia Patients

Correction of Point-of-Care International Normalized Ratio (INR) Values in Patients with Sickle Cell Disease

Effects of Hydroxyurea and Renin-Angiotensin Blockade on Kidney Function in Sickle Cell Disease

Cancer Incidence and Chemotherapy Tolerance in Patients with Sickle Cell Disease

Real World Outcomes of Sars-Cov-2 Thrombosis Rates across Three University Health Systems in the Chicago Metropolitan Area

Phase 1 Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of FT-4202, an Allosteric Activator of Pyruvate Kinase-R, in Healthy and Sickle Cell Disease Subjects

Thrombomodulin and Endothelial Dysfunction in Sickle Cell Anemia

Manifestations of Reduced Kidney Function Occur at a Higher Estimated Glomerular Filtration Rate in Sickle Cell Anemia

Risk Factors for Kidney Disease in Hb SC and Hb Sβ + -Thalassemia Sickle Cell Disease

The Effect of Crizanlizumab Plus Standard of Care (SoC) Versus Soc Alone on Renal Function in Patients with Sickle Cell Disease and Chronic Kidney Disease: A Randomized, Multicenter, Open-Label, Phase II Study (STEADFAST)

Biomarkers of Cardiopulmonary, Renal, and Liver Dysfunction in an Adult Sickle Cell Disease Cohort

Impact of Intravenous Opioid Shortage on Managing Pain Crisis in Sickle Cell Disease

Progression of Albuminuria in Sickle Cell Anemia: A Multicenter, Longitudinal Study

Maximum Tolerated Dose Versus Fixed Low-Dose Hydroxyurea for Treatment of Adults with Sickle Cell Anemia - Retrospective Comparison of Two Studies

Kidney Ultrasound Findings in Sickle Cell Anemia According to Kidney Disease and the APOL1 G1/G2 Risk Variants

Pulmonary Function Abnormalities in Adults with Sickle Cell Anemia

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American Society of Hematology

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ASH Publications

American Society of Hematology

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